Notch Activation Induces Endothelial Cell Cycle Arrest and Participates in Contact Inhibition: Role of p21^Cip1 Repression

REFERENCES

• Artavanis-Tsakonas, S., Rand M. D., and Lake R. J.. 1999. Notch signaling: cell fate control and signal integration in development. Science 284:770–776.
   PubMed Web of Science ®Google Scholar
• Carlesso, N., Aster J. C., Sklar J., and Scadden D. T.. 1999. Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics. Blood 93:838–848.
   PubMed Web of Science ®Google Scholar
• Cheng, M., Olivier P., Diehl J. A., Fero M., Roussel M. F., Roberts J. M., and Sherr C. J.. 1999. The p21(Cip1) and p27(Kip1) CDK ′inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 18:1571–1583.
   PubMed Web of Science ®Google Scholar
• DeCaprio, J. A., Ludlow J. W., Figge J., Shew J. Y., Huang C. M., Lee W. H., Marsilio E., Paucha E., and Livingston D. M.. 1988. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54:275–283.
   PubMed Web of Science ®Google Scholar
• el-Deiry, W. S., Tokino T., Velculescu V. E., Levy D. B., Parsons R., Trent J. M., Lin D., Mercer W. E., Kinzler K. W., and Vogelstein B.. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817–825.
   PubMed Web of Science ®Google Scholar
• Firpo, E. J., Koff A., Solomon M. J., and Roberts J. M.. 1994. Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes. Mol. Cell. Biol. 14:4889–4901.
   PubMed Web of Science ®Google Scholar
• Grandori, C., Wu K. J., Fernandez P., Ngouenet C., Grim J., Clurman B. E., Moser M. J., Oshima J., Russell D. W., Swisshelm K., Frank S., Amati B., Dalla-Favera R., and Monnat R. J., Jr. 2003. Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev. 17:1569–1574.
   PubMed Web of Science ®Google Scholar
• Hanahan, D., and Folkman J.. 1996. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353–364.
   PubMed Web of Science ®Google Scholar
• Henderson, A. M., Wang S. J., Taylor A. C., Aitkenhead M., and Hughes C. C.. 2001. The basic helix-loop-helix transcription factor HESR1 regulates endothelial cell tube formation. J. Biol. Chem. 276:6169–6176.
   PubMedGoogle Scholar
• Hirano, M., Hirano K., Nishimura J., and Kanaide H.. 2001. Transcriptional up-regulation of p27(Kip1) during contact-induced growth arrest in vascular endothelial cells. Exp. Cell Res. 271:356–367.
   PubMedGoogle Scholar
• Hobson, B., and Denekamp J.. 1984. Endothelial proliferation in tumours and normal tissues: continuous labelling studies. Br. J. Cancer 49:405–413.
   PubMed Web of Science ®Google Scholar
• Iso, T., Hamamori Y., and Kedes L.. 2003. Notch signaling in vascular development. Arterioscler. Thromb. Vasc. Biol. 23:543–553.
   PubMed Web of Science ®Google Scholar
• Jundt, F., Anagnostopoulos I., Forster R., Mathas S., Stein H., and Dorken B.. 2002. Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood 99:3398–3403.
   PubMed Web of Science ®Google Scholar
• Karsan, A., Yee E., Poirier G. G., Zhou P., Craig R., and Harlan J. M.. 1997. Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms. Am. J. Pathol. 151:1775–1784.
   PubMedGoogle Scholar
• Krebs, L. T., Xue Y., Norton C. R., Shutter J. R., Maguire M., Sundberg J. P., Gallahan D., Closson V., Kitajewski J., Callahan R., Smith G. H., Stark K. L., and Gridley T.. 2000. Notch signaling is essential for vascular morphogenesis in mice. Genes Dev. 14:1343–1352.
   PubMed Web of Science ®Google Scholar
• LaBaer, J., Garrett M. D., Stevenson L. F., Slingerland J. M., Sandhu C., Chou H. S., Fattaey A., and Harlow E.. 1997. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11:847–862.
   PubMed Web of Science ®Google Scholar
• Leong, K. G., Hu X., Li L., Noseda M., Larrivee B., Hull C., Hood L., Wong F., and Karsan A.. 2002. Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation. Mol. Cell. Biol. 22:2830–2841.
   PubMedGoogle Scholar
• Li, Y., Jenkins C. W., Nichols M. A., and Xiong Y.. 1994. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene 9:2261–2268.
   PubMed Web of Science ®Google Scholar
• MacKenzie, F., Duriez P., Wong F., Noseda M., and Karsan A.. 2004. Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways. J. Biol. Chem. 279:11657–11663.
   PubMedGoogle Scholar
• Mailhos, C., Modlich U., Lewis J., Harris A., Bicknell R., and Ish-Horowicz D.. 2001. Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation 69:135–144.
   PubMed Web of Science ®Google Scholar
• Micchelli, C. A., Esler W. P., Kimberly W. T., Jack C., Berezovska O., Kornilova A., Hyman B. T., Perrimon N., and Wolfe M. S.. 2003. Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J. 17:79–81.
   PubMedGoogle Scholar
• Nakajima, M., Yuasa S., Ueno M., Takakura N., Koseki H., and Shirasawa T.. 2003. Abnormal blood vessel development in mice lacking presenilin-1. Mech. Dev. 120:657–667.
   PubMedGoogle Scholar
• Noseda, M., McLean G., Niessen K., Chang L., Pollet I., Montpetit R., Shahidi R., Dorovini-Zis K., Li L., Beckstead B., Durand R. E., Hoodless P. A., and Karsan A.. 2004. Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ. Res. 94:910–917.
   PubMed Web of Science ®Google Scholar
• Nourse, J., Firpo E., Flanagan W. M., Coats S., Polyak K., Lee M. H., Massague J., Crabtree G. R., and Roberts J. M.. 1994. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570–573.
   PubMed Web of Science ®Google Scholar
• Polyak, K., Kato J. Y., Solomon M. J., Sherr C. J., Massague J., Roberts J. M., and Koff A.. 1994. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 8:9–22.
   PubMed Web of Science ®Google Scholar
• Rangarajan, A., Talora C., Okuyama R., Nicolas M., Mammucari C., Oh H., Aster J. C., Krishna S., Metzger D., Chambon P., Miele L., Aguet M., Radtke F., and Dotto G. P.. 2001. Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J. 20:3427–3436.
   PubMed Web of Science ®Google Scholar
• Reaume, A. G., Conlon R. A., Zirngibl R., Yamaguchi T. P., and Rossant J.. 1992. Expression analysis of a Notch homologue in the mouse embryo. Dev. Biol. 154:377–387.
   PubMedGoogle Scholar
• Ronchini, C., and Capobianco A. J.. 2001. Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol. Cell. Biol. 21:5925–5934.
   PubMed Web of Science ®Google Scholar
• Ronchini, C., and Capobianco A. J.. 2000. Notch(ic)-ER chimeras display hormone-dependent transformation, nuclear accumulation, phosphorylation and CBF1 activation. Oncogene 19:3914–3924.
   PubMedGoogle Scholar
• Seiffert, D., Bradley J. D., Rominger C. M., Rominger D. H., Yang F., Meredith J. E., Jr., Wang Q., Roach A. H., Thompson L. A., Spitz S. M., Higaki J. N., Prakash S. R., Combs A. P., Copeland R. A., Arneric S. P., Hartig P. R., Robertson D. W., Cordell B., Stern A. M., Olson R. E., and Zaczek R.. 2000. Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors. J. Biol. Chem. 275:34086–34091.
   PubMed Web of Science ®Google Scholar
• Shen, J., Bronson R. T., Chen D. F., Xia W., Selkoe D. J., and Tonegawa S.. 1997. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell 89:629–639.
   PubMed Web of Science ®Google Scholar
• Sherr, C. J. 2000. Cancer cell cycles revisited. Cancer Res. 60:3689–3695.
   PubMed Web of Science ®Google Scholar
• Sherr, C. J., and Roberts J. M.. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1149–1163.
   PubMed Web of Science ®Google Scholar
• Shirayoshi, Y., Yuasa Y., Suzuki T., Sugaya K., Kawase E., Ikemura T., and Nakatsuji N.. 1997. Proto-oncogene of int-3, a mouse Notch homologue, is expressed in endothelial cells during early embryogenesis. Genes Cells 2:213–224.
   PubMed Web of Science ®Google Scholar
• Shutter, J. R., Scully S., Fan W., Richards W. G., Kitajewski J., Deblandre G. A., Kintner C. R., and Stark K. L.. 2000. Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev. 14:1313–1318.
   PubMed Web of Science ®Google Scholar
• Sriuranpong, V., Borges M. W., Ravi R. K., Arnold D. R., Nelkin B. D., Baylin S. B., and Ball D. W.. 2001. Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res. 61:3200–3205.
   PubMed Web of Science ®Google Scholar
• Taichman, D. B., Loomes K. M., Schachtner S. K., Guttentag S., Vu C., Williams P., Oakey R. J., and Baldwin H. S.. 2002. Notch1 and Jagged1 expression by the developing pulmonary vasculature. Dev. Dyn. 225:166–175.
   PubMedGoogle Scholar
• Talora, C., Sgroi D. C., Crum C. P., and Dotto G. P.. 2002. Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev. 16:2252–2263.
   PubMed Web of Science ®Google Scholar
• Taylor, K. L., Henderson A. M., and Hughes C. C.. 2002. Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. Microvasc. Res. 64:372–383.
   PubMedGoogle Scholar
• Uyttendaele, H., Ho J., Rossant J., and Kitajewski J.. 2001. Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc. Natl. Acad. Sci. USA 98:5643–5648.
   PubMed Web of Science ®Google Scholar
• Uyttendaele, H., Marazzi G., Wu G., Yan Q., Sassoon D., and Kitajewski J.. 1996. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development 122:2251–2259.
   PubMed Web of Science ®Google Scholar
• Weng, A. P., Nam Y., Wolfe M. S., Pear W. S., Griffin J. D., Blacklow S. C., and Aster J. C.. 2003. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol. Cell. Biol. 23:655–664.
   PubMed Web of Science ®Google Scholar
• Xue, Y., Gao X., Lindsell C. E., Norton C. R., Chang B., Hicks C., Gendron-Maguire M., Rand E. B., Weinmaster G., and Gridley T.. 1999. Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum. Mol Genet. 8:723–730.
   PubMed Web of Science ®Google Scholar
• Yang, Z. Y., Simari R. D., Perkins N. D., San H., Gordon D., Nabel G. J., and Nabel E. G.. 1996. Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. Proc. Natl. Acad. Sci. USA 93:7905–7910.
   PubMed Web of Science ®Google Scholar
• Zhang, W. W., Labrecque S., Azoulay E., Dudley R., and Matlashewski G.. 2001. Development of a p53 responsive GFP reporter; identification of live cells with p53 activity. J. Biotechnol. 84:79–86.
   PubMedGoogle Scholar