7
Views
18
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Id2 Is Dispensable for Myc-Induced Epidermal Neoplasia

, , &
Pages 2083-2090 | Received 17 Oct 2003, Accepted 09 Dec 2003, Published online: 27 Mar 2023

REFERENCES

  • Barone, M. V., Pepperkok R., Peverali F. A., and Philipson L.. 1994. Id proteins control growth induction in mammalian cells. Proc. Natl. Acad. Sci. USA 91:4985–4988.
  • Benezra, R. 2001. Role of Id proteins in embryonic and tumor angiogenesis. Trends Cardiovasc. Med. 11:237–241.
  • Benezra, R., Davis R. L., Lockshon D., Turner D. L., and Weintraub H.. 1990. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61:49–59.
  • Benezra, R., Rafii S., and Lyden D.. 2001. The Id proteins and angiogenesis. Oncogene 20:8334–8341.
  • Brysk, M. M., Arany I., Brysk H., Chen S. H., Calhoun K. H., and Tyring S. K.. 1995. Gene expression of markers associated with proliferation and differentiation in human keratinocytes cultured from epidermis and from buccal mucosa. Arch. Oral Biol. 40:855–862.
  • Coller, H. A., Grandori C., Tamayo P., Colbert T., Lander E. S., Eisenman R. N., and Golub T. R.. 2000. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc. Natl. Acad. Sci. USA 97:3260–3265.
  • de Bruin, A., Wu L., Saavedra H. I., Wilson P., Yang Y., Rosol T. J., Weinstein M., Robinson M. L., and Leone G.. 2003. Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc. Natl. Acad. Sci. USA 100:6546–6551.
  • Fuchs, E., and Raghavan S.. 2002. Getting under the skin of epidermal morphogenesis. Nat. Rev. Genet. 3:199–209.
  • Fukuma, M., Okita H., Hata J., and Umezawa A.. 2003. Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/Ets protein in Ewing sarcoma. Oncogene 22:1–9.
  • Guo, Q. M., Malek R. L., Kim S., Chiao C., He M., Ruffy M., Sanka K., Lee N. H., Dang C. V., and Liu E. T.. 2000. Identification of c-Myc responsive genes using rat cDNA microarray. Cancer Res. 60:5922–5928.
  • Hara, E., Yamaguchi T., Nojima H., Ide T., Campisi J., Okayama H., and Oda K.. 1994. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. J. Biol. Chem. 269:2139–2145.
  • Hollnagel, A., Oehlmann V., Heymer J., Rüther U., and Nordheim A.. 1999. Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J. Biol. Chem. 274:19838–19845.
  • Iavarone, A., Garg P., Lasorella A., Hsu J., and Israel M. A.. 1994. The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Dev. 8:1270–1284.
  • Israel, M. A., Hernandez M. C., Florio M., Andres-Barquin P. J., Mantani A., Carter J. H., and Julin C. M.. 1999. Id gene expression as a key mediator of tumor cell biology. Cancer Res. 59:1726S–1730S.
  • Jen, Y., Manova K., and Benezra R.. 1997. Each member of the Id gene family exhibits a unique expression pattern in mouse gastrulation and neurogenesis. Dev. Dyn. 208:92–106.
  • Jen, Y., Manova K., and Benezra R.. 1996. Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis. Dev. Dyn. 207:235–252.
  • Kadesch, T. 1993. Consequences of heteromeric interactions among helix-loop-helix proteins. Cell Growth Differ. 4:49–55.
  • Kurabayashi, M., Jeyaseelan R., and Kedes L.. 1994. Doxorubicin represses the function of the myogenic helix-loop-helix transcription factor MyoD. Involvement of Id gene induction. J. Biol. Chem. 269:6031–6039.
  • Langlands, K., Down G. A., and Kealey T.. 2000. Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma. Cancer Res. 60:5929–5933.
  • Langlands, K., Yin X., Anand G., and Prochownik E. V.. 1997. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J. Biol. Chem. 272:19785–19793.
  • Lasorella, A., Boldrini R., Dominici C., Donfrancesco A., Yokota Y., Inserra A., and Iavarone A.. 2002. Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma. Cancer Res. 62:301–306.
  • Lasorella, A., Iavarone A., and Israel M. A.. 1996. Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins. Mol. Cell. Biol. 16:2570–2578.
  • Lasorella, A., Noseda M., Beyna M., Yokota Y., and Iavarone A.. 2000. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. Nature 407:592–598.
  • Levens, D. 2002. Disentangling the MYC web. Proc. Natl. Acad. Sci. USA 99:5757–5759.
  • Littlewood, T. D., Hancock D. C., Danielian P. S., Parker M. G., and Even G. I.. 1995. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23:1686–1690.
  • Lyden, D., Young A. Z., Zagzag D., Yan W., Gerald W., O'Reilly R., Bader B. L., Hynes R. O., Zhuang Y., Manova K., and Benezra R.. 1999. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature 401:670–677.
  • Menssen, A., and Hermeking H.. 2002. Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes. Proc. Natl. Acad. Sci. USA 99:6274–6279.
  • Nesbit, C. E., Tersak J. M., and Prochownik E. V.. 1999. MYC oncogenes and human neoplastic disease. Oncogene 18:3004–3016.
  • Norton, J. D. 2000. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J. Cell Sci. 113(Pt. 22):3897–3905.
  • Norton, J. D., Deed R. W., Craggs G., and Sablitzky F.. 1998. Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol. 8:58–65.
  • O'Hagan, R. C., Schreiber-Agus N., Chen K., David G., Engelman J. A., Schwab R., Alland L., Thomson C., Ronning D. R., Sacchettini J. C., Meltzer P., and DePinho R. A.. 2000. Gene-target recognition among members of the Myc superfamily and implications for oncogenesis. Nat. Genet. 24:113–119.
  • Ohtani, N., Zebedee Z., Huot T. J., Stinson J. A., Sugimoto M., Ohashi Y., Sharrocks A. D., Peters G., and Hara E.. 2001. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 409:1067–1070.
  • Pagliuca, A., Gallo P., De Luca P., and Lania L.. 2000. Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth. Cancer Res. 60:1376–1382.
  • Pelengaris, S., Littlewood T., Khan M., Elia G., and Evan G.. 1999. Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol. Cell 3:565–577.
  • Prabhu, S., Ignatova A., Park S. T., and Sun X. H.. 1997. Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins. Mol. Cell. Biol. 17:5888–5896.
  • Prisco, M., Peruzzi F., Belletti B., and Baserga R.. 2001. Regulation of Id gene expression by type I insulin-like growth factor: roles of Stat3 and the tyrosine 950 residue of the receptor. Mol. Cell. Biol. 21:5447–5458.
  • Riechmann, V., Vancruchten I., and Sablitzky F.. 1994. The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3. Nucleic Acids Res. 22:749–755.
  • Roberts, E. C., Deed R. W., Inoue T., Norton J. D., and Sharrocks A. D.. 2001. Id helix-loop-helix proteins antagonize Pax transcription factor activity by inhibiting DNA binding. Mol. Cell. Biol. 21:524–533.
  • Ruzinova, M. B., and Benezra R.. 2003. Id proteins in development, cell cycle and cancer. Trends Cell Biol. 13:410–418.
  • Sato, Y., Kobayashi Y., Sasaki H., Toyama T., Kondo S., Kiriyama M., and Fujii Y.. 2003. Expression of Id2 mRNA in neuroblastoma and normal ganglion. Eur. J. Surg. Oncol. 29:284–287.
  • Schuldiner, O., and Benvenisty N.. 2001. A DNA microarray screen for genes involved in c-MYC and N-MYC oncogenesis in human tumors. Oncogene 20:4984–4994.
  • Siegel, P. M., Shu W., and Massague J.. 2003. Mad upregulation and Id2 repression accompany TGF-β-mediated epithelial cell growth suppression. J. Biol. Chem. 278:35444–35450.
  • Sikder, H. A., Devlin M. K., Dunlap S., Ryu B., and Alani R. M.. 2003. Id proteins in cell growth and tumorigenesis. Cancer Cell 3:525–530.
  • Vandesompele, J., Edsjo A., De Preter K., Axelson H., Speleman F., and Pahlman S.. 2003. ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value. Oncogene 22:456–460.
  • Wang, Q., Hii G., Shusterman S., Mosse Y., Winter C. L., Guo C., Zhao H., Rappaport E., Hogarty M. D., and Maris J. M.. 2003. ID2 expression is not associated with MYCN amplification or expression in human neuroblastomas. Cancer Res. 63:1631–1635.
  • Wu, L., de Bruin A., Saavedra H. I., Starovic M., Trimboli A., Yang Y., Opavska J., Wilson P., Thompson J. C., Ostrowski M. C., Rosol T. J., Woollett L. A., Weinstein M., Cross J. C., Robinson M. L., and Leone G.. 2003. Extra-embryonic function of Rb is essential for embryonic development and viability. Nature 421:942–947.
  • Yates, P. R., Atherton G. T., Deed R. W., Norton J. D., and Sharrocks A. D.. 1999. Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. EMBO J. 18:968–976.
  • Zebedee, Z., and Hara E.. 2001. Id proteins in cell cycle control and cellular senescence. Oncogene 20:8317–8325.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.