Prox1 Is a Novel Coregulator of Ff1b and Is Involved in the Embryonic Development of the Zebra Fish Interrenal Primordium

REFERENCES

• Ahmad, W., M. Faiyaz ul Haque, V. Brancolini, H. C. Tsou, S. ul Haque, H. Lam, V. M. Aita, J. Owen, M. deBlaquiere, J. Frank, P. B. Cserhalmi-Friedman, A. Leask, A. J. McGrath, M. Peacocke, M. Ahmad, J. Ott, and A. M. Christiano. 1998. Alopecia universalis associated with a mutation in the human hairless gene. Science 279: 720–724.
   PubMed Web of Science ®Google Scholar
• Aranda, A., and A. Pascual. 2001. Nuclear hormone receptors and gene expression. Physiol. Rev. 81: 1270–1304.
   Google Scholar
• Babu, P. S., D. L. Bavers, F. Beuschlein, S. Shah, B. Jeffs, J. L. Jameson, and G. D. Hammer. 2002. Interaction between Dax-1 and steroidogenic factor-1 in vivo: increased adrenal responsiveness to ACTH in the absence of Dax-1. Endocrinology 143: 665–673.
   PubMed Web of Science ®Google Scholar
• Beckstead, R., J. A. Ortiz, C. Sanche, S. N. Prokopenko, P. Chambon, R. Losson, and H. J. Bellen. 2001. Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit betaFTZ-F1-dependent transcription. Mol. Cell 7: 753–765.
   PubMedGoogle Scholar
• Burke, Z., and G. Oliver. 2002. Prox1 is an early specific maker for the developing liver and pancreas in the mammalian foregut endoderm. Mech. Dev. 118: 147–155.
   PubMedGoogle Scholar
• Burris, T. B., W. Guo, and E. R. McCabe. 1996. The gene responsible for adrenal hypoplasia congenita, DAX-1, encodes a nuclear hormone receptor that defines a new class within the superfamily. Recent Prog. Horm. Res. 51: 241–259.
   PubMedGoogle Scholar
• Call, K. M., T. Glaser, C. Y. Ito, A. J. Buckler, J. Pelletier, D. A. Haber, E. A. Rose, A. Kral, H. Yeger, W. H. Lewis, C. Jones, and D. E. Housman. 1990. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 60: 509–520.
   PubMed Web of Science ®Google Scholar
• Chai, C., and W. K. Chan. 2000. Developmental expression of a novel Ftz-F1 homologue, ff1b (5A4), in the zebra fish Danio rerio. Mech. Dev. 91: 421–426.
   PubMedGoogle Scholar
• Chai, C., Y. W. Liu, and W. K. Chan. 2003. ff1b is required for the development of steroidogenic component of the zebra fish interrenal organ. Dev. Biol. 260: 226–244.
   PubMed Web of Science ®Google Scholar
• Crawford, P. A, J. A. Polish, G. Ganpule, and Y. Sadovsky. 1997. The activation function-2 hexamer of steroidogenic factor-1 is required, but not sufficient, for potentiation by SRC-1. Mol. Endocrinol. 11: 1626–1635.
   PubMedGoogle Scholar
• Crawford, P. A., Y. Sadovsky, and J. Milbrandt. 1997. Nuclear receptor steroidogenic factor 1 directs embryonic stem cells towards the steroidogenic lineage. Mol. Cell. Biol. 17: 3997–4006.
   PubMedGoogle Scholar
• Crawford, P. A., C. Dorn, Y. Sadovsky, and J. Milbrandt. 1998. Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1. Mol. Cell. Biol: 18: 2949–2956.
   PubMed Web of Science ®Google Scholar
• de Santa Barbara, P., N. Bonneaud, B. Boizet, M. Desclozeaux, B. Moniot, P. Sudbeck, G. Scherer, F. Poulat, and P. Berta. 1998. Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Mullerian hormone gene. Mol. Cell. Biol. 18: 6653–6665.
   PubMedGoogle Scholar
• Deutsch, G., J. Jung, M. Zheng, J. Lora, and K. S. Zaret. 2001. A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 128: 871–881.
   PubMed Web of Science ®Google Scholar
• Gao, W. 2002. M.Sc. thesis. National University of Singapore, Singapore.
   Google Scholar
• Gessler, M., A. Poustka, W. Cavenee, R. L. Neve, S. H. Orkin, and G. A. Bruns. 1990. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature 343: 774–778.
   PubMed Web of Science ®Google Scholar
• Gizard, F., B. Lavallee, F. DeWitte, E. Teissier, B. Staels, and D. W. Hum. 2002. The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells. J. Biol. Chem. 277: 39144–39155.
   PubMedGoogle Scholar
• Glass, C. K., and M. G. Rosenfeld. 2000. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 14: 121–141.
   PubMed Web of Science ®Google Scholar
• Grassi Milano, E., F. Basari, and C. Chimenti. 1997. Adrenocortical and adrenomedullary homologs in eight species of adult and developing teleosts: morphology, histology, and immunohistochemistry. Gen. Comp. Endocrinol. 108: 483–496.
   PubMed Web of Science ®Google Scholar
• Gritsman, K., J. Zhang, S. Cheng, E. Heckscher, W. S. Talbot, and A. F. Schier. 1999. The EGF-CFC protein one-eyed pinhead is essential for nodal signaling. Cell 97: 121–132.
   PubMed Web of Science ®Google Scholar
• Gubler, M. C., Y. Yang, C. Jeanpierre, S. Barbaux, and P. Niaudet. 1999. WT-1, renal development, and glomerulopahies. Adv. Nephrol. Necker Hosp. 29: 299–315.
   PubMedGoogle Scholar
• Guichet, A., J. W. Copeland, M. Erdelyi, D. Hlousek, P. Zavorszky, J. Ho, S. Brown, A. Percival-Smith, H. M. Krause, and A. Ephrussi. 1997. The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors. Nature 385: 548–352.
   PubMedGoogle Scholar
• Halpern, M. E., R. K. Ho, C. Walker, and C. B. Kimmel. 1993. Induction of muscle pioneers and floor plate is distinguished by the zebra fish no tail mutation. Cell 75: 99–111.
   PubMed Web of Science ®Google Scholar
• Halpern, M. E., C. Thisse, R. K. Ho, B. Thisse, B. Riggleman, B. Trevarrow, E. S. Weinberg, J. H. Postlethwait, and C. B. Kimmel. 1995. Cell-autonomous shift from axial to paraxial mesodermal development in zebra fish floating head mutants. Development 121: 4257–4264.
   PubMedGoogle Scholar
• Hanley, N. A., W. E. Rainey, D. I. Wilson, S. G. Ball, and K. L. Parker. 2001. Expression profiles of SF-1, DAX1, and CYP17 in the human fetal adrenal gland: potential interactions in gene regulation. Mol. Endocrinol. 15: 57–68.
   PubMedGoogle Scholar
• Harris, A. N., and P. L. Mellon. 1998. The basic helix-loop-helix, leucine zipper transcription factor, USF (upstream stimulatory factor), is a key regulator of SF-1 (steroidogenic factor-1) gene expression in pituitary gonadotrope and steroidogenic cells. Mol. Endocrinol. 12: 714–726.
   PubMedGoogle Scholar
• Hassan, B., L. Li, K. A. Bremer, W. Chang, J. Pinsonneault, and H. Vaessin. 1997. Prospero is a panneural transcription factor that modulates homeodomain protein activity. Proc. Natl. Acad. Sci. USA 94: 10991–10996.
   PubMed Web of Science ®Google Scholar
• Heery, D. M., E. Kalkhoven, S. Hoare, and M. G. Parker. 1997. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387: 733–736.
   PubMed Web of Science ®Google Scholar
• Hong, Y. K., N. Harvey, Y. H. Noh, V. Schacht, S. Hirakawam, M. Detmar, and G. Oliver. 2002. Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev. Dyn. 225: 351–357.
   PubMedGoogle Scholar
• Hoyle, C., V. Narvaez, G. Alldus, R. Lovell-Badge, and A. Swain. 2002. Dax1 expression is dependent on steroidogenic factor 1 in the developing gonad. Mol. Endocrinol. 16: 747–756.
   PubMedGoogle Scholar
• Ikeda, Y., A. Swain, T. J. Weber, K. E. Hentges, E. Zanaria, E. Lalli, K. T. Tamai, P. Sassone-Corsi, R. Lovell-Badge, G. Camerino, and K. L. Parker. 1996. Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. Mol. Endocrinol. 10: 1261–1272.
   PubMedGoogle Scholar
• Keegan, C. E., and G. D. Hammer. 2002. Recent insights into organogenesis of the adrenal cortex. Trends Endocrinol. Metab. 13: 200–208.
   PubMed Web of Science ®Google Scholar
• Kimmel, C. B., W. W. Ballard, S. R. Kimmel, B. Ullmann, and T. F. Schilling. 1995. Stages of embryonic development of the zebra fish. Dev. Dyn. 203: 253–310.
   PubMed Web of Science ®Google Scholar
• Korzh, S., A. Emelyanov, and V. Korozh. 2001. Developmental analysis of ceruloplasmin gene and liver formation in zebra fish. Mech. Dev. 103: 137–139.
   PubMedGoogle Scholar
• Kreidberg, J. A., H. Sariola, J. M. Loring, M. Maeda, J. Pelletier, D. Housman, and R. Jaenisch. 1993. WT-1 is required for early kidney development. Cell 744: 679–691.
   Google Scholar
• Lee S. L., Y. Sadovsky A. H. Swirnoff, J. A. Polish, P. Goda, G. Gavrilina, and J. Milbrandt. 1996. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science 273: 1219–1221.
   PubMedGoogle Scholar
• Lengler, J., E. Krausz, S. Tomarev, A. Prescott, R. A. Quinlan, and J. Graw. 2001. Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter. Nucleic Acids Res. 29: 515–526.
   PubMedGoogle Scholar
• Li, L. A., D. Lala, and B. C. Chung. 1998. Function of steroidogenic factor 1 (SF1) ligand-binding domain in gene activation and interaction with AP1. Biochem. Biophys. Res. Commun. 250: 318–320.
   PubMedGoogle Scholar
• Li, L. A., E. F. Chiang, J. C. Chen, N. C. Hsu, Y. J. Chen, and B. C. Chung. 1999. Function of steroidogenic factor 1 domains in nuclear localization, transactivation, and interaction with transcription factor TFIIB and c-Jun. Mol. Endocrinol. 13: 1588–1598.
   PubMedGoogle Scholar
• Lin, W. W., H. W. Wang, C. Sum, D. Liu, C. L. Hew, and B. C. Chung. 2000. Zebrafish ftz-f1 gene has two promoters, is alternatively spliced, and is expressed in digestive organs. Biochem. J. 348: 439–446.
   PubMedGoogle Scholar
• Liu, D., M. Chandy, S. K. Lee, Y. Le Drean, H. Ando, F. Xiong, L. E. Woon, and C. L. Hew. 2000. A zebra fish Ftz-F1 (Fushi tarazu factor 1) homologue requires multiple subdomains in the D and E regions for its transcriptional activity. J. Biol. Chem. 275: 16758–16766.
   PubMedGoogle Scholar
• Luo, X., Y. Ikeda, and K. L. Parker. 1994. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77: 481–490.
   PubMed Web of Science ®Google Scholar
• McKenna, N. J., and B. W. O'Malley. 2002. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108: 465–474.
   PubMed Web of Science ®Google Scholar
• Miller, J. H. 1992. A short course in bacterial genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Moore, A. W., L. McInnes, J. Kreidberg, N. D. Hastie, and A. Schedl. 1999. YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 126: 1845–1857.
   PubMedGoogle Scholar
• Muscatelli, F., T. M. Strom, A. P. Walker, E. Zanaria, D. Recan, A. Meindl, B. Bardoni, S. Guioli, G. Zehetner, W. Rabl, H. P. Schwartz, J.-C. Kaplan, G. Camerino, T. Meitinger, and A. P. Monaco. 1994. Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Nature 372: 672–676.
   PubMed Web of Science ®Google Scholar
• Nachtigal, M. W., Y. Hirokawa, D. L. Enyeart-VanHouten, J. N. Flanagan, G. D. Hammer, and H. A. Ingraham. 1998. Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression. Cell 93: 445–454.
   PubMed Web of Science ®Google Scholar
• Nomura, M., H. Nawata, and K. Morohash. 1996. Autoregulatory loop in the regulation of the mammalian ftz-f1 gene. J. Biol. Chem. 271: 8243–8249.
   PubMedGoogle Scholar
• Odenthal, J., P. Haffter, E. Vogelsang, M. Brand, F. J. van Eeden, M. Furutani-Seiki, M. Granato, M. Hammerschmidt, C. P. Heisenberg, Y. J. Jiang, D. A. Kane, R. N. Kelsh, M. C. Mullins, R. M. Warga, M. L. Allende, E. S. Weinberg, and C. Nusslein-Volhard. 1996. Mutations affecting the formation of the notochord in the zebra fish, Danio rerio. Development 123: 103–115.
   PubMed Web of Science ®Google Scholar
• Oliver, G., B. Sosa-Pineda, S. Geisendorf, E. P. Spana, C. Q. Doe, and P. Gruss. 1993. Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech. Dev. 44: 13–16.
   Google Scholar
• Ou, Q., J. F. Mouillet, X. Yan, C. Dorn, P. A. Crawford, and Y. Sadovsky. 2001. The DEAD box protein DP103 is a regulator of steroidogenic factor-1. Mol. Endocrinol. 15: 1569–1579.
   Google Scholar
• Parker, K. L. 1998. The roles of steroidogenic factor 1 in endocrine development and function. Mol. Cell. Endocrinol. 145: 15–20.
   PubMed Web of Science ®Google Scholar
• Parker, K. L., and B. P. Schimmer. 2001. Genetics of the development and function of the adrenal cortex. Rev. Endocr. Metab. Disord. 2: 245–252.
   PubMedGoogle Scholar
• Panteleyev A. A., R. Paus, W. Ahmad, J. P. Sundberg, and A. M. Christiano. 1998. Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans. Exp. Dermatol. 7: 249–267.
   PubMedGoogle Scholar
• Petrova, T. V., T. Makinen, T. P. Makela, J. Saarela, I. Virtanen, R. E. Ferrell, D. N. Finegold, D. Kerjaschki, S. Yla-Herttuala, and K. Alitalo. 2002. Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J. 21: 4593–4599.
   PubMedGoogle Scholar
• Potter, G. B., G. M. Beaudoin III, C. L. DeRenzo, J. M. Zarach, S. H. Chen, and C. C. Thompson. 2001. The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Genes Dev. 15: 2687–2701.
   PubMed Web of Science ®Google Scholar
• Robyr, D., A. P. Wolffe, and W. Wahli. 2000. Nuclear hormone receptor coregulators in action: diversity for shared tasks. Mol. Endocrinol. 14: 329–347.
   PubMedGoogle Scholar
• Roy, S., C. Wolff, and P. W. Ingham. 2001. The u-boot mutation identifies a Hedgehog-regulated myogenic switch for fiber-type diversification in the zebra fish embryo. Genes Dev. 15: 1563–1576.
   PubMed Web of Science ®Google Scholar
• Sadovsky, Y., P. A. Crawford, K. G. Woodson, J. A. Polish, M. A. Clements, L. M. Tourtellotte, K. Simburger, and J. Milbrandt. 1995. Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids. Proc. Natl. Acad. Sci. USA 92: 10939–10943.
   PubMed Web of Science ®Google Scholar
• Schier, A. F., S. C. Neuhauss, M. Harvey, J. Malicki, L. Solnica-Krezel, D. Y. Stainier, F. Zwartkruis, S. Abdelilah, D. L. Stemple, Z. Rangini, H. Yang, and W. Driever. 1996. Mutations affecting the development of the embryonic zebra fish brain. Development 123: 165–178.
   PubMed Web of Science ®Google Scholar
• Schier, A. F., S. C. Neuhauss, K. A. Helde, W. S. Talbot, and W. Driever. 1997. The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebra fish and interacts with no tail. Development 124: 327–342.
   PubMedGoogle Scholar
• Schulte-Merker, S., F. J. van Eeden, M. E. Halpern, C. B. Kimmel, and C. Nusslein-Volhard. 1994. no tail (ntl) is the zebra fish homologue of the mouse T (Brachyury) gene. Development 120: 1009–1015.
   PubMed Web of Science ®Google Scholar
• Schwartz, C. J., H. M. Sampson, D. Hlousek, A. Percival-Smith, J. W. Copeland, A. J. Simmonds, and H. M. Krause. 2001. FTZ-Factor 1 and Fushi tarazu interact via conserved nuclear receptor and coactivator motifs. EMBO J. 20: 510–519.
   PubMedGoogle Scholar
• Shen, W. H., C. C. Moore, Y. Ikeda, K. L. Parker, and H. A. Ingraham. 1994. Nuclear receptor steroidogenic factor 1 regulates the mullerian inhibiting substance gene: a link to the sex determination cascade. Cell 77: 651–661.
   PubMed Web of Science ®Google Scholar
• Shen, H. C., and H. A. Ingraham. 2002. Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Mol. Endcrinol. 16: 529–540.
   PubMedGoogle Scholar
• Shinoda, K., H. Lei, H. Yoshii, M. Nomura, M. Nagano, H. Shiba, H. Sasaki, Y. Osawa, Y. Ninomiya, O. Niwa, K.-I. Morohashi, and E. Li. 1995. Developmental defects of the ventromedial hypothalamic nucleus and pituitary gonadotroph in the Ftz-F1 disrupted mice. Dev. Dyn. 204: 22–29.
   PubMed Web of Science ®Google Scholar
• Sosa-Pineda, B., J. T. Wigle, and G. Loiver. 2000. Hepatocyte migration during liver development required Prox1. Nat. Genet. 25: 254–255.
   PubMed Web of Science ®Google Scholar
• Sugawara, T., S. Abe, N. Sakuragi, Y. Fujimoto, E. Nomura, K. Fujieda, M. Saito, and S. Fujimoto. 2001. RIP 140 modulates transcription of the steroidogenic acute regulatory protein gene through interactions with both SF-1 and DAX-1. Endocrinology 142: 3570–3577.
   PubMedGoogle Scholar
• Suzuki, T., H. Kawasaki, R. T. Yu, H. Ueda, and K. Umesono. 2001. Segmentation gene product Fushi tarazu is an LXXLL motif-dependent coactivator for orphan receptor FTZ-F1. Proc. Natl. Acad. Sci. USA 98: 12403–12408.
   PubMedGoogle Scholar
• Swain, A., E. Zanaria, A. Hacker, R. Lovell-Badge, and G. Camerino. 1996. Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function. Nat. Genet. 12: 404–409.
   PubMed Web of Science ®Google Scholar
• Talbot, W. S., B. Trevarrow, M. E., Halpern, A. E. Melby, G. Farr, J. H. Postlethwait, T. Jowett, C. B. Kimmel, and D. Kimelman. 1995. A homeobox gene essential for zebra fish notochord development. Nature 378: 150–157.
   PubMed Web of Science ®Google Scholar
• Tremblay, J. J., C. Lanctot, and J. Drouin. 1998. The pan-pituitary activator of transcription, Ptx1 (pituitary homeobox 1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the Lim-homeodomain gene Lim3/Lhx3. Mol. Endocrinol. 12: 428–441.
   PubMedGoogle Scholar
• Tremblay, J. J., and R. S. Viger. 1999. Transcription factor GATA-4 enhances Mullerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1. Mol. Endocrinol. 13: 1388–1401.
   PubMedGoogle Scholar
• Ueda, H., G. C. Sun, T. Murata, and S. Hirose. 1992. A novel DNA-binding motif abuts the zinc finger domain of insect nuclear hormone receptor FTZ-F1 and mouse embryonal long terminal repeat-binding protein. Mol. Cell. Biol. 12: 5667–5672.
   PubMedGoogle Scholar
• Westerfield, M. 2000. The zebra fish book, 4th ed. University of Oregon Press, Eugene.
   Google Scholar
• Wigle, J. T., K. Chowdhury, P. Gruss, and G. Oliver. 1999. Prox1 function is crucial for mouse lens-fibre elongation. Nat. Genet. 21: 318–322.
   PubMedGoogle Scholar
• Wigle, J. T., and G. Oliver. 1999. Prox1 function is required for the development of the murine lymphatic system. Cell 98: 769–778.
   PubMed Web of Science ®Google Scholar
• Wigle, J. T., N. Harvey, M. Detmar, I. Lagutina, G. Grosveld, M. D. Gunn, D. G. Jackson, and G. Oliver. 2002. An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J. 21: 1505–1513.
   PubMed Web of Science ®Google Scholar
• Wilson, T. E., T. J. Fahrner, and J. Milbrandt. 1993. The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Mol. Cell. Biol. 13: 5794–5804.
   PubMedGoogle Scholar
• Yu, Y., W. Li, K. Su, M. Yussa, W. Han, N. Perrimon, and L. Pick. 1997. The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz. Nature 385: 552–555.
   PubMedGoogle Scholar
• Yu, R. N., M. Ito, T. L. Saunders, S. A. Camper, and J. L. Jameson. 1998. Role of Ahch in gonadal development and gametogenesis. Nat. Genet. 20: 353–357.
   PubMed Web of Science ®Google Scholar
• Zanaria, E., F. Muscatelli, B. Bardoni, T. M. Strom, S. Guioli, W. Guo, E. Lalli, C. Moser, A. P. Walker, E. R. McCabe, T. Meitinger, A. P. Monaco, P. Sassone-Corsi, and G. Camerino. 1994. An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature 372: 635–641.
   PubMed Web of Science ®Google Scholar
• Zhang, J., W. S. Talbot, and A. F. Schier. 1998. Positional cloning identifies zebra fish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation. Cell 92: 241–251.
   PubMedGoogle Scholar
• Zinovieva, R. D., M. K. Duncan, T. R. Johnson, R. Torres, M. H. Polymeropoulos, and S. I. Tomarev. 1996. Structure and chromosomal localization of the human homeobox gene Prox1. Genomics 35: 517–522.
   PubMedGoogle Scholar