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Chromosome Structure and Dynamics

Fission Yeast Rad51 and Dmc1, Two Efficient DNA Recombinases Forming Helical Nucleoprotein Filaments

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Pages 4377-4387 | Received 28 Jan 2005, Accepted 08 Mar 2005, Published online: 27 Mar 2023

REFERENCES

  • Anderson, L. K., H. H. Offenberg, W. M. H. C. Verkuijlen, and C. Heyting. 1997. RecA-like proteins are components of early meiotic nodules in lily. Proc. Natl. Acad. Sci. USA 94:6868–6873.
  • Baudat, F., K. Manova, J. P. Yuen, M. Jasin, and S. Keeney. 2000. Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11. Mol. Cell 6:989–998.
  • Baumann, P., F. E. Benson, N. Hajibagheri, and S. C. West. 1997. Purification of human Rad51 protein by selective spermidine precipitation. Mutat. Res. DNA Repair 384:65–72.
  • Baumann, P., F. E. Benson, and S. C. West. 1996. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell 87:757–766.
  • Baumann, P., and S. C. West. 1999. Heteroduplex formation by human Rad51 protein: effects of DNA end-structure, hRP-A and hRad52. J. Mol. Biol. 291:363–374.
  • Baumann, P., and S. C. West. 1997. The human Rad51 protein: polarity of strand transfer and stimulation by hRP-A. EMBO J. 16:5198–5206.
  • Benson, F. E., A. Stasiak, and S. C. West. 1994. Purification and characterisation of the human Rad51 protein, an analogue of Escherichia coli RecA. EMBO J. 13:5764–5771.
  • Bishop, D. K. 1994. RecA homologs Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis. Cell 79:1081–1092.
  • Bishop, D. K., D. Park, L. Z. Xu, and N. Kleckner. 1992. DMC1: a meiosis-specific yeast homolog of Escherichia coli RecA required for recombination, synaptonemal complex formation, and cell cycle progression. Cell 69:439–456.
  • Bugreev, D. V., and A. V. Mazin. 2004. Ca2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity. Proc. Natl. Acad. Sci. USA 101:9988–9993.
  • Catlett, M. G., and S. L. Forsburg. 2003. Schizosaccharomyces pombe Rdh54 (TID1) acts with Rhp54 (RAD54) to repair meiotic double-strand breaks. Mol. Biol. Cell 14:4707–4720.
  • Cervantes, M. D., J. A. Farah, and G. R. Smith. 2000. Meiotic DNA breaks associated with recombination in Schizosaccharomyces pombe. Mol. Cell 5:883–888.
  • Chen, J. J., D. P. Silver, D. Walpita, S. B. Cantor, A. F. Gazdar, G. Tomlinson, F. J. Couch, B. L. Weber, T. Ashley, D. M. Livingston, and R. Scully. 1998. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2:317–328.
  • Chen, Y. K., C. H. Leng, H. Olivares, M. H. Lee, Y. C. Chang, W. M. Kung, S. C. Ti, Y. H. Lo, A. H. Wang, C. S. Chang, D. K. Bishop, Y. P. Hsueh, and T. F. Wang. 2004. Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation. Proc. Natl. Acad. Sci. USA 101:10572–10577.
  • Davies, A. A., J.-Y. Masson, M. J. McIlwraith, A. Z. Stasiak, A. Stasiak, A. R. Venkitaraman, and S. C. West. 2001. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Mol. Cell 7:273–282.
  • Davis, L., and G. R. Smith. 2001. Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA 98:8395–8402.
  • Dresser, M. E., D. J. Ewing, M. N. Conrad, A. M. Dominguez, R. Barstead, H. Jiang, and T. Kodadek. 1997. Dmc1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the Rad51 pathway. Genetics 147:533–544.
  • Enomoto, R., T. Kinebuchi, M. Sato, H. Yagi, T. Shibata, H. Kurumizaka, and S. Yokoyama. 2004. Positive role of the mammalian TBPIP/HOP2 protein in DMC1-mediated homologous pairing. J. Biol. Chem. 279:35263–35272.
  • Fukushima, K., Y. Tanaka, K. Nabeshima, T. Yoneki, T. Tougan, S. Tanaka, and H. Nojima. 2000. Dmc1 of Schizosaccharomyces pombe plays a role in meiotic recombination. Nucleic Acids Res. 28:2709–2716.
  • Grishchuk, A. L., R. Kraehenbuehl, M. Molnar, O. Fleck, and J. Kohli. 2003. Genetic and cytological characterization of the RecA-homologous proteins Rad51 and Dmc1 of Schizosaccharomyces pombe. Curr. Genet. 165:1031–1043.
  • Gupta, R. C., L. R. Bazemore, E. I. Golub, and C. M. Radding. 1997. Activities of human recombination protein Rad51. Proc. Natl. Acad. Sci. USA 94:463–468.
  • Gupta, R. C., E. Golub, B. Bi, and C. M. Radding. 2001. The synaptic activity of HsDmc1, a human recombination protein specific to meiosis. Proc. Natl. Acad. Sci. USA 98:8433–8439.
  • Habu, T., T. Taki, A. West, Y. Nishimune, and T. Morita. 1996. The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon skipped transcript in meiosis. Nucleic Acids Res. 24:470–477.
  • Habu, T., N. Wakabayashi, K. Yoshida, K. Yomogida, Y. Nishimune, and T. Morita. 2004. p53 protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis. Carcinogenesis 25:889–893.
  • Hingorani, M. M., and M. O'Donnell. 1998. Toroidal proteins: running rings around DNA. Curr. Biol. 8:R83–R86.
  • Hong, E. R. L., A. Shinohara, and D. K. Bishop. 2001. Saccharomyces cerevisiae Dmc1 protein promotes renaturation of single-strand DNA (ssDNA) and assimilation of ssDNA into homologous supercoiled duplex DNA. J. Biol. Chem. 276:41906–41912.
  • Howard-Flanders, P., S. C. West, and A. J. Stasiak. 1984. Role of RecA spiral filaments in genetic recombination. Nature 309:215–220.
  • Hunter, N., and N. Kleckner. 2001. The single-end invasion: an asymmetric intermediate at the double-strand break to double-Holliday junction transition of meiotic recombination. Cell 106:59–70.
  • James, P., J. Halladay, and E. A. Craig. 1996. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144:1425–1436.
  • Keeney, S. 2001. Mechanism and control of meiotic recombination initiation. Curr. Top. Dev. Biol. 52:1–53.
  • Kinebuchi, T., W. Kagawa, R. Enomoto, K. Tanaka, K. Miyagawa, T. Shibata, H. Kurumizaka, and S. Yokoyama. 2004. Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1. Mol. Cell 14:363–374.
  • Li, Z. F., E. I. Golub, R. Gupta, and C. M. Radding. 1997. Recombination activities of HsDmc1 protein, the meiotic human homolog of RecA protein. Proc. Natl. Acad. Sci. USA 94:11221–11226.
  • Lim, D. S., and P. Hasty. 1996. A mutation in mouse RAD51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell. Biol. 16:7133–7143.
  • Masson, J.-Y., A. A. Davies, N. Hajibagheri, E. Van Dyck, F. E. Benson, A. Z. Stasiak, A. Stasiak, and S. C. West. 1999. The meiosis-specific recombinase hDmc1 forms rings structures and interacts with hRad51. EMBO J. 18:6552–6560.
  • Masson, J.-Y., and S. C. West. 2001. The Rad51 and Dmc1 recombinases: a non-identical twin relationship. Trends Biochem. Sci. 26:131–136.
  • McIlwraith, M. J., D. R. Hall, A. Z. Stasiak, A. Stasiak, D. B. Wigley, and S. C. West. 2001. RadA protein from Archeoglobus fulgidans forms rings, nucleoprotein filaments and catalyzes homologous recombination. Nucleic Acids Res. 29:4509–4517.
  • McIlwraith, M. J., E. Van Dyck, J.-Y. Masson, A. Z. Stasiak, A. Stasiak, and S. C. West. 2000. Reconstitution of the strand invasion step of double-strand break repair using human Rad51, Rad52 and RPA proteins. J. Mol. Biol. 304:151–164.
  • Mortensen, U. H., C. Bendixen, I. Sunjevaric, and R. Rothstein. 1996. DNA strand annealing is promoted by the yeast Rad52 protein. Proc. Natl. Acad. Sci. USA 93:10729–10734.
  • Neyton, S., F. Lespinasse, P. B. Moens, R. Paul, P. Gaudray, V. Paquis-Flucklinger, and S. Santucci-Darmanin. 2004. Association between MSH4 (MutS homologue 4) and the DNA strand-exchange RAD51 and DMC1 proteins during mammalian meiosis. Mol. Hum. Reprod. 10:917–924.
  • Paques, F., and J. E. Haber. 1999. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63:349–404.
  • Passy, S. I., X. Yu, Z. Li, C. M. Radding, J.-Y. Masson, S. C. West, and E. H. Egelman. 1999. Human Dmc1 protein binds DNA as an octameric ring. Proc. Natl. Acad. Sci. USA 96:10684–10688.
  • Petersen, G., and O. Seberg. 2002. Molecular evolution and phylogenetic application of DMC1. Mol. Phylogenet. Evol. 22:43–50.
  • Pittman, D. L., J. Cobb, K. J. Schimenti, L. A. Wilson, D. M. Cooper, E. Brignull, M. A. Handel, and J. C. Schimenti. 1998. Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific recA homolog. Mol. Cell 1:697–705.
  • Pugh, B. F., and M. M. Cox. 1987. Stable binding of RecA protein to duplex DNA. J. Biol. Chem. 262:1326–1336.
  • Rockmill, B., M. Sym, H. Scherthan, and G. S. Roeder. 1995. Roles for two RecA homologs in promoting meiotic chromosome synapsis. Genes Dev. 9:2684–2695.
  • Romanienko, P. J., and R. D. Camerini-Otero. 2000. The mouse Spo11 gene is required for meiotic chromosome synapsis. Mol. Cell 6:975–987.
  • Schwacha, A., and N. Kleckner. 1997. Interhomolog bias during meiotic recombination: meiotic functions promote a highly differentiated interhomolog only pathway. Cell 90:1123–1135.
  • Sehorn, M. G., S. Sigurdsson, W. Bussen, V. M. Unger, and P. Sung. 2004. Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange. Nature 429:433–437.
  • Siaud, N., E. Dray, I. Gy, E. Gerard, N. Takvorian, and M. P. Doutriaux. 2004. Brca2 is involved in meiosis in Arabidopsis thaliana as suggested by its interaction with Dmc1. EMBO J. 23:1392–1401.
  • Smith, K. N., and A. Nicolas. 1998. Recombination at work for meiosis. Curr. Opin. Genet. Dev. 8:200–211.
  • Sogo, J., A. Stasiak, W. De Bernadin, R. Losa, and T. Koller. 1987. Binding of proteins to nucleic acids as studied by electron microscopy, p. 61–79. In J. Sommerville and U. Scheer (ed.), Electron microscopy in molecular biology. IRL Press, Oxford, England.
  • Solari, A. J. 2002. Primitive forms of meiosis: the possible evolution of meiosis. Biocell 26:1–13.
  • Stark, J. M., P. Hu, A. J. Pierce, M. E. Moynahan, N. Ellis, and M. Jasin. 2002. ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair. J. Biol. Chem. 277:20185–20194.
  • Story, R. M., I. T. Weber, and T. A. Steitz. 1992. The structure of the Escherichia coli RecA protein monomer and polymer. Nature 355:318–325.
  • Sugiyama, T., E. M. Zaitseva, and S. C. Kowalczykowski. 1997. A single-stranded DNA-binding protein is needed for efficient complex formation by the Saccharomyces cerevisiae Rad51 protein. J. Biol. Chem. 272:7940–7945.
  • Tarsounas, M., T. Morita, R. E. Pearlman, and P. B. Moens. 1999. RAD51 and DMC1 form mixed complexes associated with mouse meiotic chromosome cores and synaptonemal complexes. J. Cell Biol. 147:207–219.
  • Thresher, R. J., A. M. Makhov, S. D. Hall, R. Kolodner, and J. D. Griffith. 1995. Electron microscopic visualization of RecT protein and its complexes with DNA. J. Mol. Biol. 254:364–371.
  • Tsuzuki, T., Y. Fujii, K. Sakuma, Y. Tominaga, K. Nakao, M. Sekiguchi, A. Matsushiro, Y. Yoshimura, and T. Morita. 1996. Targeted disruption of the RAD51 gene leads to lethality in embryonic mice. Proc. Natl. Acad. Sci. USA 93:6236–6240.
  • Van Dyck, E., A. Z. Stasiak, A. Stasiak, and S. C. West. 2001. Visualization of recombination intermediates produced by RAD52-mediated single-strand annealing. EMBO J. 2:905–909.
  • Wang, W., and B. A. Malcolm. 1999. Two-stage PCR protocol allowing introduction of multiple mutations, deletions and insertions using QuikChange site-directed mutagenesis. BioTechniques 26:680–682.
  • Weinstock, G. M., K. McEntee, and I. R. Lehman. 1979. ATP-dependent renaturation of DNA catalyzed by the RecA protein of Escherichia coli. Proc. Natl. Acad. Sci. USA 76:126–130.
  • West, S. C. 1992. Enzymes and molecular mechanisms of homologous recombination. Annu. Rev. Biochem. 61:603–640.
  • Yang, S., X. Yu, E. M. Seitz, S. C. Kowalczykowski, and E. H. Egelman. 2001. Archaeal RadA protein binds DNA as both helical filaments and octameric rings. J. Mol. Biol. 314:1077–1085.
  • Yoshida, K., G. Kondoh, Y. Matsuda, T. Habu, Y. Nishimune, and T. Morita. 1998. The mouse recA-like gene DMC1 is required for homologous chromosome synapsis during meiosis. Mol. Cell 1:707–718.

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