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Cell Growth and Development

Overexpression of Inducible Cyclic AMP Early Repressor Inhibits Transactivation of Genes and Cell Proliferation in Pancreatic β Cells

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Pages 2831-2841 | Received 29 Sep 2003, Accepted 05 Jan 2004, Published online: 27 Mar 2023

REFERENCES

  • Ahn, S., Olive M., Aggarwal S., Krylov D., Ginty D. D., and Vinson C.. 1998. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol. Cell. Biol. 18:967–977.
  • Andrecht, S., Kolbus A., Hartenstein B., Angel P., and Schorpp-Kistner M.. 2002. Cell cycle promoting activity of JunB through cyclin A activation. J. Biol. Chem. 277:35961–35968.
  • Bleckmann, S. C., Blendy J. A., Rudolph D., Monaghan A. P., Schmid W., and Schutz G.. 2002. Activating transcription factor 1 and CREB are important for cell survival during early mouse development. Mol. Cell. Biol. 22:1919–1925.
  • Boam, D. S., Clark A. R., and Docherty K.. 1990. Positive and negative regulation of the human insulin gene by multiple trans-acting factors. J. Biol. Chem. 265:8285–8296.
  • Bodor, J., Spetz A. L., Strominger J. L., and Habener J. F.. 1996. cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes. Proc. Natl. Acad. Sci. USA 93:3536–3541.
  • Daniel, P. B., Walker W. H., and Habener J. F.. 1998. Cyclic AMP signaling and gene regulation. Annu. Rev. Nutr. 18:353–383.
  • De Cesare, D., and Sassone-Corsi P.. 2000. Transcriptional regulation by cyclic AMP-responsive factors. Prog. Nucleic Acids Res. Mol. Biol. 64:343–369.
  • Della Fazia, M. A., Servillo G., and Sassone-Corsi P.. 1997. Cyclic AMP signaling and cellular proliferation: regulation of CREB and CREM. FEBS Lett. 410:22–24.
  • Desdouets, C., Matestic G., Molina C. A., Foulkes N. S., Sassone-Corsi P., Brechot C., and Sobczak-Thepot J.. 1995. Cell cycle regulation of cyclin A gene expression by the cyclic AMP-responsive transcription factors CREB and CREM. Mol. Cell. Biol. 15:3301–3309.
  • Docherty, K. 1992. R. D. Lawrence Lecture. The regulation of insulin gene expression. Diabet. Med. 9:792–798.
  • Docherty, K., and Clark A. R.. 1994. Nutrient regulation of insulin gene expression. FASEB J. 8:20–27.
  • Edlund, T., Walker M. D., Barr P. J., and Rutter W. J.. 1985. Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5′ flanking elements. Science 230:912–916.
  • Fimia, G. M., and Sassone-Corsi P.. 2001. Cyclic AMP signalling. Cell Sci. 114:1971–1972.
  • Foulkes, N. S., Borrelli E., and Sassone-Corsi P.. 1991. CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64:739–749.
  • Foulkes, N. S., Borjigin J., Snyder S. H., and Sassone-Corsi P.. 1996. Transcriptional control of circadian hormone synthesis via the CREM feedback loop. Proc. Natl. Acad. Sci. USA 93:14140–14145.
  • German, M., Ashcroft S., Docherty K., Edlund H., Edlund T., Goodison S., Imura H., Kennedy G., Madsen O., and Melloul D.. 1995. The insulin gene promoter. A simplified nomenclature. Diabetes 44:1002–1004.
  • Gonzalez, G. A., and Montminy M. R.. 1989. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59:675–680.
  • Gonzalez, G. A., Yamamoto K., Fischer W. H., Karr K., Manzel P., Biggs III W., Vale W. W., and Montminy M. R.. 1989. A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. Nature 337:749–752.
  • Goodison, S., Kenna S., and Ashcroft S. J.. 1992. Control of insulin gene expression by glucose. Biochem. J. 285:563–568.
  • Hai, T., and Curran T.. 1991. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. USA 88:3720–3724.
  • Hai, T. W., Horikoshi M., Roeder R. G., and Green M. R.. 1988. Analysis of the role of the transcription factor ATF in the assembly of a functional preinitiation complex. Cell 54:1043–1051.
  • Hai, T. W., Liu F., Coukos W. J., and Green M. R.. 1989. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 3:2083–2090.
  • Hamamoto, Y., Tsuura Y., Fujimoto S., Nagata M., Takeda T., Mukai E., Fujita J., Yamada Y., and Seino Y.. 2000. Recovery of function and mass of endogenous beta cells in streptozotocin-induced diabetic rats treated with islet transplantation. Biochem. Biophys. Res. Commun. 287:104–109.
  • Hellerstrom, C., Swenne I., and Andersson A.. 1988. An islet cell replication and diabetes, p. 141–170. In Lefebvre P. J. and Pipeleers D. G. (ed.), The pathology of the endocrine pancreas in diabetes. Springer-Verlag, Heidelberg, Germany.
  • Hotta, M., Tashiro F., Ikegami H., Niwa H., Ogihara T., Yodoi J., and Miyazaki J.. 1998. Pancreatic β cell-specific expression of thioredoxin, antioxidative and antiapoptotic protein prevents autoimmune and streptozotocin-induced diabetes. Exp. Med. 188:1445–1451.
  • Hummler, E., Cole T. J., Blendy J. A., Ganss R., Aguzzi A., Schmid W., Beermann F., and Schutz G.. 1994. Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc. Natl. Acad. Sci. USA 91:5647–5651.
  • Hussain, M. A., Daniel P. B., and Habener J. F.. 2000. Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic β-cells. Diabetes 49:1681–1690.
  • Inada, A., Yamada Y., Someya Y., Kubota A., Yasuda K., Ihara Y., Kagimoto S., Kuroe A., Tsuda K., and Seino Y.. 1998. Transcriptional repressors are increased in pancreatic islets of type 2 diabetic rats. Biochem. Biophys. Res. Commun. 253:712–718.
  • Inada, A., Someya Y., Yamada Y., Ihara Y., Kubota A., Ban N., Watanabe R., Tsuda K., and Seino Y.. 1999. The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID. J. Biol. Chem. 274:21095–21103.
  • Inagaki, N., Maekawa T., Sudo T., Ishii S., Seino Y., and Imura H.. 1992. c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements. Proc. Natl. Acad. Sci. USA 89:1045–1049.
  • Ishii, S., Maekawa T., Sudo T., Sakurai A., Yasuda I., and Kishimoto A.. 1990. Structure and function of the protein CRE-BP1: heterogeneity of the protein that binds to the cAMP-responsive element. Adv. Second Messenger Phosphoprot. Res. 24:335–339.
  • Jhala, U. S., Canettieri G., Screaton R. A., Kulkarni R. N., Krojewski S., Reed J., Walker J., Lin X., White M., and Montminy M. R.. 2003. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev. 17:1575–1580.
  • Jonas, J. C., Sharma A., Hasenkamp W., Ilkova H., Patanè G., Laybutt R., Bonner-Weir S., and Weir G. C.. 1999. Chronic hyperglycemia triggers loss of pancreatic β cell differentiation in an animal model of diabetes. J. Biol. Chem. 274:14112–14121.
  • Knepel, W., Chafitz J., and Habener J. F.. 1990. Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells. Mol. Cell. Biol. 10:6799–6804.
  • Krueger, D. A., Mao D., Warner E. A., and Dowd D. R.. 1999. Functional analysis of the mouse ICER (inducible cAMP early repressor) promoter: evidence for a protein that blocks calcium responsiveness of the CAREs (cAMP autoregulatory elements). Mol. Endocrinol. 13:1207–1217.
  • Laybutt, D. R., Glandt M., Xu G., Ahn Y. B., Trivedi N., Bonner-Weir S., and Weir G. C.. 2003. Critical reduction in β-cell mass results in two distinct outcomes over time. J. Biol. Chem. 278:2997–3005.
  • Laybutt, D. R., Sharma A., Sgroi D. C., Gaudet J., Bonner-Weir S., and Weir G. C.. 2002. Genetic regulation of metabolic pathways in β-cells disrupted by hyperglycemia. J. Biol. Chem. 277:10912–10921.
  • Maekawa, T., Sakura H., Kanei-Ishii C., Sudo C., Yoshimura T., Fujisawa J., Yoshida M., and Ishii S.. 1989. Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. EMBO J. 8:2023–2028.
  • Mao, D., Warner E. A., Gurwitch S. A., and Dowd D. R.. 1998. Differential regulation and transcriptional control of immediate early gene expression in forskolin-treated WEHI7. 2 thymoma cells. Mol. Endocrinol. 12:492–503.
  • Melloul, D., Marshak S., and Cerasi E.. 2002. Regulation of insulin gene transcription. Diabetologia 45:309–326.
  • Molina, C. A., Foulkes N. S., Lalli E., and Sassone-Corsi P.. 1993. Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Cell 75:875–886.
  • Nielson, D. A., Welsh M., Casadaban M. J., and Steiner D. F.. 1985. Control of insulin gene expression in pancreatic beta cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNA. J. Biol. Chem. 260:13585–13589.
  • Oetjen, E., Diedrich T., Eggers A., Eckert B., and Knepel W.. 1994. Distinct properties of the cAMP-responsive element of the rat insulin I gene. J. Biol. Chem. 269:27036–27044.
  • Philippe, J., and Missotten M.. 1990. Functional characterization of a cAMP-responsive element of the rat insulin I gene. J. Biol. Chem. 265:1465–1469.
  • Philippe, J., Giordano E., Gjinovci A., and Meda P.. 1992. Cyclic adenosine monophosphate prevents the glucocorticoid-mediated inhibition of insulin gene expression in rodent islet cells. J. Clin. Investig. 90:2228–2233.
  • Philippe, J., Pacheco I., and Meda P.. 1994. Insulin gene transcription is decreased rapidly by lowering glucose concentrations in rat islet cells. Diabetes 43:523–528.
  • Powers, A. C., Tedeschi F., Wright K. E., Chan J. S., and Habener J. F.. 1989. Somatostatin gene expression in pancreatic islet cells is directed by cell-specific DNA control elements and DNA-binding proteins. J. Biol. Chem. 264:10048–10056.
  • Riabowol, K., Draetta G., Brizuela L., Vandre D., and Beach D.. 1989. The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell 57:393–401.
  • Rosenberg, A., Zindy F., Deist F. L., Mouly H., Metezeau P., Brechot C., and Lamas E.. 1995. Overexpression of human cyclin A advances entry into S phase. Oncogene 10:1501–1509.
  • Ryseck, R. P., and Bravo R.. 1991. c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins. Oncogene 4:533–542.
  • Sander, M., and German M. S.. 1997. The beta cell transcription factors and development of the pancreas. J. Mol. Med. 75:327–340.
  • Servillo, G., Della Fazia M. A., and Sassone-Corsi P.. 1998. Transcription factor CREM coordinates the timing of hepatocyte proliferation in the regenerating liver. Genes Dev. 12:3639–3643.
  • Shimizu, M., Nomura Y., Suzuki H., Ichikawa E., Takeuchi A., Suzuki M., Nakamura M., Nakajima T., and Oda K.. 1998. Activation of the rat cyclin A promoter by ATF2 and Jun family members and its suppression by ATF4. Exp. Cell Res. 239:93–103.
  • Walker, M. D., Edlund T., Boulet A. M., and Rutter W. J.. 1983. Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes. Nature 306:557–561.
  • Welsh, M., Nielsen D. A., MacKrell A. J., and Steiner D. F.. 1985. Control of insulin gene expression in pancreatic beta cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability. J. Biol. Chem. 260:13590–13594.
  • Yam, C. H., Fung T. K., and Poon R. Y. C.. 2000. Cyclin A in cell cycle control and cancer. Cell. Mol. Life Sci. 59:1317–1326.

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