46
Views
84
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Discrete Functions of TRAF1 and TRAF2 in Drosophila melanogaster Mediated by c-Jun N-Terminal Kinase and NF-κB-Dependent Signaling Pathways

, , , , , , & show all
Pages 7982-7991 | Received 16 Jul 2003, Accepted 14 Aug 2003, Published online: 27 Mar 2023

REFERENCES

  • Adachi-Yamada, T., K. Fujimura-Kamada, Y. Nishida, and K. Matsumoto. 1999. Distortion of proheximodistal information causes JNK-dependent apoptosis in Drosophila wing. Nature 400: 166–169.
  • Adachi-Yamada, T., M. Nakamura, K. Irie, Y. Tomoyasu, Y. Sano, E. Mori, S. Goto, N. Ueno, Y. Nishida, and K. Matsumoto. 1999. p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis. Mol. Cell. Biol. 19: 2322–2329.
  • Arch, R. H., R. W. Gedrich, and C. B. Thompson. 1998. Tumor necrosis factor receptor-associated factors (TRAFs): a family of adapter proteins that regulates life and death. Genes Dev. 12: 2821–2830.
  • Braun, A., J. A. Hoffmann, and M. Meister. 1998. Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes. Proc. Natl. Acad. Sci. USA 95: 14337–14342.
  • Bulet, P., J. L. Dimarcq, C. Hetru, M. Lagueux, M. Charlet, G. Hegy, A. Van Dorsselaer, and J. A. Hoffmann. 1993. A novel inducible antibacterial peptide of Drosophila carries an O-glycosylated substitution. J. Biol. Chem. 268: 14893–14897.
  • Cao, Z., W. J. Henzel, and X. Gao. 1996. IRAK: a kinase associated with the interleukin-1 receptor. Science 271: 1128–1131.
  • Cao, Z., J. Xiong, M. I. Takeuchi, T. Kurama, and D. V. Goeddel. 1996. TRAF6 is a signal transducer for interleukin-1. Nature 383: 443–446.
  • Cho, K. S., J. H. Lee, S. Kim, D. Kim, H. Koh, J. Lee, C. Kim, J. Kim, and J. Chung. 2001. Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway. Proc. Natl. Acad. Sci. USA 98: 6144–6149.
  • Coso, O. A., M. Chiariello, J. C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. S. Gutkind. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81: 1137–1146.
  • Dadgostar, H., and G. Cheng. 1998. An intact zinc ring finger is required for tumor necrosis factor receptor-associated factor-mediated nuclear factor-kappaB activation but is dispensable for c-Jun N-terminal kinase signaling. J. Biol. Chem. 273: 24775–24780.
  • Dadgostar, H., and G. Cheng. 2000. Membrane localization of TRAF3 enables JNK activation. J. Biol. Chem. 275: 2539–2544.
  • Ferrandon, D., A. C. Jung, M. C. Criqui, B. Lemaitre, S. Uttenweiler-Joseph, L. Michaut, J. M. Reichhart, and J. A. Hoffmann. 1998. A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. EMBO J. 17: 1217–1227.
  • Glise, B., H. Bourbon, and S. Noselli. 1995. Hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 83: 451–461.
  • Grech, A., R. Quinn, D. Srinivasan, X. Badoux, and R. Brink. 2000. Complete structural characterization of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants. Mol. Immunol. 37: 721–734.
  • Han, Z. S., H. Enslen, X. Hu, X. Meng, I. H. Wu, T. Barrett, R. J. Davis, and Y. T. Ip. 1998. A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Mol. Cell. Biol. 18: 3527–3539.
  • Hatzoglou, A., J. Roussel, M. F. Bourgeade, E. Rogier, C. Madry, J. Inoue, O. Devergne, and A. Tsapis. 2000. TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. J. Immunol. 165: 1322–1330.
  • Hedengren, M., B. Asling, M. S. Dushay, I. Ando, S. Ekengren, M. Whilborg, and D. Hultmark. 1999. Relish, a central factor in the control of humoral but no cellular immunity in Drosophila. Mol. Cell 4: 827–837.
  • Hummel, T., K. Krukkert, J. Roos, G. Davis, and C. Klambt. 2000. Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development. Neuron 26: 357–370.
  • Ip, Y. T., M. Reach, Y. Engstrom, L. Kadalayil, H. Cai. S. Gonzalez-Crespo, K. Tatei, and M. Levine. 1993. Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell 19: 753–763.
  • Ip, Y. T., and R. J. Davis. 1998. Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Curr. Opin. Cell Biol. 10: 205–219.
  • Kashiwada, M., Y. Shirakata, J. I. Inoue, H. Nakano, K. Okazaki, K. Okumura, T. Yamamoto, H. Nagaoka, and T. Takemori. 1998. Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway. J. Exp. Med. 187: 237–244.
  • Khush, R. S., and B. Lemaitre. 2000. Genes that fight infection: what the Drosophila genome says about animal immunity. Trends Genet. 16: 442–449.
  • Kopp, E., R. Medzhitov, J. Carothers, C. Xiao, I. Douglas, C. A. Janeway, and S. Ghosh. 1999. ECSIT is an evolutionarily conserved intermediated in the Toll/IL-1 signal transduction pathway. Genes Dev. 13: 2059–2071.
  • Kuan, C. Y., D. D. Yang, D. R. Samanta Roy, R. J. Davis, P. Rakic, and R. A. Flavell. 1999. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22: 667–676.
  • Kylsten, P., C. Samakovlis, and D. Hultmark. 1990. The cecropin locus in Drosophila: a compact gene cluster involved in the response to infection. EMBO J. 9: 217–224.
  • Lee, J. H., K. S. Cho, J. Lee, J. Yoo, J. Lee, and J. Chung. 2001. Diptericin-like protein: an immune response gene regulated by the antibacterial gene induction pathway in Drosophila. Gene 271: 233–238.
  • Lee, S. B., K. S. Cho, E. Kim, and J. Chung. 2003. blistery encodes Drosophila tensin protein and interacts with integrin and the JNK signaling pathway during wing development. Development 130: 4351–4361.
  • Lemaitre, B., J. Reichhart, and J. Hoffmann. 1997. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc. Natl. Acad. Sci. USA 94: 14614–14619.
  • Leo, E., K. Welsh, S. Matsuzawa, J. M. Zapata, S. Kitada, R. Mitchell, K. Ely, and J. Reed. 1999. Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-kappaB and Jun N-terminal kinase activation. J. Biol. Chem. 274: 22414–22474.
  • Liu, H., Y. C. Su, E. Becker, J. Treisman, and E. Y. Skolnik. 1999. A Drosophila TNF-receptor-associated factor (TRAF) binds the Ste20 kinase Misshapen and activates Jun kinase. Curr. Biol. 9: 101–104.
  • Lomaga, M., W. C. Yeh, I. Sarosi, G. Duncan, C. Furlonger, A. Ho, S. Morony, C. Capparelli, G. Van, S. Kaufman, A. van der Heiden, A. Itie, A. Wakeham, W. Khoo, T. Sasaki, Z. Cao, J. Penninger, C. Paige, D. Lacey, C. Dunstan, W. Boyle, D. V. Goeddel, and T. Mak. 1999. TRAF6 deficiency results in osteoporosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13: 1015–1024.
  • Magnusson, C., and D. L. Vaux. 1999. Signalling by CD95 and TNF receptors: not only life and death. Immunol. Cell Biol. 77: 44–46.
  • Mihaly, J., L. Kockel, K. Gaengel, U. Weber, D. Bohmann, and M. Mlodzik. 2001. The role of the Drosophila TAK homologue dTAK during development. Mech. Dev. 102: 67–79.
  • Minden, A., A. Lin, F. X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81: 1147–1157.
  • Nakano, H., H. Oshima, W. Chung, L. Williams-Abbott, C. F. Ware, H. Yagita, and K. Okumura. 1996. TRAF5, an activator of NF-κB and putative signal transducer for the lymphotoxin-beta receptor. J. Biol. Chem. 271: 14661–14664.
  • Nakano, H., S. Sakon, H. Koseki, T. Takemori, K. Tada, M. Matsumoto, E. Munechika, T. Sakai, T. Shirasawa, H. Akiba, T. Kobata, S. Santee, C. Ware, P. D. Rennert, M. Taniguchi, H. Yagita, and K. Okumura. 1999. Targeted disruption of TRAF5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Proc. Natl. Acad. Sci. USA 96: 9803–9808.
  • Nishina, H., C. Vaz, P. Billia, M. Nghiem, T. Sasaki, J. L. De la Pompa, K. Furlonger, C. Paige, C. C. Hui, K. D. Fischer, H. Kishimoto, T. Iwatsubo, T. Katada, J. R. Woodgett, and J. M. Penninger. 1999. Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 126: 505–516.
  • Nishitoh, H., M. Saitoh, Y. Mochida, K. Takeda, H. Nakano, M. Rothe, K. Miyazono, and H. Ichijo. 1998. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol. Cell 2: 389–395.
  • Noselli, S. 1998. JNK signaling and morphogenesis in Drosophila. Trends Genet. 14: 33–38.
  • Paricio, N., F. Feiguin, M. Boutros, S. Eaton, and M. Mlodzik. 1999. The Drosophila STE20-like kinase Misshapen is required downstream of the Frizzled receptor in planar polarity signaling. EMBO J. 18: 4669–4678.
  • Phelps, C. B., and A. H. Brand. 1998. Ectopic gene expression in Drosophila using GAL4 system. Methods 14: 367–379.
  • Reichhart, J. M., M. Meister, J. L. Dimarcq, D. Zachary, D. Hoffmann, C. Ruiz, G. Richards, and J. A. Hoffmann. 1992. Insect immunity: developmental and inducible activity of the Drosophila diptericin promoter. EMBO J. 11: 1469–1477.
  • Riesgo-Escovar, J. R., M. Jenni, A. Fritz, and E. Hafen. 1996. The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev. 10: 2759–2768.
  • Rorth, P. 1996. A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. Proc. Natl. Acad. Sci. USA 93: 12418–12422.
  • Rothe, M., V. Sarma, V. M. Dixit, and D. V. Goeddel. 1995. TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science 269: 32767–32770.
  • Shen, B., H. Liu, E. Y. Scolnik, and J. Manley. 2001. Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation. Proc. Natl. Acad. Sci. USA 98: 8596–8601.
  • Silverman, N., R. Zhou, S. Stoven, N. Pandey, D. Hultmakr, and T. Maniatis. 2000. A Drosophila IκB kinase complex required for Relish cleavage and antibacterial immunity. Genes Dev. 14: 2461–2471.
  • Sluss, H. K., Z. Han, T. Barrett, R. J. Davis, and Y. T. Ip. 1996. A JNK signal transduction pathway that mediates morphogenesis and an immune response. Genes Dev. 10: 2745–2758.
  • Takatsu, Y., M. Nakamura, M. Stapleton, M. C. Danos, K. Matsumoto, M. B. O'Connor, H. Shibuya, and N. Ueno. 2000. TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol. Cell. Biol. 20: 3015–3026.
  • Tournier, C., P. Hess, D. D. Yang, J. Xu, T. K. Turner, A. Nimnual, D. Bar-Sagi, S. N. J. ones, R. A. Flavell, and R. J. Davis. 2000. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288: 870–874.
  • Wallach, D., E. E., Varfolomeev, N. L. Malinin, Y. V. Goltsev, A. V. Kovlenko, and M. P. Boldin. 1999. Tumor necrosis factor receptor and Fas signaling mechanisms. Rev. Immunol. 17: 331–367.
  • Weber, U., N. Paricio, and M. Mlodzik. 2000. Jun mediates Frizzled induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. Development 127: 3619–3629.
  • Wicker, C., J. M. Reichhart, D. Hoffmann, D. Hultmark, C. Samakovlis, and J. A. Hoffmann. 1990. Insect immunity: characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides. J. Biol. Chem. 265: 2493–22498.
  • Xu, Y., G. Cheng, and D. Baltimore. 1996. Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses. Immunity 5: 407–415.
  • Yang, X., R. Khosravi-Far, H. Y. Chang, and D. Baltimore. 1997. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89: 1067–1076.
  • Zapata, J. M., S. Matsuzawa, A. Godzik, E. Leo, S. A. Wasserman, and J. C. Reed. 2000. The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with pelle and regulates NF-κB activity. J. Biol. Chem. 275: 12102–12107.
  • Zeilinger, J., and D. Bohmann. 1999. Thorax closure in Drosophila: involvement of Fos and the JNK pathway. Development 126: 3947–3956.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.