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DNA Dynamics and Chromosome Structure

Functional Organization of Repeat Addition Processivity and DNA Synthesis Determinants in the Human Telomerase Multimer

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Pages 3720-3733 | Received 22 Sep 2003, Accepted 04 Feb 2004, Published online: 27 Mar 2023

REFERENCES

  • Antal, M., Boros E., Solymosy F., and Kiss T.. 2002. Analysis of the structure of human telomerase RNA in vivo. Nucleic Acids Res. 30:912–920.
  • Arai, K., Masutomi K., Khurts S., Kaneko S., Kobayashi K., and Murakami S.. 2002. Two independent regions of human telomerase reverse transcriptase are important for its oligomerization and telomerase activity. J. Biol. Chem. 277:8538–8544.
  • Armbruster, B., Banik S., Guo C., Smith A., and Counter C.. 2001. N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo. Mol. Cell. Biol. 21:7775–7786.
  • Autexier, C., Pruzan R., Funk W. D., and Greider C. W.. 1996. Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA. EMBO J. 15:5928–5935.
  • Bachand, F., and Autexier C.. 1999. Functional reconstitution of human telomerase expressed in Saccharomyces cerevisiae. J. Biol. Chem. 274:38027–38031.
  • Bachand, F., and Autexier C.. 2001. Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions. Mol. Cell. Biol. 21:1888–1897.
  • Bahar, I., Erman B., Jernigan R. L., Atilgan A. R., and Covell D. G.. 1999. Collective motions in HIV-1 reverse transcriptase: examination of flexibility and enzyme function. J. Mol. Biol. 285:1023–1037.
  • Balakrishnan, M., Roques B. P., Fay P. J., and Bambara R. A.. 2003. Template dimerization promotes an acceptor invasion-induced transfer mechanism during human immunodeficiency virus type 1 minus-strand synthesis. J. Virol. 77:4710–4721.
  • Beattie, T., Zhou W., Robinson M., and Harrington L.. 2001. Functional multimerization of the human telomerase reverse transcriptase. Mol. Cell. Biol. 21:6151–6160.
  • Beattie, T., Zhou W., Robinson M., and Harrington L.. 2000. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol. Biol. Cell 11:3329–3340.
  • Bibi, E., and Kaback H. R.. 1990. In vivo expression of the lacY gene in two segments leads to functional lac permease. Proc. Natl. Acad. USA 87:4325–4329.
  • Bosoy, D., and Lue N. F.. 2004. Yeast telomerase is capable of limited repeat addition processivity. Nucleic Acids Res. 32:93–101.
  • Bryan, T., Goodrich K., and Cech T.. 2000. A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity. J. Biol. Chem. 275:24199–24207.
  • Bryan, T., Goodrich K., and Cech T.. 2000. Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Mol. Cell 6:493–499.
  • Bryan, T. M., Goodrich K. J., and Cech T. R.. 2003. Tetrahymena telomerase is active as a monomer. Mol. Biol. Cell 14:4794–4804.
  • Cameron, C. E., Ghosh M., LeGrice S. F. J., and Benkovic S. J.. 1997. Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein. Proc. Natl. Acad. Sci. USA 94:6700–6705.
  • Chen, J.-L., Blasco M. A., and Greider C. W.. 2000. Secondary structure of vertebrate telomerase RNA. Cell 100:503–514.
  • Chen, J.-L., and Greider C. W.. 2003. Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility. EMBO J. 22:304–314.
  • Chen, J.-L., and Greider C. W.. 2003. Template boundary definition in mammalian telomerase. Genes Dev. 17:2747–2752.
  • Chen, J.-L., Keyer Opperman K., and Greider C. W.. 2002. A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA. Nucleic Acids Res. 30:592–597.
  • Comolli, L. R., Smirnov I., Xu L., Blackburn E. H., and James T. L.. 2002. A molecular switch underlies a human telomerase disease. Proc. Natl. Acad. Sci. USA 99:16998–17003.
  • Friedman, K. L., and Cech T. R.. 1999. Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes Dev. 13:2863–2874.
  • Gavory, G., Farrow M., and Balasubramanian S.. 2002. Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro. Nucleic Acids Res. 30:4470–4480.
  • Gotte, M., Li X., and Wainberg M. A.. 1999. HIV-1 reverse transcription: a brief overview focused on structure-function relationships among molecules involved in initiation of the reaction. Arch. Biochem. Biophys. 365:199–210.
  • Hammond, P. W., Lively T. N., and Cech T. R.. 1997. The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers. Mol. Cell. Biol. 17:296–308.
  • Hardy, C. D., Schultz C. S., and Collins K.. 2001. Requirements for the dGTP-dependent repeat addition processivity of recombinant Tetrahymena telomerase. J. Biol. Chem. 276:4863–4871.
  • Harrington, L. 2003. Biochemical aspects of telomerase function. Cancer Lett. 194:139–154.
  • Hopfner, K. P., Eichinger A., Engh R. A., Laue F., Ankenbauer W., Huber R., and Angerer B.. 1999. Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius. Proc. Natl. Acad. Sci. USA 96:3600–3605.
  • Hossain, S., Singh S. M., and Lue N. F.. 2002. Functional analysis of the C-terminal extension of telomerase reverse transcriptase: a ′putative' thumb domain. J. Biol. Chem. 277:36174–36180.
  • Hostomsky, Z., Hostomska Z., Hudson G. O., Moomaw E. W., and Nodes B. R.. 1991. Reconstitution in vitro of RNase H activity by using purified N-terminal and C-terminal domains of human immunodeficiency virus type 1 reverse transcriptase. Proc. Natl. Acad. Sci. USA 88:1148–1152.
  • Huard, S., Moriarty T. J., and Autexier C.. 2003. The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity. Nucleic Acids Res. 31:4059–4070.
  • Kelleher, C., Teixeira M. T., Forstemann K., and Lingner J.. 2002. Telomerase: biochemical considerations for enzyme and substrate. Trends Biochem. Sci. 27:572–579.
  • Kim, N. W., Piatyszek M. A., Prowse K. R., Harley C. B., West M. D., Ho P. L. C., Coviello G. M., Wright W. E., Weinrich S. L., and Shay J. W.. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011–2015.
  • Kim, N. W., and Wu F.. 1997. Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP). Nucleic Acids Res. 25:2595–2597.
  • Lai, C., Mitchell J., and Collins K.. 2001. RNA binding domain of telomerase reverse transcriptase. Mol. Cell. Biol. 21:990–1000.
  • Lai, C. K., Miller M. C., and Collins K.. 2003. Roles for RNA in telomerase nucleotide and repeat addition processivity. Mol. Cell 11:1673–1683.
  • Lee, S. R., Wong M. Y., and Collins K.. 2003. Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate. J. Biol. Chem. 278:52531–52536.
  • Lue, N. F., Lin Y. C., and Mian I. S.. 2003. A conserved telomerase motif within the catalytic domain of telomerase reverse transcriptase is specifically required for repeat addition processivity. Mol. Cell. Biol. 23:8440–8449.
  • Ly, H., Blackburn E. H., and Parslow T. G.. 2003. Comprehensive structure-function analysis of the core domain of human telomerase RNA. Mol. Cell. Biol. 23:6849–6856.
  • Ly, H., Xu L., Rivera M. A., Parslow T. G., and Blackburn E. H.. 2003. A role for a novel ′trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase. Genes Dev. 17:1078–1083.
  • Mason, D. X., Goneska E., and Greider C. W.. 2003. Stem-loop IV of Tetrahymena telomerase RNA stimulates processivity in trans. Mol. Cell. Biol. 23:5606–5613.
  • McGuffin, L. J., Bryson K., and Jones D. T.. 2000. The PSIPRED protein structure prediction server. Bioinformatics 16:404–405.
  • Mitchell, J., and Collins K.. 2000. Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase. Mol. Cell 6:361–371.
  • Moriarty, T. J., Huard S., Dupuis S., and Autexier C.. 2002. Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit. Mol. Cell. Biol. 22:1253–1265.
  • Peng, Y., Mian I., and Lue N.. 2001. Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance. Mol. Cell 7:1201–1211.
  • Prescott, J., and Blackburn E. H.. 1997. Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev. 11:2790–2800.
  • Romero, D. P., and Blackburn E. H.. 1991. A conserved secondary structure for telomerase RNA. Cell 67:343–353.
  • Sousa, R. 1996. Structural and mechanistic relationships between nucleic acid polymerases. Trends Biochem. Sci. 21:186–190.
  • Szatmari, I., and Aradi J.. 15 January 2001. Telomeric repeat amplification, without shortening or lengthening of the telomerase products: a method to analyze the processivity of telomerase enzyme. Nucleic Acids Res. 29:E3. [Online.]
  • Theimer, C. A., Finger L. D., Trantirek L., and Feigon J.. 2003. Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA. Proc. Natl. Acad. Sci. USA 100:449–454.
  • Tzfati, Y., Knight Z., Roy J., and Blackburn E. H.. 2003. A novel pseudoknot element is essential for the action of a yeast telomerase. Genes Dev. 17:1779–1788.
  • Vulliamy, T., Marrone A., Goldman F., Dearlove A., Bessler M., Mason P., and Dokal I.. 2001. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 413:432–435.
  • Wallweber, G., Gryaznov S., Pongracz K., and Pruzan R.. 2003. Interaction of human telomerase with its primer substrate. Biochemistry 42:589–600.
  • Wang, J., Sattar A. K. M. A., Wang C. C., Karam J. D., Konigsberg W. H., and Steitz T. A.. 1997. Crystal structure of a pol α family replication DNA polymerase from bacteriophage RB69. Cell 89:1087–1099.
  • Wenz, C., Enenkel B., Amacker M., Kelleher C., Damm K., and Lingner J.. 2001. Human telomerase contains two cooperating telomerase RNA molecules. EMBO J. 20:3526–3534.
  • Xia, J., Peng Y., Mian I., and Lue N.. 2000. Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase. Mol. Cell. Biol. 20:5196–5207.
  • Zen, K. H., McKenna E., Bibi E., Hardy D., and Kaback H. R.. 1994. Expression of lactose permease in contiguous fragments as a probe for membrane-spanning domains. Biochemistry 33:8198–8206.

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