Energy Homeostasis and Gastrointestinal Endocrine Differentiation Do Not Require the Anorectic Hormone Peptide YY

REFERENCES

• Adams, S. H., W. B. Won, S. E. Schonhoff, A. B. Leiter, and J. R. Paterniti, Jr. 2004. Effects of peptide YY[3-36] on short-term food intake in mice are not affected by prevailing plasma ghrelin levels. Endocrinology 145:4967–4975.
   PubMed Web of Science ®Google Scholar
• Asakawa, A., A. Inui, N. Ueno, M. Fujimiya, M. A. Fujino, and M. Kasuga. 1999. Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice. Peptides 20:1445–1448.
   PubMed Web of Science ®Google Scholar
• Batterham, R. L., M. A. Cowley, C. J. Small, H. Herzog, M. A. Cohen, C. L. Dakin, A. M. Wren, A. E. Brynes, M. J. Low, M. A. Ghatei, R. D. Cone, and S. R. Bloom. 2002. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418:650–654.
   PubMed Web of Science ®Google Scholar
• Batterham, R. L., C. W. Le Roux, M. A. Cohen, A. J. Park, S. M. Ellis, M. Patterson, G. S. Frost, M. A. Ghatei, and S. R. Bloom. 2003. Pancreatic polypeptide reduces appetite and food intake in humans. J. Clin. Endocrinol. Metab. 88:3989–3992.
   PubMed Web of Science ®Google Scholar
• Brouns, I., L. Van Nassauw, J. Van Genechten, M. Majewski, D. W. Scheuermann, J. P. Timmermans, and D. Adriaensen. 2002. Triple immunofluorescence staining with antibodies raised in the same species to study the complex innervation pattern of intrapulmonary chemoreceptors. J. Histochem. Cytochem. 50:575–582.
   PubMed Web of Science ®Google Scholar
• Challis, B. G., A. P. Coll, G. S. Yeo, S. B. Pinnock, S. L. Dickson, R. R. Thresher, J. Dixon, D. Zahn, J. J. Rochford, A. White, R. L. Oliver, G. Millington, S. A. Aparicio, W. H. Colledge, A. P. Russ, M. B. Carlton, and S. O'Rahilly. 2004. Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc. Natl. Acad. Sci. USA 101:4695–4700.
   PubMed Web of Science ®Google Scholar
• Chelikani, P. K., A. C. Haver, and R. D. Reidelberger. 2005. Intravenous infusion of peptide YY(3-36) potently inhibits food intake in rats. Endocrinology. 146:879–888.
   PubMed Web of Science ®Google Scholar
• Cotta-De-Almeida, V., S. Schonhoff, T. Shibata, A. Leiter, and S. B. Snapper. 2003. A new method for rapidly generating gene-targeting vectors by engineering BACs through homologous recombination in bacteria. Genome Res. 13:2190–2194.
   PubMed Web of Science ®Google Scholar
• Cox, J. E., and A. Randich. 2004. Enhancement of feeding suppression by PYY(3-36) in rats with area postrema ablations. Peptides 25:985–989.
   PubMed Web of Science ®Google Scholar
• Datsenko, K. A., and B. L. Wanner. 2000. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. USA 97:6640–6645.
   PubMed Web of Science ®Google Scholar
• Edlund, H. 2002. Pancreatic organogenesis—developmental mechanisms and implications for therapy. Nat. Rev. Genet. 3:524–532.
   PubMedGoogle Scholar
• Facer, P., A. E. Bishop, G. A. Cole, M. Aitchison, C. H. Kendall, G. van Aswegen, R. J. A. Penketh, C. H. Rodek, P. McKeever, and J. M. Polak. 1989. Developmental profile of chromagranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells. Gastroenterology 97:48–57.
   PubMedGoogle Scholar
• Grandt, D., M. Schimiczek, C. Beglinger, P. Layer, H. Goebell, V. E. Eysselein, and J. R. Reeve, Jr. 1994. Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1-6 and PYY 3-36. Regul. Peptides 51:151–159.
   PubMed Web of Science ®Google Scholar
• Greeley, G. H. J., T. Hashimoto, M. Izukura, G. Gomez, J. Jeng, F. L. Hill, F. Lluis, and J. C. Thompson. 1989. A comparison of intraduodenally and intracolonically administered nutrients on the release of peptide-YY in the dog. Endocrinology 125:1761–1765.
   PubMedGoogle Scholar
• Halatchev, I. G., K. L. Ellacott, W. Fan, and R. D. Cone. 2004. Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism. Endocrinology 145:2585–2590.
   PubMed Web of Science ®Google Scholar
• Hernandez, E. J., D. C. Whitcomb, S. R. Vigna, and I. L. Taylor. 1994. Saturable binding of circulating peptide YY in the dorsal vagal complex of rats. Am. J. Physiol. 266:G511–516.
   PubMedGoogle Scholar
• Herrera, P., J. Huarte, F. Sanvito, P. Meda, L. Orci, and J. Vassalli. 1991. Embryogenesis of the murine pancreas; early expression of pancreatic polypeptide gene. Development 113:1257–1265.
   PubMed Web of Science ®Google Scholar
• Herrera, P. L. 2000. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 127:2317–2322.
   PubMed Web of Science ®Google Scholar
• Herrera, P. L., J. Huarte, R. Zufferey, A. Nichols, B. Mermillod, J. Philippe, P. Muniesa, F. Sanvito, L. Orci, and J. D. Vassalli. 1994. Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes. Proc. Natl. Acad. Sci. USA 91:12999–13003.
   PubMedGoogle Scholar
• Hogan, B., F. Costantini, and E. Lacy. 1994. Manipulating the mouse embryo, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Jackerott, M., A. Oster, and L. I. Larsson. 1996. PYY in developing murine islet cells: comparisons to development of islet hormones, NPY, and BrdU incorporation. J. Histochem. Cytochem. 44:809–817.
   PubMedGoogle Scholar
• Keire, D. A., P. Mannon, M. Kobayashi, J. H. Walsh, T. E. Solomon, and J. R. Reeve, Jr. 2000. Primary structures of PYY, [Pro(34)]PYY, and PYY-(3-36) confer different conformations and receptor selectivity. Am. J. Physiol. Gastrointest. Liver Physiol. 279:G126–G131.
   PubMed Web of Science ®Google Scholar
• Lakso, M., J. G. Pichel, J. R. Gorman, B. Sauer, Y. Okamoto, E. Lee, F. W. Alt, and H. Westphal. 1996. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc. Natl. Acad. Sci. USA 93:5860–5865.
   PubMed Web of Science ®Google Scholar
• Lopez, M. J., B. H. Upchurch, G. Rindi, and A. B. Leiter. 1995. Studies in transgenic mice reveal potential relationships between secretin-producing cells and other endocrine cell types. J. Biol. Chem. 270:885–891.
   PubMedGoogle Scholar
• Lundberg, J. M., K. Tatemoto, L. Terenius, P. M. Hellstrom, V. Mutt, T. Hokfelt, and B. Hamberger. 1982. Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility. Proc. Natl. Acad. Sci. USA 79:4471–4475.
   PubMed Web of Science ®Google Scholar
• Mentlein, R., P. Dahms, D. Grandt, and R. Kruger. 1993. Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV. Regul. Peptides 49:133–144.
   PubMed Web of Science ®Google Scholar
• Moran, T. H., U. Smedh, K. P. Kinzig, K. A. Scott, S. Knipp, and E. E. Ladenheim. 2005. Peptide YY(3-36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288:R384–R388.
   PubMed Web of Science ®Google Scholar
• Nakazato, M., N. Murakami, Y. Date, M. Kojima, H. Matsuo, K. Kangawa, and S. Matsukura. 2001. A role for ghrelin in the central regulation of feeding. Nature 409:194–198.
   PubMed Web of Science ®Google Scholar
• Negoescu, A., F. Labat-Moleur, P. Lorimier, L. Lamarcq, C. Guillermet, E. Chambaz, and E. Brambilla. 1994. F(ab) secondary antibodies: a general method for double immunolabeling with primary antisera from the same species. Efficiency control by chemiluminescence. J. Histochem. Cytochem. 42:433–437.
   PubMed Web of Science ®Google Scholar
• Oster, A., J. Jensen, P. Serup, P. Galante, O. D. Madsen, and L. I. Larsson. 1998. Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). J. Histochem. Cytochem. 46:707–715.
   PubMedGoogle Scholar
• Pappas, T. N., H. T. Debas, A. M. Chang, and I. L. Taylor. 1986. Peptide YY release by fatty acids is sufficient to inhibit gastric emptying in dogs. Gastroenterology 91:1386–1389.
   PubMed Web of Science ®Google Scholar
• Pappas, T. N., H. T. Debas, and I. L. Taylor. 1986. Enterogastrone-like effect of peptide YY is vagally mediated in the dog. J. Clin. Investig. 77:49–53.
   PubMedGoogle Scholar
• Pedersen-Bjergaard, U., U. Host, H. Kelbaek, S. Schifter, J. F. Rehfeld, J. Faber, and N. J. Christensen. 1996. Influence of meal composition on postprandial peripheral plasma concentrations of vasoactive peptides in man. Scand. J. Clin. Lab. Investig. 56:497–503.
   PubMed Web of Science ®Google Scholar
• Pittner, R. A., C. X. Moore, S. P. Bhavsar, B. R. Gedulin, P. A. Smith, C. M. Jodka, D. G. Parkes, J. R. Paterniti, V. P. Srivastava, and A. A. Young. 2004. Effects of PYY[3-36] in rodent models of diabetes and obesity. Int. J. Obes. Relat. Metab. Disord. 28:963–971.
   PubMed Web of Science ®Google Scholar
• Qian, S., H. Chen, D. Weingarth, M. E. Trumbauer, D. E. Novi, X. Guan, H. Yu, Z. Shen, Y. Feng, E. Frazier, A. Chen, R. E. Camacho, L. P. Shearman, S. Gopal-Truter, D. J. MacNeil, L. H. Van der Ploeg, and D. J. Marsh. 2002. Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol. Cell. Biol. 22:5027–5035.
   PubMed Web of Science ®Google Scholar
• Ratineau, C., A. Ronco, and A. B. Leiter. 2000. Role of the amino-terminal domain of simian virus 40 early region in inducing tumors in secretin-expressing cells in transgenic mice. Gastroenterology 119:1305–1311.
   PubMedGoogle Scholar
• Riediger, T., C. Bothe, C. Becskei, and T. A. Lutz. 2004. Peptide YY directly inhibits ghrelin-activated neurons of the arcuate nucleus and reverses fasting-induced c-Fos expression. Neuroendocrinology. 79:317–326.
   PubMed Web of Science ®Google Scholar
• Rindi, G., C. Ratineau, A. Ronco, M. E. Candusso, M. Tsai, and A. B. Leiter. 1999. Targeted ablation of secretin-producing cells in transgenic mice reveals a common differentiation pathway with multiple enteroendocrine cell lineages in the small intestine. Development 126:4149–4156.
   PubMedGoogle Scholar
• Roth, K. A., S. Kim, and J. I. Gordon. 1992. Immunocytochemical studies suggest two pathways for enteroendocrine cell differentiation in the colon. Am. J. Physiol. 263:G174–180.
   PubMedGoogle Scholar
• Scacheri, P. C., J. S. Crabtree, E. A. Novotny, L. Garrett-Beal, A. Chen, K. A. Edgemon, S. J. Marx, A. M. Spiegel, S. C. Chandrasekharappa, and F. S. Collins. 2001. Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice. Genesis 30:259–263.
   PubMed Web of Science ®Google Scholar
• Schonhoff, S. E., M. Giel-Moloney, and A. B. Leiter. 2004. Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Dev. Biol. 270:443–454.
   PubMed Web of Science ®Google Scholar
• Schwartz, M. W., and G. J. Morton. 2002. Obesity: keeping hunger at bay. Nature 418:595–597.
   PubMed Web of Science ®Google Scholar
• Soriano, P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21:70–71.
   PubMed Web of Science ®Google Scholar
• Sun, Y., S. Ahmed, and R. G. Smith. 2003. Deletion of ghrelin impairs neither growth nor appetite. Mol. Cell. Biol. 23:7973–7981.
   PubMed Web of Science ®Google Scholar
• Tatemoto, K. 1982. Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc. Natl. Acad. Sci. USA 79:2514–2518.
   PubMed Web of Science ®Google Scholar
• Teitelman, G., S. Alpert, J. M. Polak, A. Martinez, and D. Hanahan. 1993. Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118:1031–1039.
   PubMed Web of Science ®Google Scholar
• Tschop, M., T. R. Castaneda, H. G. Joost, C. Thone-Reineke, S. Ortmann, S. Klaus, M. M. Hagan, P. C. Chandler, K. D. Oswald, S. C. Benoit, R. J. Seeley, K. P. Kinzig, T. H. Moran, A. G. Beck-sickinger, N. Koglin, R. J. Rodgers, J. E. Blundell, Y. Ishii, A. H. Beattie, P. Holch, D. B. Allison, K. Raun, K. Madsen, B. S. Wulff, C. E. Stidsen, M. Birringer, O. J. Kreuzer, M. Schindler, K. Arndt, K. Rudolf, M. Mark, X. Y. Deng, D. C. Withcomb, H. Halem, J. Taylor, J. Dong, R. Datta, M. Culler, S. Craney, D. Flora, D. Smiley, and M. L. Heiman. 2004. Physiology: does gut hormone PYY3-36 decrease food intake in rodents. Nature 430:165.
   PubMedGoogle Scholar
• Ueno, N., A. Inui, M. Iwamoto, T. Kaga, A. Asakawa, M. Okita, M. Fujimiya, Y. Nakajima, Y. Ohmoto, M. Ohnaka, Y. Nakaya, J. I. Miyazaki, and M. Kasuga. 1999. Decreased food intake and body weight in pancreatic polypeptide-overexpressing mice. Gastroenterology 117:1427–1432.
   PubMed Web of Science ®Google Scholar
• Upchurch, B. H., G. W. Aponte, and A. B. Leiter. 1994. Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor. Development 120:245–252.
   PubMedGoogle Scholar
• Upchurch, B. H., B. P. Fung, G. Rindi, A. Ronco, and A. B. Leiter. 1996. Peptide YY expression is an early event in colonic endocrine cell differentiation: evidence from normal and transgenic mice. Development 122:1157–1163.
   PubMed Web of Science ®Google Scholar
• Wheeler, M. B., J. Nishitani, A. M. J. Buchan, A. S. Kopin, W. Y. Chey, T. Chang, and A. B. Leiter. 1992. Identification of a transcriptional enhancer important for enteroendocrine and pancreatic islet cell-specific expression of the secretin gene. Mol. Cell. Biol. 12:3531–3539.
   PubMedGoogle Scholar
• Yu, D., H. M. Ellis, E. C. Lee, N. A. Jenkins, N. G. Copeland, and D. L. Court. 2000. An efficient recombination system for chromosome engineering in Escherichia coli. Proc. Natl. Acad. Sci. USA 97:5978–5983.
   PubMed Web of Science ®Google Scholar