32
Views
65
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Basic Helix-Loop-Helix Proteins Bind to TrkB and p21Cip1 Promoters Linking Differentiation and Cell Cycle Arrest in Neuroblastoma Cells

, , , &
Pages 2662-2672 | Received 19 Nov 2003, Accepted 11 Jan 2004, Published online: 27 Mar 2023

REFERENCES

  • Billon, N., Carlisi D., Datto M. B., van Grunsven L. A., Watt A., Wang X. F., and Rudkin B. B.. 1999. Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. Oncogene 18:2872–2882.
  • Brodeur, G. M., Nakagawara A., Yamashiro D. J., Ikegaki N., Liu X. G., Azar C. G., Lee C. P., and Evans A. E.. 1997. Expression of TrkA, TrkB, and TrkC in human neuroblastomas. J. Neurooncol. 31:49–55.
  • Brodeur, G. M., Pritchard J., Berthold F., Carlsen N. L., Castel V., Castelberry R. P., De Bernardi B., Evans A. E., Favrot M., and Hedborg F.. 1993. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J. Clin. Oncol. 11:1466–1477.
  • Encinas, M., Iglesias M., Llecha N., and Comella J. X.. 1999. Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y. J. Neurochem. 73:1409–1421.
  • Encinas, M., Iglesias M., Liu Y., Wang H., Muhaisen A., Cena V., Gallego C., and Comella J. X.. 2000. Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J. Neurochem. 75:991–1003.
  • Feng, X., Jiang H., Baik J. C., Edgar C., and Eide F. F.. 2001. BDNF dependence in neuroblastoma. J. Neurosci Res. 64:355–363.
  • Ferguson, K. L., and Slack R. S.. 2001. The Rb pathway in neurogenesis. Neuroreport 12:A55–A62.
  • Fernandez, P. C., Frank S. R., Wang L., Schroeder M., Liu S., Greene J., Cocito A., and Amati B.. 2003. Genomic targets of the human c-Myc protein. Genes Dev. 17:1115–1129.
  • Funato, N., Ohtani K., Ohyama K., Kuroda T., and Nakamura M.. 2001. Common regulation of growth arrest and differentiation of osteoblasts by helix-loop-helix factors. Mol. Cell. Biol. 21:7416–7428.
  • Gallego, C., Gari E., Colomina N., Herrero E., and Aldea M.. 1997. The Cln3 cyclin is downregulated by translational repression and degradation during the G1 arrest caused by nitrogen deprivation in budding yeast. EMBO J. 16:7196–7206.
  • Gartel, A. L., and Tyner A. L.. 1999. Transcriptional regulation of the p21WAF1/CIP1 gene. Exp. Cell Res. 246:280–289.
  • Halevy, O., Novitch B. G., Spicer D. B., Skapek S. X., Rhee J., Hannon G. J., Beach D., and Lassar A. B.. 1995. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21. Science 267:1018–1021.
  • Iavarone, A., Garg P., Lasorella A., Hsu J., and Israel M. A.. 1994. The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Dev. 8:270–284.
  • Jaboin, J., Kim C. J., Kaplan D. R., and Thiele C. J.. 2002. Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3′-kinase pathway. Cancer Res. 62:6756–6763.
  • Kaplan, D. R., Matsumoto K., Lucarelli E., and Thiele C. J.. 1993. Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells. Neuron 11:321–331.
  • Kawasaki, H., Eckner R., Yao T. P., Taira K., Chiu R., Livingston D. M., and Yokoyama K. K.. 1998. Distinct roles of the coactivators p300 and CBP in retinoic-acid-induced F9-cell differentiation. Nature 393:284–289.
  • Kim, W. Y., Fritzsch B., Serls A., Bakel L. A., Huang E. J., Reichardt L. F., Barth D. S., and Lee J. E.. 2001. NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development 128:417–426.
  • Klein, R., Conway D., Parada L. F., and Barbacid M.. 1990. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell 61:647–656.
  • Lasorella, A., Iavarone A., and Israel M. A.. 1996. Id2 specifically alters regulation of the cell cycle by tumor suppressor. Mol. Cell. Biol. 16:2570–2578.
  • Lasorella, A., Noseda M., Beyna M., Yokota Y., and Iavarone A.. 2000. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. Nature 407:592–598.
  • Lee, E. Y., Hu N., Yuan S. S., Cox L. A., Bradley A., Lee W. H., and Herrup K.. 1994. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 8:2008–2021.
  • Lipinski, M. M., and Jacks T.. 1999. The retinoblastoma gene family in differentiation and development. Oncogene 18:7873–7882.
  • Liu, M., Iavarone A., and Freedman L. P.. 1996. Transcriptional activation of the human p21WAF1/CIP1 gene by retinoic acid receptor: correlation with retinoid induction of U937 cell differentiation. J. Biol. Chem. 271:31723–31728.
  • Lopez-Carballo, G., Moreno L., Masia S., Perez P., and Barettino D.. 2002. Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells. J. Biol. Chem. 277:25297–25304.
  • Lucarelli, E., Kaplan D., and Thiele C. J.. 1997. Activation of trk-A but not trk-B signal transduction pathway inhibits growth of neuroblastoma cells. Eur. J. Cancer 33:2068–2070.
  • Lucarelli, E., Kaplan D. R., and Thiele C. J.. 1995. Selective regulation of TrkA and TrkB receptors by retinoic acid and interferon-gamma in human neuroblastoma cell lines. J. Biol. Chem. 270:24725–24731.
  • Lyden, D., Young A. Z., Zagzag D., Yan W., Gerald W., O'Reilly R., Bader B. L., Hynes R. O., Zhuang Y., Manova K., and Benezra R.. 1999. Id1 and Id3 are required for neurogenesis, angiogenesis, and vascularization of tumour xenografts. Nature 401:670–677.
  • Massari, M. E., and Murre C.. 2000. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol. Cell. Biol. 20:429–440.
  • Matsumoto, K., Wada R. K., Yamashiro J. M., Kaplan D. R., and Thiele C. J.. 1995. Expression of brain-derived neurotrophic factor and p145TrkB affects survival, differentiation, and invasiveness of human neuroblastoma cells. Cancer Res. 55:1798–1806.
  • Matsuo, T., and Thiele C. J.. 1998. p27Kip1: a key mediator of retinoic acid induced growth arrest in the SMS-KCNR human neuroblastoma cell line. Oncogene 16:3337–3343.
  • Matsushime, H., Quelle D. E., Shurtleff S. A., Shibuya M., Sherr C. J., and Kato J. Y.. 1994. D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14:2066–2076.
  • Middlemas, D. S., Kihl B. K., Zhou J., and Zhu X.. 1999. Brain-derived neurotrophic factor promotes survival and chemoprotection of human neuroblastoma cells. J. Biol. Chem. 274:16451–16460.
  • Mori, S., Nishikawa S. I., and Yokota Y.. 2000. Lactation defect in mice lacking the helix-loop-helix inhibitor Id2. EMBO J. 19:5772–5781.
  • Mutoh, H., Naya F. J., Tsai M. J., and Leiter A. B.. 1998. The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 12:820–830.
  • Nakagawara, A., Arima-Nakagawara M., Scavarda N. J., Azar C. G., Cantor A. B., and Brodeur G. M.. 1993. Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma. N. Engl. J. Med. 328:847–854.
  • Naya, F. J., Stellrecht C. M., and Tsai M. J.. 1995. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev. 9:1009–1019.
  • Norton, J. D. 2000. ID helix-loop-helix proteins in cell growth, differentiation, and tumorigenesis. J. Cell Sci. 113:3897–3905.
  • Pahlman, S., Hoehner J. C., Nanberg E., Hedborg F., Fagerstrom S., Gestblom C., Johansson I., Larsson U., Lavenius E., and Ortoft E.. 1995. Differentiation and survival influences of growth factors in human neuroblastoma. Eur. J. Cancer 31A:453–458.
  • Parker, M. G. 1991. Nuclear hormone receptors: molecular mechanisms, cellular functions, and clinical abnormalities. Academic Press, Ltd., London, United Kingdom.
  • Parker, S. B., Eichele G., Zhang P., Rawls A., Sands A. T., Bradley A., Olson E. N., Harper J. W., and Elledge S. J.. 1995. p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science 267:1024–1027.
  • Pombo, P. M., Barettino D., Espliguero G., Metsis M., Iglesias T., and Rodriguez-Pena A.. 2000. Transcriptional repression of neurotrophin receptor trkB by thyroid hormone in the developing rat brain. J. Biol. Chem. 275:37510–37517.
  • Prabhu, S., Ignatova A., Park S. T., and Sun X. H.. 1997. Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins. Mol. Cell. Biol. 17:5888–5896.
  • Rohwedel, J., Guan K., and Wobus A. M.. 1999. Induction of cellular differentiation by retinoic acid in vitro. Cells Tissues Organs 65:90–202.
  • Shen, C. P., and Kadesch T.. 1995. B-cell-specific DNA binding by an E47 homodimer. Mol. Cell. Biol. 15:4518–4524.
  • Strohmaier, C., Carter B. D., Urfer R., Barde Y. A., and Dechant G.. 1996. A splice variant of the neurotrophin receptor TrkB with increased specificity for brain-derived neurotrophic factor. EMBO J. 15:3332–3337.
  • Takahashi, J., Palmer T. D., and Gage F. H.. 1999. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J. Neurobiol. 38:65–81.
  • Thiele, C. J., Gore S., Collins S., Waxman S., and Miller W.. 2000. Differentiate or die: the view from Montreal. Cell Death Differ. 7:1014–1017.
  • Toma, J. G., El-Bizri H., Barnabe-Heider F., Aloyz R., and Miller F. D.. 2000. Evidence that helix-loop-helix proteins collaborate with retinoblastoma tumor suppressor protein to regulate cortical. J. Neurosci. 20:7648–7656.
  • Tremblay, M., Herblot S., Lecuyer E., and Hoang T.. 2003. Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL. J. Biol. Chem. 278:12680–12687.
  • Vandesompele, J., Edsjo A., De Preter K., Axelson H., Speleman F., and Pahlman S.. 2003. ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value. Oncogene 22:456–460.
  • Wainwright, L. J., Lasorella A., and Iavarone A.. 2001. Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells. Proc. Natl. Acad. Sci. USA 98:9396–9400.
  • Wang, Q., Hii G., Shusterman S., Mosse Y., Winter C. L., Guo C., Zhao H., Rappaport E., Hogarty M. D., and Maris J. M.. 2003. ID2 expression is not associated with MYCN amplification or expression in human neuroblastomas. Cancer Res. 63:1631–1635.
  • Wang, S., Sdrulla A., Johnson J. E., Yokota Y., and Barres B. A.. 2001. A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development. Neuron 29:603–614.
  • Weintraub, H., Genetta T., and Kadesch T.. 1994. Tissue-specific gene activation by MyoD: determination of specificity by cis-acting repression elements. Genes Dev. 15:2203–2211.
  • Zhang, P., Wong C., Liu D., Finegold M., Harper J. W., and Elledge S. J.. 1999. p21CIP1 and p57KIP2 control muscle differentiation at the myogenin step. Genes Dev. 13:213–224.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.