Tumor Necrosis Factor Alpha-Induced Apoptosis Requires p73 and c-ABL Activation Downstream of RB Degradation

REFERENCES

• Agami, R., Blandino G., Oren M., and Shaul Y.. 1999. Interaction of c-Abl and p73α and their collaboration to induce apoptosis. Nature 399:809–813.
   PubMed Web of Science ®Google Scholar
• Ameyar, M., Shatrov V., Bouquet C., Capoulade C., Cai Z., Stancou R., Badie C., Haddada H., and Chouaib S.. 1999. Adenovirus-mediated transfer of wild-type p53 gene sensitizes TNF resistant MCF7 derivatives to the cytotoxic effect of this cytokine: relationship with c-myc and Rb. Oncogene 18:5464–5472.
   PubMedGoogle Scholar
• Barila, D., Rufini A., Condo I., Ventura N., Dorey K., Superti-Furga G., and Testi R.. 2003. Caspase-dependent cleavage of c-Abl contributes to apoptosis. Mol. Cell. Biol. 23:2790–2799.
   PubMedGoogle Scholar
• Baskaran, R., Wood L. D., Whitaker L. L., Canman C. E., Morgan S. E., Xu Y., Barlow C., Baltimore D., Wynshaw-Boris A., Kastan M. B., and Wang J. Y.. 1997. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 387:516–519.
   PubMed Web of Science ®Google Scholar
• Bergamaschi, D., Gasco M., Hiller L., Sullivan A., Syed N., Trigiante G., Yulug I., Merlano M., Numico G., Comino A., Attard M., Reelfs O., Gusterson B., Bell A. K., Heath V., Tavassoli M., Farrell P. J., Smith P., Lu X., and Crook T.. 2003. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell 3:387–402.
   PubMed Web of Science ®Google Scholar
• Chau, B. N., Borges H. L., Chen T. T., Masselli A., Hunton I. C., and Wang J. Y.. 2002. Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb. Nat. Cell Biol. 4:757–765.
   PubMedGoogle Scholar
• Chau, B. N., and Wang J. Y.. 2003. Coordinated regulation of life and death by RB. Nat. Rev. Cancer 3:130–138.
   PubMed Web of Science ®Google Scholar
• Chen, G., and Goeddel D. V.. 2002. TNF-R1 signaling: a beautiful pathway. Science 296:1634–1635.
   PubMed Web of Science ®Google Scholar
• Chipuk, J. E., Maurer U., Green D. R., and Schuler M.. 2003. Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell 4:371–381.
   PubMed Web of Science ®Google Scholar
• Costanzo, A., Merlo P., Pediconi N., Fulco M., Sartorelli V., Cole P. A., Fontemaggi G., Fanciulli M., Schiltz L., Blandino G., Balsano C., and Levrero M.. 2002. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol. Cell 9:175–186.
   PubMed Web of Science ®Google Scholar
• Cryns, V., and Yuan J.. 1998. Proteases to die for. Genes Dev. 12:1551–1570.
   PubMed Web of Science ®Google Scholar
• Dan, S., Naito M., Seimiya H., Kizaki A., Mashima T., and Tsuruo T.. 1999. Activation of c-Abl tyrosine kinase requires caspase activation and is not involved in JNK/SAPK activation during apoptosis of human monocytic leukemia U937 cells. Oncogene 18:1277–1283.
   PubMed Web of Science ®Google Scholar
• Ding, H. F., Lin Y. L., McGill G., Juo P., Zhu H., Blenis J., Yuan J., and Fisher D. E.. 2000. Essential role for caspase-8 in transcription-independent apoptosis triggered by p53. J. Biol. Chem. 275:38905–38911.
   PubMed Web of Science ®Google Scholar
• Druker, B. J., Tamura S., Buchdunger E., Ohno S., Segal G. M., Fanning S., Zimmermann J., and Lydon N. B.. 1996. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat. Med. 2:561–566.
   PubMed Web of Science ®Google Scholar
• Enari, M., Hase A., and Nagata S.. 1995. Apoptosis by a cytosolic extract from Fas-activated cells. EMBO J. 14:5201–5208.
   PubMedGoogle Scholar
• Field, S. J., Tsai F. Y., Kuo F., Zubiaga A. M., Kaelin W. G., Jr., Livingston D. M., Orkin S. H., and Greenberg M. E.. 1996. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85:549–561.
   PubMed Web of Science ®Google Scholar
• Flores, E. R., Tsai K. Y., Crowley D., Sengupta S., Yang A., McKeon F., and Jacks T.. 2002. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 416:560–564.
   PubMed Web of Science ®Google Scholar
• Goga, A., Liu X., Hambuch T. M., Senechal K., Major E., Berk A. J., Witte O. N., and Sawyers C. L.. 1995. p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase. Oncogene 11:791–799.
   PubMedGoogle Scholar
• Goldberg, Z., Vogt Sionov R., Berger M., Zwang Y., Perets R., Van Etten R. A., Oren M., Taya Y., and Haupt Y.. 2002. Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation. EMBO J. 21:3715–3727.
   PubMed Web of Science ®Google Scholar
• Gomez-Angelats, M., and Cidlowski J. A.. 2003. Molecular evidence for the nuclear localization of FADD. Cell Death Differ. 10:791–797.
   PubMedGoogle Scholar
• Gong, J. G., Costanzo A., Yang H. Q., Melino G., Kaelin W. G., Jr., Levrero M., and Wang J. Y.. 1999. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399:806–809.
   PubMed Web of Science ®Google Scholar
• Grob, T. J., Novak U., Maisse C., Barcaroli D., Luthi A. U., Pirnia F., Hugli B., Graber H. U., De Laurenzi V., Fey M. F., Melino G., and Tobler A.. 2001. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ. 8:1213–1223.
   PubMed Web of Science ®Google Scholar
• Gupta, S. 2002. A decision between life and death during TNF-alpha-induced signaling. J. Clin. Immunol. 22:185–194.
   PubMed Web of Science ®Google Scholar
• Harper, N., Hughes M., MacFarlane M., and Cohen G. M.. 2003. Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis. J. Biol. Chem. 278:25534–25541.
   PubMed Web of Science ®Google Scholar
• Hsu, H., Shu H. B., Pan M. G., and Goeddel D. V.. 1996. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84:299–308.
   PubMed Web of Science ®Google Scholar
• Inoue, T., Stuart J., Leno R., and Maki C. G.. 2002. Nuclear import and export signals in control of the p53-related protein p73. J. Biol. Chem. 277:15053–15060.
   PubMedGoogle Scholar
• Irwin, M., Marin M. C., Phillips A. C., Seelan R. S., Smith D. I., Liu W., Flores E. R., Tsai K. Y., Jacks T., Vousden K. H., and Kaelin W. G., Jr. 2000. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 407:645–648.
   PubMed Web of Science ®Google Scholar
• Irwin, M. S., Kondo K., Marin M. C., Cheng L. S., Hahn W. C., and Kaelin W. G.. 2003. Chemosensitivity linked to p73 function. Cancer Cell 3:403–410.
   PubMed Web of Science ®Google Scholar
• Jost, C. A., Marin M. C., and Kaelin W. G., Jr. 1997. p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature 389:191–194.
   PubMed Web of Science ®Google Scholar
• Lassus, P., Rodriguez J., and Lazebnik Y.. 2002. Confirming specificity of RNAi in mammalian cells. Sci. STKE 2002:PL13.
   PubMedGoogle Scholar
• Levrero, M., De Laurenzi V., Costanzo A., Gong J., Wang J. Y., and Melino G.. 2000. The p53/p63/p73 family of transcription factors: overlapping and distinct functions. J. Cell Sci. 113:1661–1670.
   PubMed Web of Science ®Google Scholar
• Li, H., Zhu H., Xu C. J., and Yuan J.. 1998. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491–501.
   PubMed Web of Science ®Google Scholar
• Lissy, N. A., Davis P. K., Irwin M., Kaelin W. G., and Dowdy S. F.. 2000. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Nature 407:642–645.
   PubMed Web of Science ®Google Scholar
• Liu, Z. G., Baskaran R., Lea-Chou E. T., Wood L. D., Chen Y., Karin M., and Wang J. Y.. 1996. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature 384:273–276.
   PubMed Web of Science ®Google Scholar
• Luo, X., Budihardjo I., Zou H., Slaughter C., and Wang X.. 1998. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481–490.
   PubMed Web of Science ®Google Scholar
• Melino, G., De Laurenzi V., and Vousden K. H.. 2002. p73: friend or foe in tumorigenesis. Nat. Rev. Cancer 2:605–615.
   PubMed Web of Science ®Google Scholar
• Micheau, O., Lens S., Gaide O., Alevizopoulos K., and Tschopp J.. 2001. NF-κB signals induce the expression of c-FLIP. Mol. Cell. Biol. 21:5299–5305.
   PubMed Web of Science ®Google Scholar
• Micheau, O., and Tschopp J.. 2003. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114:181–190.
   PubMed Web of Science ®Google Scholar
• Mihara, M., Erster S., Zaika A., Petrenko O., Chittenden T., Pancoska P., and Moll U. M.. 2003. p53 has a direct apoptogenic role at the mitochondria. Mol. Cell 11:577–590.
   PubMed Web of Science ®Google Scholar
• Morgan, M., Thorburn J., Pandolfi P. P., and Thorburn A.. 2002. Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms. J. Cell Biol. 157:975–984.
   PubMed Web of Science ®Google Scholar
• Phillips, A. C., Ernst M. K., Bates S., Rice N. R., and Vousden K. H.. 1999. E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways. Mol. Cell 4:771–781.
   PubMedGoogle Scholar
• Piguet, P. F., Vesin C., Guo J., Donati Y., and Barazzone C.. 1998. TNF-induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53. Eur. J. Immunol. 28:3499–3505.
   PubMed Web of Science ®Google Scholar
• Pozniak, C. D., Radinovic S., Yang A., McKeon F., Kaplan D. R., and Miller F. D.. 2000. An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science 289:304–306.
   PubMed Web of Science ®Google Scholar
• Ravi, R., and Bedi A.. 2002. Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L). Cancer Res. 62:1583–1587.
   PubMed Web of Science ®Google Scholar
• Screaton, R. A., Kiessling S., Sansom O. J., Millar C. B., Maddison K., Bird A., Clarke A. R., and Frisch S. M.. 2003. Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc. Natl. Acad. Sci. USA 100:5211–5216.
   PubMed Web of Science ®Google Scholar
• Sionov, R. V., Moallem E., Berger M., Kazaz A., Gerlitz O., Ben-Neriah Y., Oren M., and Haupt Y.. 1999. c-Abl neutralizes the inhibitory effect of Mdm2 on p53. J. Biol. Chem. 274:8371–8374.
   PubMed Web of Science ®Google Scholar
• Stiewe, T., and Putzer B. M.. 2000. Role of the p53-homologue p73 in E2F1-induced apoptosis. Nat. Genet. 26:464–469.
   PubMed Web of Science ®Google Scholar
• Taagepera, S., McDonald D., Loeb J. E., Whitaker L. L., McElroy A. K., Wang J. Y., and Hope T. J.. 1998. Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc. Natl. Acad. Sci. USA 95:7457–7462.
   PubMed Web of Science ®Google Scholar
• Tang, G., Minemoto Y., Dibling B., Purcell N. H., Li Z., Karin M., and Lin A.. 2001. Inhibition of JNK activation through NF-κB target genes. Nature 414:313–317.
   PubMed Web of Science ®Google Scholar
• Truong, T., Sun G., Doorly M., Wang J. Y., and Schwartz M. A.. 2003. Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl. Proc. Natl. Acad. Sci. USA 100:10281–10286.
   PubMedGoogle Scholar
• Tybulewicz, V. L., Crawford C. E., Jackson P. K., Bronson R. T., and Mulligan R. C.. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65:1153–1163.
   PubMed Web of Science ®Google Scholar
• Vella, V., Zhu J., Frasca F., Li C. Y., Vigneri P., Vigneri R., and Wang J. Y.. 2003. Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function. J. Biol. Chem. 278:25151–25157.
   PubMedGoogle Scholar
• Vigneri, P., and Wang J. Y.. 2001. Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase. Nat. Med. 7:228–234.
   PubMed Web of Science ®Google Scholar
• Wan, Y. Y., and DeGregori J.. 2003. The survival of antigen-stimulated T cells requires NFκB-mediated inhibition of p73 expression. Immunity 18:331–342.
   PubMed Web of Science ®Google Scholar
• Wang, C. Y., Mayo M. W., Korneluk R. G., Goeddel D. V., and Baldwin A. S., Jr. 1998. NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281:1680–1683.
   PubMed Web of Science ®Google Scholar
• Wang, J. Y. 2004. Controlling Abl: auto-inhibition and co-inhibition? Nat. Cell Biol. 6:3–7.
   PubMedGoogle Scholar
• Wang, J. Y. 2000. Regulation of cell death by the Abl tyrosine kinase. Oncogene 19:5643–5650.
   PubMedGoogle Scholar
• Wang, X. 2001. The expanding role of mitochondria in apoptosis. Genes Dev. 15:2922–2933.
   PubMed Web of Science ®Google Scholar
• Welch, P. J., and Wang J. Y.. 1993. A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 75:779–790.
   PubMed Web of Science ®Google Scholar
• Welch, P. J., and Wang J. Y.. 1995. Disruption of retinoblastoma protein function by coexpression of its C pocket fragment. Genes Dev. 9:31–46.
   PubMedGoogle Scholar
• Woodring, P. J., Hunter T., and Wang J. Y.. 2003. Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J. Cell Sci. 116:2613–2626.
   PubMed Web of Science ®Google Scholar
• Yang, A., Walker N., Bronson R., Kaghad M., Oosterwegel M., Bonnin J., Vagner C., Bonnet H., Dikkes P., Sharpe A., McKeon F., and Caput D.. 2000. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404:99–103.
   PubMed Web of Science ®Google Scholar
• Yin, X. M., Wang K., Gross A., Zhao Y., Zinkel S., Klocke B., Roth K. A., and Korsmeyer S. J.. 1999. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400:886–891.
   PubMed Web of Science ®Google Scholar
• Yuan, Z. M., Shioya H., Ishiko T., Sun X., Gu J., Huang Y. Y., Lu H., Kharbanda S., Weichselbaum R., and Kufe D.. 1999. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 399:814–817.
   PubMed Web of Science ®Google Scholar