22
Views
71
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Human Heterochromatin Protein 1 Isoforms HP1Hsα and HP1Hsβ Interfere with hTERT-Telomere Interactions and Correlate with Changes in Cell Growth and Response to Ionizing Radiation

, , , , , , , , & show all
Pages 8363-8376 | Received 19 Mar 2003, Accepted 06 Aug 2003, Published online: 27 Mar 2023

REFERENCES

  • Aagaard, L., M. Schmid, P. Warburton, and T. Jenuwein. 2000. Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres. J. Cell Sci. 113: 817–829.
  • Blobel, G. 1985. Gene gating: a hypothesis. Proc. Natl. Acad. Sci. USA 82: 8527–8529.
  • Braunstein, M., A. B. Rose, S. G. Holmes, C. D. Allis, and J. R. Broach. 1993. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev. 7: 592–604.
  • Cenci, G., G. Siriaco, G. D. Raffa, R. Kellum, and M. Gatti. 2003. The Drosophila HOAP protein is required for telomere capping. Nat. Cell Biol. 5: 82–84.
  • Cheutin, T., A. J. McNairn, T. Jenuwein, D. M. Gilbert, P. B. Singh, and T. Misteli. 2003. Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science 299: 721–725.
  • Chevillard, C., W. Reik, M. McDermott, M. Fontes, M. G. Mattei, and P. B. Singh. 1993. Chromosomal localization of human homologs of the Drosophila heterochromatin protein 1 (HP1) gene. Mamm. Genome 4: 124–126.
  • Cryderman, D. E., H. Tang, C. Bell, D. S. Gilmour, and L. L. Wallrath. 1999. Heterochromatic silencing of Drosophila heat shock genes acts at the level of promoter potentiation. Nucleic Acids Res. 27: 3364–3370.
  • de Lange, T. 1992. Human telomeres are attached to the nuclear matrix. EMBO J. 11: 717–724.
  • de Lange, T. 2002. Protection of mammalian telomeres. Oncogene 21: 532–540.
  • Dhar, S., J. A. Squire, M. P. Hande, R. J. Wellinger, and T. K. Pandita. 2000. Inactivation of 14-3-3σ influences telomere behavior and ionizing radiation-induced chromosomal instability. Mol. Cell. Biol. 20: 7764–7772.
  • Eissenberg, J. C., and S. C. Elgin. 2000. The HP1 protein family: getting a grip on chromatin. Curr. Opin. Genet. Dev. 10: 204–210.
  • Fanti, L., G. Giovinazzo, M. Berloco, and S. Pimpinelli. 1998. The heterochromatin protein 1 prevents telomere fusions in Drosophila. Mol. Cell 2: 527–538.
  • Freedman, V. H., and S. I. Shin. 1974. Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium. Cell 3: 355–359.
  • Freyer, G. A., D. A. Palmer, Y. Yu, R. C. Miller, and T. K. Pandita. 1996. Neoplastic transformation of mouse C3H10T1/2 cells following exposure to neutrons does not involve mutation of ras gene as analyzed by SSCP and cycle sequencing. Mutat. Res. 357: 237–244.
  • Fu, W., M. Killen, C. Culmsee, S. Dhar, T. K. Pandita, and M. P. Mattson. 2000. The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function. J. Mol. Neurosci. 14: 3–15.
  • Gottschling, D. E., O. M. Aparicio, B. L. Billington, and V. A. Zakian. 1990. Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription. Cell 63: 751–762.
  • Goytisolo, F. A., E. Samper, J. Martin-Caballero, P. Finnon, E. Herrera, J. M. Flores, S. D. Bouffler, and M. A. Blasco. 2000. Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J. Exp. Med. 192: 1625–1636.
  • Graham, F. L., J. Smiley, W. C. Russell, and R. Nairn. 1977. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36: 59–74.
  • Green, C. M., and G. Almouzni. 2002. When repair meets chromatin. First in series on chromatin dynamics. EMBO Rep. 3: 28–33.
  • Greider, C. W. 1999. Telomeres do D-loop-T-loop. Cell 97: 419–422.
  • Griffith, J. D., L. Comeau, S. Rosenfield, R. M. Stansel, A. Bianchi, H. Moss, and T. de Lange. 1999. Mammalian telomeres end in a large duplex loop. Cell 97: 503–514.
  • Hwang, K. K., and H. J. Worman. 2002. Gene regulation by human orthologs of Drosophila heterochromatin protein 1. Biochem. Biophys. Res. Commun. 293: 1217–1222.
  • James, T. C., J. C. Eissenberg, C. Craig, V. Dietrich, A. Hobson, and S. C. Elgin. 1989. Distribution patterns of HP1, a heterochromatin-associated nonhistone chromosomal protein of Drosophila. Eur. J. Cell Biol. 50: 170–180.
  • Kelleher, C., M. T. Teixeira, K. Forstemann, and J. Lingner. 2002. Telomerase: biochemical considerations for enzyme and substrate. Trends Biochem. Sci. 27: 572–579.
  • Kellum, R. 2003. Is HP1 an RNA detector that functions both in repression and activation? J. Cell Biol. 161: 671–672.
  • Kharbanda, S., V. Kumar, S. Dhar, P. Pandey, C. Chen, P. Majumder, Z. M. Yuan, Y. Whang, W. Strauss, T. K. Pandita, D. Weaver, and D. Kufe. 2000. Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase. Curr. Biol. 10: 568–575.
  • Kirschmann, D. A., R. A. Lininger, L. M. Gardner, E. A. Seftor, V. A. Odero, A. M. Ainsztein, W. C. Earnshaw, L. L. Wallrath, and M. J. Hendrix. 2000. Down-regulation of HP1Hsα expression is associated with the metastatic phenotype in breast cancer. Cancer Res. 60: 3359–3363.
  • Koering, C. E., A. Pollice, M. P. Zibella, S. Bauwens, A. Puisieux, M. Brunori, C. Brun, L. Martins, L. Sabatier, J. F. Pulitzer, and E. Gilson. 2002. Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity. EMBO Rep. 3: 1055–1061.
  • Lorentz, A., K. Ostermann, O. Fleck, and H. Schmidt. 1994. Switching gene swi6, involved in repression of silent mating-type loci in fission yeast, encodes a homologue of chromatin-associated proteins from Drosophila and mammals. Gene 143: 139–143.
  • Ma, J., K. K. Hwang, H. J. Worman, J. C. Courvalin, and J. C. Eissenberg. 2001. Expression and functional analysis of three isoforms of human heterochromatin-associated protein HP1 in Drosophila. Chromosoma 109: 536–544.
  • MacAuley, A., and T. Pawson. 1988. Cooperative transforming activities of ras, myc, and src viral oncogenes in nonestablished rat adrenocortical cells. J. Virol. 62: 4712–4721.
  • Makarov, V. L., Y. Hirose, and J. P. Langmore. 1997. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88: 657–666.
  • Mathog, D., M. Hochstrasser, Y. Gruenbaum, H. Saumweber, and J. Sedat. 1984. Characteristic folding pattern of polytene chromosomes in Drosophila salivary gland nuclei. Nature 308: 414–421.
  • McElligott, R., and R. J. Wellinger. 1997. The terminal DNA structure of mammalian chromosomes. EMBO J. 16: 3705–3714.
  • Minc, E., Y. Allory, H. J. Worman, J. C. Courvalin, and B. Buendia. 1999. Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. Chromosoma 108: 220–234.
  • Morgan, S. E., C. Lovly, T. K. Pandita, Y. Shiloh, and M. B. Kastan. 1997. Fragments of ATM which have dominant-negative or complementing activity. Mol. Cell. Biol. 17: 2020–2029.
  • Nielsen, A. L., J. A. Ortiz, J. You, M. Oulad-Abdelghani, R. Khechumian, A. Gansmuller, P. Chambon, and R. Losson. 1999. Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J. 18: 6385–6395.
  • Nielsen, A. L., M. Oulad-Abdelghani, J. A. Ortiz, E. Remboutsika, P. Chambon, and R. Losson. 2001. Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins. Mol. Cell 7: 729–739.
  • Pandita, T. K. 2002. ATM function and telomere stability. Oncogene 21: 611–618.
  • Pandita, T. K. 1983. Effect of temperature variation on sister chromatid exchange frequency in cultured human lymphocytes. Hum. Genet. 63: 189–190.
  • Pandita, T. K., and C. R. Geard. 1996. Chromosome aberrations in human fibroblasts induced by monoenergetic neutrons. I. Relative biological effectiveness. Radiat. Res. 145: 730–739.
  • Pandita, T. K., E. J. Hall, T. K. Hei, M. A. Piatyszek, W. E. Wright, C. Q. Piao, R. K. Pandita, J. C. Willey, C. R. Geard, M. B. Kastan, and J. W. Shay. 1996. Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. Oncogene 13: 1423–1430.
  • Pandita, T. K., S. Pathak, and C. R. Geard. 1995. Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells. Cytogenet. Cell Genet. 71: 86–93.
  • Paro, R., and D. S. Hogness. 1991. The polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila. Proc. Natl. Acad. Sci. USA 88: 263–267.
  • Piacentini, L., L. Fanti, M. Berloco, B. Perrini, and S. Pimpinelli. 2003. Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin. J. Cell Biol. 161: 707–714.
  • Sawant, S. G., V. Gregoire, S. Dhar, C. B. Umbricht, S. Cvilic, S. Sukumar, and T. K. Pandita. 1999. Telomerase activity as a measure for monitoring radiocurability of tumor cells. FASEB J. 13: 1047–1054.
  • Sharma, G. G., A. Gupta, H. Wang, H. Scherthan, S. Dhar, V. Gandhi, G. Iliakis, J. W. Shay, C. S. Young, and T. K. Pandita. 2003. hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene 22: 131–146.
  • Smerdon, M. J., and A. Conconi. 1999. Modulation of DNA damage and DNA repair in chromatin. Prog. Nucleic Acid Res. Mol. Biol. 62: 227–255.
  • Smilenov, L. B., S. Dhar, and T. K. Pandita. 1999. Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment. Mol. Cell. Biol. 19: 6963–6971.
  • Smilenov, L. B., W. Mellado, P. H. Rao, S. G. Sawant, C. B. Umbricht, S. Sukumar, and T. K. Pandita. 1998. Molecular cloning and chromosomal localization of Chinese hamster telomeric protein chTRF1. Its potential role in chromosomal instability. Oncogene 17: 2137–2142.
  • Smilenov, L. B., S. E. Morgan, W. Mellado, S. G. Sawant, M. B. Kastan, and T. K. Pandita. 1997. Influence of ATM function on telomere metabolism. Oncogene 15: 2659–2665.
  • Song, K., Y. Jung, D. Jung, and I. Lee. 2001. Human Ku70 interacts with heterochromatin protein 1α. J. Biol. Chem. 276: 8321–8327.
  • Stansel, R. M., T. de Lange, and J. D. Griffith. 2001. T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. EMBO J. 20: 5532–5540.
  • Taggart, A. K., S. C. Teng, and V. A. Zakian. 2002. Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science 297: 1023–1026.
  • van Steensel, B., and T. de Lange. 1997. Control of telomere length by the human telomeric protein TRF1. Nature 385: 740–743.
  • van Steensel, B., A. Smogorzewska, and T. de Lange. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401–413.
  • Vaziri, H., J. A. Squire, T. K. Pandita, G. Bradley, R. M. Kuba, H. Zhang, S. Gulyas, R. P. Hill, G. P. Nolan, and S. Benchimol. 1999. Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts. Mol. Cell. Biol. 19: 2373–2379.
  • Wang, G., A. Ma, C. M. Chow, D. Horsley, N. R. Brown, I. G. Cowell, and P. B. Singh. 2000. Conservation of heterochromatin protein 1 function. Mol. Cell. Biol. 20: 6970–6983.
  • Wellinger, R. J., and D. Sen. 1997. The DNA structures at the ends of eukaryotic chromosomes. Eur. J. Cancer 33: 735–749.
  • Wong, K. K., S. Chang, S. R. Weiler, S. Ganesan, J. Chaudhuri, C. Zhu, S. E. Artandi, K. L. Rudolph, G. J. Gottlieb, L. Chin, F. W. Alt, and R. A. DePinho. 2000. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat. Genet. 26: 85–88.
  • Wood, L. D., T. L. Halvorsen, S. Dhar, J. A. Baur, R. K. Pandita, W. E. Wright, M. P. Hande, G. Calaf, T. K. Hei, F. Levine, J. W. Shay, J. J. Wang, and T. K. Pandita. 2001. Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression. Oncogene 20: 278–288.
  • Wright, W. E., and J. W. Shay. 1992. Telomere positional effects and the regulation of cellular senescence. Trends Genet. 8: 193–197.
  • Zhao, T., T. Heyduk, C. D. Allis, and J. C. Eissenberg. 2000. Heterochromatin protein 1 binds to nucleosomes and DNA in vitro. J. Biol. Chem. 275: 28332–28338.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.