60
Views
97
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Bone Morphogenetic Protein 2-Induced Osteoblast Differentiation Requires Smad-Mediated Down-Regulation of Cdk6

, , , , , , & show all
Pages 6560-6568 | Received 31 Mar 2004, Accepted 08 May 2004, Published online: 27 Mar 2023

REFERENCES

  • Bai, S., Shi X., Yang X., and Cao X.. 2000. Smad6 as a transcriptional corepressor. J. Biol. Chem. 275:8267–8270.
  • Chen, Q., Lin J., Jinno S., and Okayama H.. 2003. Overexpression of Cdk6-cyclin D3 highly sensitizes cells to physical and chemical transformation. Oncogene 22:992–1001.
  • Deng, C., Zhang P., Harper J. W., Elledge S. J., and Leder P.. 1995. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82:675–684.
  • DiChiara, M. R., Kiely J. M., Gimbrone M. A., Jr., Lee M. E., Perrella M. A., and Topper J. N.. 2000. Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals. J. Exp. Med. 192:695–704.
  • Hinds, P. W., and Weinberg R. A.. 1994. Tumor suppressor genes. Curr. Opin. Genet. Dev. 4:135–141.
  • Kretzschmar, M., and Massague J.. 1998. SMADs: mediators and regulators of TGF-beta signaling. Curr. Opin. Genet. Dev. 8:103–111.
  • Lee, K. S., Kim H. J., Li Q. L., Chi X. Z., Ueta C., Komori T., Wozney J. M., Kim E. G., Choi J. Y., Ryoo H. M., and Bae S. C.. 2000. Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol. Cell. Biol. 20:8783–8792.
  • Lin, J., Jinno S., and Okayama H.. 2001. Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence. Oncogene 20:2000–2009.
  • Lopez-Rovira, T., Chalaux E., Rosa J. L., Bartrons R., and Ventura F.. 2000. Interaction and functional cooperation of NF-kappa B with Smads. Transcriptional regulation of the JunB promoter. J. Biol. Chem. 275:28937–28946.
  • Matushansky, I., Radparvar F., and Skoultchi A. I.. 2003. CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells. Oncogene 22:4143–4149.
  • Meyerson, M., Enders G. H., Wu C. L., Su L. K., Gorka C., Nelson C., Harlow E., and Tsai L. H.. 1992. A family of human cdc2-related protein kinases. EMBO J. 11:2909–2917.
  • Nakashima, K., Zhou X., Kunkel G., Zhang Z., Deng J. M., Behringer R. R., and de Crombrugghe B.. 2002. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108:17–29.
  • Nakayama, K., Ishida N., Shirane M., Inomata A., Inoue T., Shishido N., Horii I., and Loh D. Y.. 1996. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85:707–720.
  • Nevins, J. R. 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424–429.
  • Nishimori, S., Tanaka Y., Chiba T., Fujii M., Imamura T., Miyazono K., Ogasawara T., Kawaguchi H., Igarashi T., Fujita T., Tanaka K., and Toyoshima H.. 2001. Smad-mediated transcription is required for transforming growth factor-beta 1-induced p57(Kip2) proteolysis in osteoblastic cells. J. Biol. Chem. 276:10700–10705.
  • Patel, M. S., and Karsenty G.. 2002. Regulation of bone formation and vision by LRP5. N. Engl. J. Med. 346:1572–1574.
  • Reddi, A. H. 1998. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat. Biotechnol. 16:247–252.
  • Sherr, C. J. 1994. G1 phase progression: cycling on cue. Cell 79:551–555.
  • Sherr, C. J., and Roberts J. M.. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1501–1512.
  • Shi, X., Yang X., Chen D., Chang Z., and Cao X.. 1999. Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling. J. Biol. Chem. 274:13711–13717.
  • Takeda, K., Ichijo H., Fujii M., Mochida Y., Saitoh M., Nishitoh H., Sampath T. K., and Miyazono K.. 1998. Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA. J. Biol. Chem. 273:17079–17085.
  • Tanaka, K., and Okayama H.. 2000. A Pcl-like cyclin activates the Res2p-Cdc10p cell cycle “start” transcriptional factor complex in fission yeast. Mol. Biol. Cell 11:2845–2862.
  • Thomas, D. M., Carty S. A., Piscopo D. M., Lee J. S., Wang W. F., Forrester W. C., and Hinds P. W.. 2001. The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Mol. Cell 8:303–316.
  • Urano, T., Yashiroda H., Muraoka M., Tanaka K., Hosoi T., Inoue S., Ouchi Y., and Toyoshima H.. 1999. p57(Kip2) is degraded through the proteasome in osteoblasts stimulated to proliferation by transforming growth factor beta1. J. Biol. Chem. 274:12197–12200.
  • Verschueren, K., Remacle J. E., Collart C., Kraft H., Baker B. S., Tylzanowski P., Nelles L., Wuytens G., Su M. T., Bodmer R., Smith J. C., and Huylebroeck D.. 1999. SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5′-CACCT sequences in candidate target genes. J. Biol. Chem. 274:20489–20498.
  • Vidal, A., and Koff A.. 2000. Cell-cycle inhibitors: three families united by a common cause. Gene 247:1–15.
  • Wang, H., Goode T., Iakova P., Albrecht J. H., and Timchenko N. A.. 2002. C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest. EMBO J. 21:930–941.
  • Yan, Y., Frisen J., Lee M. H., Massague J., and Barbacid M.. 1997. Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev. 11:973–983.
  • Yoshida, Y., Tanaka S., Umemori H., Minowa O., Usui M., Ikematsu N., Hosoda E., Imamura T., Kuno J., Yamashita T., Miyazono K., Noda M., Noda T., and Yamamoto T.. 2000. Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell 103:1085–1097.
  • Zhang, P., Liegeois N. J., Wong C., Finegold M., Hou H., Thompson J. C., Silverman A., Harper J. W., DePinho R. A., and Elledge S. J.. 1997. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature 387:151–158.
  • Zhang, Y. W., Yasui N., Ito K., Huang G., Fujii M., Hanai J., Nogami H., Ochi T., Miyazono K., and Ito Y.. 2000. A RUNX2/PEBP2alphaA/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc. Natl. Acad. Sci. USA 97:10549–10554.
  • Zhu, H., Kavsak P., Abdollah S., Wrana J. L., and Thomsen G. H.. 1999. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400:687–693.
  • Zimmermann, M. 1983. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109–110.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.