REFERENCES
- Aaronson, D. S., and C. M. Horvath. 2002. A road map for those who don't know JAK-STAT. Science 296: 1653–1655.
- Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1994. Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
- Berk, A. J. 1999. Activation of RNA polymerase II transcription. Curr. Opin. Cell Biol. 11: 330–335.
- Bhattacharya, S., R. Eckner, S. Grossman, E. Oldread, Z. Arany, A. D'Andrea, and D. M. Livingston. 1996. Cooperation of Stat2 and p300/CBP in signalling induced by interferon α. Nature 383: 344–347.
- Biron, C. A. 2001. Interferons alpha and beta as immune regulators—a new look. Immunity 14: 661–664.
- Boube, M., L. Joulia, D. L. Cribbs, and H. M. Bourbon. 2002. Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Cell 110: 143–151.
- Boyer, T. G., M. E. Martin, E. Lees, R. P. Ricciardi, and A. J. Berk. 1999. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein. Nature 399: 276–279.
- Burakov, D., L. A. Crofts, C. P. Chang, and L. P. Freedman. 2002. Reciprocal recruitment of DRIP/mediator and p160 coactivator complexes in vivo by estrogen receptor. J. Biol. Chem. 277: 14359–14362.
- Burakov, D., C. W. Wong, C. Rachez, B. J. Cheskis, and L. P. Freedman. 2000. Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex. J. Biol. Chem. 275: 20928–20934.
- Darnell, J. E., Jr., I. M. Kerr, and G. M. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415–1421.
- Dotson, M. R., C. X. Yuan, R. G. Roeder, L. C. Myers, C. M. Gustafsson, Y. W. Jiang, Y. Li, R. D. Kornberg, and F. J. Asturias. 2000. Structural organization of yeast and mammalian mediator complexes. Proc. Natl. Acad. Sci. USA 97: 14307–14310.
- Fondell, J. D., H. Ge, and R. G. Roeder. 1996. Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc. Natl. Acad. Sci. USA 93: 8329–8333.
- Ge, K., M. Guermah, C. X. Yuan, M. Ito, A. E. Wallberg, B. M. Spiegelman, and R. G. Roeder. 2002. Transcription coactivator TRAP220 is required for PPARγ2-stimulated adipogenesis. Nature 417: 563–567.
- Gu, W., S. Malik, M. Ito, C. X. Yuan, J. D. Fondell, X. Zhang, E. Martinez, J. Qin, and R. G. Roeder. 1999. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol. Cell 3: 97–108. (Erratum, 3: 541.)
- Hermanson, O., C. K. Glass, and M. G. Rosenfeld. 2002. Nuclear receptor coregulators: multiple modes of modification. Trends Endocrinol. Metab. 13: 55–60.
- Hittelman, A. B., D. Burakov, J. A. Iniguez-Lluhi, L. P. Freedman, and M. J. Garabedian. 1999. Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. EMBO J. 18: 5380–5388.
- Horvath, C. M. 2000. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem. Sci. 25: 496–502.
- Horvath, C. M., G. R. Stark, I. M. Kerr, and J. E. Darnell. 1996. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol. Cell. Biol. 16: 6957–6964.
- Horvath, C. M., Z. Wen, and J. E. Darnell, Jr. 1995. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 9: 984–994.
- Ikeda, K., T. Stuehler, and M. Meisterernst. 2002. The H1 and H2 regions of the activation domain of herpes simplex virion protein 16 stimulate transcription through distinct molecular mechanisms. Genes Cells 7: 49–58.
- Ito, M., H. J. Okano, R. B. Darnell, and R. G. Roeder. 2002. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J. 21: 3464–3475.
- Ito, M., and R. G. Roeder. 2001. The TRAP/SMCC/Mediator complex and thyroid hormone receptor function. Trends Endocrinol. Metab. 12: 127–134.
- Ito, M., C. X. Yuan, S. Malik, W. Gu, J. D. Fondell, S. Yamamura, Z. Y. Fu, X. Zhang, J. Qin, and R. G. Roeder. 1999. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol. Cell 3: 361–370.
- Kang, Y. K., M. Guermah, C. X. Yuan, and R. G. Roeder. 2002. The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. Proc. Natl. Acad. Sci. USA 99: 2642–2647.
- Kessler, D. S., S. A. Veals, X.-Y. Fu, and D. E. Levy. 1990. Interferon-α regulates nuclear translocation and DNA-binding affinity of ISGF-3, a multimeric transcriptional activator. Genes Dev. 4: 1753–1765.
- Kim, Y. J., S. Bjorklund, Y. Li, M. H. Sayre, and R. D. Kornberg. 1994. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 77: 599–608.
- Kingston, R. E. 1999. A shared but complex bridge. Nature 399: 199–200.
- Lau, J. F., and C. M. Horvath. 2002. Mechanisms of type I interferon cell signaling and STAT-mediated transcriptional responses. Mt. Sinai J. Med. 69: 156–168.
- Lau, J. F., J.-P. Parisien, and C. M. Horvath. 2000. Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors. Proc. Natl. Acad. Sci. USA 97: 7278–7283.
- Lee, Y. C., J. M. Park, S. Min, S. J. Han, and Y. J. Kim. 1999. An activator binding module of yeast RNA polymerase II holoenzyme. Mol. Cell. Biol. 19: 2967–2976.
- Lemon, B., and R. Tjian. 2000. Orchestrated response: a symphony of transcription factors for gene control. Genes Dev. 14: 2551–2569.
- Levy, D. E., D. J. Lew, T. Decker, D. S. Kessler, and J. E. Darnell, Jr. 1990. Synergistic interaction between interferon-α and interferon-γ through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J. 9: 1105–1111.
- Li, Y., S. Bjorklund, Y. W. Jiang, Y. J. Kim, W. S. Lane, D. J. Stillman, and R. D. Kornberg. 1995. Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. USA 92: 10864–10868.
- Lorch, Y., J. Beve, C. M. Gustafsson, L. C. Myers, and R. D. Kornberg. 2000. Mediator-nucleosome interaction. Mol. Cell 6: 197–201.
- Malik, S., W. Gu, W. Wu, J. Qin, and R. G. Roeder. 2000. The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. Mol. Cell 5: 753–760.
- Malik, S., and R. G. Roeder. 2000. Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells. Trends Biochem. Sci. 25: 277–283.
- Merika, M., and D. Thanos. 2001. Enhanceosomes. Curr. Opin. Genet. Dev. 11: 205–208.
- Mittler, G., E. Kremmer, H. T. Timmers, and M. Meisterernst. 2001. Novel critical role of a human Mediator complex for basal RNA polymerase II transcription. EMBO Rep. 2: 808–813.
- Muller, M., C. Laxton, J. Briscoe, C. Schindler, T. Improta, J. E. Darnell, Jr., G. R. Stark, and I. M. Kerr. 1993. Complementation of a mutant cell line: central role of the 91-kDa polypeptide of ISGF3 in the interferon-α and -γ signal transduction pathway. EMBO J. 12: 4221–4228.
- Myers, L. C., and R. D. Kornberg. 2000. Mediator of transcriptional regulation. Annu. Rev. Biochem. 69: 729–749.
- Naar, A. M., P. A. Beaurang, S. Zhou, S. Abraham, W. Solomon, and R. Tjian. 1999. Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature 398: 828–832.
- Naar, A. M., B. D. Lemon, and R. Tjian. 2001. Transcriptional coactivator complexes. Annu. Rev. Biochem. 70: 475–501.
- Park, C., M. J. Lecomte, and C. Schindler. 1999. Murine Stat2 is uncharacteristically divergent. Nucleic Acids Res. 27: 4191–4199.
- Paulson, M., S. Pisharody, L. Pan, S. Guadagno, A. L. Mui, and D. E. Levy. 1999. Stat protein transactivation domains recruit p300/CBP through widely divergent sequences. J. Biol. Chem. 274: 25343–25349.
- Paulson, M., C. Press, E. Smith, N. Tanese, and D. E. Levy. 2002. IFN-stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff. Nat. Cell Biol. 4: 140–147.
- Pokholok, D. K., N. M. Hannett, and R. A. Young. 2002. Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo. Mol. Cell 9: 799–809.
- Qureshi, S. A., S. Leung, I. M. Kerr, G. R. Stark, and J. E. Darnell, Jr. 1996. Function of Stat2 protein in transcriptional activation by IFN-α. Mol. Cell. Biol. 16: 288–293.
- Rachez, C., and L. P. Freedman. 2001. Mediator complexes and transcription. Curr. Opin. Cell Biol. 13: 274–280.
- Rachez, C., M. Gamble, C. P. Chang, G. B. Atkins, M. A. Lazar, and L. P. Freedman. 2000. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. Mol. Cell. Biol. 20: 2718–2726.
- Rachez, C., B. D. Lemon, Z. Suldan, V. Bromleigh, M. Gamble, A. M. Naar, H. Erdjument-Bromage, P. Tempst, and L. P. Freedman. 1999. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature 398: 824–828.
- Rachez, C., Z. Suldan, J. Ward, C. P. Chang, D. Burakov, H. Erdjument-Bromage, P. Tempst, and L. P. Freedman. 1998. A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev. 12: 1787–1800.
- Ryu, S., S. Zhou, A. G. Ladurner, and R. Tjian. 1999. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Nature 397: 446–450.
- Samuel, C. E. 2001. Antiviral actions of interferons. Clin. Microbiol. Rev. 14: 778–809.
- Shim, E. Y., A. K. Walker, and T. K. Blackwell. 2002. Broad requirement for the mediator subunit RGR-1 for transcription in the C. elegans embryo. J. Biol. Chem. 277: 30413–30416.
- Shuai, K., C. M. Horvath, L. H. Tsai-Huang, S. Qureshi, D. Cowburn, and J. E. Darnell, Jr. 1994. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76: 821–828.
- Stocklin, E., M. Wissler, F. Gouilleux, and B. Groner. 1996. Functional interactions between Stat5 and the glucocorticoid receptor. Nature 383: 726–728.
- Stoecklin, E., M. Wissler, R. Moriggl, and B. Groner. 1997. Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription. Mol. Cell. Biol. 17: 6708–6716.
- Struhl, K. 1998. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 12: 599–606.
- Sun, X., Y. Zhang, H. Cho, P. Rickert, E. Lees, W. Lane, and D. Reinberg. 1998. NAT, a human complex containing Srb polypeptides, that functions as a negative regulator of activated transcription. Mol. Cell 2: 213–222.
- Veals, S. A., C. Schindler, D. Leonard, X.-Y. Fu, R. Aebersold, J. E. Darnell, Jr., and D. E. Levy. 1992. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding protein. Mol. Cell. Biol. 12: 3315–3324.
- Vidal, M., C. V. Ramana, and A. S. Dusso. 2002. Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance Stat1-mediated transcription. Mol. Cell. Biol. 22: 2777–2787.
- Zhang, Z., S. Jones, J. S. Hagood, N. L. Fuentes, and G. M. Fuller. 1997. STAT3 acts as a co-activator of glucocorticoid receptor signaling. J. Biol. Chem. 272: 30607–30610.