32
Views
184
CrossRef citations to date
0
Altmetric
Cell Growth and Development

N-Terminal Fragment of c-FLIP(L) Processed by Caspase 8 Specifically Interacts with TRAF2 and Induces Activation of the NF-κB Signaling Pathway

&
Pages 2627-2636 | Received 22 Oct 2003, Accepted 05 Jan 2004, Published online: 27 Mar 2023

REFERENCES

  • Alam, A., Cohen L. Y., Aouad S., and Sékaly R. P.. 1999. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. J. Exp. Med. 190:1879–1890.
  • Alderson, M. R., Armitage R. J., Maraskovsky E., Tough T. W., Roux E., Schooley K., Ramsdell F., and Lynch D. H.. 1993. Fas transduces activation signals in normal human T lymphocytes. J. Exp. Med. 178:2231–2235.
  • Boatright, K. M., Renatus M., Scott F. L., Sperandio S., Shin H., Pedersen I. M., Ricci J. E., Edris W. A., Sutherlin D. P., Green D. R., and Salvesen G. S.. 2003. A unified model for apical caspase activation. Mol. Cell 11:529–541.
  • Budd, R. C. 2002. Death receptors couple to both cell proliferation and apoptosis. J. Clin. Investig. 109:437–441.
  • Chang, D. W., Xing Z., Pan Y., Algeciras-Schimnich A., Barnhart B. C., Yaish-Ohad S., Peter M. E., and Yang X.. 2002. c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. EMBO J. 21:3704–3714.
  • Chaudhary, P. M., Eby M. T., Jasmin A., Kumar A., Liu L., and Hood L.. 2000. Activation of the NF-κB pathway by caspase 8 and its homologs. Oncogene 19:4451–4460.
  • Chun, H. J., Zheng L., Ahmad M., Wang J., Speirs C. K., Siegel R. M., Dale J. K., Puck J., Davis J., Hall C. G., Skoda-Smith S., Atkinson T. P., Straus S. E., and Lenardo M. J.. 2002. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 419:395–399.
  • Cryns, V., and Yuan J.. 1998. Proteases to die for. Genes Dev. 12:1551–1570.
  • Devin, A., Cook A., Lin Y., Rodriguez Y., Kelliher M., and Liu Z. G.. 2000. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity 12:419–429.
  • Donepudi, M., Sweeney A. M., Briand C., and Grütter M. G.. 2003. Insights into the regulatory mechanism for caspase-8 activation. Mol. Cell 11:543–549.
  • Gaide, O., Favier B., Legler D. F., Bonnet D., Brissoni B., Valitutti S., Bron C., Tschopp J., and Thome M.. 2002. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-κB activation. Nat. Immunol. 3:836–843.
  • Ghosh, S., and Karin M.. 2002. Missing pieces in the NF-κB puzzle. Cell 109:S81–S96.
  • Hara, H., Wada T., Bakal C., Kozieradzki I., Suzuki S., Suzuki N., Nghiem M., Griffiths E. K., Krawczyk C., Bauer B., D'Acquisto F., Ghosh S., Yeh W. C., Baier G., Rottapel R., and Penninger J. M.. 2003. The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity 18:763–775.
  • Hu, W. H., Johnson H., and Shu H. B.. 2000. Activation of NF-κB by FADD, Casper, and caspase-8. J. Biol. Chem. 275:10838–10844.
  • Hua, Z. C., Sohn S. J., Kang C., Cado D., and Winoto A.. 2003. A function of Fas-associated death domain protein in cell cycle progression localized to a single amino acid at its C-terminal region. Immunity 18:513–521.
  • Irmler, M., Thome M., Hahne M., Schneider P., Hofmann K., Steiner V., Bodmer J. L., Schröter M., Burns K., Mattmann C., Rimoldi D., French L. E., and Tschopp J.. 1997. Inhibition of death receptor signals by cellular FLIP. Nature 388:190–195.
  • Irmler, M., Steiner V., Ruegg C., Wajant H., and Tschopp J.. 2000. Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis. FEBS Lett. 468:129–133.
  • Jun, J. E., Wilson L. E., Vinuesa C. G., Lesage S., Blery M., Miosge L. A., Cook M. C., Kucharska E. M., Hara H., Penninger J. M., Domashenz H., Hong N. A., Glynne R. J., Nelms K. A., and Goodnow C. C.. 2003. Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity 18:751–762.
  • Kataoka, T., Budd R. C., Holler N., Thome M., Martinon F., Irmler M., Burns K., Hahne M., Kennedy N., Kovacsovics K., and Tschopp J.. 2000. The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways. Curr. Biol. 10:640–648.
  • Kelliher, M. A., Grimm S., Ishida Y., Kuo F., Stanger B. Z., and Leder P.. 1998. The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity 8:297–303.
  • Kennedy, N. J., Kataoka T., Tschopp J., and Budd R. C.. 1999. Caspase activation is required for T cell proliferation. J. Exp. Med. 190:1891–1895.
  • Kim, J. W., Choi E. J., and Joe C. O.. 2000. Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP. Oncogene 19:4491–4499.
  • Krammer, P. H. 2000. CD95's deadly mission in the immune system. Nature 407:789–795.
  • Krueger, A., Baumann S., Krammer P. H., and Kirchhoff S.. 2001. FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis. Mol. Cell. Biol. 21:8247–8254.
  • Krueger, A., Schmitz I., Baumann S., Krammer P. H., and Kirchhoff S.. 2001. Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J. Biol. Chem. 276:20633–20640.
  • Lee, S. Y., Reichlin A., Santana A., Sokol K. A., Nussenzweig M. C., and Choi Y.. 1997. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival. Immunity 7:703–713.
  • Lens, S. M. A., Kataoka T., Fortner K. A., Tinel A., Ferrero I., MacDonald R. H., Hahne M., Beermann F., Attinger A., Orbea H. A., Budd R. C., and Tschopp J.. 2002. The caspase 8 inhibitor c-FLIPL modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes. Mol. Cell. Biol. 22:5419–5433.
  • Leo, E., Deveraux Q. L., Buchholtz C., Welsh K., Matsuzawa S., Stennicke H. R., Salvesen G. S., and Reed J. C.. 2001. TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-α-induced apoptosis. J. Biol. Chem. 276:8087–8093.
  • Lin, Y., Devin A., Rodriguez Y., and Liu Z. G.. 1999. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev. 13:2514–2526.
  • Locksley, R. M., Killeen N., and Lenardo M. J.. 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104:487–501.
  • Martinon, F., Holler N., Richard C., and Tschopp J.. 2000. Activation of a pro-apoptotic amplification loop through inhibition of NF-κB-dependent survival signals by caspase-mediated inactivation of RIP. FEBS Lett. 468:134–136.
  • Micheau, O., Thome M., Schneider P., Holler N., Tschopp J., Nicholson D. W., Briand C., and Grütter M. G.. 2002. The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J. Biol. Chem. 277:45162–45171.
  • Nagata, S. 1997. Apoptosis by death factor. Cell 88:355–365.
  • Newton, K., Harris A. W., Bath M. L., Smith K. G. C., and Strasser A.. 1998. A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J. 17:706–718.
  • Newton, K., Kurts C., Harris A. W., and Strasser A.. 2001. Effects of a dominant interfering mutant of FADD on signal transduction in activated T cells. Curr. Biol. 11:273–276.
  • Nicholson, D. W. 1999. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ. 6:1028–1042.
  • Salmena, L., Lemmers B., Hakem A., Matysiak-Zablocki E., Murakami K., Au P. Y. B., Berry D. M., Tamblyn L., Shehabeldin A., Migon E., Wakeham A., Bouchard D., Yeh W. C., McGlade J. C., Ohashi P. S., and Hakem R.. 2003. Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev. 17:883–895.
  • Scaffidi, C., Schmitz I., Krammer P. H., and Peter M. E.. 1999. The role of c-FLIP in modulation of CD95-induced apoptosis. J. Biol. Chem. 274:1541–1548.
  • Schneider, P., Holler N., Bodmer J. L., Hahne M., Frei K., Fontana A., and Tschopp J.. 1998. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J. Exp. Med. 187:1205–1213.
  • Shu, H. B., Halpin D. R., and Goeddel D. V.. 1997. Casper is a FADD- and caspase-related inducer of apoptosis. Immunity 6:751–763.
  • Tada, K., Okazaki T., Sakon S., Kobarai T., Kurosawa K., Yamaoka S., Hashimoto H., Mak T. W., Yagita H., Okumura K., Yeh W. C., and Nakano H.. 2001. Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-κB activation and protection from cell death. J. Biol. Chem. 276:36530–36534.
  • Thome, M., Martinon F., Hofmann K., Rubio V., Steiner V., Schneider P., Mattmann C., and Tschopp J.. 1999. Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-κB transcription factor and c-Jun N-terminal kinase. J. Biol. Chem. 274:9962–9968.
  • Thome, M., and Tschopp J.. 2001. Regulation of lymphocyte proliferation and death by FLIP. Nat. Rev. Immunol. 1:50–58.
  • Tibbetts, M. D., Zheng L., and Lenardo M. J.. 2003. The death effector domain protein family: regulators of cellular homeostasis. Nat. Immunol. 4:404–409.
  • Tschopp, J., Irmler M., and Thome M.. 1998. Inhibition of Fas death signals by FLIPs. Curr. Opin. Immunol. 10:552–558.
  • Tsitsikov, E. N., Laouini D., Dunn I. F., Sannikova T. Y., Davidson L., Alt F. W., and Geha R. S.. 2001. TRAF1 is a negative regulator of TNF signaling: enhanced TNF signaling in TRAF1-deficient mice. Immunity 15:647–657.
  • Walsh, C. M., Wen B. G., Chinnaiyan A. M., O'Rourke K., Dixit V. M., and Hedrick S. M.. 1998. A role for FADD in T cell activation and development. Immunity 8:439–449.
  • Yeh, W. C., Shahinian A., Speiser D., Kraunus J., Billia F., Wakeham A., de la Pompa J. L., Ferrick D., Hum B., Iscove N., Ohashi P., Rothe M., Goeddel D. V., and Mak T. W.. 1997. Early lethality, functional NF-κB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity 7:715–725.
  • Zhang, J., Cado D., Chen A., Kabra N. H., and Winoto A.. 1998. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 392:296–300.
  • Zörnig, M., Hueber A. O., and Evan G.. 1998. p53-dependent impairment of T cell proliferation in FADD dominant-negative transgenic mice. Curr. Biol. 8:467–470.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.