12
Views
73
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Growth Factor-Mediated Induction of HDM2 Positively Regulates Hypoxia-Inducible Factor 1α Expression

, &
Pages 2905-2914 | Received 12 Sep 2003, Accepted 06 Jan 2004, Published online: 27 Mar 2023

REFERENCES

  • Alvarez-Tejado, M., Alfranca A., Aragones J., Vara A., Landazuri M. O., and del Peso L.. 2002. Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J. Biol. Chem. 277:13508–13517.
  • Arany, Z., Huang L. E., Eckner R., Bhattacharya S., Jiang C., Goldberg M. A., Bunn H. F., and Livingston D. M.. 1996. An essential role for p300/CBP in the cellular response to hypoxia. Proc. Natl. Acad. Sci. USA 93:12969–12973.
  • Arsham, A. M., Plas D. R., Thompson C. B., and Simon M. C.. 2002. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J. Biol. Chem. 277:15162–15170.
  • Ashcroft, M., Ludwig R. L., Woods D. B., Copeland T. D., Weber H. O., MacRae E. J., and Vousden K. H.. 2002. Phosphorylation of HDM2 by Akt. Oncogene 21:1955–1962.
  • Ashcroft, M., Taya Y., and Vousden K. H.. 2000. Stress signals utilize multiple pathways to stabilize p53. Mol. Cell. Biol. 20:3224–3233.
  • Blagosklonny, M. V., An W. G., Romanova L. Y., Trepel J., Fojo T., and Neckers L.. 1998. p53 inhibits hypoxia-inducible factor-stimulated transcription. J. Biol. Chem. 273:11995–11998.
  • Blancher, C., Moore J. W., Robertson N., and Harris A. L.. 2001. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway. Cancer Res. 61:7349–7355.
  • Bunz, F., Hwang P. M., Torrance C., Waldman T., Zhang Y., Dillehay L., Williams J., Lengauer C., Kinzler K. W., and Vogelstein B.. 1999. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J. Clin. Investig. 104:263–269.
  • Chan, D. A., Sutphin P. D., Denko N. C., and Giaccia A. J.. 2002. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J. Biol. Chem. 277:40112–40117.
  • Cockman, M. E., Masson N., Mole D. R., Jaakkola P., Chang G. W., Clifford S. C., Maher E. R., Pugh C. W., Ratcliffe P. J., and Maxwell P. H.. 2000. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 275:25733–25741.
  • Dubs-Poterszman, M. C., Tocque B., and Wasylyk B.. 1995. MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest. Oncogene 11:2445–2449.
  • Franke, T. F., Yang S. I., Chan T. O., Datta K., Kazlauskas A., Morrison D. K., Kaplan D. R., and Tsichlis P. N.. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727–736.
  • Fukuda, R., Hirota K., Fan F., Jung Y. D., Ellis L. M., and Semenza G. L.. 2002. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J. Biol. Chem. 277:38205–38211.
  • Gross, T. S., Akeno N., Clemens T. L., Komarova S., Srinivasan S., Weimer D. A., and Mayorov S.. 2001. Selected contribution: osteocytes upregulate HIF-1alpha in response to acute disuse and oxygen deprivation. J. Appl. Physiol. 90:2514–2519.
  • Harris, A. L. 2002. Hypoxia—a key regulatory factor in tumour growth. Nat. Rev. Cancer 2:38–47.
  • Hudson, C. C., Liu M., Chiang G. G., Otterness D. M., Loomis D. C., Kaper F., Giaccia A. J., and Abraham R. T.. 2002. Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin. Mol. Cell. Biol. 22:7004–7014.
  • Ivan, M., Kondo K., Yang H., Kim W., Valiando J., Ohh M., Salic A., Asara J. M., Lane W. S., and Kaelin W. G., Jr. 2001. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292:464–468.
  • Jaakkola, P., Mole D. R., Tian Y. M., Wilson M. I., Gielbert J., Gaskell S. J., Kriegsheim A., Hebestreit H. F., Mukherji M., Schofield C. J., Maxwell P. H., Pugh C. W., and Ratcliffe P. J.. 2001. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292:468–472.
  • Jeong, J. W., Bae M. K., Ahn M. Y., Kim S. H., Sohn T. K., Bae M. H., Yoo M. A., Song E. J., Lee K. J., and Kim K. W.. 2002. Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell 111:709–720.
  • Jiang, B. H., Zheng J. Z., Leung S. W., Roe R., and Semenza G. L.. 1997. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. J. Biol. Chem. 272:19253–19260.
  • Laughner, E., Taghavi P., Chiles K., Mahon P. C., and Semenza G. L.. 2001. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol. Cell. Biol. 21:3995–4004.
  • Lohrum, M. A., Ashcroft M., Kubbutat M. H., and Vousden K. H.. 2000. Identification of a cryptic nucleolar-localization signal in MDM2. Nat. Cell Biol. 2:179–181.
  • Marechal, V., Elenbaas B., Piette J., Nicolas J. C., and Levine A. J.. 1994. The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes. Mol. Cell. Biol. 14:7414–7420.
  • Maxwell, P. H., Wiesener M. S., Chang G. W., Clifford S. C., Vaux E. C., Cockman M. E., Wykoff C. C., Pugh C. W., Maher E. R., and Ratcliffe P. J.. 1999. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271–275.
  • Mayo, L. D., Dixon J. E., Durden D. L., Tonks N. K., and Donner D. B.. 2002. PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J. Biol. Chem. 277:5484–5489.
  • Mayo, L. D., and Donner D. B.. 2001. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl. Acad. Sci. USA 98:11598–11603.
  • Mottet, D., Dumont V., Deccache Y., Demazy C., Ninane N., Raes M., and Michiels C.. 2003. Regulation of HIF-1alpha protein level during hypoxic conditions by the PI3K/AKT/GSK3beta pathway in HepG2 cells. J. Biol. Chem. 33:31277–31286.
  • Pennacchietti, S., Michieli P., Galluzzo M., Mazzone M., Giordano S., and Comoglio P. M.. 2003. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 3:347–361.
  • Phillips, A. C., Ernst M. K., Bates S., Rice N. R., and Vousden K. H.. 1999. E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways. Mol. Cell 4:771–781.
  • Polsky, D., Melzer K., Hazan C., Panageas K. S., Busam K., Drobnjak M., Kamino H., Spira J. G., Kopf A. W., Houghton A., Cordon-Cardo C., and Osman I.. 2002. HDM2 protein overexpression and prognosis in primary malignant melanoma. J. Natl. Cancer Inst. 94:1803–1806.
  • Ravi, R., Mookerjee B., Bhujwalla Z. M., Sutter C. H., Artemov D., Zeng Q., Dillehay L. E., Madan A., Semenza G. L., and Bedi A.. 2000. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 14:34–44.
  • Ries, S., Biederer C., Woods D., Shifman O., Shirasawa S., Sasazuki T., McMahon M., Oren M., and McCormick F.. 2000. Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell 103:321–330.
  • Seger, Y. R., Garcia-Cao M., Piccinin S., Cunsolo C. L., Doglioni C., Blasco M. A., Hannon G. J., and Maestro R.. 2002. Transformation of normal human cells in the absence of telomerase activation. Cancer Cell 2:401–413.
  • Semenza, G. L. 2002. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol. Med. 8:S62–S67.
  • Treins, C., Giorgetti-Peraldi S., Murdaca J., Semenza G. L., and Van Obberghen E.. 2002. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J. Biol. Chem. 277:27975–27981.
  • Vousden, K. H. 2002. Activation of the p53 tumor suppressor protein. Biochim. Biophys. Acta 1602:47–59.
  • Yu, F., White S. B., Zhao Q., and Lee F. S.. 2001. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl. Acad. Sci. USA 98:9630–9635.
  • Zhou, B. P., Liao Y., Xia W., Zou Y., Spohn B., and Hung M. C.. 2001. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat. Cell Biol. 3:973–982.
  • Zundel, W., Schindler C., Haas-Kogan D., Koong A., Kaper F., Chen E., Gottschalk A. R., Ryan H. E., Johnson R. S., Jefferson A. B., Stokoe D., and Giaccia A. J.. 2000. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 14:391–396.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.