Activity of Metal-Responsive Transcription Factor 1 by Toxic Heavy Metals and H₂O₂ In Vitro Is Modulated by Metallothionein

REFERENCES

• Adilakshmi, T., and R. O. Laine. 2002. Ribosomal protein S25 mRNA partners with MTF-1 and La to provide a p53-mediated mechanism for survival or death. J. Biol. Chem. 277: 4147-4151.
   PubMed Web of Science ®Google Scholar
• Andrews, G. K. 2000. Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem. Pharmacol. 59: 95–104.
   PubMed Web of Science ®Google Scholar
• Andrews, G. K., D. K. Lee, R. Ravindra, P. Lichtlen, M. Sirito, M. Sawadogo, and W. Schaffner. 2001. The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development. EMBO J. 20: 1114–1122.
   PubMed Web of Science ®Google Scholar
• Apuy, J. L., X. Chen, D. H. Russell, T. O. Baldwin, and D. P. Giedroc. 2001. Ratiometric pulsed alkylation/mass spectrometry of the cysteine pairs in individual zinc fingers of MRE-binding transcription factor-1 (MTF-1) as a probe of zinc chelate stability. Biochemistry 40: 15164–15175.
   PubMedGoogle Scholar
• Arnosti, D. N., A. Merino, D. Reinberg, and W. Schaffner. 1993. Oct-2 facilitates functional preinitiation complex assembly and is continuously required at the promoter for multiple rounds of transcription. EMBO J. 12: 157–166.
   PubMedGoogle Scholar
• Bird, A. J., H. Zhao, H. Luo, L. T. Jensen, C. Srinivasan, M. Evans-Galea, D. R. Winge, and D. J. Eide. 2000. A dual role for zinc fingers in both DNA binding and zinc sensing by the Zap1 transcriptional activator. EMBO J. 19: 3704–3713.
   PubMedGoogle Scholar
• Bittel, D., T. Dalton, S. L. Samson, L. Gedamu, and G. K. Andrews. 1998. The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals. J. Biol. Chem. 273: 7127–7133.
   PubMed Web of Science ®Google Scholar
• Brown, K. R., G. l. Keller, I. J. Pickering, H. H. Harris, G. N. George, and D. R. Woinge. 2002. Structures of cuprous-thiolate clusters of the Mac1 and Ace1 transcriptional activators. Biochemistry 41: 6469–6476.
   PubMedGoogle Scholar
• Brugnera, E., O. Georgiev, F. Radtke, R. Heuchel, E. Baker, G. R. Sutherland, and W. Schaffner. 1994. Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1. Nucleic Acids Res. 22: 3167–3173.
   PubMed Web of Science ®Google Scholar
• Buhler, R. H., and J. H. Kagi. 1974. Human hepatic metallothioneins. FEBS Lett. 39: 229–234.
   PubMed Web of Science ®Google Scholar
• Cano-Gauci, D. F., and B. Sarkar. 1996. Reversible zinc exchange between metallothionein and the estrogen receptor zinc finger. FEBS Lett. 386: 1–4.
   PubMed Web of Science ®Google Scholar
• Chen, X., M. Chu, and D. P. Giedroc. 1999. MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex. Biochemistry 38: 12915–12925.
   PubMed Web of Science ®Google Scholar
• Culotta, V. C., and D. H. Hamer. 1989. Fine mapping of a mouse metallothionein gene metal response element. Mol. Cell. Biol. 9: 1376–1380.
   PubMed Web of Science ®Google Scholar
• Culotta, V. C., T. Hsu, S. Hu, P. Furst, and D. Hamer. 1989. Copper and the ACE1 regulatory protein reversibly induce yeast metallothionein gene transcription in a mouse extract. Proc. Natl. Acad. Sci. 86: 8377–8381.
   PubMedGoogle Scholar
• Dalton, T., R. D. Palmiter, and G. K. Andrews. 1994. Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements. Nucleic Acids Res. 22: 5016–5023.
   PubMed Web of Science ®Google Scholar
• Dalton, T. P., D. Bittel, and G. K. Andrews. 1997. Reversible activation of mouse metal response element-binding transcription factor 1 DNA binding involves zinc interaction with the zinc finger domain. Mol. Cell. Biol. 17: 2781–2789.
   PubMed Web of Science ®Google Scholar
• Dalton, T. P., Q. Li, D. Bittel, L. Liang, and G. K. Andrews. 1996. Oxidative stress activates metal-responsive transcription factor-1 binding activity. Occupancy in vivo of metal response elements in the metallothionein-I gene promoter. J. Biol. Chem. 271: 26233–26241.
   PubMed Web of Science ®Google Scholar
• Daniels, P. J., D. Bittel, I. V. Smirnova, D. R. Winge, and G. K. Andrews. 2002. Mammalian metal response element-binding transcription factor-1 functions as a zinc sensor in yeast, but not as a sensor of cadmium or oxidative stress. Nucleic Acids Res. 30: 3130–3140.
   PubMedGoogle Scholar
• Datta, P. K., and S. T. Jacob. 1997. Activation of the metallothionein-I gene promoter in response to cadmium and USF in vitro. Biochem. Biophys. Res. Commun. 230: 159–163.
   PubMed Web of Science ®Google Scholar
• Davis, S. R., and R. J. Cousins. 2000. Metallothionein expression in animals: a physiological perspective on function. J. Nutr. 130: 1085–1088.
   PubMed Web of Science ®Google Scholar
• Furst, P., S. Hu, R. Hackett, and D. Hamer. 1988. Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein. Cell 55: 705–717.
   PubMed Web of Science ®Google Scholar
• Giedroc, D. P., X. Chen, and J. L. Apuy. 2001. Metal response element (MRE)-binding transcription factor-1 (MTF-1): structure, function, and regulation. Antioxid. Redox Signal. 3: 577–596.
   PubMed Web of Science ®Google Scholar
• Giedroc, D. P., X. Chen, M. A. Pennella, and A. C. LiWang. 2001. Conformational heterogeneity in the C-terminal zinc fingers of human MTF-1: an NMR and zinc-binding study. J. Biol. Chem. 276: 42322–42332.
   PubMedGoogle Scholar
• Green, C. J., P. Lichtlen, N. T. Huynh, M. Yanovsky, K. R. Laderoute, W. Schaffner, and B. J. Murphy. 2001. Placenta growth factor gene expression is induced by hypoxia in fibroblasts: a central role for metal transcription factor-1. Cancer Res. 61: 2696–2703.
   PubMed Web of Science ®Google Scholar
• Gunes, C., R. Heuchel, O. Georgiev, K. H. Muller, P. Lichtlen, H. Bluthmann, S. Marino, A. Aguzzi, and W. Schaffner. 1998. Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J. 17: 2846–2854.
   PubMed Web of Science ®Google Scholar
• Hentze, M. W., and L. C. Kuhn. 1996. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc. Natl. Acad. Sci. 93: 8175–8182.
   PubMed Web of Science ®Google Scholar
• Heuchel, R., F. Radtke, O. Georgiev, G. Stark, M. Aguet, and W. Schaffner. 1994. The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J. 13: 2870–2875.
   PubMed Web of Science ®Google Scholar
• Hidalgo, J., M. Aschner, P. Zatta, and M. Vasak. 2001. Roles of the metallothionein family of proteins in the central nervous system. Brain Res. Bull. 55: 133–145.
   PubMed Web of Science ®Google Scholar
• Hider, R. C., D. Bittel, and G. K. Andrews. 1999. Competition between iron(III)-selective chelators and zinc finger domains for zinc(II). Biochem. Pharmacol. 57: 1031–1035.
   PubMedGoogle Scholar
• Jacob, S. T., K. Ghoshal, and J. F. Sheridan. 1999. Induction of metallothionein by stress and its molecular mechanisms. Gene Expr. 7: 301–310.
   PubMed Web of Science ®Google Scholar
• Jiang, H., P. J. Daniels, and G. K. Andrews. 2003. Putative zinc-sensing zinc fingers of metal response element-binding transcription factor-1 stabilize a metal-dependent chromatin complex on the endogenous metallothionein-I promoter. J. Biol. Chem. 278: 30394–30402.
   PubMedGoogle Scholar
• Jimenez, I., M. Gotteland, A. Zarzuelo, R. Uauy, and H. Speisky. 1997. Loss of the metal binding properties of metallothionein induced by hydrogen peroxide and free radicals. Toxicology 120: 37–46.
   PubMedGoogle Scholar
• Kimura, T., N. Itoh, M. Takehara, I. Oguro, J. Ishizaki, T. Nakanishi, and K. Tanaka. 2002. MRE-binding transcription factor-1 is activated during endotoxemia: a central role for metallothionein. Toxicol. Lett. 129: 77–84.
   PubMedGoogle Scholar
• Kobayashi, H., Y. Uchida, Y. Ihara, K. Nakajima, S. Kohsaka, T. Miyatake, and S. Tsuji. 1993. Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system. Brain Res. Mol. Brain Res. 19: 188–194.
   PubMedGoogle Scholar
• Langmade, S. J., R. Ravindra, P. J. Daniels, and G. K. Andrews. 2000. The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene. J. Biol. Chem. 275: 34803–34809.
   PubMed Web of Science ®Google Scholar
• LaRochelle, O., V. Gagne, J. Charron, J. W. Soh, and C. Seguin. 2001. Phosphorylation is involved in the activation of metal-regulatory transcription factor 1 in response to metal ions. J. Biol. Chem. 276: 41879–41888.
   PubMed Web of Science ®Google Scholar
• Li, Q., N. Hu, M. A. Daggett, W. A. Chu, D. Bittel, J. A. Johnson, and G. K. Andrews. 1998. Participation of upstream stimulator factor (USF) in cadmium-induction of the mouse metallothionein-I gene. Nucleic Acids Res. 26: 5182–5189.
   PubMedGoogle Scholar
• Lichtlen, P., Y. Wang, T. Belser, O. Georgiev, U. Certa, R. Sack, and W. Schaffner. 2001. Target gene search for the metal-responsive transcription factor MTF-1. Nucleic Acids Res. 29: 1514–1523.
   PubMed Web of Science ®Google Scholar
• Lichtlen, P., and W. Schaffner. 2001. Putting its fingers on stressful situations: the heavy metal-regulatory transcription factor MTF-1. Bioassays 23: 1010–1017.
   PubMedGoogle Scholar
• Masters, B. A., E. J. Kelly, C. J. Quaife, R. L. Brinster, and R. D. Palmiter. 1994. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. 91: 584–588.
   PubMed Web of Science ®Google Scholar
• Matsuo, K., J. Silke, O. Georgiev, P. Marti, N. Giovannini, and D. Rungger. 1998. An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA. EMBO J. 17: 1446–1453.
   PubMedGoogle Scholar
• Mueller, P. R., S. J. Salser, and B. Wold. 1988. Constitutive and metal-inducible protein:DNA interactions at the mouse metallothionein I promoter examined by in vivo and in vitro footprinting. Genes Dev. 2: 412–427.
   PubMedGoogle Scholar
• Mueller-Storm, H. P., J. M. Sogo, and W. Schaffner. 1989. An enhancer stimulates transcription in trans when attached to the promoter via a protein bridge. Cell 58: 767–777.
   PubMedGoogle Scholar
• Muller, H. P., Brugnera, E., Georgiev, O., Badzong, M., Müller, K. H., and Schaffner, W. 1995. Analysis of the heavy metal-responsive transcription factor MTF-1 from human and mouse. Somat. Cell Mol. Genet. 21: 289–297.
   PubMedGoogle Scholar
• Muller, M. M., S. Ruppert, W. Schaffner, and P. Matthias. 1988. A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. Nature 336: 544–551.
   PubMedGoogle Scholar
• Murata, M., P. Gong, K. Suzuki, and S. Koizumi. 1999. Differential metal response and regulation of human heavy metal-inducible genes. J. Cell Physiol. 180: 105–113.
   PubMed Web of Science ®Google Scholar
• Murphy, B. J., G. K. Andrews, D. Bittel, D. J. Discher, J. McCue, C. J. Green, M. Yanovsky, A. Giaccia, R. M. Sutherland, K. R. Laderoute, and K. A. Webster. 1999. Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1. Cancer Res. 59: 1315–1322.
   PubMed Web of Science ®Google Scholar
• Ogra, Y., K. Suzuki, P. Gong, F. Otsuka, and S. Koizumi. 2001. Negative regulatory role of Sp1 in metal responsive element-mediated transcriptional activation. J. Biol. Chem. 276: 16534–16539.
   PubMed Web of Science ®Google Scholar
• Onosaka, S., K. S. Min, C. Fukuhara, K. Tanaka, S. Tashiro, I. Shimizu, M. Furuta, T. Yasutomi, K. Kobashi, and K. Yamamoto. 1986. Concentrations of metallothionein and metals in malignant and non-malignant tissues in human liver. Toxicology 38: 261–268.
   PubMed Web of Science ®Google Scholar
• Palmiter, R. D. 1998. The elusive function of metallothioneins. Proc. Natl. Acad. Sci. 95: 8428–8430.
   PubMed Web of Science ®Google Scholar
• Palmiter, R. D. 1994. Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1. Proc. Natl. Acad. Sci. 91: 1219–1223.
   PubMed Web of Science ®Google Scholar
• Palmiter, R. D., S. D. Findley, T. E. Whitmore, and D. M. Durnam. 1992. MT-III, a brain-specific member of the metallothionein gene family. Proc. Natl. Acad. Sci. 89: 6333–6337.
   PubMed Web of Science ®Google Scholar
• Pena, M. M., K. A. Koch, and D. J. Thiele. 1998. Dynamic regulation of copper uptake and detoxification genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 18: 2514–2523.
   PubMed Web of Science ®Google Scholar
• Quaife, C. J., S. D. Findley, J. C. Erickson, G. J. Froelick, E. J. Kelly, B. P. Zambrowicz, and R. D. Palmiter. 1994. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Biochemistry 33: 7250–7259.
   PubMed Web of Science ®Google Scholar
• Quesada, A. R., R. W. Byrnes, S. O. Krezoski, and D. H. Petering. 1996. Direct reaction of H2O2 with sulfhydryl groups in HL-60 cells: zinc-metallothionein and other sites. Arch. Biochem. Biophys. 334: 241–250.
   PubMed Web of Science ®Google Scholar
• Radtke, F., R. Heuchel, O. Georgiev, M. Hergersberg, M. Gariglio, Z. Dembic, and W. Schaffner. 1993. Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter. EMBO J. 12: 1355–1362.
   PubMed Web of Science ®Google Scholar
• Roesijadi, G., R. Bogumil, M. Vasak, and J. H. Kagi. 1998. Modulation of DNA binding of a tramtrack zinc finger peptide by the metallothionein-thionein conjugate pair. J. Biol. Chem. 273: 17425–17432.
   PubMed Web of Science ®Google Scholar
• Rouault, T., and R. Klausner. 1997. Regulation of iron metabolism in eukaryotes. Curr. Top. Cell Regul. 35: 1–19.
   PubMedGoogle Scholar
• Saydam, N., T. K. Adams, F. Steiner, W. Schaffner, and J. H. Freedman. 2002. Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription. J. Biol. Chem. 277: 20438–20445.
   PubMed Web of Science ®Google Scholar
• Saydam, N., O. Georgiev, M. Y. Nakano, U. F. Greber, and W. Schaffner. 2001. Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals. J. Biol. Chem. 276: 25487–25495.
   PubMed Web of Science ®Google Scholar
• Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with mini-extracts prepared from a small number of cells. Nucleic Acids Res. 17: 6419.
   PubMed Web of Science ®Google Scholar
• Searle, P. F. 1990. Zinc dependent binding of a liver nuclear factor to metal response element MRE-a of the mouse metallothionein-I gene and variant sequences. Nucleic Acids Res. 18: 4683–4690.
   PubMed Web of Science ®Google Scholar
• Smirnova, I. V., D. C. Bittel, R. Ravindra, H. Jiang, G. K. Andrews. 2000. Zinc and cadmium can promote rapid nuclear translocation of metal response element-binding transcription factor-1. J. Biol. Chem. 275: 9377–9384.
   PubMed Web of Science ®Google Scholar
• Stillman, M. J. 1995. Metallothioneins. Coord. Chem. Rev. 144: 461–511.
   Web of Science ®Google Scholar
• Stuart, G. W., P. F. Searle, and R. D. Palmiter. 1985. Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences. Nature 317: 828–831.
   PubMed Web of Science ®Google Scholar
• Thiele, D. J. 1988. ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene. Mol. Cell. Biol. 8: 2745–2752.
   PubMed Web of Science ®Google Scholar
• Vallee, B. L., and K. H. Falchuk. 1993. The biochemical basis of zinc physiology. Physiol. Rev. 73: 79–118.
   PubMed Web of Science ®Google Scholar
• Vanacore, R. M., J. D. Eskew, P. J. Morales, L. Sung, and A. Smith. 2000. Role for copper in transient oxidation and nuclear translocation of MTF-1, but not of NF-kappa B, by the heme-hemopexin transport system. Antioxid. Redox Signal. 2: 739–752.
   PubMedGoogle Scholar
• Vasak, M. 1991. Metal removal and substitution in vertebrate and invertebrate metallothioneins. Methods Enzymol. 205: 452–458.
   PubMed Web of Science ®Google Scholar
• Vasak, M. 1991. Standard isolation procedure for metallothionein. Methods Enzymol. 205: 41–44.
   PubMedGoogle Scholar
• Vasak, M., and D. W. Hasler. 2000. Metallothioneins: new functional and structural insights. Curr. Opi. Chem. Biol. 4: 177–183.
   PubMed Web of Science ®Google Scholar
• Vasak, M., and J. H. Kagi. 1994. Metallothioneins, vol. 4. Wiley and Sons, Chichester, England.
   Google Scholar
• Weaver, R. F., and C. Weissmann. 1979. Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S beta-globin mRNA precursor and mature 10 s beta-globin mRNA have identical map coordinates. Nucleic Acids Res. 7: 1175–1193.
   PubMedGoogle Scholar
• Westin, G., T. Gerster, M. M. Müller, G. Schaffner, and W. Schaffner. 1987. OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts. Nucleic Acids Res. 15: 6787–6798.
   PubMed Web of Science ®Google Scholar
• Westin, G., and W. Schaffner. 1988. Heavy metal ions in transcription factors from HeLa cells: Sp1, but not octamer transcription factor requires zinc for DNA binding and for activator function. Nucleic Acids Res. 16: 5771–5781.
   PubMed Web of Science ®Google Scholar
• Westin, G., and W. Schaffner. 1988. A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene. EMBO J. 7: 3763–3770.
   PubMed Web of Science ®Google Scholar
• Winge, D. R. 1998. Copper-regulatory domain involved in gene expression. Prog. Nucleic Acid Res. Mol. Biol. 58: 165–195.
   Google Scholar
• Yagle, M. K., and R. D. Palmiter. 1985. Coordinate regulation of mouse metallothionein I and II genes by heavy metals and glucocorticoids. Mol. Cell. Biol. 5: 291–294.
   PubMed Web of Science ®Google Scholar
• Zeng, J., R. Heuchel, W. Schaffner, and J. H. Kagi. 1991. Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Sp1. FEBS Lett. 279: 310–312.
   PubMed Web of Science ®Google Scholar
• Zeng, J., B. L. Vallee, and J. H. Kagi. 1991. Zinc transfer from transcription factor IIIA fingers to thionein clusters. Proc. Natl. Acad. Sci. 88: 9984–9988.
   PubMed Web of Science ®Google Scholar
• Zhang, B., D. Egli, O. Georgiev, and W. Schaffner. 2001. The Drosophila homolog of mammalian zinc finger factor MTF-1 activates transcription in response to heavy metals. Mol. Cell. Biol. 21: 4505–4514.
   PubMed Web of Science ®Google Scholar