Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage

REFERENCES

• Alvarez-Gonzalez, R., H. Spring, M. Muller, and A. Burkle. 1999. Selective loss of poly(ADP-ribose) and the 85-kDa fragment of poly(ADP-ribose) polymerase in nucleoli during alkylation-induced apoptosis of HeLa cells. J. Biol. Chem. 274: 32122–32126.
   PubMed Web of Science ®Google Scholar
• Barja, G. 2002. Endogenous oxidative stress: relationship to aging, longevity and caloric restriction. Ageing Res. Rev. 1: 397–411.
   PubMedGoogle Scholar
• Benitez-Bribiesca, L., and P. Sanchez-Suarez. 1999. Oxidative damage, bleomycin, and gamma radiation induce different types of DNA strand breaks in normal lymphocytes and thymocytes. A comet assay study. Ann. N. Y. Acad. Sci. 887: 133–149.
   PubMed Web of Science ®Google Scholar
• Bohr, V. A. 2002. Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells. Free Radic. Biol. Med. 32: 804–812.
   PubMed Web of Science ®Google Scholar
• Bohr, V. A., M. Cooper, D. Orren, A. Machwe, J. Piotrowski, J. Sommers, P. Karmakar, and R. Brosh. 2000. Werner syndrome protein: biochemical properties and functional interactions. Exp. Gerontol. 35: 695–702.
   PubMed Web of Science ®Google Scholar
• Brosh, R. M., Jr., D. K. Orren, J. O. Nehlin, P. H. Ravn, M. K. Kenny, A. Machwe, and V. A. Bohr. 1999. Functional and physical interaction between WRN helicase and human replication protein A. J. Biol. Chem. 274: 18341–18350.
   PubMed Web of Science ®Google Scholar
• Brosh, R. M., Jr., C. von Kobbe, J. A. Sommers, P. Karmakar, P. L. Opresko, J. Piotrowski, I. Dianova, G. L. Dianov, and V. A. Bohr. 2001. Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. EMBO J. 20: 5791–5801.
   PubMed Web of Science ®Google Scholar
• Burkle, A. 2001. PARP-1: a regulator of genomic stability linked with mammalian longevity. Chembiochem. Eur. J. Chem. Biol. 2: 725–728.
   PubMed Web of Science ®Google Scholar
• Chapman, M. L., M. R. Zaun, and R. W. Gracy. 1983. Changes in NAD levels in human lymphocytes and fibroblasts during aging and in premature aging syndromes. Mech. Ageing Dev. 21: 157–167.
   PubMedGoogle Scholar
• Dantzer, F., R. G. de La, J. Menissier-de Murcia, Z. Hostomsky, G. de Murcia, and V. Schreiber. 2000. Base excision repair is impaired in mammalian cells lacking poly(ADP-ribose) polymerase-1. Biochemistry 39: 7559–7569.
   PubMed Web of Science ®Google Scholar
• Desnoyers, S., S. H. Kaufmann, and G. G. Poirier. 1996. Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors. Exp. Cell Res. 227: 146–153.
   PubMedGoogle Scholar
• Duvic, M., and N. A. Lemak. 1995. Werner's syndrome. Dermatol. Clin. 13: 163–168.
   PubMedGoogle Scholar
• Friedberg, E. C., G. C. Walker, and W. Siede. 1995. DNA repair and mutagenesis, p. 135–190. American Society for Microbiology, Washington, D.C.
   Google Scholar
• Galande, S., and T. Kohwi-Shigematsu. 1999. Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences. J. Biol. Chem. 274: 20521–20528.
   PubMedGoogle Scholar
• Giner, H., F. Simonin, G. de Murcia, and J. Menissier-de Murcia. 1992. Overproduction and large-scale purification of the human poly(ADP-ribose) polymerase using a baculovirus expression system. Gene 114: 279–283.
   PubMedGoogle Scholar
• Grube, K., and A. Burkle. 1992. Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span. Proc. Natl. Acad. Sci. USA 89: 11759–11763.
   PubMed Web of Science ®Google Scholar
• Harrigan, J. A., P. L. Opresko, C. von Kobbe, P. S. Kedar, R. Prasad, S. H. Wilson, and V. A. Bohr. 2003. The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity. J. Biol. Chem. 278: 22686–22695.
   PubMedGoogle Scholar
• Kamath-Loeb, A. S., E. Johansson, P. M. Burgers, and L. A. Loeb. 2000. Functional interaction between the Werner Syndrome protein and DNA polymerase delta. Proc. Natl. Acad. Sci. USA 97: 4603–4608.
   PubMedGoogle Scholar
• Lebel, M., J. Lavoie, I. Gaudreault, M. Bronsard, and R. Drouin. 2003. Genetic cooperation between the Werner syndrome protein and Poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. Am. J. Pathol. 162: 1559–1569.
   PubMed Web of Science ®Google Scholar
• Lebel, M., E. A. Spillare, C. C. Harris, and P. Leder. 1999. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. J. Biol. Chem. 274: 37795–37799.
   PubMedGoogle Scholar
• Machwe, A., R. Ganunis, V. A. Bohr, and D. K. Orren. 2000. Selective blockage of the 3′→5′ exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA. Nucleic Acids Res. 28: 2762–2770.
   PubMed Web of Science ®Google Scholar
• Malanga, M., J. M. Pleschke, H. E. Kleczkowska, and F. R. Althaus. 1998. Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions. J. Biol. Chem. 273: 11839–11843.
   PubMed Web of Science ®Google Scholar
• Marciniak, R. A., D. B. Lombard, F. B. Johnson, and L. Guarente. 1998. Nucleolar localization of the Werner syndrome protein in human cells. Proc. Natl. Acad. Sci. USA 95: 6686–6892.
   Google Scholar
• Marklund, S., I. Nordensson, and O. Back. 1981. Normal CuZn superoxide dismutase, Mn superoxide dismutase, catalase and glutathione peroxidase in Werner's syndrome. J. Gerontol. 36: 405–409.
   PubMedGoogle Scholar
• Marnett, L. J. 2000. Oxyradicals and DNA damage. Carcinogenesis 21: 361–370.
   PubMed Web of Science ®Google Scholar
• Martin, G. M. 1978. Genetic syndromes in man with potential relevance to the pathobiology of aging. Birth Defects Orig. Artic. Ser. 14: 5–39.
   PubMedGoogle Scholar
• Masson, M., C. Niedergang, V. Schreiber, S. Muller, J. Menissier-de Murcia, and G. de Murcia. 1998. XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol. Cell. Biol. 18: 3563–3571.
   PubMed Web of Science ®Google Scholar
• Muiras, M. L., M. Muller, F. Schachter, and A. Burkle. 1998. Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians. J. Mol. Med. 76: 346–354.
   PubMed Web of Science ®Google Scholar
• Oakley, T. J., and I. D. Hickson. 2002. Defending genome integrity during S-phase: putative roles for RecQ helicases and topoisomerase III. DNA Repair 1: 175–207.
   PubMedGoogle Scholar
• Opresko, P. L., C. von Kobbe, J. P. Laine, J. Harrigan, I. D. Hickson, and V. A. Bohr. 2002. Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J. Biol. Chem. 277: 41110–41119.
   PubMed Web of Science ®Google Scholar
• Orren, D. K., R. M. Brosh, Jr., J. O. Nehlin, A. Machwe, M. D. Gray, and V. A. Bohr. 1999. Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO. Nucleic Acids Res. 27: 3557–3566.
   PubMedGoogle Scholar
• Pichierri, P., A. Franchitto, P. Mosesso, and F. Palitti. 2000. Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage. Mutat. Res. 456: 45–57.
   PubMed Web of Science ®Google Scholar
• Pichierri, P., A. Franchitto, P. Mosesso, and F. Palitti. 2001. Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle. Mol. Biol. Cell 12: 2412–2421.
   PubMedGoogle Scholar
• Pleschke, J. M., H. E. Kleczkowska, M. Strohm, and F. R. Althaus. 2000. Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins. J. Biol. Chem. 275: 40974–40980.
   PubMed Web of Science ®Google Scholar
• Poot, M., K. A. Gollahon, M. J. Emond, J. R. Silber, and P. S. Rabinovitch. 2002. Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype. FASEB J. 16: 757–758.
   PubMedGoogle Scholar
• Poot, M., K. A. Gollahon, and P. S. Rabinovitch. 1999. Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase. Hum. Genet. 104: 10–14.
   PubMedGoogle Scholar
• Poot, M., H. Hoehn, T. M. Runger, and G. M. Martin. 1992. Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cells. Exp. Cell Res. 202: 267–273.
   PubMed Web of Science ®Google Scholar
• Povirk, L. F. 1996. DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes. Fundam. Mol. Mech. Mutagen. 355: 71–89.
   PubMed Web of Science ®Google Scholar
• Prasad, R., O. I. Lavrik, S. J. Kim, P. Kedar, X. P. Yang, B. J. Vande Berg, and S. H. Wilson. 2001. DNA polymerase beta-mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis. J. Biol. Chem. 276: 32411–32414.
   PubMed Web of Science ®Google Scholar
• Rajaee-Behbahani, N., P. Schmezer, A. Burkle, and H. Bartsch. 2000. Quantitative assessment of bleomycin-induced poly(ADP-ribosyl)ation in human lymphocytes by immunofluorescence and image analysis. J. Immunol. Methods 244: 145–151.
   PubMedGoogle Scholar
• Schreiber, V., J. C. Ame, P. Dolle, I. Schultz, B. Rinaldi, V. Fraulob, J. Menissier-de Murcia, and G. de Murcia. 2002. Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. J. Biol. Chem. 277: 23028–23036.
   PubMed Web of Science ®Google Scholar
• Spector, A., and W. H. Garner. 1981. Hydrogen peroxide and human cataract. Exp. Eye Res. 33: 673–681.
   PubMed Web of Science ®Google Scholar
• Spillare, E. A., A. I. Robles, X. W. Wang, J. C. Shen, C. E. Yu, G. D. Schellenberg, and C. C. Harris. 1999. p53-mediated apoptosis is attenuated in Werner syndrome cells. Genes Dev. 13: 1355–1360.
   PubMed Web of Science ®Google Scholar
• Stadtman, E. R. 1992. Protein oxidation and aging. Science 257: 1220–1225.
   PubMed Web of Science ®Google Scholar
• Szekely, A. M., Y. H. Chen, C. Zhang, J. Oshima, and S. M. Weissman. 2000. Werner protein recruits DNA polymerase delta to the nucleolus. Proc. Natl. Acad. Sci. USA 97: 11365–11370.
   PubMedGoogle Scholar
• Takeuchi, F., F. Hanaoka, M. Goto, M. Yamada, and T. Miyamoto. 1982. Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblasts. Exp. Gerontol. 17: 473–480.
   PubMedGoogle Scholar
• Tong, W. M., U. Cortes, and Z. Q. Wang. 2001. Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis. Biochim. Biophys. Acta 1552: 27–37.
   PubMed Web of Science ®Google Scholar
• von Kobbe, C., and V. A. Bohr. 2002. A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092. J. Cell Sci. 115: 3901–3907.
   PubMed Web of Science ®Google Scholar
• von Kobbe, C., P. Karmakar, L. Dawut, P. Opresko, X. Zeng, R. M. Brosh, Jr., I. D. Hickson, and V. A. Bohr. 2002. Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J. Biol. Chem. 277: 22035–22044.
   PubMed Web of Science ®Google Scholar
• Weirich-Schwaiger, H., H. G. Weirich, B. Gruber, M. Schweiger, and M. Hirsch-Kauffmann. 1994. Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes. Mutat. Res. 316: 37–48.
   PubMed Web of Science ®Google Scholar
• Yu, C. E., J. Oshima, Y. H. Fu, E. M. Wijsman, F. Hisama, R. Alisch, S. Matthews, J. Nakura, T. Miki, S. Ouais, G. M. Martin, J. Mulligan, and G. D. Schellenberg. 1996. Positional cloning of the Werner's syndrome gene. Science 272: 258–262.
   PubMed Web of Science ®Google Scholar
• Ziegler, M., and S. L. Oei. 2001. A cellular survival switch: poly(ADP-ribosyl)ation stimulates DNA repair and silences transcription. Bioessays 23: 543–548.
   PubMedGoogle Scholar