Role of the Steroid Receptor Coactivator SRC-3 in Cell Growth

REFERENCES

• Abraham, R. T. 2002. Identification of TOR Signaling Complexes. More TORC for the cell growth engine. Cell 111: 9–12.
   PubMed Web of Science ®Google Scholar
• Anzick, S. L., J. Kononen, R. L. Walker, D. O. Azorsa, M. M. Tanner, X. Y. Guan, G. Sauter, O. P. Kallioniemi, J. M. Trent, and P. S. Meltzer. 1997. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277: 965–968.
   PubMed Web of Science ®Google Scholar
• Bautista, S., H. Valles, R. L. Walker, S. Anzick, R. Zeillinger, P. Meltzer, and C. Theillet. 1998. In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity. Clin. Cancer Res. 4: 2925–2929.
   PubMedGoogle Scholar
• Bodine, S. C., T. N. Stitt, M. Gonzalez, W. O. Kline, G. L. Stover, R. Bauerlein, E. Zlotchenko, A. Scrimgeour, J. C. Lawrence, D. J. Glass, and G. D. Yancopoulos. 2001. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat. Cell Biol. 3: 1014–1019.
   PubMed Web of Science ®Google Scholar
• Bouras, T., M. C. Southey, and D. J. Venter. 2001. Overexpression of the steroid receptor coactivator AIB1 in breast cancer correlates with the absence of estrogen and progesterone receptors and positivity for p53 and HER2/neu. Cancer Res. 61: 903–907.
   PubMed Web of Science ®Google Scholar
• Burcin, M. M., G. Schiedner, S. Kochanek, S. Y. Tsai, and B. W. O'Malley. 1999. Adenovirus-mediated regulable target gene expression in vivo. Proc. Natl. Acad. Sci. USA 96: 355–360.
   PubMed Web of Science ®Google Scholar
• Cavailles, V., S. Dauvois, P. S. Danielian, and M. G. Parker. 1994. Interaction of proteins with transcriptionally active estrogen receptors. Proc. Natl. Acad. Sci. USA 91: 10009–10013.
   PubMed Web of Science ®Google Scholar
• Chen, D., H. Ma, H. Hong, S. S. Koh, S. M. Huang, B. T. Schurter, D. W. Aswad, and M. R. Stallcup. 1999. Regulation of transcription by a protein methyltransferase. Science 284: 2174–2177.
   PubMed Web of Science ®Google Scholar
• Chen, H., R. J. Lin, R. L. Schiltz, D. Chakravarti, A. Nash, L. Nagy, M. L. Privalsky, Y. Nakatani, and R. M. Evans. 1997. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90: 569–580.
   PubMed Web of Science ®Google Scholar
• Chen, W. S., P. Z. Xu, K. Gottlob, M. L. Chen, K. Sokol, T. Shiyanova, I. Roninson, W. Weng, R. Suzuki, K. Tobe, T. Kadowaki, and N. Hay. 2001. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15: 2203–2208.
   PubMed Web of Science ®Google Scholar
• Conlon, I., and M. Raff. 1999. Size control in animal development. Cell 96: 235–244.
   PubMed Web of Science ®Google Scholar
• Crackower, M. A., G. Y. Oudit, I. Kozieradzki, R. Sarao, H. Sun, T. Sasaki, E. Hirsch, A. Suzuki, T. Shioi, J. Irie-Sasaki, R. Sah, H. Y. Cheng, V. O. Rybin, G. Lembo, L. Fratta, A. J. Oliveira-dos-Santos, J. L. Benovic, C. R. Kahn, S. Izumo, S. F. Steinberg, M. P. Wymann, P. H. Backx, and J. M. Penninger. 2002. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 110: 737–749.
   PubMed Web of Science ®Google Scholar
• Elbashir, S. M., J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494–498.
   PubMed Web of Science ®Google Scholar
• Fingar, D. C., S. Salama, C. Tsou, E. Harlow, and J. Blenis. 2002. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16: 1472–1487.
   PubMed Web of Science ®Google Scholar
• Font de Mora, J., and M. Brown. 2000. AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Mol. Cell. Biol. 20: 5041–5047.
   PubMedGoogle Scholar
• Gehin, M., M. Mark, C. Dennefeld, A. Dierich, H. Gronemeyer, and P. Chambon. 2002. The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol. Cell. Biol. 22: 5923–5937.
   PubMedGoogle Scholar
• Glaeser, M., T. Floetotto, B. Hanstein, M. W. Beckmann, and D. Niederacher. 2001. Gene amplification and expression of the steroid receptor coactivator SRC3 (AIB1) in sporadic breast and endometrial carcinomas. Horm. Metab. Res. 33: 121–126.
   PubMed Web of Science ®Google Scholar
• Gnanapragasam, V. J., H. Y. Leung, A. S. Pulimood, D. E. Neal, and C. N. Robson. 2001. Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer. Br. J. Cancer 85: 1928–1936.
   PubMed Web of Science ®Google Scholar
• Heinlein, C. A., and C. Chang. 2002. Androgen receptor (AR) coregulators: an overview. Endocr. Rev. 23: 175–200.
   PubMed Web of Science ®Google Scholar
• Hong, H., K. Kohli, A. Trivedi, D. L. Johnson, and M. R. Stallcup. 1996. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc. Natl. Acad. Sci. USA 93: 4948–4952.
   PubMedGoogle Scholar
• Inoki, K., Y. Li, T. Zhu, J. Wu, and K. L. Guan. 2002. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4: 648–657.
   PubMed Web of Science ®Google Scholar
• Jefferson, L. S., J. R. Fabian, and S. R. Kimball. 1999. Glycogen synthase kinase-3 is the predominant insulin-regulated eukaryotic initiation factor 2B kinase in skeletal muscle. Int. J. Biochem. Cell Biol. 31: 191–200.
   PubMed Web of Science ®Google Scholar
• Johnston, G. C., J. R. Pringle, and L. H. Hartwell. 1977. Coordination of growth with cell division in the yeast Saccharomyces cerevisiae. Exp. Cell Res. 105: 79–98.
   PubMed Web of Science ®Google Scholar
• Kamei, Y., L. Xu, T. Heinzel, J. Torchia, R. Kurokawa, B. Gloss, S. C. Lin, R. A. Heyman, D. W. Rose, C. K. Glass, and M. G. Rosenfeld. 1996. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85: 403–414.
   PubMed Web of Science ®Google Scholar
• Katso, R., K. Okkenhaug, K. Ahmadi, S. White, J. Timms, and M. D. Waterfield. 2001. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol. 17: 615–675.
   PubMed Web of Science ®Google Scholar
• Kim, D. H., D. Sarbassov dos, S. M. Ali, J. E. King, R. R. Latek, H. Erdjument-Bromage, P. Tempst, and D. M. Sabatini. 2002. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110: 163–175.
   PubMed Web of Science ®Google Scholar
• Kozma, S. C., and G. Thomas. 2002. Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. Bioessays 24: 65–71.
   PubMed Web of Science ®Google Scholar
• Kwon, C. H., X. Zhu, J. Zhang, L. L. Knoop, R. Tharp, R. J. Smeyne, C. G. Eberhart, P. C. Burger, and S. J. Baker. 2001. Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat. Genet. 29: 404–411.
   PubMed Web of Science ®Google Scholar
• Lawlor, M. A., A. Mora, P. R. Ashby, M. R. Williams, V. Murray-Tait, L. Malone, A. R. Prescott, J. M. Lucocq, and D. R. Alessi. 2002. Essential role of PDK1 in regulating cell size and development in mice. EMBO J. 21: 3728–3738.
   PubMed Web of Science ®Google Scholar
• Li, H., P. J. Gomes, and J. D. Chen. 1997. RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc. Natl. Acad. Sci. USA 94: 8479–8484.
   PubMed Web of Science ®Google Scholar
• List, H. J., R. Reiter, B. Singh, A. Wellstein, and A. T. Riegel. 2001. Expression of the nuclear coactivator AIB1 in normal and malignant breast tissue. Breast Cancer Res. Treat. 68: 21–28.
   Google Scholar
• McKenna, N. J., R. B. Lanz, and B. W. O'Malley. 1999. Nuclear receptor coregulators: cellular and molecular biology. Endocr. Rev. 20: 321–344.
   PubMed Web of Science ®Google Scholar
• McKenna, N. J., and B. W. O'Malley. 2002. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108: 465–474.
   PubMed Web of Science ®Google Scholar
• McKenna, N. J., and B. W. O'Malley. 2002. Minireview: nuclear receptor coactivators-an update. Endocrinology 143: 2461–2465.
   PubMed Web of Science ®Google Scholar
• Nicholson, K. M., and N. G. Anderson. 2002. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 14: 381–395.
   PubMed Web of Science ®Google Scholar
• Onate, S. A., S. Y. Tsai, M. J. Tsai, and B. W. O'Malley. 1995. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270: 1354–1357.
   PubMed Web of Science ®Google Scholar
• Potter, C. J., H. Huang, and T. Xu. 2001. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105: 357–368.
   PubMed Web of Science ®Google Scholar
• Rosenfeld, M. G., and C. K. Glass. 2001. Coregulator codes of transcriptional regulation by nuclear receptors. J. Biol. Chem. 276: 36865–36868.
   PubMed Web of Science ®Google Scholar
• Sakakura, C., A. Hagiwara, R. Yasuoka, Y. Fujita, M. Nakanishi, K. Masuda, A. Kimura, Y. Nakamura, J. Inazawa, T. Abe, and H. Yamagishi. 2000. Amplification and over-expression of the AIB1 nuclear receptor co- activator gene in primary gastric cancers. Int. J. Cancer 89: 217–223.
   PubMedGoogle Scholar
• Schmelzle, T., and M. N. Hall. 2000. TOR, a central controller of cell growth. Cell 103: 253–262.
   PubMed Web of Science ®Google Scholar
• Sekulic, A., C. C. Hudson, J. L. Homme, P. Yin, D. M. Otterness, L. M. Karnitz, and R. T. Abraham. 2000. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 60: 3504–3513.
   PubMed Web of Science ®Google Scholar
• Shibata, A., Y. Hayashi, T. Imai, H. Funahashi, A. Nakao, and H. Seo. 2001. Somatic gene alteration of AIB1 gene in patients with breast cancer. Endocr. J. 48: 199–204.
   PubMedGoogle Scholar
• Shioi, T., J. R. McMullen, P. M. Kang, P. S. Douglas, T. Obata, T. F. Franke, L. C. Cantley, and S. Izumo. 2002. Akt/protein kinase B promotes organ growth in transgenic mice. Mol. Cell. Biol. 22: 2799–2809.
   PubMed Web of Science ®Google Scholar
• Stocker, H., and E. Hafen. 2000. Genetic control of cell size. Curr. Opin. Genet. Dev. 10: 529–535.
   PubMed Web of Science ®Google Scholar
• Suen, C. S., T. J. Berrodin, R. Mastroeni, B. J. Cheskis, C. R. Lyttle, and D. E. Frail. 1998. A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity. J. Biol. Chem. 273: 27645–27653.
   PubMedGoogle Scholar
• Takeshita, A., G. R. Cardona, N. Koibuchi, C. S. Suen, and W. W. Chin. 1997. TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J. Biol. Chem. 272: 27629–27634.
   PubMedGoogle Scholar
• Tan, J. A., S. H. Hall, P. Petrusz, and F. S. French. 2000. Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator. Endocrinology 141: 3440–3450.
   PubMedGoogle Scholar
• Testa, J. R., and A. Bellacosa. 2001. AKT plays a central role in tumorigenesis. Proc. Natl. Acad. Sci. USA 98: 10983–10985.
   PubMed Web of Science ®Google Scholar
• Torchia, J., D. W. Rose, J. Inostroza, Y. Kamei, S. Westin, C. K. Glass, and M. G. Rosenfeld. 1997. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387: 677–684.
   PubMed Web of Science ®Google Scholar
• Tsai, M. J., and B. W. O'Malley. 1994. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 63: 451–486.
   PubMed Web of Science ®Google Scholar
• Tsai, S. Y., B. W. O'Malley, F. J. DeMayo, Y. Wang, and S. S. Chua. 1998. A novel RU486 inducible system for the activation and repression of genes. Adv. Drug Deliv. Rev. 30: 23–31.
   PubMedGoogle Scholar
• Tuttle, R. L., N. S. Gill, W. Pugh, J. P. Lee, B. Koeberlein, E. E. Furth, K. S. Polonsky, A. Naji, and M. J. Birnbaum. 2001. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat. Med. 7: 1133–1137.
   PubMed Web of Science ®Google Scholar
• Vivanco, I., and C. L. Sawyers. 2002. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer 2: 489–501.
   PubMed Web of Science ®Google Scholar
• Voegel, J. J., M. J. Heine, C. Zechel, P. Chambon, and H. Gronemeyer. 1996. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J. 15: 3667–3675.
   PubMed Web of Science ®Google Scholar
• Wang, Y., M. C. Wu, J. S. Sham, W. Zhang, W. Q. Wu, and X. Y. Guan. 2002. Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma. A broad survey using high-throughput tissue microarray. Cancer 95: 2346–2352.
   PubMed Web of Science ®Google Scholar
• Wang, Z., D. W. Rose, O. Hermanson, F. Liu, T. Herman, W. Wu, D. Szeto, A. Gleiberman, A. Krones, K. Pratt, R. Rosenfeld, C. K. Glass, and M. G. Rosenfeld. 2000. Regulation of somatic growth by the p160 coactivator p/CIP. Proc. Natl. Acad. Sci. USA 97: 13549–13554.
   PubMedGoogle Scholar
• Weinkove, D., and S. J. Leevers. 2000. The genetic control of organ growth: insights from Drosophila. Curr. Opin. Genet. Dev. 10: 75–80.
   PubMed Web of Science ®Google Scholar
• Wu, R. C., J. Qin, Y. Hashimoto, J. Wong, J. Xu, S. Y. Tsai, M. J. Tsai, and B. W. O'Malley. 2002. Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase. Mol. Cell. Biol. 22: 3549–3561.
   PubMedGoogle Scholar
• Xu, J., L. Liao, G. Ning, H. Yoshida-Komiya, C. Deng, and B. W. O'Malley. 2000. The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc. Natl. Acad. Sci. USA 97: 6379–6384.
   PubMedGoogle Scholar
• Xu, J., Y. Qiu, F. J. DeMayo, S. Y. Tsai, M. J. Tsai, and B. W. O'Malley. 1998. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science 279: 1922–1925.
   PubMedGoogle Scholar