26
Views
31
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Meox Homeodomain Proteins Are Required for Bapx1 Expression in the Sclerotome and Activate Its Transcription by Direct Binding to Its Promoter

, , &
Pages 2757-2766 | Received 10 Sep 2003, Accepted 12 Dec 2003, Published online: 27 Mar 2023

REFERENCES

  • Akazawa, H., Komuro I., Sugitani Y., Yazaki Y., Nagai R., and Noda T.. 2000. Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation. Genes Cells 5:499–513.
  • Cai, R. L. 1998. Human CART1, a paired-class homeodomain protein, activates transcription through palindromic binding sites. Biochem. Biophys. Res. Commun. 250:305–311.
  • Candia, A. F., Hu J., Crosby J., Lalley P. A., Noden D., Nadeau J. H., and Wright C. V.. 1992. Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development 116:1123–1136.
  • Candia, A. F., and Wright C. V.. 1996. Differential localization of Mox-1 and Mox-2 proteins indicates distinct roles during development. Int. J. Dev. Biol. 40:1179–1184.
  • Chiang, C., Litingtung Y., Lee E., Young K. E., Corden J. L., Westphal H., and Beachy P. A.. 1996. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383:407–413.
  • Deutsch, U., Dressler G. R., and Gruss P.. 1988. Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development. Cell 53:617–625.
  • Fan, C. M., and Tessier-Lavigne M.. 1994. Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell 79:1175–1186.
  • Gehring, W. J., Affolter M., and Burglin T.. 1994. Homeodomain proteins. Annu. Rev. Biochem. 63:487–526.
  • Herbrand, H., Pabst O., Hill R., and Arnold H. H.. 2002. Transcription factors Nkx3.1 and Nkx3.2 (Bapx1) play an overlapping role in sclerotomal development of the mouse. Mech. Dev. 117:217–224.
  • Johnson, R. L., Laufer E., Riddle R. D., and Tabin C.. 1994. Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites. Cell 79:1165–1173.
  • Lettice, L. A., Purdie L. A., Carlson G. J., Kilanowski F., Dorin J., and Hill R. E.. 1999. The mouse bagpipe gene controls development of axial skeleton, skull, and spleen. Proc. Natl. Acad. Sci. USA 96:9695–9700.
  • Lettice, L., Hecksher-Sorensen J., and Hill R.. 2001. The role of Bapx1 (Nkx3.2) in the development and evolution of the axial skeleton. J. Anat. 199:181–187.
  • Mankoo, B. S., Collins N. S., Ashby P., Grigorieva E., Pevny L. H., Candia A., Wright C. V., Rigby P. W., and Pachnis V.. 1999. Mox2 is a component of the genetic hierarchy controlling limb muscle development. Nature 400:69–73.
  • Mankoo, B. S., Skuntz S., Harrigan I., Grigorieva E., Candia A., Wright C. V., Arnheiter H., and Pachnis V.. 2003. The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites. Development 130:4655–4664.
  • Martínez-Morales, J. R., Dolez V., Rodrigo I., Zaccarini R., Leconte L., Bovolenta P., and Saule S.. 2003. OTX2 activates the molecular network underlying retina pigment epithelium differentiation. J. Biol. Chem. 278:21721–21731.
  • Murtaugh, L. C., Zeng L., Chyung J. H., and Lassar A. B.. 2001. The chick transcriptional repressor Nkx3.2 acts downstream of Shh to promote BMP-dependent axial chondrogenesis. Dev. Cell 1:411–422.
  • Neubüser, A., Koseki H., and Balling R.. 1995. Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1. Dev. Biol. 170:701–716.
  • Peters, H., Neubüser A., Kratochwil K., and Balling R.. 1998. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev. 12:2735–2747.
  • Peters, H., Wilm B., Sakai N., Imai K., Maas R., and Balling R.. 1999. Pax1 and Pax9 synergistically regulate vertebral column development. Development 126:5399–5408.
  • Planque, N., Leconte L., Coquelle F. M., Martin P., and Saule S.. 2001. Specific Pax-6/microphthalmia transcription factor interactions involve their DNA-binding domains and inhibit transcriptional properties of both proteins. J. Biol. Chem. 276:29330–29337.
  • Rodrigo, I., Hill R. E., Balling R., Munsterberg A., and Imai K.. 2003. Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome. Development 130:473–482.
  • Stamataki, D., Kastrinaki M., Mankoo B. S., Pachnis V., and Karagogeos D.. 2001. Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors. FEBS Lett. 499:274–278.
  • Takeda, K., Yokoyama S., Yasumoto K., Saito H., Udono T., Takahashi K., and Shibahara S.. 2003. OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium. Biochem. Biophys. Res. Commun. 300:908–914.
  • Timmons, P. M., Wallin J., Rigby P. W., and Balling R.. 1994. Expression and function of Pax 1 during development of the pectoral girdle. Development 120:2773–2785.
  • Tribioli, C., Frasch M., and Lufkin T.. 1997. Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton. Mech. Dev. 65:145–162.
  • Tribioli, C., and Lufkin T.. 1999. The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Development 126:5699–5711.
  • Wilm, B., Dahl E., Peters H., Balling R., and Imai K.. 1998. Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency. Proc. Natl. Acad. Sci. USA 95:8692–8697.
  • Zeng, L., Kempf H., Murtaugh L. C., Sato M. E., and Lassar A. B.. 2002. Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev. 16:1990–2005.
  • Zhao, G. Q., Eberspaecher H., Seldin M. F., and de Crombrugghe B.. 1994. The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development. Mech. Dev. 48:245–254.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.