A Human Sodium-Dependent Vitamin C Transporter 2 Isoform Acts as a Dominant-Negative Inhibitor of Ascorbic Acid Transport

REFERENCES

• Agus, D. B., Vera J. C., and Golde D. W.. 1999. Stromal cell oxidation: a mechanism by which tumors obtain vitamin C. Cancer Res. 59:4555–4558.
   PubMed Web of Science ®Google Scholar
• Carcamo, J. M., Pedraza A., Borquez-Ojeda O., and Golde D. W.. 2002. Vitamin C suppresses TNF alpha-induced NF kappa B activation by inhibiting I kappa B alpha phosphorylation. Biochemistry 41:12995–13002.
   PubMed Web of Science ®Google Scholar
• Daruwala, R., Song J., Koh W. S., Rumsey S. C., and Levine M.. 1999. Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. FEBS Lett. 460:480–484.
   PubMed Web of Science ®Google Scholar
• Doege, H., Bocianski A., Scheepers A., Axer H., Eckel J., Joost H. G., and Schurmann A.. 2001. Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. Biochem. J. 359:443–449.
   PubMed Web of Science ®Google Scholar
• Gamba, G. 2001. Alternative splicing and diversity of renal transporters. Am. J. Physiol Renal Physiol. 281:F781–F794.
   PubMedGoogle Scholar
• Kodaman, P. H., and Behrman H. R.. 1999. Hormone-regulated and glucose-sensitive transport of dehydroascorbic acid in immature rat granulosa cells. Endocrinology 140:3659–3665.
   PubMed Web of Science ®Google Scholar
• Kyte, J., and Doolittle R. F.. 1982. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:105–132.
   PubMed Web of Science ®Google Scholar
• Laggner, H., Besau V., and Goldenberg H.. 1999. Preferential uptake and accumulation of oxidized vitamin C by THP-1 monocytic cells. Eur. J. Biochem. 262:659–665.
   PubMedGoogle Scholar
• Levine, M., Rumsey S. C., Daruwala R., Park J. B., and Wang Y.. 1999. Criteria and recommendations for vitamin C intake. JAMA 281:1415–1423.
   PubMed Web of Science ®Google Scholar
• Liang, W. J., Johnson D., and Jarvis S. M.. 2001. Vitamin C transport systems of mammalian cells. Mol. Membr. Biol. 18:87–95.
   PubMed Web of Science ®Google Scholar
• Liang, W. J., Johnson D., Ma L. S., Jarvis S. M., and Wei-Jun L.. 2002. Regulation of the human vitamin C transporters expressed in COS-1 cells by protein kinase C. Am. J. Physiol Cell Physiol. 283:C1696–C1704.
   PubMedGoogle Scholar
• Lutsenko, E. A., Carcamo J. M., and Golde D. W.. 2002. Vitamin C prevents DNA mutation induced by oxidative stress. J. Biol. Chem. 277:16895–16899.
   PubMed Web of Science ®Google Scholar
• Nishikimi, M., Fukuyama R., Minoshima S., Shimizu N., and Yagi K.. 1994. Cloning and chromosomal mapping of the human nonfunctional gene for l-gulono-gamma-lactone oxidase, the enzyme for l-ascorbic acid biosynthesis missing in man. J. Biol. Chem. 269:13685–13688.
   PubMed Web of Science ®Google Scholar
• Nualart, F. J., Rivas C. I., Montecinos V. P., Godoy A. S., Guaiquil V. H., Golde D. W., and Vera J. C.. 2003. Recycling of vitamin C by a bystander effect. J. Biol. Chem. 278:10128–10133.
   PubMed Web of Science ®Google Scholar
• Pear, W. S., Nolan G. P., Scott M. L., and Baltimore D.. 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90:8392–8396.
   PubMed Web of Science ®Google Scholar
• Perez-Cruz, I., Carcamo J. M., and Golde D. W.. 2003. Vitamin C inhibits FAS-induced apoptosis in monocytes and U937 cells. Blood 102:336–343.
   PubMed Web of Science ®Google Scholar
• Qutob, S., Dixon S. J., and Wilson J. X.. 1998. Insulin stimulates vitamin C recycling and ascorbate accumulation in osteoblastic cells. Endocrinology 139:51–56.
   PubMed Web of Science ®Google Scholar
• Rajan, D. P., Huang W., Dutta B., Devoe L. D., Leibach F. H., Ganapathy V., and Prasad P. D.. 1999. Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. Biochem. Biophys. Res. Commun. 262:762–768.
   PubMed Web of Science ®Google Scholar
• Rumsey, S. C., Daruwala R., Al-Hasani H., Zarnowski M. J., Simpson I. A., and Levine M.. 2000. Dehydroascorbic acid transport by GLUT4 in Xenopus oocytes and isolated rat adipocytes. J. Biol. Chem. 275:28246–28253.
   PubMedGoogle Scholar
• Sotiriou, S., Gispert S., Cheng J., Wang Y., Chen A., Hoogstraten-Miller S., Miller G. F., Kwon O., Levine M., Guttentag S. H., and Nussbaum R. L.. 2002. Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat. Med. 8:514–517.
   PubMed Web of Science ®Google Scholar
• Spielholz, C., Golde D. W., Houghton A. N., Nualart F., and Vera J. C.. 1997. Increased facilitated transport of dehydroascorbic acid without changes in sodium-dependent ascorbate transport in human melanoma cells. Cancer Res. 57:2529–2537.
   PubMed Web of Science ®Google Scholar
• Tatsumi, S., Miyamoto K., Kouda T., Motonaga K., Katai K., Ohkido I., Morita K., Segawa H., Tani Y., Yamamoto H., Taketani Y., and Takeda E.. 1998. Identification of three isoforms for the Na+-dependent phosphate cotransporter (NaPi-2) in rat kidney. J. Biol. Chem. 273:28568–28575.
   PubMedGoogle Scholar
• Tsukaguchi, H., Tokui T., Mackenzie B., Berger U. V., Chen X. Z., Wang Y., Brubaker R. F., and Hediger M. A.. 1999. A family of mammalian Na+-dependent l-ascorbic acid transporters. Nature 399:70–75.
   PubMed Web of Science ®Google Scholar
• Vera, J. C., Rivas C. I., Fischbarg J., and Golde D. W.. 1993. Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid. Nature 364:79–82.
   PubMed Web of Science ®Google Scholar
• Vera, J. C., Rivas C. I., Velasquez F. V., Zhang R. H., Concha I. I., and Golde D. W.. 1995. Resolution of the facilitated transport of dehydroascorbic acid from its intracellular accumulation as ascorbic acid. J. Biol. Chem. 270:23706–23712.
   PubMedGoogle Scholar
• Vera, J. C., Rivas C. I., Zhang R. H., Farber C. M., and Golde D. W.. 1994. Human HL-60 myeloid leukemia cells transport dehydroascorbic acid via the glucose transporters and accumulate reduced ascorbic acid. Blood 84:1628–1634.
   PubMed Web of Science ®Google Scholar
• Vera, J. C., Rivas C. I., Zhang R. H., and Golde D. W.. 1998. Colony-stimulating factors signal for increased transport of vitamin C in human host defense cells. Blood 91:2536–2546.
   PubMedGoogle Scholar
• Wang, H., Dutta B., Huang W., Devoe L. D., Leibach F. H., Ganapathy V., and Prasad P. D.. 1999. Human Na+-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant. Biochim. Biophys. Acta 1461:1–9.
   PubMed Web of Science ®Google Scholar
• Wang, Y., Mackenzie B., Tsukaguchi H., Weremowicz S., Morton C. C., and Hediger M. A.. 2000. Human vitamin C (l-ascorbic acid) transporter SVCT1. Biochem. Biophys. Res. Commun. 267:488–494.
   PubMedGoogle Scholar
• Wu, X., Li W., Sharma V., Godzik A., and Freeze H. H.. 2002. Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. Mol. Genet. Metab. 76:37–45.
   PubMed Web of Science ®Google Scholar