69
Views
168
CrossRef citations to date
0
Altmetric
Mammalian Genetic Models with Minimal or Complex Phenotypes

Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice

, , , , , , & show all
Pages 4448-4464 | Received 18 Dec 2003, Accepted 08 Feb 2004, Published online: 27 Mar 2023

REFERENCES

  • Anonymous. 1994. Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium. Cell 78:23–33.
  • Baxter, R. C., and Martin J. L.. 1989. Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity-labeling. Proc. Natl. Acad. Sci. USA 86:6898–6902.
  • Birchmeier, C., and Birchmeier W.. 1993. Molecular aspects of mesenchymal-epithelial interactions. Annu. Rev. Cell Biol. 9:511–540.
  • Brown, A. L., Graham D. E., Nissley S. P., Hill D. J., Strain A. J., and Rechler M. M.. 1986. Developmental regulation of insulin-like growth factor II mRNA in different rat tissues. J. Biol. Chem. 261:13144–13150.
  • Buchner, G., Montini E., Andolfi G., Quaderi N., Cainarca S., Messali S., Bassi M. T., Ballabio A., Meroni G., and Franco B.. 1999. MID2, a homologue of the Opitz syndrome gene MID1: similarities in subcellular localization and differences in expression during development. Hum. Mol. Genet. 8:1397–1407.
  • Cohen, P., Miyazaki M., Socci N. D., Hagge-Greenberg A., Liedtke W., Soukas A. A., Sharma R., Hudgins L. C., Ntambi J. M., and Friedman J. M.. 2002. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297:240–243.
  • DeChiara, T. M., Efstratiadis A., and Robertson E. J.. 1990. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 345:78–80.
  • Deshler, J. O., Highett M. I., Abramson T., and Schnapp B. J.. 1998. A highly conserved RNA-binding protein for cytoplasmic mRNA localization in vertebrates. Curr. Biol. 8:489–496.
  • Deshler, J. O., Highett M. I., and Schnapp B. J.. 1997. Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum. Science 276:1128–1131.
  • Doyle, G. A., Betz N. A., Leeds P. F., Fleisig A. J., Prokipcak R. D., and Ross J.. 1998. The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins. Nucleic Acids Res. 26:5036–5044.
  • Doyle, G. A., Bourdeau-Heller J. M., Coulthard S., Meisner L. F., and Ross J.. 2000. Amplification in human breast cancer of a gene encoding a c-myc mRNA-binding protein. Cancer Res. 60:2756–2759.
  • Eom, T., Antar L. N., Singer R. H., and Bassell G. J.. 2003. Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapses. J. Neurosci. 23:10433–10444.
  • Farrell, J. J., Taupin D., Koh T. J., Chen D., Zhao C. M., Podolsky D. K., and Wang T. C.. 2002. TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury. J. Clin. Investig. 109:193–204.
  • Furuse, M., Fujita K., Hiiragi T., Fujimoto K., and Tsukita S.. 1998. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol. 141:1539–1550.
  • Gress, T. M., Muller-Pillasch F., Geng M., Zimmerhackl F., Zehetner G., Friess H., Buchler M., Adler G., and Lehrach H.. 1996. A pancreatic cancer-specific expression profile. Oncogene 13:1819–1830.
  • Havin, L., Git A., Elisha Z., Oberman F., Yaniv K., Schwartz S. P., Standart N., and Yisraeli J. K.. 1998. RNA-binding protein conserved in both microtubule- and microfilament-based RNA localization. Genes Dev. 12:1593–1598.
  • Hayano, T., Yanagida M., Yamauchi Y., Shinkawa T., Isobe T., and Takahashi N.. 2003. Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome. J. Biol. Chem. 278:34309–34319.
  • Herrick, D. J., and Ross J.. 1994. The half-life of c-myc mRNA in growing and serum-stimulated cells: influence of the coding and 3′ untranslated regions and role of ribosome translocation. Mol. Cell. Biol. 14:2119–2128.
  • Hubberstey, A. V., and Mottillo E. P.. 2002. Cyclase-associated proteins: CAPacity for linking signal transduction and actin polymerization. FASEB J. 16:487–499.
  • Ioannidis, P., Trangas T., Dimitriadis E., Samiotaki M., Kyriazoglou I., Tsiapalis C. M., Kittas C., Agnantis N., Nielsen F. C., Nielsen J., Christiansen J., and Pandis N.. 2001. C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors. Int. J. Cancer. 94:480–484.
  • Jensen, K. B., Dredge B. K., Stefani G., Zhong R., Buckanovich R. J., Okano H. J., Yang Y. Y., and Darnell R. B.. 2000. Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability. Neuron 25:359–371.
  • Kaestner, K. H., Silberg D. G., Traber P. G., and Schutz G.. 1997. The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation. Genes Dev. 11:1583–1595.
  • Karlsson, L., Lindahl P., Heath J. K., and Betsholtz C.. 2000. Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development 127:3457–3466.
  • Kim-Ha, J., Kerr K., and Macdonald P. M.. 1995. Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential. Cell 81:403–412.
  • Leeds, P., Kren B. T., Boylan J. M., Betz N. A., Steer C. J., Gruppuso P. A., and Ross J.. 1997. Developmental regulation of CRD-BP, an RNA-binding protein that stabilizes c-myc mRNA in vitro. Oncogene 14:1279–1286.
  • Leighton, P. A., Ingram R. S., Eggenschwiler J., Efstratiadis A., and Tilghman S. M.. 1995. Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature 375:34–39.
  • Li, C., and Wong W. H.. 2001. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc. Natl. Acad. Sci. USA 98:31–36.
  • Liu, J. P., Baker J., Perkins A. S., Robertson E. J., and Efstratiadis A.. 1993. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75:59–72.
  • McCarthy, J. C. 1967. Effects of litter size and maternal weight on foetal and placental weight in mice. J. Reprod Fertil. 14:507–510.
  • McCright, B., Gao X., Shen L., Lozier J., Lan Y., Maguire M., Herzlinger D., Weinmaster G., Jiang R., and Gridley T.. 2001. Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development 128:491–502.
  • Mori, H., Sakakibara S., Imai T., Nakamura Y., Iijima T., Suzuki A., Yuasa Y., Takeda M., and Okano H.. 2001. Expression of mouse igf2 mRNA-binding protein 3 and its implications for the developing central nervous system. J. Neurosci Res. 64:132–143.
  • Moriyama, K., and Yahara I.. 2002. Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover. J. Cell Sci. 115:1591–1601.
  • Mueller-Pillasch, F., Lacher U., Wallrapp C., Micha A., Zimmerhackl F., Hameister H., Varga G., Friess H., Buchler M., Beger H. G., Vila M. R., Adler G., and Gress T. M.. 1997. Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein. Oncogene 14:2729–2733.
  • Mueller-Pillasch, F., Pohl B., Wilda M., Lacher U., Beil M., Wallrapp C., Hameister H., Knochel W., Adler G., and Gress T. M.. 1999. Expression of the highly conserved RNA binding protein KOC in embryogenesis. Mech. Dev. 88:95–99.
  • Nagai, N., Hosokawa M., Itohara S., Adachi E., Matsushita T., Hosokawa N., and Nagata K.. 2000. Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis. J. Cell Biol. 150:1499–1506.
  • Nielsen, F. C., Nielsen J., and Christiansen J.. 2001. A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking. Scand. J. Clin. Lab. Investig. Suppl. 234:93–99.
  • Nielsen, F. C., Nielsen J., Kristensen M. A., Koch G., and Christiansen J.. 2002. Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains. J. Cell Sci. 115:2087–2097.
  • Nielsen, J., Adolph S. K., Rajpert-De Meyts E., Lykke-Andersen J., Koch G., Christiansen J., and Nielsen F. C.. 2003. Nuclear transit of human zipcode-binding protein IMP1. Biochem. J. 376:383–391.
  • Nielsen, J., Christiansen J., Lykke-Andersen J., Johnsen A. H., Wewer U. M., and Nielsen F. C.. 1999. A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. Mol. Cell. Biol. 19:1262–1270.
  • Nielsen, J., Cilius Nielsen F., Kragh Jakobsen R., and Christiansen J.. 2000. The biphasic expression of IMP/Vg1-RBP is conserved between vertebrates and Drosophila. Mech. Dev. 96:129–132.
  • Ntambi, J. M. 1999. Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J. Lipid Res. 40:1549–1558.
  • Ntambi, J. M., Miyazaki M., Stoehr J. P., Lan H., Kendziorski C. M., Yandell B. S., Song Y., Cohen P., Friedman J. M., and Attie A. D.. 2002. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc. Natl. Acad. Sci. USA 99:11482–11486.
  • Oleynikov, Y., and Singer R. H.. 2003. Real-time visualization of ZBP1 association with beta-actin mRNA during transcription and localization. Curr. Biol. 13:199–207.
  • Pabst, O., Zweigerdt R., and Arnold H. H.. 1999. Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen. Development 126:2215–2225.
  • Ross, A. F., Oleynikov Y., Kislauskis E. H., Taneja K. L., and Singer R. H.. 1997. Characterization of a beta-actin mRNA zipcode-binding protein. Mol. Cell. Biol. 17:2158–2165.
  • Ross, J., Lemm I., and Berberet B.. 2001. Overexpression of an mRNA-binding protein in human colorectal cancer. Oncogene 20:6544–6550.
  • Ruggiu, M., Speed R., Taggart M., McKay S. J., Kilanowski F., Saunders P., Dorin J., and Cooke H. J.. 1997. The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis. Nature 389:73–77.
  • Runge, S., Nielsen F. C., Nielsen J., Lykke-Andersen J., Wewer U. M., and Christiansen J.. 2000. H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein. J. Biol. Chem. 275:29562–29569.
  • Spicer, S. S., Ge Z. H., Tashian R. E., Hazen-Martin D. J., and Schulte B. A.. 1990. Comparative distribution of carbonic anhydrase isozymes III and II in rodent tissues. Am. J. Anat. 187:55–64.
  • Taupin, D., and Podolsky D. K.. 2003. Trefoil factors: initiators of mucosal healing. Nat. Rev. Mol. Cell. Biol. 4:721–732.
  • Trumpp, A., Refaeli Y., Oskarsson T., Gasser S., Murphy M., Martin G. R., and Bishop J. M.. 2001. c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature 414:768–773.
  • Ueki, I., Ooi G. T., Tremblay M. L., Hurst K. R., Bach L. A., and Boisclair Y. R.. 2000. Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system. Proc. Natl. Acad. Sci. USA 97:6868–6873.
  • Wagner, M., Kunsch S., Duerschmied D., Beil M., Adler G., Mueller F., and Gress T. M.. 2003. Transgenic overexpression of the oncofetal RNA binding protein KOC leads to remodeling of the exocrine pancreas. Gastroenterology 124:1901–1914.
  • Wisdom, R., and Lee W.. 1991. The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors. Genes Dev. 5:232–243.
  • Yaniv, K., Fainsod A., Kalcheim C., and Yisraeli J. K.. 2003. The RNA-binding protein Vg1 RBP is required for cell migration during early neural development. Development 130:5649–5661.
  • Yaniv, K., and Yisraeli J. K.. 2002. The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis. Gene 287:49–54.
  • Zaina, S., Newton R. V., Paul M. R., and Graham C. F.. 1998. Local reduction of organ size in transgenic mice expressing a soluble insulin-like growth factor II/mannose-6-phosphate receptor. Endocrinology 139:3886–3895.
  • Zambrowicz, B. P., Friedrich G. A., Buxton E. C., Lilleberg S. L., Person C., and Sands A. T.. 1998. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature 392:608–611.
  • Zhang, J. Y., Chan E. K., Peng X. X., and Tan E. M.. 1999. A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma. J. Exp. Med. 189:1101–1110.
  • Zhang, Q., Yaniv K., Oberman F., Wolke U., Git A., Fromer M., Taylor W. L., Meyer D., Standart N., Raz E., and Yisraeli J. K.. 1999. Vg1 RBP intracellular distribution and evolutionarily conserved expression at multiple stages during development. Mech. Dev. 88:101–106.
  • Zhou, Z., Licklider L. J., Gygi S. P., and Reed R.. 2002. Comprehensive proteomic analysis of the human spliceosome. Nature 419:182–185.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.