Histone Deacetylase 1/mSin3A Disrupts Gamma Interferon-Induced CIITA Function and Major Histocompatibility Complex Class II Enhanceosome Formation

REFERENCES

• Ashburner, B. P., S. D. Westerheide, and A. S. Baldwin, Jr. 2001. The p65 (RelA) subunit of NF-êB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol. Cell. Biol. 21: 7065–7077.
   PubMed Web of Science ®Google Scholar
• Ayer, D. E. 1999. Histone deacetylases: transcriptional repression with SINers and NuRDs. Trends Cell Biol. 9: 193–198.
   PubMedGoogle Scholar
• Beresford, G. W., and J. M. Boss. 2001. CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter. Nat. Immunol. 2: 652–657.
   PubMed Web of Science ®Google Scholar
• Cressman, D. E., K. C. Chin, D. J. Taxman, and J. P. Ting. 1999. A defect in the nuclear translocation of CIITA causes a form of type II bare lymphocyte syndrome. Immunity 10: 163–171.
   PubMed Web of Science ®Google Scholar
• Cressman, D. E., W. J. O'Connor, S. F. Greer, X. S. Zhu, and J. P. Ting. 2001. Mechanisms of nuclear import and export that control the subcellular localization of class II transactivator. J. Immunol. 167: 3626–3634.
   PubMed Web of Science ®Google Scholar
• Fontes, J. D., B. Jiang, and B. M. Peterlin. 1997. The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32. Nucleic Acids Res. 25: 2522–2528.
   PubMed Web of Science ®Google Scholar
• Fontes, J. D., S. Kanazawa, D. Jean, and B. M. Peterlin. 1999. Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes. Mol. Cell. Biol. 19: 941–947.
   PubMedGoogle Scholar
• Grozinger, C. M., and S. L. Schreiber. 2002. Deacetylase enzymes: biological functions and the use of small-molecule inhibitors. Chem. Biol. 9: 3–16.
   PubMed Web of Science ®Google Scholar
• Hake, S. B., K. Masternak, C. Kammerbauer, C. Janzen, W. Reith, and V. Steimle. 2000. CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation. Mol. Cell. Biol. 20: 7716–7725.
   PubMedGoogle Scholar
• Harton, J. A., D. E. Cressman, K. C. Chin, C. J. Der, and J. P. Ting. 1999. GTP binding by class II transactivator: role in nuclear import. Science 285: 1402–1405.
   PubMedGoogle Scholar
• Harton, J. A., M. W. Linhoff, J. Zhang, and J. P. Ting. 2002. CATERPILLER: a large family of mammalian genes containing CARD, Pyrin, nucleotide binding and leucine-rich repeat domains. J. Immunol. 169: 4088–4093.
   PubMed Web of Science ®Google Scholar
• Harton, J. A., and J. P. Ting. 2000. Class II transactivator: mastering the art of major histocompatibility complex expression. Mol. Cell. Biol. 20: 6185–6194.
   PubMedGoogle Scholar
• Hassig, C. A., T. C. Fleischer, A. N. Billin, S. L. Schreiber, and D. E. Ayer. 1997. Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell 89: 341–347.
   PubMed Web of Science ®Google Scholar
• Hassig, C. A., J. K. Tong, T. C. Fleischer, T. Owa, P. G. Grable, D. E. Ayer, and S. L. Schreiber. 1998. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Proc. Natl. Acad. Sci. USA 95: 3519–3524.
   PubMedGoogle Scholar
• Juan, L. J., W. J. Shia, M. H. Chen, W. M. Yang, E. Seto, Y. S. Lin, and C. W. Wu. 2000. Histone deacetylases specifically down-regulate p53-dependent gene activation. J. Biol. Chem. 275: 20436–20443.
   PubMed Web of Science ®Google Scholar
• Kretsovali, A., T. Agalioti, C. Spilianakis, E. Tzortzakaki, M. Merika, and J. Papamatheakis. 1998. Involvement of CREB binding protein in expression of major histocompatibility complex class II genes via interaction with the class II transactivator. Mol. Cell. Biol. 18: 6777–6783.
   PubMed Web of Science ®Google Scholar
• Kretsovali, A., C. Spilianakis, A. Dimakopoulos, T. Makatounakis, and J. Papamatheakis. 2001. Self-association of class II transactivator correlates with its intracellular localization and transactivation. J. Biol. Chem. 276: 32191–32197.
   PubMedGoogle Scholar
• Landmann, S., A. Muhlethaler-Mottet, L. Bernasconi, T. Suter, J. M. Waldburger, K. Masternak, J. F. Arrighi, C. Hauser, A. Fontana, and W. Reith. 2001. Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class II transactivator (CIITA) expression. J. Exp. Med. 194: 379–391.
   PubMedGoogle Scholar
• Lee, L. F., G. Li, D. J. Templeton, and J. P. Ting. 1998. Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK). J. Biol. Chem. 273: 28253–28260.
   PubMed Web of Science ®Google Scholar
• Li, J., J. Wang, Z. Nawaz, J. M. Liu, J. Qin, and J. Wong. 2000. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. EMBO J. 19: 4342–4350.
   PubMed Web of Science ®Google Scholar
• Linhoff, M. W., J. A. Harton, D. E. Cressman, B. K. Martin, and J. P. Ting. 2001. Two distinct domains within CIITA mediate self-association: involvement of the GTP-binding and leucine-rich repeat domains. Mol. Cell. Biol. 21: 3001–3011.
   PubMedGoogle Scholar
• Linhoff, M. W., K. L. Wright, and J. P. Ting. 1997. CCAAT-binding factor NF-Y and RFX are required for in vivo assembly of a nucleoprotein complex that spans 250 base pairs: the invariant chain promoter as a model. Mol. Cell. Biol. 17: 4589–4596.
   PubMedGoogle Scholar
• Mach, B., V. Steimle, E. Martinez-Soria, and W. Reith. 1996. Regulation of MHC class II genes: lessons from a disease. Annu. Rev. Immunol. 14: 301–331.
   PubMed Web of Science ®Google Scholar
• Magner, W. J., A. L. Kazim, C. Stewart, M. A. Romano, G. Catalano, C. Grande, N. Keiser, F. Santaniello, and T. B. Tomasi. 2000. Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors. J. Immunol. 165: 7017–7024.
   PubMed Web of Science ®Google Scholar
• Mahanta, S. K., T. Scholl, F. C. Yang, and J. L. Strominger. 1997. Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein. Proc. Natl. Acad. Sci. USA 94: 6324–6329.
   PubMedGoogle Scholar
• Masternak, K., A. Muhlethaler-Mottet, J. Villard, M. Zufferey, V. Steimle, and W. Reith. 2000. CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. Genes Dev. 14: 1156–1166.
   PubMed Web of Science ®Google Scholar
• Masternak, K., and W. Reith. 2002. Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation. EMBO J. 21: 1379–1388.
   PubMedGoogle Scholar
• McDevitt, H. O. 1998. The role of MHC class II molecules in susceptibility and resistance to autoimmunity. Curr. Opin. Immunol. 10: 677–681.
   PubMed Web of Science ®Google Scholar
• Moreno, C. S., G. W. Beresford, P. Louis-Plence, A. C. Morris, and J. M. Boss. 1999. CREB regulates MHC class II expression in a CIITA-dependent manner. Immunity 10: 143–151.
   PubMedGoogle Scholar
• Mudhasani, R., and J. D. Fontes. 2002. The class II transactivator requires brahma-related gene 1 to activate transcription of major histocompatibility complex class II genes. Mol. Cell. Biol. 22: 5019–5026.
   PubMedGoogle Scholar
• Muhlethaler-Mottet, A., L. A. Otten, V. Steimle, and B. Mach. 1997. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J. 16: 2851–2860.
   PubMed Web of Science ®Google Scholar
• Murphy, M., J. Ahn, K. K. Walker, W. H. Hoffman, R. M. Evans, A. J. Levine, and D. L. George. 1999. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev. 13: 2490–2501.
   PubMed Web of Science ®Google Scholar
• Narlikar, G. J., H. Y. Fan, and R. E. Kingston. 2002. Cooperation between complexes that regulate chromatin structure and transcription. Cell 108: 475–487.
   PubMed Web of Science ®Google Scholar
• Ng, H. H., and A. Bird. 2000. Histone deacetylases: silencers for hire. Trends Biochem. Sci. 25: 121–126.
   PubMed Web of Science ®Google Scholar
• Ng, H. H., Y. Zhang, B. Hendrich, C. A. Johnson, B. M. Turner, H. Erdjument-Bromage, P. Tempst, D. Reinberg, and A. Bird. 1999. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat. Genet. 23: 58–61.
   PubMed Web of Science ®Google Scholar
• Osborne, A., H. Zhang, W. M. Yang, E. Seto, and G. Blanck. 2001. Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation. Mol. Cell. Biol. 21: 6495–6506.
   PubMedGoogle Scholar
• Panek, R. B., Y. J. Lee, Y. Itoh-Lindstrom, J. P. Ting, and E. N. Benveniste. 1994. Characterization of astrocyte nuclear proteins involved in IFN-gamma- and TNF-alpha-mediated class II MHC gene expression. J. Immunol. 153: 4555–4564.
   PubMedGoogle Scholar
• Pattenden, S. G., R. Klose, E. Karaskov, and R. Bremner. 2002. Interferon-gamma-induced chromatin remodeling at the CIITA locus is BRG1 dependent. EMBO J. 21: 1978–1986.
   PubMedGoogle Scholar
• Piskurich, J. F., M. W. Linhoff, Y. Wang, and J. P. Ting. 1999. Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor beta. Mol. Cell. Biol. 19: 431–440.
   PubMedGoogle Scholar
• Raval, A., T. K. Howcroft, J. D. Weissman, S. Kirshner, X. S. Zhu, K. Yokoyama, J. Ting, and D. S. Singer. 2001. Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250. Mol. Cell 7: 105–115.
   PubMedGoogle Scholar
• Riley, J. L., S. D. Westerheide, J. A. Price, J. A. Brown, and J. M. Boss. 1995. Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA). Immunity 2: 533–543.
   PubMedGoogle Scholar
• Scholl, T., S. K. Mahanta, and J. L. Strominger. 1997. Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5. Proc. Natl. Acad. Sci. USA 94: 6330–6334.
   PubMedGoogle Scholar
• Sisk, T. J., T. Gourley, S. Roys, and C. H. Chang. 2000. MHC class II transactivator inhibits IL-4 gene transcription by competing with NF-AT to bind the coactivator CREB binding protein (CBP)/p300. J. Immunol. 165: 2511–2517.
   PubMed Web of Science ®Google Scholar
• Spilianakis, C., J. Papamatheakis, and A. Kretsovali. 2000. Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes. Mol. Cell. Biol. 20: 8489–8498.
   PubMed Web of Science ®Google Scholar
• Steimle, V., L. A. Otten, M. Zufferey, and B. Mach. 1993. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell 75: 135–146.
   PubMed Web of Science ®Google Scholar
• Taunton, J., C. A. Hassig, and S. L. Schreiber. 1996. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272: 408–411.
   PubMed Web of Science ®Google Scholar
• Ting, J. P., and J. Trowsdale. 2002. Genetic control of MHC class II expression. Cell 109(Suppl.): S21–S33.
   PubMedGoogle Scholar
• Wen, Y. D., V. Perissi, L. M. Staszewski, W. M. Yang, A. Krones, C. K. Glass, M. G. Rosenfeld, and E. Seto. 2000. The histone deacetylase-3 complex contains nuclear receptor corepressors. Proc. Natl. Acad. Sci. USA 97: 7202–7207.
   PubMed Web of Science ®Google Scholar
• Wolffe, A. P. 1996. Histone deacetylase: a regulator of transcription. Science 272: 371–372.
   PubMed Web of Science ®Google Scholar
• Wong, A., N. Ghosh, K. P. McKinnon, W. Reed, J. F. Piskurich, K. L. Wright, and J. P. Ting. 2002. Regulation and specificity of MHC2TA promoter usage in T lymphocytes and cell line. J. Immunol. 169: 3112–3119.
   PubMedGoogle Scholar
• Wright, K. L., K. C. Chin, M. Linhoff, C. Skinner, J. A. Brown, J. M. Boss, G. R. Stark, and J. P. Ting. 1998. CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promoters in vivo. Proc. Natl. Acad. Sci. USA 95: 6267–6272.
   PubMedGoogle Scholar
• Wright, K. L., T. L. Moore, B. J. Vilen, A. M. Brown, and J. P. Ting. 1995. Major histocompatibility complex class II-associated invariant chain gene expression is up-regulated by cooperative interactions of Sp1 and NF-Y. J. Biol. Chem. 270: 20978–20986.
   PubMed Web of Science ®Google Scholar
• Wright, K. L., and J. P. Ting. 1992. In vivo footprint analysis of the HLA-DRA gene promoter: cell-specific interaction at the octamer site and up-regulation of X box binding by interferon gamma. Proc. Natl. Acad. Sci. USA 89: 7601–7605.
   PubMedGoogle Scholar
• Yang, W. M., Y. L. Yao, J. M. Sun, J. R. Davie, and E. Seto. 1997. Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J. Biol. Chem. 272: 28001–28007.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., G. LeRoy, H. P. Seelig, W. S. Lane, and D. Reinberg. 1998. The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Cell 95: 279–289.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., H. H. Ng, H. Erdjument-Bromage, P. Tempst, A. Bird, and D. Reinberg. 1999. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 13: 1924–1935.
   PubMed Web of Science ®Google Scholar
• Zhong, H., M. J. May, E. Jimi, and S. Ghosh. 2002. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol. Cell 9: 625–636.
   PubMed Web of Science ®Google Scholar
• Zhu, X. S., M. W. Linhoff, G. Li, K. C. Chin, S. N. Maity, and J. P. Ting. 2000. Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter. Mol. Cell. Biol. 20: 6051–6061.
   PubMed Web of Science ®Google Scholar
• Zhu, X. S., and J. P. Ting. 2001. A 36-amino-acid region of CIITA is an effective inhibitor of CBP: novel mechanism of gamma interferon-mediated suppression of collagen α2(I) and other promoters. Mol. Cell. Biol. 21: 7078–7088.
   PubMed Web of Science ®Google Scholar