35
Views
47
CrossRef citations to date
0
Altmetric
Cell Growth and Development

A Novel Notch Protein, N2N, Targeted by Neutrophil Elastase and Implicated in Hereditary Neutropenia

, , , , , & show all
Pages 58-70 | Received 01 Jul 2003, Accepted 09 Oct 2003, Published online: 27 Mar 2023

REFERENCES

  • Allen, D. H., and Tracy P. B.. 1995. Human coagulation factor V is activated to the functional cofactor by elastase and cathepsin G expressed at the monocyte surface. J. Biol. Chem. 270:1408–1415.
  • Ancliff, P. J., Gale R. E., Liesner R., Hann I. M., and Linch D. C.. 2001. Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease. Blood 98:2645–2650.
  • Ancliff, P. J., Gale R. E., Watts M. J., Liesner R., Hann I. M., Strobel S., and Linch D. C.. 2002. Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia. Blood 100:707–709.
  • Aronheim, A., Broder Y. C., Cohen A., Fritsch A., Belisle B., and Abo A.. 1998. Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton. Curr. Biol. 8:1125–1128.
  • Aronheim, A., Zandi E., Hennemann H., Elledge S. J., and Karin M.. 1997. Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol. Cell. Biol. 17:3094–3102.
  • Benson, K. F., Li F. Q., Person R. E., Albani D., Duan Z., Wechsler J., Meade-White K., Williams K., Acland G. M., Niemeyer G., Lothrop C. D., and Horwitz M.. 2003. Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase. Nat. Genet. 35:90–96.
  • Ben-Yaacov, S., Le Borgne R., Abramson I., Schweisguth F., and Schejter E. D.. 2001. Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling. J. Cell Biol. 152:1–13.
  • Berdnik, D., Torok T., Gonzalez-Gaitan M., and Knoblich J. A.. 2002. The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev. Cell 3:221–231.
  • Bigas, A., Martin D. I., and Milner L. A.. 1998. Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines. Mol. Cell. Biol. 18:2324–2333.
  • Cepinskas, G., Sandig M., and Kvietys P. R.. 1999. PAF-induced elastase-dependent neutrophil transendothelial migration is associated with the mobilization of elastase to the neutrophil surface and localization to the migrating front. J. Cell Sci. 112:1937–1945.
  • Clark, J. M., Vaughan D. W., Aiken B. M., and Kagan H. M.. 1980. Elastase-like enzymes in human neutrophils localized by ultrastructural cytochemistry. J. Cell Biol. 84:102–119.
  • Dale, D. C., Person R. E., Bolyard A. A., Aprikyan A. G., Bos C., Bonilla M. A., Boxer L. A., Kannourakis G., Zeidler C., Welte K., Benson K. F., and Horwitz M.. 2000. Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. Blood 96:2317–2322.
  • Dall'Acqua, W., Halin C., Rodrigues M. L., and Carter P.. 1999. Elastase substrate specificity tailored through substrate-assisted catalysis and phage display. Protein Eng. 12:981–987.
  • Devriendt, K., Kim A. S., Mathijs G., Frints S. G., Schwartz M., Van Den Oord J. J., Verhoef G. E., Boogaerts M. A., Fryns J. P., You D., Rosen M. K., and Vandenberghe P.. 2001. Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia. Nat. Genet. 27:313–317.
  • Feng, L., Seymour A. B., Jiang S., To A., Peden A. A., Novak E. K., Zhen L., Rusiniak M. E., Eicher E. M., Robinson M. S., Gorin M. B., and Swank R. T.. 1999. The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness. Hum. Mol. Genet. 8:323–330.
  • Fortini, M. E. 2002. Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nat. Rev. Mol. Cell Biol. 3:673–684.
  • Fuks, A., Zucker-Franklin D., and Franklin E. C.. 1983. Identification of elastases associated with purified plasma membranes isolated from human monocytes and lymphocytes. Biochim. Biophys. Acta 755:195–203.
  • Gardiner, E. E., De Luca M., McNally T., Michelson A. D., Andrews R. K., and Berndt M. C.. 2001. Regulation of P-selectin binding to the neutrophil P-selectin counter-receptor P-selectin glycoprotein ligand-1 by neutrophil elastase and cathepsin G. Blood 98:1440–1447.
  • Hamada, Y., Kadokawa Y., Okabe M., Ikawa M., Coleman J. R., and Tsujimoto Y.. 1999. Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality. Development 126:3415–3424.
  • Hermand, D., Westerling T., Pihlak A., Thuret J. Y., Vallenius T., Tiainen M., Vandenhaute J., Cottarel G., Mann C., and Makela T. P.. 2001. Specificity of Cdk activation in vivo by the two Caks Mcs6 and Csk1 in fission yeast. EMBO J. 20:82–90.
  • Horwitz, M., Benson K. F., Duan Z., Person R. E., Wechsler J., Williams K., Albani D., and Li F. Q.. 2003. Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis. Curr. Opin. Hematol. 10:49–54.
  • Horwitz, M., Benson K. F., Person R. E., Aprikyan A. G., and Dale D. C.. 1999. Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis. Nat. Genet. 23:433–436.
  • Huizing, M., Scher C. D., Strovel E., Fitzpatrick D. L., Hartnell L. M., Anikster Y., and Gahl W. A.. 2002. Nonsense mutations in ADTB3A cause complete deficiency of the beta3A subunit of adaptor complex-3 and severe Hermansky-Pudlak syndrome type 2. Pediatr. Res. 51:150–158.
  • Isakoff, S. J., Cardozo T., Andreev J., Li Z., Ferguson K. M., Abagyan R., Lemmon M. A., Aronheim A., and Skolnik E. Y.. 1998. Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast. EMBO J. 17:5374–5387.
  • Kaup, M., Dassler K., Reineke U., Weise C., Tauber R., and Fuchs H.. 2002. Processing of the human transferrin receptor at distinct positions within the stalk region by neutrophil elastase and cathepsin G. Biol. Chem. 383:1011–1020.
  • Kojika, S., and Griffin J. D.. 2001. Notch receptors and hematopoiesis. Exp. Hematol. 29:1041–1052.
  • Kumano, K., Chiba S., Shimizu K., Yamagata T., Hosoya N., Saito T., Takahashi T., Hamada Y., and Hirai H.. 2001. Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression. Blood 98:3283–3289.
  • Li, F. Q., and Horwitz M.. 2001. Characterization of mutant neutrophil elastase in severe congenital neutropenia. J. Biol. Chem. 276:14230–14241.
  • McCright, B., Gao X., Shen L., Lozier J., Lan Y., Maguire M., Herzlinger D., Weinmaster G., Jiang R., and Gridley T.. 2001. Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development 128:491–502.
  • Milner, L. A., and Bigas A.. 1999. Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation. Blood 93:2431–2448.
  • Ohishi, K., Varnum-Finney B., and Bernstein I. D.. 2002. The notch pathway: modulation of cell fate decisions in hematopoiesis. Int. J. Hematol. 75:449–459.
  • Ohishi, K., Varnum-Finney B., Flowers D., Anasetti C., Myerson D., and Bernstein I. D.. 2000. Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1. Blood 95:2847–2854.
  • Ohishi, K., Varnum-Finney B., Serda R. E., Anasetti C., and Bernstein I. D.. 2001. The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells. Blood 98:1402–1407.
  • Owen, C. A., Campbell M. A., Sannes P. L., Boukedes S. S., and Campbell E. J.. 1995. Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases. J. Cell Biol. 131:775–789.
  • Saito, T., Chiba S., Ichikawa M., Kunisato A., Asai T., Shimizu K., Yamaguchi T., Yamamoto G., Seo S., Kumano K., Nakagami-Yamaguchi E., Hamada Y., Aizawa S., and Hirai H.. 2003. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 18:675–685.
  • Samis, J. A., Kam E., Nesheim M. E., and Giles A. R.. 1998. Neutrophil elastase cleavage of human factor IX generates an activated factor IX-like product devoid of coagulant function. Blood 92:1287–1296.
  • Schroeder, T., and Just U.. 2000. Notch signalling via RBP-J promotes myeloid differentiation. EMBO J. 19:2558–2568.
  • Shaye, D. D., and Greenwald I.. 2002. Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans. Nature 420:686–690.
  • Small, D., Kovalenko D., Kacer D., Liaw L., Landriscina M., Di Serio C., Prudovsky I., and Maciag T.. 2001. Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype. J. Biol. Chem. 276:32022–32030.
  • Solecki, D. J., Liu X. L., Tomoda T., Fang Y., and Hatten M. E.. 2001. Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation. Neuron 31:557–568.
  • Takemaru, K. I., and Moon R. T.. 2000. The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression. J. Cell Biol. 149:249–254.
  • Tan-Pertel, H. T., Walker L., Browning D., Miyamoto A., Weinmaster G., and Gasson J. C.. 2000. Notch signaling enhances survival and alters differentiation of 32D myeloblasts. J. Immunol. 165:4428–4436.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.