Molecular and Cellular Biology, Volume 24, Issue 5 (2004)

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Molecular and Cellular Biology, Volume 24, Issue 5 (2004)

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Cell Growth and Development

Article
ATM and the Catalytic Subunit of DNA-Dependent Protein Kinase Activate NF-κB through a Common MEK/Extracellular Signal-Regulated Kinase/p90rsk Signaling Pathway in Response to Distinct Forms of DNA Damage
Ganesh R. Panta, Swayamjot Kaur, Lakita G. Cavin, Maria L. Cortés, Frank Mercurio, Leonard Lothstein, Trevor W. Sweatman, Mervyn Israel & Marcello Arsura
Pages: 1823-1835
Published online: 27 Mar 2023
AbstractforATM and the Catalytic Subunit of DNA-Dependent Protein Kinase Activate NF-κB through a Common MEK/Extracellular Signal-Regulated Kinase/p90rsk Signaling Pathway in Response to Distinct Forms of DNA Damage | Full Text | References | PDF (540.1 KB)
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Article
Cyclic AMP-Dependent Protein Kinase Regulates the Subcellular Localization of Snf1-Sip1 Protein Kinase
Kristina Hedbacker, Robert Townley & Marian Carlson
Pages: 1836-1843
Published online: 27 Mar 2023
AbstractforCyclic AMP-Dependent Protein Kinase Regulates the Subcellular Localization of Snf1-Sip1 Protein Kinase | Full Text | References | PDF (285.3 KB)
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Article
The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H2O2 and Plays an Integral Role in Insulin Signal Transduction
Kalyankar Mahadev, Hiroyuki Motoshima, Xiangdong Wu, Jean Marie Ruddy, Rebecca S. Arnold, Guangjie Cheng, J. David Lambeth & Barry J. Goldstein
Pages: 1844-1854
Published online: 27 Mar 2023
AbstractforThe NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H2O2 and Plays an Integral Role in Insulin Signal Transduction | Full Text | References | PDF (480.8 KB)
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Article
Differential and Common Leukemogenic Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1
Nicolas Pineault, Carolina Abramovich, Hideaki Ohta & R. Keith Humphries
Pages: 1907-1917
Published online: 27 Mar 2023
AbstractforDifferential and Common Leukemogenic Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1 | Full Text | References | PDF (605 KB)
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Article
Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation
Yu-Hua Tseng, Kristina M. Kriauciunas, Efi Kokkotou & C. Ronald Kahn
Pages: 1918-1929
Published online: 27 Mar 2023
AbstractforDifferential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation | Full Text | References | PDF (742.8 KB)
  • 106 Views
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Article
Persistent Signaling by Dysregulated Thrombin Receptor Trafficking Promotes Breast Carcinoma Cell Invasion
Michelle A. Booden, Lynn B. Eckert, Channing J. Der & JoAnn Trejo
Pages: 1990-1999
Published online: 27 Mar 2023
AbstractforPersistent Signaling by Dysregulated Thrombin Receptor Trafficking Promotes Breast Carcinoma Cell Invasion | Full Text | References | PDF (751.5 KB)
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Article
Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled
Feng Cong, Liang Schweizer & Harold Varmus
Pages: 2000-2011
Published online: 27 Mar 2023
AbstractforCasein Kinase Iε Modulates the Signaling Specificities of Dishevelled | Full Text | References | PDF (489.6 KB)
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Article
Biochemical Characterization of the Drosophila Wingless Signaling Pathway Based on RNA Interference
Hiroko Matsubayashi, Sonoka Sese, Jong-Seo Lee, Tadaoki Shirakawa, Takeshi Iwatsubo, Taisuke Tomita & Shin-ichi Yanagawa
Pages: 2012-2024
Published online: 27 Mar 2023
AbstractforBiochemical Characterization of the Drosophila Wingless Signaling Pathway Based on RNA Interference | Full Text | References | PDF (592.1 KB)
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Article
Defects in Translational Regulation Mediated by the α Subunit of Eukaryotic Initiation Factor 2 Inhibit Antiviral Activity and Facilitate the Malignant Transformation of Human Fibroblasts
Darren J. Perkins & Glen N. Barber
Pages: 2025-2040
Published online: 27 Mar 2023
AbstractforDefects in Translational Regulation Mediated by the α Subunit of Eukaryotic Initiation Factor 2 Inhibit Antiviral Activity and Facilitate the Malignant Transformation of Human Fibroblasts | Full Text | References | PDF (1.1 MB)
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Article
A Microdomain Formed by the Extracellular Ends of the Transmembrane Domains Promotes Activation of the G Protein-Coupled α-Factor Receptor
Jennifer C. Lin, Ken Duell & James B. Konopka
Pages: 2041-2051
Published online: 27 Mar 2023
AbstractforA Microdomain Formed by the Extracellular Ends of the Transmembrane Domains Promotes Activation of the G Protein-Coupled α-Factor Receptor | Full Text | References | PDF (493.8 KB)
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Article
Id2 Is Dispensable for Myc-Induced Epidermal Neoplasia
Daniel J. Murphy, Lamorna Brown Swigart, Mark A. Israel & Gerard I. Evan
Pages: 2083-2090
Published online: 27 Mar 2023
AbstractforId2 Is Dispensable for Myc-Induced Epidermal Neoplasia | Full Text | References | PDF (1 MB)
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Article
Immortalization of Human Mammary Epithelial Cells Is Associated with Inactivation of the p14ARF-p53 Pathway
Vladimir A. Shamanin & Elliot J. Androphy
Pages: 2144-2152
Published online: 27 Mar 2023
AbstractforImmortalization of Human Mammary Epithelial Cells Is Associated with Inactivation of the p14ARF-p53 Pathway | Full Text | References | PDF (317.1 KB)
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Article
A Transforming Growth Factor β-Induced Smad3/Smad4 Complex Directly Activates Protein Kinase A
Lizhi Zhang, Chao Jun Duan, Charles Binkley, Gangyong Li, Michael D. Uhler, Craig D. Logsdon & Diane M. Simeone
Pages: 2169-2180
Published online: 27 Mar 2023
AbstractforA Transforming Growth Factor β-Induced Smad3/Smad4 Complex Directly Activates Protein Kinase A | Full Text | References | PDF (553.5 KB)
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Article
Control of Cyclin G2 mRNA Expression by Forkhead Transcription Factors: Novel Mechanism for Cell Cycle Control by Phosphoinositide 3-Kinase and Forkhead
Lorena Martínez-Gac, Miriam Marqués, Zaira García, Miguel R. Campanero & Ana C. Carrera
Pages: 2181-2189
Published online: 27 Mar 2023
AbstractforControl of Cyclin G2 mRNA Expression by Forkhead Transcription Factors: Novel Mechanism for Cell Cycle Control by Phosphoinositide 3-Kinase and Forkhead | Full Text | References | PDF (338 KB)
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Article
Site-Selective Regulation of Platelet-Derived Growth Factor β Receptor Tyrosine Phosphorylation by T-Cell Protein Tyrosine Phosphatase
Camilla Persson, Catrine Sävenhed, Annie Bourdeau, Michel L. Tremblay, Boyka Markova, Frank D. Böhmer, Fawaz G. Haj, Benjamin G. Neel, Ari Elson, Carl-Henrik Heldin, Lars Rönnstrand, Arne Östman & Carina Hellberg
Pages: 2190-2201
Published online: 27 Mar 2023
AbstractforSite-Selective Regulation of Platelet-Derived Growth Factor β Receptor Tyrosine Phosphorylation by T-Cell Protein Tyrosine Phosphatase | Full Text | References | PDF (474.7 KB)
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Gene Expression

Article
An Intronic Enhancer Regulates Splicing of the Twintron of Drosophila melanogaster prospero Pre-mRNA by Two Different Spliceosomes
Petra Scamborova, Anthony Wong & Joan A. Steitz
Pages: 1855-1869
Published online: 27 Mar 2023
AbstractforAn Intronic Enhancer Regulates Splicing of the Twintron of Drosophila melanogaster prospero Pre-mRNA by Two Different Spliceosomes | Full Text | References | PDF (998.9 KB)
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Article
Human Checkpoint Protein hRad9 Functions as a Negative Coregulator To Repress Androgen Receptor Transactivation in Prostate Cancer Cells
Liang Wang, Cheng-Lung Hsu, Jing Ni, Peng-Hui Wang, Shuyuan Yeh, Peter Keng & Chawnshang Chang
Pages: 2202-2213
Published online: 27 Mar 2023
AbstractforHuman Checkpoint Protein hRad9 Functions as a Negative Coregulator To Repress Androgen Receptor Transactivation in Prostate Cancer Cells | Full Text | References | PDF (509.7 KB)
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Transcriptional Regulation

Article
The scl +18/19 Stem Cell Enhancer Is Not Required for Hematopoiesis: Identification of a 5′ Bifunctional Hematopoietic-Endothelial Enhancer Bound by Fli-1 and Elf-1
Berthold Göttgens, Cyril Broccardo, Maria-Jose Sanchez, Sophie Deveaux, George Murphy, Joachim R. Göthert, Ekaterini Kotsopoulou, Sarah Kinston, Liz Delaney, Sandie Piltz, Linda M. Barton, Kathy Knezevic, Wendy N. Erber, C. Glenn Begley, Jonathan Frampton & Anthony R. Green
Pages: 1870-1883
Published online: 27 Mar 2023
AbstractforThe scl +18/19 Stem Cell Enhancer Is Not Required for Hematopoiesis: Identification of a 5′ Bifunctional Hematopoietic-Endothelial Enhancer Bound by Fli-1 and Elf-1 | Full Text | References | PDF (927.4 KB)
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Article
Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans
Yannick Doyon, William Selleck, William S. Lane, Song Tan & Jacques Côté
Pages: 1884-1896
Published online: 27 Mar 2023
AbstractforStructural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans | Full Text | References | PDF (742.9 KB)
  • 318 Views
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Article
Architectural Arrangement of Cloned Proximal Sequence Element-Binding Protein Subunits on Drosophila U1 and U6 snRNA Gene Promoters
Cheng Li, Gale A. Harding, Jason Parise, Kathleen J. McNamara-Schroeder & William E. Stumph
Pages: 1897-1906
Published online: 27 Mar 2023
AbstractforArchitectural Arrangement of Cloned Proximal Sequence Element-Binding Protein Subunits on Drosophila U1 and U6 snRNA Gene Promoters | Full Text | References | PDF (723.3 KB)
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Article
DNA Methylation May Restrict but Does Not Determine Differential Gene Expression at the Sgy/Tead2 Locus during Mouse Development
Kotaro J. Kaneko, Theo Rein, Zong-Sheng Guo, Keith Latham & Melvin L. DePamphilis
Pages: 1968-1982
Published online: 27 Mar 2023
AbstractforDNA Methylation May Restrict but Does Not Determine Differential Gene Expression at the Sgy/Tead2 Locus during Mouse Development | Full Text | References | PDF (985.8 KB)
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Article
Accelerated Response of the myogenin Gene to Denervation in Mutant Mice Lacking Phosphorylation of Myogenin at Threonine 87
Chris S. Blagden, Larry Fromm & Steven J. Burden
Pages: 1983-1989
Published online: 27 Mar 2023
AbstractforAccelerated Response of the myogenin Gene to Denervation in Mutant Mice Lacking Phosphorylation of Myogenin at Threonine 87 | Full Text | References | PDF (536.1 KB)
  • 8 Views
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Article
General Transcriptional Coactivator PC4 Activates p53 Function
Sourav Banerjee, B. R. Prashanth Kumar & Tapas K. Kundu
Pages: 2052-2062
Published online: 27 Mar 2023
AbstractforGeneral Transcriptional Coactivator PC4 Activates p53 Function | Full Text | References | PDF (817.3 KB)
  • 22 Views
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Article
Developmentally Essential Protein Flightless I Is a Nuclear Receptor Coactivator with Actin Binding Activity
Young-Ho Lee, Hugh D. Campbell & Michael R. Stallcup
Pages: 2103-2117
Published online: 27 Mar 2023
AbstractforDevelopmentally Essential Protein Flightless I Is a Nuclear Receptor Coactivator with Actin Binding Activity | Full Text | References | PDF (411.1 KB)
  • 28 Views
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Article
Quantitative Proteomic Identification of Six4 as the Trex-Binding Factor in the Muscle Creatine Kinase Enhancer
Charis L. Himeda, Jeffrey A. Ranish, John C. Angello, Pascal Maire, Ruedi Aebersold & Stephen D. Hauschka
Pages: 2132-2143
Published online: 27 Mar 2023
AbstractforQuantitative Proteomic Identification of Six4 as the Trex-Binding Factor in the Muscle Creatine Kinase Enhancer | Full Text | References | PDF (461.4 KB)
  • 40 Views
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Article
Direct Interaction between Nucleosome Assembly Protein 1 and the Papillomavirus E2 Proteins Involved in Activation of Transcription
Manuela Rehtanz, Hanns-Martin Schmidt, Ursula Warthorst & Gertrud Steger
Pages: 2153-2168
Published online: 27 Mar 2023
AbstractforDirect Interaction between Nucleosome Assembly Protein 1 and the Papillomavirus E2 Proteins Involved in Activation of Transcription | Full Text | References | PDF (760.1 KB)
  • 8 Views
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Dna Dynamics and Chromosome Structure

Article
Replication Protein A (RPA) Phosphorylation Prevents RPA Association with Replication Centers
Vitaly M. Vassin, Marc S. Wold & James A. Borowiec
Pages: 1930-1943
Published online: 27 Mar 2023
AbstractforReplication Protein A (RPA) Phosphorylation Prevents RPA Association with Replication Centers | Full Text | References | PDF (1.2 MB)
  • 97 Views
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Article
Functional Subdomain in the Ankyrin Domain of Tankyrase 1 Required for Poly(ADP-Ribosyl)ation of TRF1 and Telomere Elongation
Hiroyuki Seimiya, Yukiko Muramatsu, Susan Smith & Takashi Tsuruo
Pages: 1944-1955
Published online: 27 Mar 2023
AbstractforFunctional Subdomain in the Ankyrin Domain of Tankyrase 1 Required for Poly(ADP-Ribosyl)ation of TRF1 and Telomere Elongation | Full Text | References | PDF (864.1 KB)
  • 47 Views
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Article
Barrier Proteins Remodel and Modify Chromatin To Restrict Silenced Domains
Masaya Oki, Lourdes Valenzuela, Tomoko Chiba, Takashi Ito & Rohinton T. Kamakaka
Pages: 1956-1967
Published online: 27 Mar 2023
AbstractforBarrier Proteins Remodel and Modify Chromatin To Restrict Silenced Domains | Full Text | References | PDF (783.5 KB) | Supplemental
  • 34 Views
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Article
Cell Cycle Localization, Dimerization, and Binding Domain Architecture of the Telomere Protein cPot1
Chao Wei & Carolyn M. Price
Pages: 2091-2102
Published online: 27 Mar 2023
AbstractforCell Cycle Localization, Dimerization, and Binding Domain Architecture of the Telomere Protein cPot1 | Full Text | References | PDF (622.6 KB)
  • 8 Views
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Article
Formation of Boundaries of Transcriptionally Silent Chromatin by Nucleosome-Excluding Structures
Xin Bi, Qun Yu, Joseph J. Sandmeier & Yanfei Zou
Pages: 2118-2131
Published online: 27 Mar 2023
AbstractforFormation of Boundaries of Transcriptionally Silent Chromatin by Nucleosome-Excluding Structures | Full Text | References | PDF (1.1 MB)
  • 80 Views
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Mammalian Genetic Models With Minimal Or Complex Phenotypes

Article
Null Mutation of the Lmo4 Gene or a Combined Null Mutation of the Lmo1/Lmo3 Genes Causes Perinatal Lethality, and Lmo4 Controls Neural Tube Development in Mice
E. Tse, A. J. H. Smith, S. Hunt, I. Lavenir, A. Forster, A. J. Warren, G. Grutz, L. Foroni, M. B. L. Carlton, W. H. Colledge, T. Boehm & T. H. Rabbitts
Pages: 2063-2073
Published online: 27 Mar 2023
AbstractforNull Mutation of the Lmo4 Gene or a Combined Null Mutation of the Lmo1/Lmo3 Genes Causes Perinatal Lethality, and Lmo4 Controls Neural Tube Development in Mice | Full Text | References | PDF (895.9 KB)
  • 51 Views
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Article
Defective Neural Tube Closure and Anteroposterior Patterning in Mice Lacking the LIM Protein LMO4 or Its Interacting Partner Deaf-1
Kyungmin Hahm, Eleanor Y. M. Sum, Yuko Fujiwara, Geoffrey J. Lindeman, Jane E. Visvader & Stuart H. Orkin
Pages: 2074-2082
Published online: 27 Mar 2023
AbstractforDefective Neural Tube Closure and Anteroposterior Patterning in Mice Lacking the LIM Protein LMO4 or Its Interacting Partner Deaf-1 | Full Text | References | PDF (869.3 KB)
  • 35 Views
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