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Cell Growth and Development

c-Jun-Deficient Cells Undergo Premature Senescence as a Result of Spontaneous DNA Damage Accumulation

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Pages 9006-9018 | Received 28 Jan 2004, Accepted 23 Jun 2004, Published online: 27 Mar 2023

REFERENCES

  • Baus, F., Gire V., Fisher D., Piette J., and Dulic V.. 2003. Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts. EMBO J. 22:3992–4002.
  • Black, E. J., Clark W., and Gillespie D. A.. 2000. Transient deactivation of ERK signalling is sufficient for stable entry into G0 in primary avian fibroblasts. Curr. Biol. 10:1119–1122.
  • Burma, S., Chen B. P., Murphy M., Kurimasa A., and Chen D. J.. 2001. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem. 276:42462–42467.
  • Chevray, P. M., and Nathans D.. 1992. Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Proc. Natl. Acad. Sci. USA 89:5789–5793.
  • Chiang, Y. C., Teng S. C., Su Y. N., Hsieh F. J., and Wu K. J.. 2003. c-Myc directly regulates the transcription of the NBS1 gene involved in DNA double-strand break repair. J. Biol. Chem. 278:19286–19291.
  • Clark, W., and Gillespie D. A.. 1997. Transformation by v-Jun prevents cell cycle exit and promotes apoptosis in the absence of serum growth factors. Cell Growth Differ. 8:371–380.
  • Cressman, V. L., Backlund D. C., Avrutskaya A. V., Leadon S. A., Godfrey V., and Koller B. H.. 1999. Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice. Mol. Cell. Biol. 19:7061–7075.
  • Deng, C. X., and Wang R. H.. 2003. Roles of BRCA1 in DNA damage repair: a link between development and cancer. Hum. Mol. Genet. 12:R113–R123.
  • Eferl, R., and Wagner E. F.. 2003. AP-1: a double-edged sword in tumorigenesis. Nat. Rev. Cancer 3:859–868.
  • Frank, K. M., Sharpless N. E., Gao Y., Sekiguchi J. M., Ferguson D. O., Zhu C., Manis J. P., Horner J., DePinho R. A., and Alt F. W.. 2000. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol. Cell 5:993–1002.
  • Frit, P., Kwon K., Coin F., Auriol J., Dubaele S., Salles B., and Egly J. M.. 2002. Transcriptional activators stimulate DNA repair. Mol. Cell 10:1391–1401.
  • Gjerset, R. A., Lebedeva S., Haghighi A., Turla S. T., and Mercola D.. 1999. Inhibition of the Jun kinase pathway blocks DNA repair, enhances p53-mediated apoptosis and promotes gene amplification. Cell Growth Differ. 10:545–554.
  • Grandori, C., Wu K. J., Fernandez P., Ngouenet C., Grim J., Clurman B. E., Moser M. J., Oshima J., Russell D. W., Swisshelm K., Frank S., Amati B., Dalla-Favera R., and Monnat R. J., Jr. 2003. Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev. 17:1569–1574.
  • Grollman, A. P., and Moriya M.. 1993. Mutagenesis by 8-oxoguanine: an enemy within. Trends Genet. 9:246–249.
  • Halliwell, B. 2003. Oxidative stress in cell culture: an under-appreciated problem? FEBS Lett. 540:3–6.
  • Hartmann, A., Agurell E., Beevers C., Brendler-Schwaab S., Burlinson B., Clay P., Collins A., Smith A., Speit G., Thybaud V., and Tice R. R.. 2003. Recommendations for conducting the in vivo alkaline Comet assay. 4th International Comet Assay Workshop. Mutagenesis 18:45–51.
  • Hayakawa, J., Depatie C., Ohmichi M., and Mercola D.. 2003. The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair. J. Biol. Chem. 278:20582–20592.
  • Hennigan, R. F., and Stambrook P. J.. 2001. Dominant negative c-jun inhibits activation of the cyclin D1 and cyclin E kinase complexes. Mol. Biol. Cell 12:2352–2363.
  • Johnson, R. S., van Lingen B., Papaioannou V. E., and Spiegelman B. M.. 1993. A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev. 7:1309–1317.
  • Leadon, S. A. 1999. Transcription-coupled repair of DNA damage: unanticipated players, unexpected complexities. Am. J. Hum. Genet. 64:1259–1263.
  • Maclaren, A., Clark W., Black E. J., Gregory D., Fujii H., and Gillespie D. A.. 2003. v-Jun stimulates both cdk2 kinase activity and G1/S progression via transcriptional repression of p21 CIP1. Oncogene 22:2383–2395.
  • MacLaren, A., Clark W., and Gillespie D. A.. 2000. v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release. Oncogene 19:5906–5918.
  • Maki, Y., Bos T. J., Davis C., Starbuck M., and Vogt P. K.. 1987. Avian sarcoma virus 17 carries the jun oncogene. Proc. Natl. Acad. Sci. USA 84:2848–2852.
  • Nussenzweig, A., Chen C., da Costa Soares V., Sanchez M., Sokol K., Nussenzweig M. C., and Li G. C.. 1996. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature 382:551–555.
  • Nyberg, K. A., Michelson R. J., Putnam C. W., and Weinert T. A.. 2002. Toward maintaining the genome: DNA damage and replication checkpoints. Annu. Rev. Genet. 36:617–656.
  • Parrinello, S., Samper E., Krtolica A., Goldstein J., Melov S., and Campisi J.. 2003. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat. Cell Biol. 5:741–747.
  • Potapova, O., Basu S., Mercola D., and Holbrook N. J.. 2001. Protective role for c-Jun in the cellular response to DNA damage. J. Biol. Chem. 276:28546–28553.
  • Potapova, O., Haghighi A., Bost F., Liu C., Birrer M. J., Gjerset R., and Mercola D.. 1997. The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin. J. Biol. Chem. 272:14041–14044.
  • Ries, S., Biederer C., Woods D., Shifman O., Shirasawa S., Sasazuki T., McMahon M., Oren M., and McCormick F.. 2000. Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell 103:321–330.
  • Scherer, S. J., Maier S. M., Seifert M., Hanselmann R. G., Zang K. D., Muller-Hermelink H. K., Angel P., Welter C., and Schartl M.. 2000. p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV. J. Biol. Chem. 275:37469–37473.
  • Schreiber, M., Kolbus A., Piu F., Szabowski A., Mohle-Steinlein U., Tian J., Karin M., Angel P., and Wagner E. F.. 1999. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 13:607–619.
  • Shaulian, E., Schreiber M., Piu F., Beeche M., Wagner E. F., and Karin M.. 2000. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell 103:897–907.
  • Sherr, C. J., and DePinho R. A.. 2000. Cellular senescence: mitotic clock or culture shock? Cell 102:407–410.
  • Siliciano, J. D., Canman C. E., Taya Y., Sakaguchi K., Appella E., and Kastan M. B.. 1997. DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev. 11:3471–3481.
  • Wada, T., Joza N., Cheng H. Y., Sasaki T., Kozieradzki I., Bachmaier K., Katada T., Schreiber M., Wagner E. F., Nishina H., and Penninger J. M.. 2004. MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat. Cell Biol. 6:215–226.
  • Weiss, R. S., Enoch T., and Leder P.. 2000. Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress. Genes Dev. 14:1886–1898.
  • Wisdom, R., Johnson R. S., and Moore C.. 1999. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J. 18:188–197.
  • Xanthoudakis, S., and Curran T.. 1992. Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J. 11:653–665.
  • Xu, Y., Yang E. M., Brugarolas J., Jacks T., and Baltimore D.. 1998. Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm−/− mice. Mol. Cell. Biol. 18:4385–4390.

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