Ionizing Radiation Induces Delayed Hyperrecombination in Mammalian Cells

REFERENCES

• Barcellos-Hoff, M. H., and Brooks A. L.. 2001. Extracellular signaling through the microenvironment: a hypothesis relating carcinogenesis, bystander effects, and genomic instability. Radiat. Res. 156:618–627.
   PubMed Web of Science ®Google Scholar
• Benjamin, M. B., and Little J. B.. 1992. X rays induce interallelic homologous recombination at the human thymidine kinase gene. Mol. Cell. Biol. 12:2730–2738.
   PubMed Web of Science ®Google Scholar
• Brennan, R. J., and Schiestl R. H.. 2001. Persistent genomic instability in the yeast Saccharomyces cerevisiae induced by ionizing radiation and DNA-damaging agents. Radiat. Res. 155:768–777.
   PubMedGoogle Scholar
• Cahill, D. P., Kinzler K. W., Vogelstein B., and Lengauer C.. 1999. Genetic instability and darwinian selection in tumours. Trends Cell Biol. 9:M57–M60.
   PubMed Web of Science ®Google Scholar
• Camphausen, K., Moses M. A., Menard C., Sproull M., Beecken W. D., Folkman J., and O'Reilly M. S.. 2003. Radiation abscopal antitumor effect is mediated through p53. Cancer Res. 63:1990–1993.
   PubMed Web of Science ®Google Scholar
• Cao, J., DePrimo S. E., and Stringer J. R.. 1997. Cell cycle dependence of radiation-induced homologous recombination in cultured monkey cells. Mutat. Res. 374:233–243.
   PubMedGoogle Scholar
• Chang, W. P., and Little J. B.. 1991. Delayed reproductive cell death in X-irradiated Chinese hamster ovary cells. Int. J. Radiat. Biol. 60:483–496.
   PubMed Web of Science ®Google Scholar
• Chang, W. P., and Little J. B.. 1992. Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype. Mutat. Res. 270:191–199.
   PubMed Web of Science ®Google Scholar
• Coleman, W. B., and Tsongalis G. J.. 1999. The role of genomic instability in human carcinogenesis. Anticancer Res. 19:4645–4664.
   PubMedGoogle Scholar
• Cornforth, M. N. 1998. Radiation-induced damage and the formation of chromosomal aberrations, p. 559–585. In Nickoloff J. A. and Hoekstra M. F. (ed.), DNA damage and repair, vol. II. DNA repair in higher eukaryotes. Humana Press, Totowa, N.J.
   Google Scholar
• Day, J. P., Limoli C. L., and Morgan W. F.. 1998. Recombination involving interstitial telomere repeat-like sequences promotes chromosomal instability in Chinese hamster cells. Carcinogenesis 19:259–265.
   PubMedGoogle Scholar
• Deng, W. P., and Nickoloff J. A.. 1992. Site-directed mutagenesis of virtually any plasmid by eliminating a unique site. Anal. Biochem. 200:81–88.
   PubMed Web of Science ®Google Scholar
• Fabre, F., and Roman H.. 1977. Genetic evidence for inducibility of recombination competence in yeast. Proc. Natl. Acad. Sci. USA 74:1667–1671.
   PubMed Web of Science ®Google Scholar
• Grosovsky, A. J., Parks K. K., Giver C. R., and Nelson S. L.. 1996. Clonal analysis of delayed karyotypic abnormalities and gene mutations in radiation-induced genetic instability. Mol. Cell. Biol. 16:6252–6262.
   PubMed Web of Science ®Google Scholar
• Kadhim, M. A., Walker C. A., Plumb M. A., and Wright E. G.. 1996. No association between p53 status and alpha-particle-induced chromosomal instability in human lymphoblastoid cells. Int. J. Radiat. Biol. 69:167–174.
   PubMed Web of Science ®Google Scholar
• Kaplan, M. I., and Morgan W. F.. 1998. The nucleus is the target for radiation-induced chromosomal instability. Radiat. Res. 150:382–390.
   PubMedGoogle Scholar
• Lengauer, C., Kinzler K. W., and Vogelstein B.. 1998. Genetic instabilities in human cancers. Nature 396:643–649.
   PubMed Web of Science ®Google Scholar
• Liber, H. L., and Phillips E. N.. 1998. Interrelationships between radiation-induced mutations and modifications in gene expression linked to cancer. Crit. Rev. Eukaryot. Gene Expr. 8:257–276.
   PubMedGoogle Scholar
• Limoli, C. L., Corcoran J. J., Jordan R., Morgan W. F., and Schwartz J. L.. 2001. A role for chromosomal instability in the development of and selection for radioresistant cell variants. Br. J. Cancer 84:489–492.
   PubMedGoogle Scholar
• Limoli, C. L., Corcoran J. J., Milligan J. R., Ward J. F., and Morgan W. F.. 1999. Critical target and dose and dose-rate responses for the induction of chromosomal instability by ionizing radiation. Radiat. Res. 151:677–685.
   PubMed Web of Science ®Google Scholar
• Limoli, C. L., Hartmann A., Shephard L., Yang C. R., Boothman D. A., Bartholomew J., and Morgan W. F.. 1998. Apoptosis, reproductive failure, and oxidative stress in Chinese hamster ovary cells with compromised genomic integrity. Cancer Res. 58:3712–3718.
   PubMed Web of Science ®Google Scholar
• Limoli, C. L., Kaplan M. I., Corcoran J., Meyers M., Boothman D. A., and Morgan W. F.. 1997. Chromosomal instability and its relationship to other end points of genomic instability. Cancer Res. 57:5557–5563.
   PubMed Web of Science ®Google Scholar
• Limoli, C. L., Kaplan M. I., Phillips J. W., Adair G. M., and Morgan W. F.. 1997. Differential induction of chromosomal instability by DNA strand-breaking agents. Cancer Res. 57:4048–4056.
   PubMed Web of Science ®Google Scholar
• Limoli, C. L., Ponnaiya B., Corcoran J. J., Giedzinski E., Kaplan M. I., Hartmann A., and Morgan W. F.. 2000. Genomic instability induced by high and low LET ionizing radiation. Adv. Space Res. 25:2107–2117.
   PubMed Web of Science ®Google Scholar
• Little, J. B., Nagasawa H., Pfenning T., and Vetrovs H.. 1997. Radiation-induced genomic instability: delayed mutagenic and cytogenetic effects of X rays and alpha particles. Radiat. Res. 148:299–307.
   PubMed Web of Science ®Google Scholar
• Lorimore, S. A., Kadhim M. A., Pocock D. A., Papworth D., Stevens D. L., Goodhead D. T., and Wright E. G.. 1998. Chromosomal instability in the descendants of unirradiated surviving cells after alpha-particle irradiation. Proc. Natl. Acad. Sci. USA 95:5730–5733.
   PubMed Web of Science ®Google Scholar
• Lorimore, S. A., and Wright E. G.. 2003. Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review. Int. J. Radiat. Biol. 79:15–25.
   PubMed Web of Science ®Google Scholar
• Marder, B. A., and Morgan W. F.. 1993. Delayed chromosomal instability induced by DNA damage. Mol. Cell. Biol. 13:6667–6677.
   PubMed Web of Science ®Google Scholar
• McIlrath, J., Lorimore S. A., Coates P. J., and Wright E. G.. 2003. Radiation-induced genomic instability in immortalized haemopoietic stem cells. Int. J. Radiat. Biol. 79:27–34.
   PubMed Web of Science ®Google Scholar
• Mitchel, R. E., Jackson J. S., Morrison D. P., and Carlisle S. M.. 2003. Low doses of radiation increase the latency of spontaneous lymphomas and spinal osteosarcomas in cancer-prone, radiation-sensitive Trp53 heterozygous mice. Radiat. Res. 159:320–327.
   PubMed Web of Science ®Google Scholar
• Morgan, W. F. 2003. Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation? Oncogene 22:7094–7099.
   PubMed Web of Science ®Google Scholar
• Morgan, W. F. 2003. Non-targeted and delayed effects of exposure to ionizing radiation. I. Radiation-induced genomic instability and bystander effects in vitro. Radiat. Res. 159:567–580.
   PubMed Web of Science ®Google Scholar
• Morgan, W. F. 2003. Non-targeted and delayed effects of exposure to ionizing radiation. II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat. Res. 159:581–596.
   PubMed Web of Science ®Google Scholar
• Morgan, W. F., and Murnane J. P.. 1995. A role for genomic instability in cellular radioresistance? Cancer Metastasis Rev. 14:49–58.
   PubMed Web of Science ®Google Scholar
• Nickoloff, J. A. 2002. Recombination: mechanisms and roles in tumorigenesis, p. 49–59. In Bertino J. R. (ed.), Encyclopedia of cancer, 2nd ed., vol. 4. Elsevier Science, San Diego, Calif.
   Google Scholar
• Ponnaiya, B., Cornforth M. N., and Ullrich R. L.. 1997. Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: the difference is as clear as black and white. Radiat. Res. 147:121–125.
   PubMed Web of Science ®Google Scholar
• Redpath, J. L., Short S. C., Woodcock M., and Johnston P. J.. 2003. Low-dose reduction in transformation frequency compared to unirradiated controls: the role of hyper-radiosensitivity to cell death. Radiat. Res. 159:433–436.
   PubMed Web of Science ®Google Scholar
• Seymour, C. B., and Mothersill C.. 1997. Delayed expression of lethal mutations and genomic instability in the progeny of human epithelial cells that survived in a bystander-killing environment. Radiat. Oncol. Investig. 5:106–110.
   PubMedGoogle Scholar
• Smith, L. E., Nagar S., Kim G. J., and Morgan W. F.. 2003. Radiation-induced genomic instability: radiation quality and dose response. Health Phys. 85:23–29.
   PubMed Web of Science ®Google Scholar
• Ward, J. F. 1998. Nature of lesions formed by ionizing radiation, p. 65–84. In Nickoloff J. A. and Hoekstra M. F. (ed.), DNA damage and repair, vol. II. DNA repair in higher eukaryotes. Humana Press, Totowa, N.J.
   Google Scholar
• Watson, G. E., Lorimore S. A., Clutton S. M., Kadhim M. A., and Wright E. G.. 1997. Genetic factors influencing alpha-particle-induced chromosomal instability. Int. J. Radiat. Biol. 71:497–503.
   PubMed Web of Science ®Google Scholar
• Watson, G. E., Lorimore S. A., Macdonald D. A., and Wright E. G.. 2000. Chromosomal instability in unirradiated cells induced in vivo by a bystander effect of ionizing radiation. Cancer Res. 60:5608–5611.
   PubMed Web of Science ®Google Scholar
• Watson, G. E., Pocock D. A., Papworth D., Lorimore S. A., and Wright E. G.. 2001. In vivo chromosomal instability and transmissible aberrations in the progeny of haemopoietic stem cells induced by high- and low-LET radiations. Int. J. Radiat. Biol. 77:409–417.
   PubMed Web of Science ®Google Scholar