Gads/Grb2-Mediated Association with LAT Is Critical for the Inhibitory Function of Gab2 in T Cells

REFERENCES

• Asada, H., N. Ishii, Y. Sasaki, K. Endo, H. Kasai, N. Tanaka, T. Takeshita, S. Tsuchiya, T. Konno, and K. Sugamura. 1999. Grf40, a novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. J. Exp. Med. 189: 1383–1390.
   PubMedGoogle Scholar
• Berry, D., P. Nash, S. Liu, T. Pawson, and C. McGlade. 2002. A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling. Curr. Biol. 12: 1336.
   PubMedGoogle Scholar
• Berry, D. M., S. J. Benn, A. M. Cheng, and C. J. McGlade. 2001. Caspase-dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor. Oncogene 20: 1203–1211.
   PubMedGoogle Scholar
• Boerth, N. J., J. J. Sadler, D. E. Bauer, J. L. Clements, S. M. Gheith, and G. A. Koretzky. 2000. Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling. J. Exp. Med. 192: 1047–1058.
   PubMedGoogle Scholar
• Bourgin, C., R. P. Bourette, S. Arnaud, Y. Liu, L. R. Rohrschneider, and G. Mouchiroud. 2002. Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation. Mol. Cell. Biol. 22: 3744–3756.
   PubMedGoogle Scholar
• Brinster, R. L., H. Y. Chen, M. E. Trumbauer, M. K. Yagle, and R. D. Palmiter. 1985. Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc. Natl. Acad. Sci. USA 82: 4438–4442.
   PubMed Web of Science ®Google Scholar
• Burack, W. R., A. M. Cheng, and A. S. Shaw. 2002. Scaffolds, adaptors and linkers of TCR signaling: theory and practice. Curr. Opin. Immunol. 14: 312–316.
   PubMedGoogle Scholar
• Finco, T. S., T. Kadlecek, W. Zhang, L. E. Samelson, and A. Weiss. 1998. LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity 9: 617–626.
   PubMed Web of Science ®Google Scholar
• Gadina, M., C. Sudarshan, R. Visconti, Y. J. Zhou, H. Gu, B. G. Neel, and J. J. O'Shea. 2000. The docking molecule Gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines. J. Biol. Chem. 275: 26959–26966.
   PubMedGoogle Scholar
• Gu, H., K. Saito, L. D. Klaman, J. Shen, T. Fleming, Y. Wang, J. C. Pratt, G. Lin, B. Lim, J. P. Kinet, and B. G. Neel. 2001. Essential role for Gab2 in the allergic response. Nature 412: 186–190.
   PubMed Web of Science ®Google Scholar
• Hermiston, M. L., Z. Xu, R. Majeti, and A. Weiss. 2002. Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. J. Clin. Investig. 109: 9–14.
   PubMedGoogle Scholar
• Hibi, M., and T. Hirano. 2000. Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors. Leuk. Lymphoma 37: 299–307.
   PubMed Web of Science ®Google Scholar
• Ishii, N., Y. Owada, M. Yamada, S. Miura, K. Murata, H. Asao, H. Kondo, and K. Sugamura. 2001. Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice. Mol. Cell. Biol. 21: 8626–8637.
   PubMedGoogle Scholar
• Itoh, K., M. Sakakibara, S. Yamasaki, A. Takeuchi, H. Arase, M. Miyazaki, N. Nakajima, M. Okada, and T. Saito. 2002. Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly. J. Immunol. 168: 541–544.
   PubMedGoogle Scholar
• Koretzky, G. A., and P. S. Myung. 2001. Positive and negative regulation of T-cell activation by adaptor proteins. Nat. Rev. Immunol. 1: 95–107.
   PubMedGoogle Scholar
• Kosugi, A., S. Saitoh, S. Noda, K. Yasuda, F. Hayashi, M. Ogata, and T. Hamaoka. 1999. Translocation of tyrosine-phosphorylated TCRzeta chain to glycolipid-enriched membrane domains upon T cell activation. Int. Immunol. 11: 1395–1401.
   PubMedGoogle Scholar
• Lewitzky, M., C. Kardinal, N. H. Gehring, E. K. Schmidt, B. Konkol, M. Eulitz, W. Birchmeier, U. Schaeper, and S. M. Feller. 2001. The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif. Oncogene 20: 1052–1062.
   PubMed Web of Science ®Google Scholar
• Liu, S. K., D. M. Berry, and C. J. McGlade. 2001. The role of Gads in hematopoietic cell signalling. Oncogene 20: 6284–6290.
   PubMedGoogle Scholar
• Liu, S. K., and C. J. McGlade. 1998. Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc. Oncogene 17: 3073–3082.
   PubMedGoogle Scholar
• Liu, S. K., C. A. Smith, R. Arnold, F. Kiefer, and C. J. McGlade. 2000. The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR. J. Immunol. 165: 1417–1426.
   PubMedGoogle Scholar
• Liu, Y., and L. R. Rohrschneider. 2002. The gift of Gab. FEBS Lett. 515: 1–7.
   PubMed Web of Science ®Google Scholar
• Lock, L. S., I. Royal, M. A. Naujokas, and M. Park. 2000. Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases. J. Biol. Chem. 275: 31536–31545.
   PubMedGoogle Scholar
• Ma, W., C. Xia, P. Ling, M. Qiu, Y. Luo, T. H. Tan, and M. Liu. 2001. Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes. Oncogene 20: 1703–1714.
   PubMed Web of Science ®Google Scholar
• Montixi, C., C. Langlet, A. M. Bernard, J. Thimonier, C. Dubois, M. A. Wurbel, J. P. Chauvin, M. Pierres, and H. T. He. 1998. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J. 17: 5334–5348.
   PubMed Web of Science ®Google Scholar
• Nakano, H., T. Yamazaki, M. Ikeda, H. Masai, S. Miyatake, and T. Saito. 1994. Purification of glutathione S-transferase fusion proteins as a non-degraded form by using a protease-negative E. coli strain, AD202. Nucleic Acids Res. 22: 543–544.
   PubMedGoogle Scholar
• Nishida, K., L. Wang, E. Morii, S. J. Park, M. Narimatsu, S. Itoh, S. Yamasaki, M. Fujishima, K. Ishihara, M. Hibi, Y. Kitamura, and T. Hirano. 2002. Requirement of Gab2 for mast cell development and KitL/c-Kit signaling. Blood 99: 1866–1869.
   PubMedGoogle Scholar
• Nishida, K., Y. Yoshida, M. Itoh, T. Fukada, T. Ohtani, T. Shirogane, T. Atsumi, M. Takahashi-Tezuka, K. Ishihara, M. Hibi, and T. Hirano. 1999. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood 93: 1809–1816.
   PubMed Web of Science ®Google Scholar
• Nishida, M., K. Nagata, Y. Hachimori, M. Horiuchi, K. Ogura, V. Mandiyan, J. Schlessinger, and F. Inagaki. 2001. Novel recognition mode between Vav and Grb2 SH3 domains. EMBO J. 20: 2995–3007.
   PubMed Web of Science ®Google Scholar
• Pratt, J. C., V. E. Igras, H. Maeda, S. Baksh, E. W. Gelfand, S. J. Burakoff, B. G. Neel, and H. Gu. 2000. Cutting edge: gab2 mediates an inhibitory phosphatidylinositol 3′-kinase pathway in T cell antigen receptor signaling. J. Immunol. 165: 4158–4163.
   PubMedGoogle Scholar
• Schaeper, U., N. H. Gehring, K. P. Fuchs, M. Sachs, B. Kempkes, and W. Birchmeier. 2000. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J. Cell Biol. 149: 1419–1432.
   PubMed Web of Science ®Google Scholar
• Weber, J. R., S. Orstavik, K. M. Torgersen, N. C. Danbolt, S. F. Berg, J. C. Ryan, K. Tasken, J. B. Imboden, and J. T. Vaage. 1998. Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J. Exp. Med. 187: 1157–1161.
   PubMedGoogle Scholar
• Weidner, K. M., S. Di Cesare, M. Sachs, V. Brinkmann, J. Behrens, and W. Birchmeier. 1996. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 384: 173–176.
   PubMed Web of Science ®Google Scholar
• Wolf, I., B. J. Jenkins, Y. Liu, M. Seiffert, J. M. Custodio, P. Young, and L. R. Rohrschneider. 2002. Gab3, a new DOS/Gab family member, facilitates macrophage differentiation. Mol. Cell. Biol. 22: 231–244.
   PubMedGoogle Scholar
• Yamasaki, S., K. Nishida, M. Hibi, M. Sakuma, R. Shiina, A. Takeuchi, H. Ohnishi, T. Hirano, and T. Saito. 2001. Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. J. Biol. Chem. 276: 45175–45183.
   PubMedGoogle Scholar
• Yamasaki, S., M. Tachibana, N. Shinohara, and M. Iwashima. 1997. Lck-independent triggering of T-cell antigen receptor signal transduction by staphylococcal enterotoxins. J. Biol. Chem. 272: 14787–14791.
   PubMed Web of Science ®Google Scholar
• Yoder, J., C. Pham, Y. M. Iizuka, O. Kanagawa, S. K. Liu, J. McGlade, and A. M. Cheng. 2001. Requirement for the SLP-76 adaptor GADS in T cell development. Science 291: 1987–1991.
   PubMedGoogle Scholar
• Zhang, W., R. P. Trible, M. Zhu, S. K. Liu, C. J. McGlade, and L. E. Samelson. 2000. Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling. J. Biol. Chem. 275: 23355–23361.
   PubMed Web of Science ®Google Scholar
• Zhumabekov, T., P. Corbella, M. Tolaini, and D. Kioussis. 1995. Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J. Immunol. Methods 185: 133–140.
   PubMedGoogle Scholar