Degradation of Transcription Repressor ZBRK1 through the Ubiquitin-Proteasome Pathway Relieves Repression of Gadd45a upon DNA Damage

REFERENCES

• Aberle, H., A. Bauer, J. Stappert, A. Kispert, and R. Kemler. 1997. β-Catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 16: 3797–3804.
   PubMed Web of Science ®Google Scholar
• Bellefroid, E. J., D. A. Poncelet, P. J. Lecocq, O. Revelant, and J. A. Martial. 1991. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Proc. Natl. Acad. Sci. USA 88: 3608–3612.
   PubMedGoogle Scholar
• Bignell, G. R., W. Warren, S. Seal, M. Takahashi, E. Rapley, R. Barfoot, H. Green, C. Brown, P. J. Biggs, S. R. Lakhani, C. Jones, J. Hansen, E. Blair, B. Hofmann, R. Siebert, G. Turner, D. G. Evans, C. Schrander-Stumpel, F. A. Beemer, A. van den Ouweland, D. Halley, B. Delpech, M. G. Cleveland, I. Leigh, J. Leisti, and S. Rasmussen. 2000. Identification of the familial cylindromatosis tumour-suppressor gene. Nat. Genet. 25: 160–165.
   PubMed Web of Science ®Google Scholar
• Chen, A., F. E. Kleiman, J. L. Manley, T. Ouchi, and Z. Q. Pan. 2002. Auto-ubiquitination of the BRCA1/BARD1 RING ubiquitin ligase. J. Biol. Chem. 277: 22085–22092.
   PubMed Web of Science ®Google Scholar
• Coux, O., K. Tanaka, and A. L. Goldberg. 1996. Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem. 65: 801–847.
   PubMed Web of Science ®Google Scholar
• Fan, S., J. Wang, R. Yuan, Y. Ma, Q. Meng, M. R. Erdos, R. G. Pestell, F. Yuan, K. J. Auborn, I. D. Goldberg, and E. M. Rosen. 1999. BRCA1 inhibition of estrogen receptor signaling in transfected cells. Science 284: 1354–1356.
   PubMed Web of Science ®Google Scholar
• Friedman, J. R., W. J. Fredericks, D. E. Jensen, D. W. Speicher, X. P. Huang, E. G. Neilson, and F. J. Rauscher III. 1996. KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Genes Dev. 10: 2067–2078.
   PubMed Web of Science ®Google Scholar
• Glotzer, M., A. W. Murray, and M. W. Kirschner. 1991. Cyclin is degraded by the ubiquitin pathway. Nature 349: 132–138.
   PubMed Web of Science ®Google Scholar
• Harkin, D. P., J. M. Bean, D. Miklos, Y. H. Song, V. B. Truong, C. Englert, F. C. Christians, L. W. Ellisen, S. Maheswaran, J. D. Oliner, and D. A. Haber. 1999. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell 97: 575–586.
   PubMed Web of Science ®Google Scholar
• Hashizume, R., M. Fukuda, I. Maeda, H. Nishikawa, D. Oyake, Y. Yabuki, H. Ogata, and T. Ohta. 2001. The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J. Biol. Chem. 276: 14537–14540.
   PubMed Web of Science ®Google Scholar
• Hershko, A., and A. Ciechanover. 1998. The ubiquitin system. Annu. Rev. Biochem. 67: 425–479.
   PubMed Web of Science ®Google Scholar
• Hofmann, F., F. Martelli, D. M. Livingston, and Z. Wang. 1996. The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes Dev. 10: 2949–2959.
   PubMed Web of Science ®Google Scholar
• Hollander, M. C., M. S. Sheikh, D. V. Bulavin, K. Lundgren, L. Augeri-Henmueller, R. Shehee, T. A. Molinaro, K. E. Kim, E. Tolosa, J. D. Ashwell, M. P. Rosenberg, Q. Zhan, P. M. Fernandez-Salguero, W. F. Morgan, C. X. Deng, and A. J. Fornace, Jr. 1999. Genomic instability in Gadd45a-deficient mice. Nat. Genet. 23: 176–184.
   PubMed Web of Science ®Google Scholar
• Jin, S., M. J. Antinore, F. D. Lung, X. Dong, H. Zhao, F. Fan, A. B. Colchagie, P. Blanck, P. P. Roller, A. J. Fornace, Jr., and Q. Zhan. 2000. The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression. J. Biol. Chem. 275: 16602–16608.
   PubMed Web of Science ®Google Scholar
• Jin, S., F. Fan, W. Fan, H. Zhao, T. Tong, P. Blanck, I. Alomo, B. Rajasekaran, and Q. Zhan. 2001. Transcription factors Oct-1 and NF-YA regulate the p53-independent induction of the GADD45 following DNA damage. Oncogene 20: 2683–2690.
   PubMed Web of Science ®Google Scholar
• Jin, Y., X. L. Xu, M. C. Yang, F. Wei, T. C. Ayi, A. M. Bowcock, and R. Baer. 1997. Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains. Proc. Natl. Acad. Sci. USA 94: 12075–12080.
   PubMed Web of Science ®Google Scholar
• Kastan, M. B., Q. Zhan, W. S. El-Deiry, F. Carrier, T. Jacks, W. V. Walsh, B. S. Plunkett, B. Vogelstein, and A. J. Fornace, Jr. 1992. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587–597.
   PubMed Web of Science ®Google Scholar
• Kearsey, J. M., P. J. Coates, A. R. Prescott, E. Warbrick, and P. A. Hall. 1995. Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1. Oncogene 11: 1675–1683.
   PubMed Web of Science ®Google Scholar
• Khanna, K. K., and S. P. Jackson. 2001. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27: 247–254.
   PubMed Web of Science ®Google Scholar
• Kim, S. S., Y. M. Chen, E. O'Leary, R. Witzgall, M. Vidal, and J. V. Bonventre. 1996. A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Proc. Natl. Acad. Sci. USA 93: 15299–15304.
   PubMedGoogle Scholar
• Kim, S. T., D. S. Lim, C. E. Canman, and M. B. Kastan. 1999. Substrate specificities and identification of putative substrates of ATM kinase family members. J. Biol. Chem. 274: 37538–37543.
   PubMed Web of Science ®Google Scholar
• King, R. W., M. Glotzer, and M. W. Kirschner. 1996. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. Mol. Biol. Cell 7: 1343–1357.
   PubMed Web of Science ®Google Scholar
• Lechner, M. S., G. E. Begg, D. W. Speicher, and F. J. Rauscher III. 2000. Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential. Mol. Cell. Biol. 20: 6449–6465.
   PubMed Web of Science ®Google Scholar
• Li, C. D., C. Larsson, A. Futreal, J. Lancaster, C. Phelan, U. Aspenblad, B. Sundelin, Y. Liu, P. Ekman, G. Auer, and U. S. R. Bergerheim. 1998. Identification of two distinct deleted regions on chromosome 13 in prostate cancer. Oncogene 16: 481–487.
   PubMed Web of Science ®Google Scholar
• Li, S., P. L. Chen, T. Subramanian, G. Chinnadurai, G. Tomlinson, C. K. Osborne, Z. D. Sharp, and W. H. Lee. 1999. Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. J. Biol. Chem. 274: 11334–11338.
   PubMed Web of Science ®Google Scholar
• Li, S., N. S. Ting, L. Zheng, P. L. Chen, Y. Ziv, Y. Shiloh, E. Y. Lee, and W. H. Lee. 2000. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 406: 210–215.
   PubMed Web of Science ®Google Scholar
• Loda, M., B. Cukor, S. W. Tam, P. Lavin, M. Fiorentino, G. F. Draetta, J. M. Jessup, and M. Pagano. 1997. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat. Med. 3: 231–234.
   PubMed Web of Science ®Google Scholar
• Maki, C. G., J. M. Huibregtse, and P. M. Howley. 1996. In vivo ubiquitination and proteasome-mediated degradation of p531. Cancer Res. 56: 2649–2654.
   PubMed Web of Science ®Google Scholar
• Mallery, D. L., C. J. Vandenberg, and K. Hiom. 2002. Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains. EMBO J. 21: 6755–6762.
   PubMed Web of Science ®Google Scholar
• Margolin, J. F., J. R. Friedman, W. K. Meyer, H. Vissing, H. J. Thiesen, and F. J. Rauscher III. 1994. Kruppel-associated boxes are potent transcriptional repression domains. Proc. Natl. Acad. Sci. USA 91: 4509–4513.
   PubMed Web of Science ®Google Scholar
• Maxwell, P. H., M. S. Wiesener, G. W. Chang, S. C. Clifford, E. C. Vaux, M. E. Cockman, C. C. Wykoff, C. W. Pugh, E. R. Maher, and P. J. Ratcliffe. 1999. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271–275.
   PubMed Web of Science ®Google Scholar
• Moosmann, P., O. Georgiev, B. Le Douarin, J. P. Bourquin, and W. Schaffner. 1996. Transcriptional repression by RING finger protein TIF1 β that interacts with the KRAB repressor domain of KOX1. Nucleic Acids Res. 24: 4859–4867.
   PubMedGoogle Scholar
• Palombella, V. J., O. J. Rando, A. L. Goldberg, and T. Maniatis. 1994. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78: 773–785.
   PubMed Web of Science ®Google Scholar
• Pickart, C. M. 2001. Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70: 503–533.
   PubMed Web of Science ®Google Scholar
• Pickart, C. M. 2000. Ubiquitin in chains. Trends Biochem. Sci. 25: 544–548.
   PubMed Web of Science ®Google Scholar
• Rechsteiner, M., and S. W. Rogers. 1996. PEST sequences and regulation by proteolysis. Trends Biochem. Sci. 21: 267–271.
   PubMed Web of Science ®Google Scholar
• Ruffner, H., C. A. Joazeiro, D. Hemmati, T. Hunter, and I. M. Verma. 2001. Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc. Natl. Acad. Sci. USA 98: 5134–5139.
   PubMed Web of Science ®Google Scholar
• Schultz, D. C., K. Ayyanathan, D. Negorev, G. G. Maul, and F. J. Rauscher III. 2002. SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev. 16: 919–932.
   PubMed Web of Science ®Google Scholar
• Schultz, D. C., J. R. Friedman, and F. J. Rauscher III. 2001. Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD. Genes Dev. 15: 428–443.
   PubMed Web of Science ®Google Scholar
• Smith, M. L., I. T. Chen, Q. Zhan, I. Bae, C. Y. Chen, T. M. Gilmer, M. B. Kastan, P. M. O'Connor, and A. J. Fornace, Jr. 1994. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 266: 1376–1380.
   PubMed Web of Science ®Google Scholar
• Somasundaram, K., H. B. Zhang, Y. X. Zeng, Y. Houvras, Y. Peng, H. X. Zhang, G. S. Wu, J. D. Licht, B. L. Weber, and W. S. El-Deiry. 1997. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor P21WAF1/CiP1. Nature 389: 187–190.
   PubMed Web of Science ®Google Scholar
• Thompson, L. H., and D. Schild. 2002. Recombinational DNA repair and human disease. Mutat. Res. 509: 49–78.
   PubMed Web of Science ®Google Scholar
• Tomlinson, G. E., T. T. Chen, V. A. Stastny, A. K. Virmani, M. A. Spillman, V. Tonk, J. L. Blum, N. R. Schneider, I. I. Wistuba, J. W. Shay, J. D. Minna, and A. F. Gazdar. 1998. Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier. Cancer Res. 58: 3237–3242.
   PubMedGoogle Scholar
• Treier, M., L. M. Staszewski, and D. Bohmann. 1994. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 78: 787–798.
   PubMed Web of Science ®Google Scholar
• Venkitaraman, A. R. 2002. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108: 171–182.
   PubMed Web of Science ®Google Scholar
• Vissing, H., W. K. Meyer, L. Aagaard, N. Tommerup, and H. J. Thiesen. 1995. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. FEBS Lett. 369: 153–157.
   PubMedGoogle Scholar
• Wang, Q., H. Zhang, K. Kajino, and M. I. Greene. 1998. BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells. Oncogene 17: 1939–1948.
   PubMed Web of Science ®Google Scholar
• Wang, X. W., Q. Zhan, J. D. Coursen, M. A. Khan, H. U. Kontny, L. Yu, M. C. Hollander, P. M. O'Connor, A. J. Fornace, Jr., and C. C. Harris. 1999. GADD45 induction of a G2/M cell cycle checkpoint. Proc. Natl. Acad. Sci. USA 96: 3706–3711.
   PubMed Web of Science ®Google Scholar
• Witzgall, R., E. O'Leary, A. Leaf, D. Onaldi, and J. V. Bonventre. 1994. The Kruppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. Proc. Natl. Acad. Sci. USA 91: 4514–4518.
   PubMed Web of Science ®Google Scholar
• Xia, Y., G. M. Pao, H. W. Chen, I. M. Verma, and T. Hunt. 2003. Enhancement of Brca1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J. Biol. Chem. 278: 5255–5263.
   PubMed Web of Science ®Google Scholar
• Yamano, H., J. Gannon, and T. Hunt. 1996. The role of proteolysis in cell cycle progression in S. pombe. EMBO J. 15: 5268–5279.
   PubMedGoogle Scholar
• Yarden, R. I., and L. C. Brody. 1999. BRCA1 interacts with components of the histone deacetylase complex. Proc. Natl. Acad. Sci. USA 96: 4983–4988.
   PubMed Web of Science ®Google Scholar
• Zhan, Q., M. J. Antinore, X. W. Wang, F. Carrier, M. L. Smith, C. C. Harris, and A. J. Fornace, Jr. 1999. Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene 18: 2892–2900.
   PubMed Web of Science ®Google Scholar
• Zhan, Q., I. Bae, M. B. Kastan, and A. J. Fornace, Jr. 1994. The p53-dependent gamma-ray response of GADD45. Cancer Res. 54: 2755–2760.
   PubMed Web of Science ®Google Scholar
• Zhan, Q., I. T. Chen, M. J. Antinore, and A. J. Fornace, Jr. 1998. Tumor suppressor p53 can participate in transcriptional induction of the Gadd45 promoter in the absence of direct DNA binding. Mol. Cell. Biol. 18: 2768–2778.
   PubMed Web of Science ®Google Scholar
• Zhan, Q., S. Fan, M. L. Smith, I. Bae, K. Yu, I. Alamo, Jr., P. M. O'Connor, and A. J. Fornace, Jr. 1996. Abrogation of p53 function affects gadd gene responses to DNA base-damaging agents and starvation. DNA Cell Biol. 15: 805–815.
   PubMedGoogle Scholar
• Zheng, L., L. A. Annab, C. A. Afshari, W. H. Lee, and T. G. Boyer. 2001. BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor. Proc. Natl. Acad. Sci. USA 98: 9587–9592.
   PubMed Web of Science ®Google Scholar
• Zheng, L., S. Li, T. G. Boyer, and W. H. Lee. 2000. Lessons learned from BRCA1 and BRCA2. Oncogene 19: 6159–6175.
   PubMedGoogle Scholar
• Zheng, L., H. Pan, S. Li, A. Flesken-Nikitin, P. L. Chen, T. G. Boyer, and W. H. Lee. 2000. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol. Cell 6: 757–768.
   PubMedGoogle Scholar