64
Views
42
CrossRef citations to date
0
Altmetric
Mammalian Genetic Models with Minimal or Complex Phenotypes

The Iroquois Homeobox Gene Irx2 Is Not Essential for Normal Development of the Heart and Midbrain-Hindbrain Boundary in Mice

, , , , , , , , , , & show all
Pages 8216-8225 | Received 11 Apr 2003, Accepted 14 Aug 2003, Published online: 27 Mar 2023

REFERENCES

  • Ang, S. L., R. A. Conlon, O. Jin, and J. Rossant. 1994. Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. Development 120: 2979–2989.
  • Bao, Z. Z., B. G. Bruneau, J. G. Seidman, C. E. Seidman, and C. L. Cepko. 1999. Regulation of chamber-specific gene expression in the developing heart by Irx4. Science 283: 1161–1164.
  • Bellefroid, E. J., A. Kobbe, P. Gruss, T. Pieler, J. B. Gurdon, and N. Papalopulu. 1998. Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification. EMBO J. 17: 191–203.
  • Bosse, A., A. Zülch, M. B. Becker, M. Torres, J. L. Gómez-Skarmeta, J. Modolell, and P. Gruss. 1997. Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech. Dev. 69: 169–181.
  • Briscoe, J., A. Pierani, T. M. Jessell, and J. Ericson. 2000. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. Cell 101: 435–445.
  • Bruneau, B. G., Z. Z. Bao, M. Tanaka, J. J. Schott, S. Izumo, C. L. Cepko, J. G. Seidman, and C. E. Seidman. 2000. Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2.5 and dHand. Dev. Biol. 217: 266–277.
  • Bruneau, B. G., Z. Z. Bao, D. Fatkin, J. Xavier-Neto, D. Georgakopoulos, C. T. Maguire, C. I. Berul, D. A. Kass, M. L. Kuroski-de Bold, A. J. de Bold, D. A. Conner, N. Rosenthal, C. L. Cepko, C. E. Seidman, and J. G. Seidman. 2001. Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Mol. Cell. Biol. 21: 1730–1736.
  • Cavodeassi, F., J. Modolell, and J. L. Gómez-Skarmeta. 2001. The Iroquois family of genes: from body building to neural patterning. Development 128: 2847–2855.
  • Christoffels, V. M., A. G. Keijser, A. C. Houweling, D. E. W. Clout, and A. F. Moorman. 2000. Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart. Dev. Biol. 224: 263–274.
  • Cohen, D. R., C. W. Cheng, S. H. Cheng, and C.-C. Hui. 2000. Expression of two novel mouse Iroquois homeobox genes during neurogenesis. Mech. Dev. 91: 317–321.
  • Ding, Q., J. Motoyama, S. Gasca, R. Mo, H. Sasaki, J. Rossant, and C.-C. Hui. 1998. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125: 2533–2543.
  • Dressler, G. R., U. Deutsch, K. Chowdhury, H. O. Nornes, and P. Gruss. 1990. Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system. Development 109: 787–795.
  • Glavic, A., J. L. Gómez-Skarmeta, and R. Mayor. 2001. Xiro-1 controls mesoderm patterning by repressing bmp-4 expression in the Spemann organizer. Dev. Dyn. 222: 368–376.
  • Glavic, A., J. L. Gómez-Skarmeta, and R. Mayor. 2002. The homeoprotein Xiro1 is required for midbrain-hindbrain boundary formation. Development 129: 1609–1621.
  • Gómez-Skarmeta, J. L., and J. Modolell. 2002. Iroquois genes: genomic organization and function in vertebrate neural development. Curr. Opin. Genet. Dev. 12: 403–408.
  • Gómez-Skarmeta, J. L., A. Glavic, E. de la Calle-Mustienes, J. Modolell, and R. Mayor. 1998. Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate. EMBO J. 17: 181–190.
  • Harlow, E., and D. Lane. 1988. Antibodies: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
  • Houweling, A. C., R. Dildrop, T. Peters, J. Mummenhoff, A. F. Moorman, U. Rüther, and V. M. Christoffels. 2001. Gene and cluster-specific expression of the Iroquois family members during mouse development. Mech. Dev. 107: 169–174.
  • Itoh, M., T. Kudoh, M. Dedekian, C. H. Kim, and A. B. Chitnis. 2002. A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary. Development 129: 2317–2327.
  • Jin, Z., J. Zhang, A. Klar, A. Chédotal, Y. Rao, C. L. Cepko, and Z. Z. Bao. 2003. Irx4-mediated regulation of Slit1 expression contributes to the definition of early axonal paths inside the retina. Development 130: 1037–1048.
  • Kobayashi, D., M. Kobayashi, K. Matsumoto, T. Ogura, M. Nakafuku, and K. Shimamura. 2002. Early subdivisions in the neural plate define distinct competence for inductive signals. Development 129: 83–93.
  • Kudoh, T., and I. B. Dawid. 2001. Role of the iroquois3 homeobox gene in organizer formation. Proc. Natl. Acad. Sci. USA 98: 7852–7857.
  • Mo, R., A. M. Freer, D. L. Zinyk, M. A. Crackower, J. Michaud, H. H. Heng, K. W. Chik, X. M. Shi, L. C. Tsui, S. H. Cheng, A. L. Joyner, and C.-C. Hui. 1997. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 124: 113–123.
  • Mummenhoff, J., A. C. Houweling, T. Peters., V. M. Christoffels, and U. Rüther. 2001. Expression of Irx6 during mouse embryogenesis. Mech. Dev. 103: 193–195.
  • Mungrue, I. N., R. Gros, X. You, A. Pirani, A. Azad, T. Csont, R. Schulz, J. Butany, D. J. Stewart, and M. Husain. 2002. Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death. J. Clin. Investig. 109: 735–743.
  • Peters, T., R. Dildrop, K. Ausmeier, and U. Rüther. 2000. Organization of mouse Iroquois homeobox genes in two clusters suggests a conserved regulation and function in vertebrate development. Genome Res. 10: 1453–1462.
  • Peters, T., K. Ausmeier, R. Dildrop, and U. Rüther. 2002. The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb deletion including the entire Iroquois B gene cluster. Mamm. Genome 13: 186–188.
  • Tanaka, A., K. Miyamoto, N. Minamino, M. Takeda, B. Sato, H. Matsuo, and K. Matsumoto. 1992. Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Proc. Natl. Acad. Sci. USA 89: 8928–8932.
  • van der Hoeven, F., T. Schimmang, A. Volkmann, M. G. Mattei, B. Kyewski, and U. Rüther. 1994. Programmed cell death is affected in the novel mouse mutant Fused toes (Ft). Development 120: 2601–2607.
  • Wurst, W., and L. Bally-Cuif. 2001. Neural plate patterning: upstream and downstream of the isthmic organizer. Nat. Rev. Neurosci. 2: 99–108.
  • Zülch, A., M. B. Becker, and P. Gruss. 2001. Expression pattern of Irx1 and Irx2 during mouse digit development. Mech. Dev. 106: 159–162.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.