79
Views
147
CrossRef citations to date
0
Altmetric
Mammalian Genetic Models with Minimal or Complex Phenotypes

Characterization of Mice Lacking the Tetraspanin Superfamily Member CD151

, , , , , , , , & show all
Pages 5978-5988 | Received 23 Dec 2003, Accepted 28 Mar 2004, Published online: 27 Mar 2023

REFERENCES

  • Ashman, L. K., Aylett G., Mehrabani P., Bendall L., Niutta S., Cambareri A. C., Cole S. R., and Berndt M.. 1991. The murine monoclonal antibody, 14A2. H1, identified a novel platelet surface antigen. Br. J. Haematol. 79:263–270.
  • Berditchevski, F. 2001. Complexes of tetraspanins with integrins: more than meets the eye. J. Cell Sci. 114:4143–4151.
  • Berditchevski, F., Gilbert E., Griffiths M. R., Fitter S., Ashman L., and Jenner S. J.. 2001. Analysis of the CD151-alpha3beta1 integrin and CD151-tetraspanin interactions by mutagenesis. J. Biol. Chem. 276:41165–41174.
  • Berditchevski, F., Odintsova E., Sawada S., and Gilbert E.. 2002. Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling. J. Biol. Chem. 277:36991–37000.
  • Boucheix, C., and Rubinstein E.. 2001. Tetraspanins. Cell. Mol. Life Sci. 58:1189–1205.
  • Chattopadhyay, N., Wang Z., Ashman L. K., Brady-Kalnay S., and Kreidberg J.. 2003. α3β1 integrin: CD151, a component of the cadherin-catenin complex, regulates PTPu expression and cell-cell adhesion. J. Cell Biol. 163:1351–1362.
  • DiPersio, C. M., Hodivala-Dilke K. M., Jaenisch R., Kreidberg J. A., and Hynes R. O.. 1997. alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. J. Cell Biol. 137:729–742.
  • Fitter, S., Seldin M. F., and Ashman L. K.. 1998. Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms. Biochim. Biophys. Acta 1398:75–85.
  • Fitter, S., Sincock P., Jolliffe C., and Ashman L. K.. 1999. Transmembrane 4 superfamily protein CD151 (PETA-3) associates with beta 1 and alpha IIb beta 3 integrins in haemopoietic cell lines and modulates cell-cell adhesion. Biochem. J. 338:61–70.
  • Fitter, S., Tetaz T., Berndt M., and Ashman L. K.. 1995. Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3. Blood 86:1348–1355.
  • Flint, M., Maidens C., Loomis-Price L., Shotton C., Dubuisson J., Monk P., Higginbottom A., Levy S., and McKeating J.. 1999. Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81. J. Virol. 73:6235–6244.
  • Fuchs, E., Dowling J., Segre J., Lo S. H., and Yu Q. C.. 1997. Integrators of epidermal growth and differentiation: distinct functions for beta 1 and beta 4 integrins. Curr. Opin. Genet. Dev. 7:672–682.
  • Geisert, E. E., Jnr, Williams R. W., Geisert G. R., Fan L., Asbury A. M., Maecker H. T., Deng J., and Levy S.. 2002. Increased brain size and glial cell number in CD81-null mice. J. Comp. Neurol. 453:22–32.
  • Georges-Labouesse, E., Messaddeq N., Yehia G., Cadalbert L., Dierich A., and Le Meur M.. 1996. Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Nat. Genet. 13:370–373.
  • Giancotti, F. G., and Ruoslahti E.. 1999. Integrin signaling. Science 285:1028–1032.
  • Goldfinger, L. E., Hopkinson S. B., deHart G. W., Collawn S., Couchman J. R., and Jones J. C.. 1999. The alpha3 laminin subunit, alpha6beta4 and alpha3beta1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin. J. Cell Sci. 112:2615–2629.
  • Hakkinen, L., Koivisto L., and Larjava H.. 2002. An improved method for culture of epidermal keratinocytes from mouse skin. Methods Cell Sci. 23:189–196.
  • Hasegawa, H., Utsunomiya Y., Kishimoto K., Yanagisawa K., and Fujita S.. 1996. SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane-4 superfamily. J. Virol. 70:3258–3263.
  • Hemler, M. E. 2001. Specific tetraspanin functions. J. Cell Biol. 155:1103–1107.
  • Hynes, R. 2002. Integrins: bidirectional, allosteric signaling machines. Cell 110:673–687.
  • Iwamoto, R., Higashiyama S., Mitamura T., Taniguchi M., Klagsbrun M., and Mekada E.. 1994. Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity. EMBO J. 13:2322–2330.
  • Kaji, K., Oda S., Shikano T., Ohnuki T., Uematsu Y., Sakagami J., Tada N., Miyazaki S., and Kudo A.. 2000. The gamete fusion process is defective in eggs of Cd9-deficient mice. Nat. Genet. 24:279–282.
  • Kazarov, A. R., Yang X., Stipp C. S., Sehgal B., and Hemler M. E.. 2002. An extracellular site on tetraspanin CD151 determines alpha 3 and alpha 6 integrin-dependent cellular morphology. J. Cell Biol. 158:1299–1309.
  • Kelic, S., Levy S., Suarez C., and Weinstein D. E.. 2001. CD81 regulates neuron-induced astrocyte cell-cycle exit. Mol. Cell. Neurosci. 17:551–560.
  • Knobeloch, K. P., Wright M. D., Ochsenbein A. F., Liesenfeld O., Lohler J., Zinkernagel R. M., Horak I., and Orinska Z.. 2000. Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions. Mol. Biol. Cell 20:5363–5369.
  • Kontgen, F., Suss G., Stewart C., Steinmetz M., and Bluethmann H.. 1993. Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. Int. Immunol. 5:957–964.
  • Kreidberg, J. A., Donovan M. J., Goldstein S. L., Rennke H., Shepherd K., Jones R. C., and Jaenisch R.. 1996. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development 122:3537–3547.
  • Lammerding, J., Kazarov A. R., Huang H., Lee R. T., and Hemler M. E.. 2003. Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening. Proc. Natl. Acad. Sci. USA 100:7616–7621.
  • Le Naour, F., Rubinstein E., Jasmin C., Prenant M., and Boucheix C.. 2000. Severely reduced female fertility in CD9-deficient mice. Science 287:319–321.
  • Maecker, H. T., and Levy S.. 1997. Normal lymphocyte development but delayed humoral immune response in CD81-null mice. J. Exp. Med. 185:1505–1510.
  • Maecker, H. T., Todd S. C., and Levy S.. 1997. The tetraspanin superfamily: molecular facilitators. FASEB J. 11:428–442.
  • Mayer, U., Saher G., Fassler R., Bornemann A., Echtermeyer F., von der Mark H., Miosge N., Poschl E., and von der Mark K.. 1997. Absence of integrin alpha 7 causes a novel form of muscular dystrophy. Nat. Genet. 17:318–323.
  • Mazzalupo, S., Wawersik M. J., and Coulombe P. A.. 2002. An ex vivo assay to assess the potential of skin keratinocytes for wound epithelialization. J. Investig. Dermatol. 118:866–870.
  • Mittelbrunn, M., Yanez-Mo M., Sancho D., Ursa A., and Sanchez-Madrid F.. 2002. Cutting edge: dynamic redistribution of tetraspanin CD81 at the central zone of the immune synapse in both T lymphocytes and APC. J. Immunol. 169:6691–6695.
  • Miyado, K., Yamada G., Yamada S., Hasuwa H., Nakamura Y., Ryu F., Suzuki K., Kosai K., Inoue K., Ogura A., Okabe M., and Mekada E.. 2000. Requirement of CD9 on the egg plasma membrane for fertilization. Science 287:321–324.
  • Miyazaki, T., Muller U., and Campbell K. S.. 1997. Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81. EMBO J. 16:4217–4225.
  • Penas, P. F., Garcia-Diez A., Sanchez-Madrid F., and Yanez-Mo M.. 2000. Tetraspanins are localized at motility-related structures and involved in normal human keratinocyte wound healing migration. J. Investig. Dermatol. 114:1126–1135.
  • Sawada, S., Yoshimoto M., Odintsova E., Hotchin N. A., and Berditchevski F.. 2003. The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras. J. Biol. Chem. 278:26323–26326.
  • Schwenk, F., Baron U., and Rajewsky K.. 1995. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23:5080–5081.
  • Serru, V., Le Naour F., Billard M., Azorsa D., Lanza F., Boucheix C., and Rubinstein E.. 1999. Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. Biochem. J. 340:103–111.
  • Silvie, O., Rubinstein E., Franetich J., Prenant M., Belnoue E., Renia L., Hannoun L., Eling W., Levy S., Boucheix C., and Mazier D.. 2003. Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity. Nat. Med. 9:93–96.
  • Sincock, P., Mayrhofer G., and Ashman L. K.. 1997. Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin. J. Histochem. Cytochem. 45:515–525.
  • Sincock, P. M., Fitter S., Parton R. G., Berndt M. C., Gamble J. R., and Ashman L. K.. 1999. PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function. J. Cell Sci. 112:833–844.
  • Sterk, L., Geuijen C., Oomen L., Calafat J., Janssen H., and Sonnenberg A.. 2000. The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alha6beta4 and may regulate the spatial organization of hemidesmosomes. J. Cell Biol. 149:969–982.
  • Sterk, L. M., Geuijen C. A., van den Berg J. G., Claessen N., Weening J. J., and Sonnenberg A.. 2002. Association of the tetraspanin CD151 withthe laminin-binding integrins alpha3beta1, alpha6beta1, alpha6beta4 and alpha7beta1 in cells in culture and in vivo. J. Cell Sci. 115:1161–1173.
  • Stipp, C. S., and Hemler M. E.. 2000. Transmembrane-4-superfamily proteins CD151 and CD81 associate with alpha 3 beta 1 integrin, and selectively contribute to alpha 3 beta 1-dependent neurite outgrowth. J. Cell Sci. 113:1871–1882.
  • Tarrant, J., Robb L., van Spriel A., and Wright M.. 2003. Tetraspanins: molecular organisers of the leukocyte surface. Trends Immunol. 24:610–617.
  • Tarrant, J. M., Groom J., Metcalf D., Li R., Borobokas B., Wright M. D., Tarlinton D., and Robb L.. 2002. The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses. Mol. Cell. Biol. 22:5006–5018.
  • Tokuhara, T., Hasegawa H., Hattori N., Ishida H., Taki T., Tachibana I., Sasaki S., and Miyake M.. 2001. Clinical significance of CD151 gene expression in non-small cell lung cancer. Clin. Cancer Res. 7:4109–4114.
  • Travis, G., Brennan M., Danielson P., Kozak C., and Sutcliffe J.. 1989. Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds). Nature 338:70–73.
  • van der Neut, R., Krimpenfort P., Calafat J., Niessen C. M., and Sonnenberg A.. 1996. Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice. Nat. Genet. 13:366–369.
  • van Spriel, A. B., Puls K. L., Sofi M., Hochrein D. P., Hochrein H., Orinska Z., Knobeloch K. P., Plebanski M., and Wright M. D.. 2003. A regulatory role for CD37 in T cell proliferation. J. Immunol. 172:2953–2961.
  • Yanez-Mo, M., Alfranca A., Cabanas C., Marazuela M., Tejedor R., Ursa M., Ashman L. K., de Landazuri M., and Sanchez-Madrid F.. 1998. Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/PETA-3 with alpha3 beta1 integrin localized at endothelial lateral junctions. J. Cell Biol. 141:791–804.
  • Yanez-Mo, M., Mittelbrunn M., and Sanchez-Madrid F.. 2001. Tetraspanins and intercellular interactions. Microcirculation 8:153–168.
  • Yauch, R. L., Berditchevski F., Harler M. B., Reichner J., and Hemler M. E.. 1998. Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. Mol. Biol. Cell 9:2751–2765.
  • Yauch, R. L., Kazarov A. R., Desai B., Lee R., and Hemler M. E.. 2000. Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. J. Biol. Chem. 275:9230–9238.
  • Zemni, R., Bienvenu T., Vinet M., Sefiani A., Carrie A., Billuart P., McDonell N., Couvert P., Francis F., Chafey P., Fauchereau F., Friocourt G., des Portes V., Cardona A., Frints S., Meindl A., Brandau O., Ronce N., Moraine C., van Bokhoven H., Ropers H., Sudbrak R., Kahn A., Fryns J., Beldjord C., and Chelly J.. 2000. A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation. Nat. Genet. 24:167–170.
  • Zhang, X. A., Bontrager A. L., and Hemler M. E.. 2001. Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. J. Biol. Chem. 276:25005–25013.
  • Zhang, X. A., Kazarov A. R., Yang X., Bontrager A. L., Stipp C. S., and Hemler M. E.. 2002. Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis. Mol. Biol. Cell 13:1–11.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.