The Cyclin A1-CDK2 Complex Regulates DNA Double-Strand Break Repair

REFERENCES

• Akyuz, N., Boehden G. S., Susse S., Rimek A., Preuss U., Scheidtmann K. H., and Wiesmüller L.. 2002. DNA substrate dependence of p53-mediated regulation of double-strand break repair. Mol. Cell. Biol. 22:6306–6317.
   PubMed Web of Science ®Google Scholar
• Allen, C., Kurimasa A., Brenneman M. A., Chen D. J., and Nickoloff J. A.. 2002. DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proc. Natl. Acad. Sci. USA 99:3758–3763.
   PubMed Web of Science ®Google Scholar
• Bäumer, N., Marquardt T., Stoykova A., Ashery-Padan R., Chowdhury K., and Gruss P.. 2002. Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle. Development 129:4535–4545.
   PubMedGoogle Scholar
• Bill, C. A., Yu Y., Miselis N. R., Little J. B., and Nickoloff J. A.. 1997. A role for p53 in DNA end rejoining by human cell extracts. Mutat. Res. 385:21–29.
   PubMedGoogle Scholar
• Borellini, F., and Glazer R. I.. 1993. Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1. J. Biol. Chem. 268:7923–7928.
   PubMedGoogle Scholar
• Chan, D. W., Chen B. P., Prithivirajsingh S., Kurimasa A., Story M. D., Qin J., and Chen D. J.. 2002. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev. 16:2333–2338.
   PubMed Web of Science ®Google Scholar
• Chen, F., Peterson S. R., Story M. D., and Chen D. J.. 1996. Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair. Mutat. Res. 362:9–19.
   PubMedGoogle Scholar
• Coverley, D., Laman H., and Laskey R. A.. 2002. Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat. Cell. Biol. 4:523–528.
   PubMed Web of Science ®Google Scholar
• Difilippantonio, M. J., Zhu J., Chen H. T., Meffre E., Nussenzweig M. C., Max E. E., Ried T., and Nussenzweig A.. 2000. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404:510–514.
   PubMed Web of Science ®Google Scholar
• Ferguson, D. O., Sekiguchi J. M., Chang S., Frank K. M., Gao Y., DePinho R. A., and Alt F. W.. 2000. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc. Natl. Acad. Sci. USA 97:6630–6633.
   PubMed Web of Science ®Google Scholar
• Follows, G. A., Tagoh H., Lefevre P., Hodge D., Morgan G. J., and Bonifer C.. 2003. Epigenetic consequences of AML1-ETO action at the human c-FMS locus. EMBO J. 22:2798–2809.
   PubMed Web of Science ®Google Scholar
• Frasca, D., Barattini P., Tocchi G., Guidi L., Pierelli L., and Doria G.. 2001. Role of DNA-dependent protein kinase in recognition of radiation-induced DNA damage in human peripheral blood mononuclear cells. Int. Immunol. 13:791–797.
   PubMedGoogle Scholar
• Fukushima, T., Takata M., Morrison C., Araki R., Fujimori A., Abe M., Tatsumi K., Jasin M., Dhar P. K., Sonoda E., Chiba T., and Takeda S.. 2001. Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair. J. Biol. Chem. 276:44413–44418.
   PubMedGoogle Scholar
• Khanna, K. K., and Jackson S. P.. 2001. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27:247–254.
   PubMed Web of Science ®Google Scholar
• Koutsodontis, G., Tentes I., Papakosta P., Moustakas A., and Kardassis D.. 2001. Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein. J. Biol. Chem. 276:29116–29125.
   PubMedGoogle Scholar
• Lee, H., Sun D., Larner J. M., and Wu F. S.. 1999. The tumor suppressor p53 can reduce stable transfection in the presence of irradiation. J. Biomed. Sci. 6:285–292.
   PubMedGoogle Scholar
• Lieber, M. R., Ma Y., Pannicke U., and Schwarz K.. 2003. Mechanism and regulation of human non-homologous DNA end-joining. Nat. Rev. Mol. Cell. Biol. 4:712–720.
   PubMed Web of Science ®Google Scholar
• Linggi, B., Müller-Tidow C., van de Locht L., Hu M., Nip J., Serve H., Berdel W. E., van der Reijden B., Quelle D. E., Rowley J. D., Cleveland J., Jansen J. H., Pandolfi P. P., and Hiebert S. W.. 2002. The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia. Nat. Med. 8:743–750.
   PubMed Web of Science ®Google Scholar
• Liu, D., Matzuk M. M., Sung W. K., Guo Q., Wang P., and Wolgemuth D. J.. 1998. Cyclin A1 is required for meiosis in the male mouse. Nat. Genet. 20:377–380.
   PubMed Web of Science ®Google Scholar
• Lundberg, A. S., and Weinberg R. A.. 1998. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18:753–761.
   PubMed Web of Science ®Google Scholar
• Maxwell, S. A., and Davis G. E.. 2000. Differential gene expression in p53-mediated apoptosis-resistant versus apoptosis-sensitive tumor cell lines. Proc. Natl. Acad. Sci. USA 97:13009–13014.
   PubMed Web of Science ®Google Scholar
• Müller, C., Readhead C., Diederichs S., Idos G., Yang R., Tidow N., Serve H., Berdel W. E., and Koeffler H. P.. 2000. Methylation of the cyclin A1 promoter correlates with gene silencing in somatic cell lines, while tissue-specific expression of cyclin A1 is methylation independent. Mol. Cell. Biol. 20:3316–3329.
   PubMedGoogle Scholar
• Müller, C., Yang R., Beck-von-Peccoz L., Idos G., Verbeek W., and Koeffler H. P.. 1999. Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene. J. Biol. Chem. 274:11220–11228.
   PubMedGoogle Scholar
• Müller, C., Yang R., Idos G., Tidow N., Diederichs S., Koch O. M., Verbeek W., Bender T. P., and Koeffler H. P.. 1999. c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression. Blood 94:4255–4262.
   PubMedGoogle Scholar
• Müller, C., Yang R., Park D. J., Serve H., Berdel W. E., and Koeffler H. P.. 2000. The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia. Blood 96:3894–3899.
   PubMed Web of Science ®Google Scholar
• Müller-Tidow, C., Metzelder S. K., Buerger H., Packeisen J., Ganser A., Heil G., Kugler K., Adiguzel G., Schwable J., Steffen B., Ludwig W. D., Heinecke A., Buchner T., Berdel W. E., and Serve H.. 2004. Expression of the p14ARF tumor suppressor predicts survival in acute myeloid leukemia. Leukemia 18:720–726.
   PubMed Web of Science ®Google Scholar
• Müller-Tidow, C., Steffen B., Cauvet T., Tickenbrock L., Ji P., Diederichs S., Sargin B., Kohler G., Stelljes M., Puccetti E., Ruthardt M., deVos S., Hiebert S. W., Koeffler H. P., Berdel W. E., and Serve H.. 2004. Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Mol. Cell. Biol. 24:2890–2904.
   PubMed Web of Science ®Google Scholar
• Murphy, M., Stinnakre M. G., Senamaud-Beaufort C., Winston N. J., Sweeney C., Kubelka M., Carrington M., Brechot C., and Sobczak-Thepot J.. 1997. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nat. Genet. 15:83–86.
   PubMed Web of Science ®Google Scholar
• Nussenzweig, A., Chen C., da Costa Soares V., Sanchez M., Sokol K., Nussenzweig M. C., and Li G. C.. 1996. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature 382:551–555.
   PubMed Web of Science ®Google Scholar
• Okorokov, A. L., Warnock L., and Milner J.. 2002. Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation. Carcinogenesis. 23:549–557.
   PubMedGoogle Scholar
• Ouyang, H., Nussenzweig A., Kurimasa A., Soares V. C., Li X., Cordon-Cardo C., Li W., Cheong N., Nussenzweig M., Iliakis G., Chen D. J., and Li G. C.. 1997. Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo. J. Exp. Med. 186:921–929.
   PubMed Web of Science ®Google Scholar
• Patton, W. P., Chakravarthy U., Davies R. J., and Archer D. B.. 1999. Comet assay of UV-induced DNA damage in retinal pigment epithelial cells. Investig. Ophthalmol. Vis. Sci. 40:3268–3275.
   PubMed Web of Science ®Google Scholar
• Pierce, A. J., Hu P., Han M., Ellis N., and Jasin M.. 2001. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 15:3237–3242.
   PubMed Web of Science ®Google Scholar
• Porse, B. T., Pedersen T. A., Xu X., Lindberg B., Wewer U. M., Friis-Hansen L., and Nerlov C.. 2001. E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. Cell 107:247–258.
   PubMed Web of Science ®Google Scholar
• Richardson, C., and Jasin M.. 2000. Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells. Mol. Cell. Biol. 20:9068–9075.
   PubMed Web of Science ®Google Scholar
• Spruck, C. H., Won K. A., and Reed S. I.. 1999. Deregulated cyclin E induces chromosome instability. Nature 401:297–300.
   PubMed Web of Science ®Google Scholar
• Steffen, B., Serve H., Berdel W. E., Agrawal S., Linggi B., Buchner T., Hiebert S. W., and Müller-Tidow C.. 2003. Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia. Proc. Natl. Acad. Sci. USA 100:8448–8453.
   PubMedGoogle Scholar
• Sweeney, C., Murphy M., Kubelka M., Ravnik S. E., Hawkins C. F., Wolgemuth D. J., and Carrington M.. 1996. A distinct cyclin A is expressed in germ cells in the mouse. Development 122:53–64.
   PubMed Web of Science ®Google Scholar
• Tang, W., Willers H., and Powell S. N.. 1999. p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts. Cancer Res. 59:2562–2565.
   PubMedGoogle Scholar
• Torgeman, A., Mor-Vaknin N., Zelin E., Ben-Aroya Z., Lochelt M., Flugel R. M., and Aboud M.. 2001. Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C. Virology 281:10–20.
   PubMedGoogle Scholar
• Tuteja, R., and Tuteja N.. 2000. Ku autoantigen: a multifunctional DNA-binding protein. Crit. Rev. Biochem. Mol. Biol. 35:1–33.
   PubMed Web of Science ®Google Scholar
• van der Meer, T., Chan W. Y., Palazon L. S., Nieduszynski C., Murphy M., Sobczak-Thepot J., Carrington M., and Colledge W. H.. 2004. Cyclin A1 protein shows haplo-insufficiency for normal fertility in male mice. Reproduction 127:503–511.
   PubMedGoogle Scholar
• Walker, J. R., Corpina R. A., and Goldberg J.. 2001. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412:607–614.
   PubMed Web of Science ®Google Scholar
• Yang, R., Morosetti R., and Koeffler H. P.. 1997. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Cancer Res. 57:913–920.
   PubMed Web of Science ®Google Scholar
• Yang, R., Müller C., Huynh V., Fung Y. K., Yee A. S., and Koeffler H. P.. 1999. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. 19:2400–2407.
   PubMed Web of Science ®Google Scholar
• Yang, R., Nakamaki T., Lubbert M., Said J., Sakashita A., Freyaldenhoven B. S., Spira S., Huynh V., Müller C., and Koeffler H. P.. 1999. Cyclin A1 expression in leukemia and normal hematopoietic cells. Blood 93:2067–2074.
   PubMed Web of Science ®Google Scholar
• Yang, T., Namba H., Hara T., Takmura N., Nagayama Y., Fukata S., Ishikawa N., Kuma K., Ito K., and Yamashita S.. 1997. p53 induced by ionizing radiation mediates DNA end-jointing activity, but not apoptosis of thyroid cells. Oncogene 14:1511–1519.
   PubMedGoogle Scholar
• Zhou, X. Y., Wang X., Wang H., Chen D. J., Li G. C., Iliakis G., and Wang Y.. 2002. Ku affects the ATM-dependent S phase checkpoint following ionizing radiation. Oncogene 21:6377–6381.
   PubMedGoogle Scholar