Swi1 and Swi3 Are Components of a Replication Fork Protection Complex in Fission Yeast

REFERENCES

• Alcasabas, A. A., Osborn A. J., Bachant J., Hu F., Werler P. J., Bousset K., Furuya K., Diffley J. F., Carr A. M., and Elledge S. J.. 2001. Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat. Cell Biol. 3:958–965.
   PubMed Web of Science ®Google Scholar
• Alfa, C., Fantes P., Hyams J., McLeod M., and Warbrick E.. 1993. Experiments with fission yeast. Cold Spring Harbor Laboraotry Press, New York, N.Y.
   Google Scholar
• al-Khodairy, F., Fotou E., Sheldrick K. S., Griffiths D. J., Lehmann A. R., and Carr A. M.. 1994. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. Mol. Biol. Cell 5:147–160.
   PubMed Web of Science ®Google Scholar
• Bähler, J., Wu J. Q., Longtine M. S., Shah N. G., McKenzie III A., Steever A. B., Wach A., Philippsen P., and Pringle J. R.. 1998. Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast 14:943–951.
   PubMed Web of Science ®Google Scholar
• Barnes, J. W., Tischkau S. A., Barnes J. A., Mitchell J. W., Burgoon P. W., Hickok J. R., and Gillette M. U.. 2003. Requirement of mammalian Timeless for circadian rhythmicity. Science 302:439–442.
   PubMed Web of Science ®Google Scholar
• Benard, M., Maric C., and Pierron G.. 2001. DNA replication-dependent formation of joint DNA molecules in Physarum polycephalum. Mol. Cell 7:971–980.
   PubMedGoogle Scholar
• Boddy, M. N., Furnari B., Mondesert O., and Russell P.. 1998. Replication checkpoint enforced by kinases Cds1 and Chk1. Science 280:909–912.
   PubMed Web of Science ®Google Scholar
• Boddy, M. N., Gaillard P. H., McDonald W. H., Shanahan P., Yates III J. R., and Russell P.. 2001. Mus81-Eme1 are essential components of a Holliday junction resolvase. Cell 107:537–548.
   PubMed Web of Science ®Google Scholar
• Boddy, M. N., Lopez-Girona A., Shanahan P., Interthal H., Heyer W. D., and Russell P.. 2000. Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1. Mol. Cell. Biol. 20:8758–8766.
   PubMed Web of Science ®Google Scholar
• Boddy, M. N., and Russell P.. 2001. DNA replication checkpoint. Curr. Biol. 11:R953–R956.
   PubMed Web of Science ®Google Scholar
• Brewer, B. J., and Fangman W. L.. 1987. The localization of replication origins on ARS plasmids in S. cerevisiae. Cell 51:463–471.
   PubMed Web of Science ®Google Scholar
• Chan, R. C., Chan A., Jeon M., Wu T. F., Pasqualone D., Rougvie A. E., and Meyer B. J.. 2003. Chromosome cohesion is regulated by a clock gene paralogue TIM-1. Nature 424:1002–1009.
   PubMed Web of Science ®Google Scholar
• Dalgaard, J. Z., and Klar A. J.. 2000. swi1 and swi3 perform imprinting, pausing, and termination of DNA replication in S. pombe. Cell 102:745–751.
   PubMedGoogle Scholar
• Doe, C. L., Ahn J. S., Dixon J., and Whitby M. C.. 2002. Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks. J. Biol. Chem. 277:32753–32759.
   PubMed Web of Science ®Google Scholar
• Du, L.-L., Nakamura T., Moser B. A., and Russell P.. 2003. Retention but not recruitment of Crb2 at double-strand breaks requires Rad1 and Rad3 complexes. Mol. Cell. Biol. 23:6150–6158.
   PubMedGoogle Scholar
• Fantes, P. 1979. Epistatic gene interactions in the control of division in fission yeast. Nature 279:428–430.
   PubMedGoogle Scholar
• Foss, E. J. 2001. Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae. Genetics 157:567–577.
   PubMedGoogle Scholar
• Friedberg, E. C., Walker G. C., and Siede W.. 1995. DNA repair and mutagenesis. ASM Press, Washington, D.C.
   Google Scholar
• Gaillard, P. H., Noguchi E., Shanahan P., and Russell P.. 2003. The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism. Mol. Cell 12:747–759.
   PubMedGoogle Scholar
• Gotter, A. L. 2003. Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association. J. Mol. Biol. 331:167–176.
   PubMedGoogle Scholar
• Grewal, S. I., and Klar A. J.. 1997. A recombinationally repressed region between mat2 and mat3 loci shares homology to centromeric repeats and regulates directionality of mating-type switching in fission yeast. Genetics 146:1221–1238.
   PubMed Web of Science ®Google Scholar
• Gutz, H., and Schmidt H.. 1985. Switching genes in Schizosaccharomyces pombe. Curr. Genet. 9:325–331.
   PubMedGoogle Scholar
• Iino, Y., and Yamamoto M.. 1997. The Schizosaccharomyces pombe cdc6 gene encodes the catalytic subunit of DNA polymerase delta. Mol. Gen. Genet. 254:93–97.
   PubMedGoogle Scholar
• Karthikeyan, R., Vonarx E. J., Straffon A. F., Simon M., Faye G., and Kunz B. A.. 2000. Evidence from mutational specificity studies that yeast DNA polymerases delta and epsilon replicate different DNA strands at an intracellular replication fork. J. Mol. Biol. 299:405–419.
   PubMed Web of Science ®Google Scholar
• Katou, Y., Kanoh Y., Bando M., Noguchi H., Tanaka H., Ashikari T., Sugimoto K., and Shirahige K.. 2003. S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424:1078–1083.
   PubMed Web of Science ®Google Scholar
• Kaykov, A., Holmes A. M., and Arcangioli B.. 2004. Formation, maintenance and consequences of the imprint at the mating-type locus in fission yeast. EMBO J. 23:930–938.
   PubMedGoogle Scholar
• Kearsey, S. E., Montgomery S., Labib K., and Lindner K.. 2000. Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18. EMBO J. 19:1681–1690.
   PubMedGoogle Scholar
• Kim, S. M., and Huberman J. A.. 2001. Regulation of replication timing in fission yeast. EMBO J. 20:6115–6126.
   PubMedGoogle Scholar
• Kolodner, R. D., Putnam C. D., and Myung K.. 2002. Maintenance of genome stability in Saccharomyces cerevisiae. Science 297:552–557.
   PubMed Web of Science ®Google Scholar
• Krawchuk, M. D., and Wahls W. P.. 1999. High-efficiency gene targeting in Schizosaccharomyces pombe using a modular, PCR-based approach with long tracts of flanking homology. Yeast 15:1419–1427.
   PubMed Web of Science ®Google Scholar
• Lindsay, H. D., Griffiths D. J., Edwards R. J., Christensen P. U., Murray J. M., Osman F., Walworth N., and Carr A. M.. 1998. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. Genes Dev. 12:382–395.
   PubMed Web of Science ®Google Scholar
• Lopes, M., Cotta-Ramusino C., Liberi G., and Foiani M.. 2003. Branch migrating sister chromatid junctions form at replication origins through Rad51/Rad52-independent mechanisms. Mol. Cell 12:1499–1510.
   PubMedGoogle Scholar
• Lopes, M., Cotta-Ramusino C., Pellicioli A., Liberi G., Plevani P., Muzi-Falconi M., Newlon C. S., and Foiani M.. 2001. The DNA replication checkpoint response stabilizes stalled replication forks. Nature 412:557–561.
   PubMed Web of Science ®Google Scholar
• MacQueen, A. J., and Villeneuve A. M.. 2001. Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2. Genes Dev. 15:1674–1687.
   PubMed Web of Science ®Google Scholar
• Mayer, M. L., Pot I., Chang M., Xu H., Aneliunas V., Kwok T., Newitt R., Aebersold R., Boone C., Brown G. W., and Hieter P.. 2004. Identification of protein complexes required for efficient sister chromatid cohesion. Mol. Biol. Cell 15:1736–1745.
   PubMed Web of Science ®Google Scholar
• McGlynn, P., and Lloyd R. G.. 2002. Recombinational repair and restart of damaged replication forks. Nat. Rev. Mol. Cell Biol. 3:859–870.
   PubMed Web of Science ®Google Scholar
• Moreno, S., Klar A., and Nurse P.. 1991. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194:795–823.
   PubMed Web of Science ®Google Scholar
• Muris, D. F., Vreeken K., Carr A. M., Broughton B. C., Lehmann A. R., Lohman P. H., and Pastink A.. 1993. Cloning the RAD51 homologue of Schizosaccharomyces pombe. Nucleic Acids Res. 21:4586–4591.
   PubMedGoogle Scholar
• Muris, D. F., Vreeken K., Carr A. M., Murray J. M., Smit C., Lohman P. H., and Pastink A.. 1996. Isolation of the Schizosaccharomyces pombe RAD54 homologue, rhp54+, a gene involved in the repair of radiation damage and replication fidelity. J. Cell Sci. 109:73–81.
   PubMedGoogle Scholar
• Nasmyth, K., and Nurse P.. 1981. Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe. Mol. Gen. Genet. 182:119–124.
   PubMedGoogle Scholar
• Noguchi, E., Noguchi C., Du L. L., and Russell P.. 2003. Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1. Mol. Cell. Biol. 23:7861–7874.
   PubMed Web of Science ®Google Scholar
• Ogawa, Y., Takahashi T., and Masukata H.. 1999. Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins. Mol. Cell. Biol. 19:7228–7236.
   PubMed Web of Science ®Google Scholar
• Osborn, A. J., and Elledge S. J.. 2003. Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev. 17:1755–1767.
   PubMed Web of Science ®Google Scholar
• Osborn, A. J., Elledge S. J., and Zou L.. 2002. Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol. 12:509–516.
   PubMed Web of Science ®Google Scholar
• Osman, F., Dixon J., Doe C. L., and Whitby M. C.. 2003. Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis. Mol. Cell 12:761–774.
   PubMedGoogle Scholar
• Ostermann, K., Lorentz A., and Schmidt H.. 1993. The fission yeast rad22 gene, having a function in mating-type switching and repair of DNA damages, encodes a protein homolog to Rad52 of Saccharomyces cerevisiae. Nucleic Acids Res. 21:5940–5944.
   PubMedGoogle Scholar
• Paques, F., and Haber J.. 1999. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63:349–404.
   PubMed Web of Science ®Google Scholar
• Pavlov, Y. I., Newlon C. S., and Kunkel T. A.. 2002. Yeast origins establish a strand bias for replicational mutagenesis. Mol. Cell 10:207–213.
   PubMedGoogle Scholar
• Rabitsch, K. P., Toth A., Galova M., Schleiffer A., Schaffner G., Aigner E., Rupp C., Penkner A. M., Moreno-Borchart A. C., Primig M., Esposito R. E., Klein F., Knop M., and Nasmyth K.. 2001. A screen for genes required for meiosis and spore formation based on whole-genome expression. Curr. Biol. 11:1001–1009.
   PubMedGoogle Scholar
• Rigaut, G., Shevchenko A., Rutz B., Wilm M., Mann M., and Seraphin B.. 1999. A generic protein purification method for protein complex characterization and proteome exploration. Nat. Biotechnol. 17:1030–1032.
   PubMed Web of Science ®Google Scholar
• Sanchez, J. A., Kim S. M., and Huberman J. A.. 1998. Ribosomal DNA replication in the fission yeast, Schizosaccharomyces pombe. Exp. Cell Res. 238:220–230.
   PubMedGoogle Scholar
• Schmidt, H., Kapitza P., and Gutz H.. 1987. Switching genes in Schizosaccharomyces pombe: their influence on cell viability and recombination. Curr. Genet. 11:303–308.
   Google Scholar
• Segurado, M., Gomez M., and Antequera F.. 2002. Increased recombination intermediates and homologous integration hot spots at DNA replication origins. Mol. Cell 10:907–916.
   PubMedGoogle Scholar
• Shcherbakova, P. V., and Pavlov Y. I.. 1996. 3′→5′ exonucleases of DNA polymerases epsilon and delta correct base analog induced DNA replication errors on opposite DNA strands in Saccharomyces cerevisiae. Genetics 142:717–726.
   PubMed Web of Science ®Google Scholar
• Sogo, J. M., Lopes M., and Foiani M.. 2002. Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science 297:599–602.
   PubMed Web of Science ®Google Scholar
• Stewart, E., Chapman C. R., Al-Khodairy F., Carr A. M., and Enoch T.. 1997. rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. EMBO J. 16:2682–2692.
   PubMed Web of Science ®Google Scholar
• Tanaka, K., and Russell P.. 2001. Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1. Nat. Cell Biol. 3:966–972.
   PubMed Web of Science ®Google Scholar
• Tercero, J. A., and Diffley J. F.. 2001. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 412:553–557.
   PubMed Web of Science ®Google Scholar
• Uetz, P., Giot L., Cagney G., Mansfield T. A., Judson R. S., Knight J. R., Lockshon D., Narayan V., Srinivasan M., Pochart P., Qureshi-Emili A., Li Y., Godwin B., Conover D., Kalbfleisch T., Vijayadamodar G., Yang M., Johnston M., Fields S., and Rothberg J. M.. 2000. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403:623–627.
   PubMed Web of Science ®Google Scholar
• Vengrova, S., Codlin S., and Dalgaard J. Z.. 2002. RTS1—an eukaryotic terminator of replication. Int. J. Biochem. Cell Biol. 34:1031–1034.
   PubMedGoogle Scholar
• Vengrova, S., and Dalgaard J. Z.. 2004. RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching. Genes Dev. 18:794–804.
   PubMedGoogle Scholar
• Virgin, J. B., Bailey J. P., Hasteh F., Neville J., Cole A., and Tromp G.. 2001. Crossing over is rarely associated with mitotic intragenic recombination in Schizosaccharomyces pombe. Genetics 157:63–77.
   PubMedGoogle Scholar
• Waga, S., and Stillman B.. 1998. The DNA replication fork in eukaryotic cells. Annu. Rev. Biochem. 67:721–751.
   PubMed Web of Science ®Google Scholar
• Warren, C. D., Eckley D. M., Lee M. S., Hanna J. S., Hughes A., Peyser B., Jie C., Irizarry R., and Spencer F. A.. 2004. S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion. Mol. Biol. Cell 15:1724–1735.
   PubMed Web of Science ®Google Scholar
• Washburn, M. P., Wolters D., and Yates III J. R.. 2001. Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat. Biotechnol. 19:242–247.
   PubMed Web of Science ®Google Scholar
• Wellinger, R. E., Schar P., and Sogo J. M.. 2003. Rad52-independent accumulation of joint circular minichromosomes during S phase in Saccharomyces cerevisiae. Mol. Cell. Biol. 23:6363–6372.
   PubMedGoogle Scholar
• Woodgate, R. 1999. A plethora of lesion-replicating DNA polymerases. Genes Dev. 13:2191–2195.
   PubMed Web of Science ®Google Scholar
• Yanow, S. K., Lygerou Z., and Nurse P.. 2001. Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication. EMBO J. 20:4648–4656.
   PubMedGoogle Scholar
• Yonemasu, R., McCready S. J., Murray J. M., Osman F., Takao M., Yamamoto K., Lehmann A. R., and Yasui A.. 1997. Characterization of the alternative excision repair pathway of UV-damaged DNA in Schizosaccharomyces pombe. Nucleic Acids Res. 25:1553–1558.
   PubMedGoogle Scholar
• Zou, H., and Rothstein R.. 1997. Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism. Cell 90:87–96.
   PubMedGoogle Scholar