Negative Control of the Myc Protein by the Stress-Responsive Kinase Pak2

REFERENCES

• Alarcon-Vargas, D., Tansey W. P., and Ronai Z.. 2002. Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127-189 of c-myc. Oncogene 21:4384–4391.
   PubMedGoogle Scholar
• Alexandrow, M. G., Kawabata M., Aakre M., and Moses H. L.. 1995. Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1. Proc. Natl. Acad. Sci. USA 92:3239–3243.
   PubMedGoogle Scholar
• Alitalo, K., Ramsay G., Bishop J. M., Pfeifer S. O., Colby W. W., and Levinson A. D.. 1983. Identification of nuclear proteins encoded by viral and cellular myc oncogenes. Nature 306:274–277.
   PubMedGoogle Scholar
• Amati, B., Alevizopoulos K., and Vlach J.. 1998. Myc and the cell cycle. Front. Biosci. 3:D250–D268.
   PubMed Web of Science ®Google Scholar
• Axelson, H., Henriksson M., Wang Y., Magnusson K. P., and Klein G.. 1995. The amino-terminal phosphorylation sites of C-MYC are frequently mutated in Burkitt's lymphoma lines but not in mouse plasmacytomas and rat immunocytomas. Eur. J. Cancer 31A:2099–2104.
   PubMedGoogle Scholar
• Bahram, F., von der Lehr N., Cetinkaya C., and Larsson L. G.. 2000. c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover. Blood 95:2104–2110.
   PubMed Web of Science ®Google Scholar
• Bahram, F., Wu S., Oberg F., Luscher B., and Larsson L. G.. 1999. Posttranslational regulation of Myc function in response to phorbol ester/interferon-gamma-induced differentiation of v-Myc-transformed U-937 monoblasts. Blood 93:3900–3912.
   PubMed Web of Science ®Google Scholar
• Bechade, C., Calothy G., Pessac B., Martin P., Coll J., Denhez F., Saule S., Ghysdael J., and Stehelin D.. 1985. Induction of proliferation or transformation of neuroretina cells by the mil and myc viral oncogenes. Nature 316:559–562.
   PubMed Web of Science ®Google Scholar
• Blackwell, T. K., Kretzner L., Blackwood E. M., Eisenman R. N., and Weintraub H.. 1990. Sequence-specific DNA binding by the c-Myc protein. Science 250:1149–1151.
   PubMed Web of Science ®Google Scholar
• Blackwood, E. M., and Eisenman R. N.. 1991. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251:1211–1217.
   PubMed Web of Science ®Google Scholar
• Blackwood, E. M., Luscher B., and Eisenman R. N.. 1992. Myc and Max associate in vivo. Genes Dev. 6:71–80.
   PubMed Web of Science ®Google Scholar
• Chang, D. W., Claassen G. F., Hann S. R., and Cole M. D.. 2000. The c-Myc transactivation domain is a direct modulator of apoptotic versus proliferative signals. Mol. Cell. Biol. 20:4309–4319.
   PubMed Web of Science ®Google Scholar
• Chong, C., Tan L., Lim L., and Manser E.. 2001. The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J. Biol. Chem. 276:17347–17353.
   PubMed Web of Science ®Google Scholar
• Claassen, G. F., and Hann S. R.. 1999. Myc-mediated transformation: the repression connection. Oncogene 18:2925–2933.
   PubMedGoogle Scholar
• Clark, G. J., Cox A. D., Graham S. M., and Der C. J.. 1995. Biological assays for Ras transformation. Methods Enzymol. 255:395–412.
   PubMed Web of Science ®Google Scholar
• Dang, C. V. 1999. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol. Cell. Biol. 19:1–11.
   PubMed Web of Science ®Google Scholar
• Dang, C. V., Resar L. M., Emison E., Kim S., Li Q., Prescott J. E., Wonsey D., and Zeller K.. 1999. Function of the c-Myc oncogenic transcription factor. Exp. Cell Res. 253:63–77.
   PubMed Web of Science ®Google Scholar
• Davis, L. J., and Halazonetis T. D.. 1993. Both the helix-loop-helix and the leucine zipper motifs of c-Myc contribute to its dimerization specificity with Max. Oncogene 8:125–132.
   PubMedGoogle Scholar
• DePinho, R. A., Schreiber-Agus N., and Alt F. W.. 1991. myc family oncogenes in the development of normal and neoplastic cells. Adv. Cancer Res. 57:1–46.
   PubMed Web of Science ®Google Scholar
• Dierlamm, J., Rosenberg C., Stul M., Pittaluga S., Wlodarska I., Michaux L., Dehaen M., Verhoef G., Thomas J., de Kelver W., Bakker-Schut T., Cassiman J. J., Raap A. K., De Wolf-Peeters C., Van den Berghe H., and Hagemeijer A.. 1997. Characteristic pattern of chromosomal gains and losses in marginal zone B cell lymphoma detected by comparative genomic hybridization. Leukemia 11:747–758.
   PubMed Web of Science ®Google Scholar
• Eilers, M., Picard D., Yamamoto K. R., and Bishop J. M.. 1989. Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature 340:66–68.
   PubMedGoogle Scholar
• Evan, G. I., Lewis G. K., Ramsay G., and Bishop J. M.. 1985. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol. 5:3610–3616.
   PubMed Web of Science ®Google Scholar
• Evan, G. I., Wyllie A. H., Gilbert C. S., Littlewood T. D., Land H., Brooks M., Waters C. M., Penn L. Z., and Hancock D. C.. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119–128.
   PubMed Web of Science ®Google Scholar
• Falcone, G., Summerhayes I. C., Paterson H., Marshall C. J., and Hall A.. 1987. Partial transformation of mouse fibroblastic and epithelial cell lines with the v-myc oncogene. Exp. Cell Res. 168:273–284.
   PubMedGoogle Scholar
• Fernandez, P. C., Frank S. R., Wang L., Schroeder M., Liu S., Greene J., Cocito A., and Amati B.. 2003. Genomic targets of the human c-Myc protein. Genes Dev. 17:1115–1129.
   PubMed Web of Science ®Google Scholar
• Grandori, C., and Eisenman R. N.. 1997. Myc target genes. Trends Biochem. Sci. 22:177–181.
   PubMedGoogle Scholar
• Gregory, M. A., and Hann S. R.. 2000. c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells. Mol. Cell. Biol. 20:2423–2435.
   PubMed Web of Science ®Google Scholar
• Guo, Q. M., Malek R. L., Kim S., Chiao C., He M., Ruffy M., Sanka K., Lee N. H., Dang C. V., and Liu E. T.. 2000. Identification of c-myc responsive genes using rat cDNA microarray. Cancer Res 60:5922–5928.
   PubMed Web of Science ®Google Scholar
• Gupta, S., Seth A., and Davis R. J.. 1993. Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62. Proc. Natl. Acad. Sci. USA 90:3216–3220.
   PubMed Web of Science ®Google Scholar
• Hann, S. R., and Eisenman R. N.. 1984. Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells. Mol. Cell. Biol. 4:2486–2497.
   PubMed Web of Science ®Google Scholar
• Harder, H. C., and Rosenberg B.. 1970. Inhibitory effects of anti-tumor platinum compounds on DNA, RNA and protein syntheses in mammalian cells in vitro. Int. J. Cancer 6:207–216.
   PubMed Web of Science ®Google Scholar
• Henriksson, M., Bakardjiev A., Klein G., and Luscher B.. 1993. Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential. Oncogene 8:3199–3209.
   PubMedGoogle Scholar
• Henriksson, M., and Luscher B.. 1996. Proteins of the Myc network: essential regulators of cell growth and differentiation. Adv. Cancer Res. 68:109–182.
   PubMed Web of Science ®Google Scholar
• Hermeking, H., Funk J. O., Reichert M., Ellwart J. W., and Eick D.. 1995. Abrogation of p53-induced cell cycle arrest by c-Myc: evidence for an inhibitor of p21WAF1/CIP1/SDI1. Oncogene 11:1409–1415.
   PubMedGoogle Scholar
• Huang, Z., Ling J., and Traugh J. A.. 2003. Localization of p21-activated protein kinase gamma-PAK/Pak2 in the endoplasmic reticulum is required for induction of cytostasis. J. Biol. Chem. 278:13101–13109.
   PubMedGoogle Scholar
• Kretzner, L., Blackwood E. M., and Eisenman R. N.. 1992. Myc and Max proteins possess distinct transcriptional activities. Nature 359:426–429.
   PubMedGoogle Scholar
• Lafage-Pochitaloff, M., Courcoul M., Simonetti J., Sainty D., Dastugue N., Tabilio A., Hagemeijer A., and Birg F.. 1992. Expression of the ETS2 and transferrin receptor genes in Philadelphia-positive chronic myeloid leukemia patients with a reciprocal t(3;21). Genes Chromosomes Cancer 5:1–13.
   PubMedGoogle Scholar
• Laherty, C. D., Yang W. M., Sun J. M., Davie J. R., Seto E., and Eisenman R. N.. 1997. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Cell 89:349–356.
   PubMed Web of Science ®Google Scholar
• Li, Z., Calcar S. V., Qu C., Cavenee W. K., Zhang M. Q., and Ren B.. 2003. A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc. Natl. Acad. Sci. USA 100:8164–8169.
   PubMed Web of Science ®Google Scholar
• Luscher, B., and Eisenman R. N.. 1992. Mitosis-specific phosphorylation of the nuclear oncoproteins Myc and Myb. J. Cell Biol. 118:775–784.
   PubMedGoogle Scholar
• Luscher, B., Kuenzel E. A., Krebs E. G., and Eisenman R. N.. 1989. Myc oncoproteins are phosphorylated by casein kinase II. EMBO J. 8:1111–1119.
   PubMedGoogle Scholar
• Lutterbach, B., and Hann S. R.. 1994. Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis. Mol. Cell. Biol. 14:5510–5522.
   PubMed Web of Science ®Google Scholar
• Lutterbach, B., and Hann S. R.. 1997. Overexpression of c-Myc and cell immortalization alters c-Myc phosphorylation. Oncogene 14:967–975.
   PubMedGoogle Scholar
• Marcu, K. B., Bossone S. A., and Patel A. J.. 1992. myc function and regulation. Annu. Rev. Biochem. 61:809–860.
   PubMed Web of Science ®Google Scholar
• Miah, S. M. S., Sada K., Tuazon P. T., Ling J., Maeno K., Kyo S., Qu X., Tohyama Y., Traugh J. A., and Yamamura H.. 2004. Activation of Syk protein tyrosine kinase in response to osmotic stress requires interaction with p21-activated protein kinase Pak2/γ-PAK. Mol. Cell. Biol. 24:71–83.
   PubMedGoogle Scholar
• Nair, S. K., and Burley S. K.. 2003. X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors. Cell 112:193–205.
   PubMed Web of Science ®Google Scholar
• Nesbit, C. E., Tersak J. M., and Prochownik E. V.. 1999. MYC oncogenes and human neoplastic disease. Oncogene 18:3004–3016.
   PubMed Web of Science ®Google Scholar
• Noguchi, K., Kitanaka C., Yamana H., Kokubu A., Mochizuki T., and Kuchino Y.. 1999. Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase. J. Biol. Chem. 274:32580–32587.
   PubMed Web of Science ®Google Scholar
• O'Hagan, R. C., Schreiber-Agus N., Chen K., David G., Engelman J. A., Schwab R., Alland L., Thomson C., Ronning D. R., Sacchettini J. C., Meltzer P., and DePinho R. A.. 2000. Gene-target recognition among members of the myc superfamily and implications for oncogenesis. Nat. Genet. 24:113–119.
   PubMed Web of Science ®Google Scholar
• Perlman, E. J., Lumadue J. A., Hawkins A. L., Cohen K., Colombani P., and Griffin C. A.. 1995. Primary cutaneous neuroendocrine tumors. Diagnostic use of cytogenetic and MIC2 analysis. Cancer Genet. Cytogenet. 82:30–34.
   PubMedGoogle Scholar
• Prendergast, G. C., Lawe D., and Ziff E. B.. 1991. Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation. Cell 65:395–407.
   PubMed Web of Science ®Google Scholar
• Prendergast, G. C., and Ziff E. B.. 1991. Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region. Science 251:186–189.
   PubMed Web of Science ®Google Scholar
• Prendergast, G. C., and Ziff E. B.. 1992. A new bind for Myc. Trends Genet. 8:91–96.
   PubMedGoogle Scholar
• Pulverer, B. J., Fisher C., Vousden K., Littlewood T., Evan G., and Woodgett J. R.. 1994. Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo. Oncogene 9:59–70.
   PubMed Web of Science ®Google Scholar
• Rabbitts, P. H., Forster A., Stinson M. A., and Rabbitts T. H.. 1985. Truncation of exon 1 from the c-myc gene results in prolonged c-myc mRNA stability. EMBO J. 4:3727–3733.
   PubMed Web of Science ®Google Scholar
• Refaeli, Y., Van Parijs L., London C. A., Tschopp J., and Abbas A. K.. 1998. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 8:615–623.
   PubMed Web of Science ®Google Scholar
• Roig, J., Huang Z., Lytle C., and Traugh J. A.. 2000. p21-activated protein kinase gamma-PAK is translocated and activated in response to hyperosmolarity. Implication of Cdc42 and phosphoinositide 3-kinase in a two-step mechanism for gamma-PAK activation. J. Biol. Chem. 275:16933–16940.
   PubMedGoogle Scholar
• Roig, J., and Traugh J. A.. 2001. Cytostatic p21 G protein-activated protein kinase gamma-PAK. Vitam. Horm. 62:167–198.
   PubMedGoogle Scholar
• Roig, J., Tuazon P. T., and Traugh J. A.. 2001. Cdc42-independent activation and translocation of the cytostatic p21-activated protein kinase gamma-PAK by sphingosine. FEBS Lett. 507:195–199.
   PubMedGoogle Scholar
• Rooney, R. D., Tuazon P. T., Meek W. E., Carroll E. J., Hagen J. J., Gump E. L., Monnig C. A., Lugo T., and Traugh J. A.. 1996. Cleavage arrest of early frog embryos by the G protein-activated protein kinase PAK I. J. Biol. Chem. 271:21498–21504.
   PubMedGoogle Scholar
• Rudel, T., and Bokoch G. M.. 1997. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science 276:1571–1574.
   PubMed Web of Science ®Google Scholar
• Sakamuro, D., and Prendergast G. C.. 1999. New Myc-interacting proteins: a second Myc network emerges. Oncogene 18:2942–2954.
   PubMed Web of Science ®Google Scholar
• Sears, R., Nuckolls F., Haura E., Taya Y., Tamai K., and Nevins J. R.. 2000. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev. 14:2501–2514.
   PubMed Web of Science ®Google Scholar
• Seoane, J., Pouponnot C., Staller P., Schader M., Eilers M., and Massague J.. 2001. TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat. Cell Biol. 3:400–408.
   PubMed Web of Science ®Google Scholar
• Seth, A., Alvarez E., Gupta S., and Davis R. J.. 1991. A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression. J. Biol. Chem. 266:23521–23524.
   PubMedGoogle Scholar
• Slavutsky, I., de Vinuesa M. L., Larripa I., Dupont J., and de Salum S. B.. 1986. Translocation (2;3) in hematologic malignancies. Cancer Genet. Cytogenet. 21:335–342.
   PubMed Web of Science ®Google Scholar
• Small, M. B., Hay N., Schwab M., and Bishop J. M.. 1987. Neoplastic transformation by the human gene N-myc. Mol. Cell. Biol. 7:1638–1645.
   PubMed Web of Science ®Google Scholar
• Soucek, L., Helmer-Citterich M., Sacco A., Jucker R., Cesareni G., and Nasi S.. 1998. Design and properties of a Myc derivative that efficiently homodimerizes. Oncogene 17:2463–2472.
   PubMed Web of Science ®Google Scholar
• Spencer, C. A., and Groudine M.. 1991. Control of c-myc regulation in normal and neoplastic cells. Adv. Cancer Res 56:1–48.
   PubMed Web of Science ®Google Scholar
• Street, A. J., Blackwood E., Luscher B., and Eisenman R. N.. 1990. Mutational analysis of the carboxy-terminal casein kinase II phosphorylation site in human c-myc. Curr. Top. Microbiol. Immunol. 166:251–258.
   PubMedGoogle Scholar
• Tuazon, P. T., Spanos W. C., Gump E. L., Monnig C. A., and Traugh J. A.. 1997. Determinants for substrate phosphorylation by p21-activated protein kinase (gamma-PAK). Biochemistry 36:16059–16064.
   PubMedGoogle Scholar
• Van Parijs, L., Refaeli Y., Lord J. D., Nelson B. H., Abbas A. K., and Baltimore D.. 1999. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity 11:281–288.
   PubMed Web of Science ®Google Scholar
• Vennstrom, B., Sheiness D., Zabielski J., and Bishop J. M.. 1982. Isolation and characterization of c-myc, a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29. J. Virol. 42:773–779.
   PubMed Web of Science ®Google Scholar
• Walter, B. N., Huang Z., Jakobi R., Tuazon P. T., Alnemri E. S., Litwack G., and Traugh J. A.. 1998. Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity. J. Biol. Chem. 273:28733–28739.
   PubMed Web of Science ®Google Scholar