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Chromosome Structure and Dynamics

Recombination at Long Mutant Telomeres Produces Tiny Single- and Double-Stranded Telomeric Circles

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Pages 4406-4412 | Received 06 Jan 2005, Accepted 07 Mar 2005, Published online: 27 Mar 2023

REFERENCES

  • Backert, S. 2002. R-loop-dependent rolling-circle replication and a new model for DNA concatemer resolution by mitochondrial plasmid mp1. EMBO J. 21:3128–3136.
  • Bailey, S. M., and E. H. Goodwin. 2004. DNA and telomeres: beginnings and endings. Cytogenet. Genome Res. 104:109–115.
  • Bryan, T. M., A. Englezou, L. Dalla-Pozza, M. A. Dunham, and R. R. Reddel. 1997. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat. Med. 3:1271–1274.
  • Bryan, T. M., A. Englezou, J. Gupta, S. Bacchetti, and R. R. Reddel. 1995. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14:4240–4248.
  • Bucholc, M., Y. Park, and A. J. Lustig. 2001. Intrachromatid excision of telomeric DNA as a mechanism for telomere size control in Saccharomyces cerevisiae.. Mol. Cell. Biol. 21:6559–6573.
  • Cech, T. R. 2004. Beginning to understand the end of the chromosome. Cell 116:273–279.
  • Cesare, A. J., and J. D. Griffith. 2004. Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops. Mol. Cell. Biol. 24:9948–9957.
  • Cesare, A. J., N. Quinney, S. Willcox, D. Subramanian, and J. D. Griffith. 2003. Telomere looping in P. sativum (common garden pea). Plant J. 36:271–279.
  • Chan, S. R., and E. H. Blackburn. 2004. Telomeres and telomerase. Philos. Trans. R. Soc. London B 359:109–121.
  • Chen, Q., A. Ijpma, and C. W. Greider. 2001. Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events. Mol. Cell. Biol. 21:1819–1827.
  • Church, G. M., and W. Gilbert. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81:1991–1995.
  • Cohen, H., and D. A. Sinclair. 2001. Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase. Proc. Natl. Acad. Sci. USA 98:3174–3179.
  • Cohen, S., and M. Mechali. 2002. Formation of extrachromosomal circles from telomeric DNA in Xenopus laevis.. EMBO Rep. 3:1168–1174.
  • Cong, Y. S., W. E. Wright, and J. W. Shay. 2002. Human telomerase and its regulation. Microbiol. Mol. Biol. Rev. 66:407–425.
  • Cristofalo, V. J., A. Lorenzini, R. G. Allen, C. Torres, and M. Tresini. 2004. Replicative senescence: a critical review. Mech. Ageing Dev. 125:827–848.
  • Dunham, M. A., A. A. Neumann, C. L. Fasching, and R. R. Reddel. 2000. Telomere maintenance by recombination in human cells. Nat. Genet. 26:447–450.
  • Evans, S. K., and V. Lundblad. 2000. Positive and negative regulation of telomerase access to the telomere. J. Cell Sci. 113:3357–3364.
  • Griffith, J. D., and G. Christiansen. 1978. Electron microscope visualization of chromatin and other DNA-protein complexes. Annu. Rev. Biophys. Bioeng. 7:19–35.
  • Griffith, J. D., L. Comeau, S. Rosenfield, R. M. Stansel, A. Bianchi, H. Moss, and T. de Lange. 1999. Mammalian telomeres end in a large duplex loop. Cell 97:503–514.
  • Hartig, J. S., and E. T. Kool. 2004. Small circular DNAs for synthesis of the human telomere repeat: varied sizes, structures and telomere-encoding activities. Nucleic Acids Res. 32:e152.
  • Huang, P., P. F. Lester, D. Maddison, R. L. Borts, R. H. Hickson, I. D. Louis, E. J. 2001. SGS1 is required for telomere elongation in the absence of telomerase. Curr. Biol. 11:125–129.
  • Krauskopf, A., and E. H. Blackburn. 1996. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 383:354–357.
  • Krauskopf, A., and E. H. Blackburn. 1998. Rap1 protein regulates telomere turnover in yeast. Proc. Natl. Acad. Sci. USA 95:12486–12491.
  • Le, S., J. K. Moore, J. E. Haber, and C. W. Greider. 1999. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics 152:143–152.
  • Li, B., and A. J. Lustig. 1996. A novel mechanism for telomere size control in Saccharomyces cerevisiae.. Genes Dev. 10:1310–1326.
  • Lundblad, V., and E. H. Blackburn. 1993. An alternative pathway for yeast telomere maintenance rescues est1− senescence. Cell 73:347–360.
  • Lundblad, V., and J. W. Szostak. 1989. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57:633–643.
  • McEachern, M. J., and E. H. Blackburn. 1996. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev. 10:1822–1834.
  • McEachern, M. J., and E. H. Blackburn. 1995. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 376:403–409.
  • McEachern, M. J., and S. Iyer. 2001. Short telomeres in yeast are highly recombinogenic. Mol. Cell 7:695–704.
  • Munoz-Jordan, J. L., G. A. Cross, T. de Lange, and J. D. Griffith. 2001. t-loops at trypanosome telomeres. EMBO J. 20:579–588.
  • Murti, K. G., and D. M. Prescott. 1999. Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops. Proc. Natl. Acad. Sci. USA 96:14436–14439.
  • Nabetani, A., O. Yokoyama, and F. Ishikawa. 2004. Localization of hRad9, hHus1, hRad1, and hRad17 and caffeine-sensitive DNA replication at the alternative lengthening of telomeres-associated promyelocytic leukemia body. J. Biol. Chem. 279:25849–25857.
  • Natarajan, S., C. Groff-Vindman, and M. J. McEachern. 2003. Factors influencing the recombinational expansion and spread of telomeric tandem arrays in Kluyveromyces lactis.. Eukaryot. Cell 2:1115–1127.
  • Natarajan, S., and M. J. McEachern. 2002. Recombinational telomere elongation promoted by DNA circles. Mol. Cell. Biol. 22:4512–4521.
  • Neidle, S., and G. N. Parkinson. 2003. The structure of telomeric DNA. Curr. Opin. Struct. Biol. 13:275–283.
  • Nikitina, T., and C. L. Woodcock. 2004. Closed chromatin loops at the ends of chromosomes. J. Cell Biol. 166:161–165.
  • Reddel, R. R., and T. M. Bryan. 2003. Alternative lengthening of telomeres: dangerous road less travelled. Lancet 361:1840–1841.
  • Scheel, C., and C. Poremba. 2002. Telomere lengthening in telomerase-negative cells: the ends are coming together. Virchows Arch. 440:573–582.
  • Shay, J. W., and S. Bacchetti. 1997. A survey of telomerase activity in human cancer. Eur. J. Cancer 33:787–791.
  • Shay, J. W., and W. E. Wright. 2004. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis [Online.] doi:10.1093/carcin/bgh296.
  • Singer, M. S., and D. E. Gottschling. 1994. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science 266:404–409.
  • Smogorzewska, A., and T. de Lange. 2004. Regulation of telomerase by telomeric proteins. Annu. Rev. Biochem. 73:177–208.
  • Stansel, R. M., T. de Lange, and J. D. Griffith. 2001. T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. EMBO J. 20:5532–5540.
  • Teng, S. C., J. Chang, B. McCowan, and V. A. Zakian. 2000. Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process. Mol. Cell 6:947–952.
  • Teng, S. C., and V. A. Zakian. 1999. Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae.. Mol. Cell. Biol. 19:8083–8093.
  • Tomaska, L., M. J. McEachern, and J. Nosek. 2004. Alternatives to telomerase: keeping linear chromosomes via telomeric circles. FEBS Lett. 567:142–146.
  • Tomaska, L., J. Nosek, A. M. Makhov, A. Pastorakova, and J. D. Griffith. 2000. Extragenomic double-stranded DNA circles in yeast with linear mitochondrial genomes: potential involvement in telomere maintenance. Nucleic Acids Res. 28:4479–4487.
  • Tomaska, L., S. Willcox, J. Slezakova, J. Nosek, and J. D. Griffith. 2004. Taz1 binding to a fission yeast model telomere: formation of telomeric loops and higher order structures. J. Biol. Chem. 279:50764–50772.
  • Topcu, Z., K. Nickles, C. Davis, and M. J. McEachern. 2005. Abrupt disruption of capping and a single source for recombinationally elongated telomeres in Kluyveromyces lactis. Proc. Natl. Acad. Sci. USA 102:3348-3353.
  • Underwood, D. H., C. Carroll, and M. J. McEachern. 2004. Genetic dissection of the Kluyveromyces lactis telomere and evidence for telomere capping defects in TER1 mutants with long telomeres. Eukaryot. Cell 3:369–384.
  • Vega, L. R., M. K. Mateyak, and V. A. Zakian. 2003. Getting to the end: telomerase access in yeast and humans. Nat. Rev. Mol. Cell Biol. 4:948–959.
  • Wang, R. C., A. Smorgorzewska, and T de Lange. 2004. Homologous recombination generates T-loop-sized deletions at human telomeres. Cell 119:335–368.
  • Wei, C., and M. Price. 2003. Protecting the terminus: t-loops and telomere end-binding proteins. Cell. Mol. Life Sci. 60:2283–2294.
  • Wray, L. V., Jr., M. M. Witte, R. C. Dickson, and M. I. Riley. 1987. Characterization of a positive regulatory gene, LAC9, that controls induction of the lactose-galactose regulon of Kluyveromyces lactis: structural and functional relationships to GAL4 of Saccharomyces cerevisiae.. Mol. Cell. Biol. 7:1111–1121.
  • Yeager, T. R., A. A. Neumann, A. Englezou, L. I. Huschtscha, J. R. Noble, and R. R. Reddel. 1999. Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res. 59:4175–4179.

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