152
Views
63
CrossRef citations to date
0
Altmetric
Nucleocytoplasmic Communication

Sec13 Shuttles between the Nucleus and the Cytoplasm and Stably Interacts with Nup96 at the Nuclear Pore Complex

, &
Pages 7271-7284 | Received 16 Jun 2003, Accepted 10 Jul 2003, Published online: 27 Mar 2023

REFERENCES

  • Aitchison, J. D., G. Blobel, and M. P. Rout. 1995. Nup120p: a yeast nucleoporin required for NPC distribution and mRNA transport. J. Cell Biol. 131: 1659–1675.
  • Belgareh, N., G. Rabut, S. W. Bai, M. van Overbeek, J. Beaudouin, N. Daigle, O. V. Zatsepina, F. Pasteau, V. Labas, M. Fromont-Racine, J. Ellenberg, and V. Doye. 2001. An evolutionary conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J. Cell Biol. 154: 1147–1160.
  • Carmo-Fonseca, M. 2002. The contribution of nuclear compartmentalization to gene regulation. Cell 108: 513–521.
  • Combet, C., C. Blanchet, C. Geourjon, and G. Deleage. 2000. NPS@Network Protein Sequence Analysis. Trends Biochem. Sci. 25: 147–150.
  • Cronshaw, J. M., A. N. Krutchinsky, W. Zhang, B. T. Chait, and M. J. Matunis. 2002. Proteomic analysis of the mammalian nuclear pore complex. J. Cell Biol. 158: 915–927.
  • Daigle, N., J. Beaudouin, L. Hartnell, G. Imreh, E. Hallberg, J. Lippincott-Schwartz, and J. Ellenberg. 2001. Nuclear pore complexes form immobile networks and a very low turnover in live mammalian cells. J. Cell Biol. 154: 71.
  • Davis, L. I., and G. Blobel. 1986. Identification and characterisation of a nuclear pore complex protein. Cell 45: 699–709.
  • Dockendorff, T. C., C. V. Heath, A. L. Goldstein, C. A. Snay, and C. N. Cole. 1997. C-terminal truncations of the yeast nucleoporin Nup145p produce a rapid temperature-conditional mRNA export defect and alterations to nuclear structure. Mol. Cell. Biol. 17: 906–920. (Erratum, Mol. Cell. Biol. 17: 2347-2350.)
  • Ellenberg, J., and J. Lippincott-Schwartz. 1997. Fluorescence photobleaching techniques, p. 79.1-79.23. In D. Spector, R. Goldman, and L. Leinwand (ed.), Cells: a laboratory manual, vol. 2. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Emtage, J., M. Bucci, J. Watkins, and S. Wente. 1997. Defining the essential functional regions of the nucleoporin Nup145p. J. Cell Sci. 110: 911–925.
  • Enninga, J., D. E. Levy, G. Blobel, and B. M. Fontoura. 2002. Role of nucleoporin induction in releasing an mRNA nuclear export block. Science 295: 1523–1525.
  • Fields, S., and O. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature 340: 245–246.
  • Finlay, D. R., E. Meier, P. Bradley, J. Horecka, and D. J. Forbes. 1991. A complex of nuclear pore proteins required for pore formation. J. Cell Biol. 114: 169–183.
  • Fontoura, B. M., G. Blobel, and M. J. Matunis. 1999. A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates nup98 and the novel nucleoporin, nup96. J. Cell Biol. 144: 1097–1112.
  • Fontoura, B. M., G. Blobel, and N. R. Yaseen. 2000. The nucleoporin nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import. J. Biol. Chem. 275: 31289–31296.
  • Fontoura, B. M. A., S. Dales, G. Blobel, and H. Zhong. 2001. The nucleoporin Nup98 associates with the intranucear filamentous protein network of TPR. Proc. Natl. Acad. Sci. USA 98: 3208–3213.
  • Galy, V., J. C. Olivo-Marin, H. Scherthan, V. Doye, N. Rascalou, and U. Nehrbass. 2000. Nuclear pore complexes in the organization of silent telomeric chromatin. Nature 403: 108–112.
  • Goldstein, A. L., C. A. Snay, C. V. Heath, and C. N. Cole. 1996. Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p. Mol. Biol. Cell 7: 917–934.
  • Guan, T., S. Muller, G. Klier, N. Pante, J. M. Blevitt, M. Haner, B. Paschal, U. Aebi, and L. Gerace. 1995. Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex. Mol. Biol. Cell 6: 1591–1603.
  • Hammond, A. T., and B. S. Glick. 2000. Dynamics of transitional endoplasmic reticulum sites in vertebrate cells. Mol. Biol. Cell 11: 3013–3030.
  • Harel, A., A. V. Orjalo, T. Vincent, A. Lachish-Zalait, S. Vasu, S. Shah, E. Zimmerman, M. Elbaum, and D. J. Forbes. 2003. Removal of a single pore subcomplex results in vertebrate nuclei devoid of nuclear pores. Mol. Cell 11: 853–864.
  • Hetzer, M., O. J. Gruss, and I. W. Mattaj. 2002. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nat. Cell Biol. 4: E177–E184.
  • James, P., J. Halladay, and E. A. Craig. 1996. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144: 1425–1436.
  • Joseph, J., S. H. Tan, T. S. Karpova, J. G. McNally, and M. Dasso. 2002. SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles. J. Cell Biol. 156: 595–602.
  • Kaiser, C., and S. Ferro-Novick. 1998. Transport from the endoplasmic reticulum to the Golgi. Curr. Opin. Cell Biol. 10: 477–482.
  • Kita, K., S. Omata, and T. Horigome. 1993. Purification and characterization of a nuclear pore glycoprotein complex containing p62. J. Biol. Chem. 113: 377–382.
  • Kunzler, M., and E. Hurt. 2001. Targeting of Ran: variation on a common theme? J. Cell Sci. 114: 3233–3241.
  • Lutzmann, M., R. Kunze, A. Buerer, U. Aebi, and E. Hurt. 2002. Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins. EMBO J. 21: 387–397.
  • Matunis, M. J., E. Coutavas, and G. Blobel. 1996. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J. Cell Biol. 135: 1457–1470.
  • Muratani, M., D. Gerlich, S. M. Janicki, M. Gebhard, R. Eils, and D. L. Spector. 2002. Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus. Nat. Cell Biol. 4: 106–110.
  • Nanduri, J., and A. M. Tartakoff. 2001. The arrest of secretion response in yeast: signaling from the secretory path to the nucleus by Wsc proteins and Pkc1p. Mol. Cell 8: 281–289.
  • Phair, R. D., and T. Misteli. 2000. High mobility of proteins in the mammalian cell nucleus. Nature 404: 604–609.
  • Rosenblum, J. S., and G. Blobel. 1999. Autoproteolysis in nucleoporin biogenesis. Proc. Natl. Acad. Sci. USA 96: 11370–11375.
  • Rout, M. P., and J. D. Aitchison. 2001. The nuclear pore complex as a transport machine. J. Biol. Chem. 276: 16593–16596.
  • Rout, M. P., J. D. Aitchison, A. Suprapto, K. Hjertaas, Y. Zhao, and B. T. Chait. 2000. The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148: 635–651.
  • Ryan, K. J., and S. R. Wente. 2002. Isolation and characterization of new Saccharomyces cerevisiae mutants perturbed in nuclear pore complex assembly. BMC Genet. 3: 17.
  • Ryan, K. J., and S. R. Wente. 2000. The nuclear pore complex: a protein machine bridging the nucleus and cytoplasm. Curr. Opin. Cell Biol. 12: 361–371.
  • Santos-Rosa, H., H. Moreno, G. Simos, A. Segref, B. Fahrenkrog, N. Pante, and E. Hurt. 1998. Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores. Mol. Cell. Biol. 18: 6826–6838.
  • Saxena, K., C. Gaitatzes, M. T. Walsh, M. Eck, E. J. Neer, and T. F. Smith. 1996. Analysis of the physical properties and molecular modeling of Sec13: a WD repeat protein involved in vesicular traffic. Biochemistry 35: 15215–15221.
  • Segref, A., K. Sharma, V. Doye, A. Hellwig, J. Huber, R. Luhrmann, and E. C. Hurt. 1997. Mex67p which is an essential factor for nuclear mRNA export binds to both poly(A)+ RNA and nuclear pores. EMBO J. 16: 3256–3271.
  • Siniossoglou, S., M. Lutzmann, H. Santos-Rosa, K. Leonard, S. Mueller, U. Aebi, and E. Hurt. 2000. Structure and assembly of the Nup84p complex. J. Cell Biol. 149: 41–53.
  • Siniossoglou, S., C. Wimmer, M. Rieger, V. Doye, H. Tekotte, C. Weise, S. Emig, A. Segref, and E. C. Hurt. 1996. A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. Cell 84: 265–275.
  • Smith, T. F., C. Gaitatzes, K. Saxena, and E. J. Neer. 1999. The WD repeat: a common architecture for diverse functions. Trends Biochem. Sci. 24: 181–185.
  • Sukegawa, J., and G. Blobel. 1993. A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm. Cell 72: 29–38.
  • Tang, B. L., F. Peter, J. Krijnse-Locker, S. H. Low, G. Griffiths, and W. Hong. 1997. The mammalian homolog of yeast Sec13p is enriched in the intermediate compartment and is essential for protein transport from the endoplasmic reticulum to the Golgi apparatus. Mol. Cell. Biol. 17: 256–266.
  • Teixeira, M. T., S. Siniossoglou, S. Podtelejnikov, J. C. Benichou, M. Mann, B. Dujon, E. Hurt, and E. Fabre. 1997. Two functionally distinct domains generated by in vivo cleavage of Nup145p: a novel biogenesis pathway for nucleoporins. EMBO J. 16: 5086–5097.
  • Vasu, S., S. Shah, A. Orjalo, M. Park, W. H. Fischer, and D. J. Forbes. 2001. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. J. Cell Biol. 155: 339–353.
  • Vasu, S. K., and D. J. Forbes. 2001. Nuclear pores and nuclear assembly. Curr. Opin. Cell Biol. 13: 363–375.
  • Walther, T. C., A. Alves, H. Pickergill, I. Loiodice, M. Hetzer, V. Galy, B. B. Hulsmann, T. Kocher, M. Wilm, T. Allen, I. W. Mattaj, and V. Doye. 2003. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell 113: 195–206.
  • Ward, T. H., R. S. Polishchuck, S. Caplan, K. Hirschberg, and J. Lippincott-Schwartz. 2001. Maintenance of Golgi structure and function depends on the integrity of endoplasmic reticulum export. J. Cell Biol. 155: 557–570.
  • Wiesmeijer, K., C. Molenaar, I. M. Bekeer, H. J. Tanke, and R. W. Dirks. 2002. Mobile foci of Sp100 do not contain PML: PML bodies are immobile but PML and Sp100 proteins are not. J. Struct. Biol. 140: 180–188.
  • Wu, X., L. H. Kasper, R. T. Mantcheva, G. T. Mantchev, M. J. Springett, and J. M. van Deursen. 2001. Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function. Proc. Natl. Acad. Sci. USA 98: 3191–3196.
  • Yaseen, N. R., and G. Blobel. 1997. Cloning and characterization of human karyopherin beta3. Proc. Natl. Acad. Sci. USA 94: 4451–4456.
  • Yaseen, N. R., and G. Blobel. 1998. GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358. J. Biol. Chem. 274: 26493–26502.
  • Yokoyama, N., N. Hayashi, T. Seki, N. Pante, T. Ohba, K. Nishii, K. Kuma, T. Hayashida, T. Miyata, U. Aebi, et al. 1995. A giant nucleopore protein that binds Ran/TC4. Nature 376: 184–188.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.