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Mammalian Genetic Models with Minimal or Complex Phenotypes

Phenotypic Analysis of Mice Deficient in the Type 2 Galanin Receptor (GALR2)

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Pages 4804-4811 | Received 08 Dec 2004, Accepted 26 Feb 2005, Published online: 27 Mar 2023

REFERENCES

  • Bartfai, T., G. Fisone, and U. Langel. 1992. Galanin and galanin antagonists: molecular and biochemical perspectives. Trends Pharmacol. Sci. 13:312–317.
  • Bartfai, T., X. Lu, H. Badie-Mahdavi, A. M. Barr, A. Mazarati, X. Y. Hua, T. Yaksh, G. Haberhauer, S. C. Ceide, L. Trembleau, L. Somogyi, L. Krock, and J. Rebek, Jr. 2004. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc. Natl. Acad. Sci. USA 101:10470–10475.
  • Bedecs, K., M. Berthold, and T. Bartfai. 1995. Galanin—10 years with a neuroendocrine peptide. Int. J. Biochem. Cell Biol. 27:337–349.
  • Blakeman, K. H., J. X. Hao, X. J. Xu, A. S. Jacoby, J. Shine, J. N. Crawley, T. Iismaa, and Z. Wiesenfeld-Hallin. 2003. Hyperalgesia and increased neuropathic pain-like response in mice lacking galanin receptor 1 receptors. Neuroscience 117:221–227.
  • Bouret, S., V. Prevot, D. Croix, A. Howard, E. Habert-Ortoli, S. Jegou, H. Vaudry, J. C. Beauvillain, and V. Mitchell. 2000. Expression of GalR1 and GalR2 galanin receptor messenger ribonucleic acid in proopiomelanocortin neurons of the rat arcuate nucleus: effect of testosterone. Endocrinology 141:1780–1794.
  • Branchek, T., K. E. Smith, and M. W. Walker. 1998. Molecular biology and pharmacology of galanin receptors. Ann. N. Y. Acad. Sci. 863:94–107.
  • Branchek, T. A., K. E. Smith, C. Gerald, and M. W. Walker. 2000. Galanin receptor subtypes. Trends Pharmacol. Sci. 21:109–117.
  • Burazin, T. C., and A. L. Gundlach. 1998. Inducible galanin and GalR2 receptor system in motor neuron injury and regeneration. J. Neurochem. 71:879–882.
  • Burgevin, M. C., I. Loquet, D. Quarteronet, and E. Habert-Ortoli. 1995. Cloning, pharmacological characterization, and anatomical distribution of a rat cDNA encoding for a galanin receptor. J. Mol. Neurosci. 6:33–41.
  • Crawley J. 2005. Behavioral neuroscience, p. 8.0.1-8.18.15. In J. Crawley, C. Gerfen, R. McKay, M. Rogawski, D. Sibley, and P. Skolnick (ed.). Current protocols in neuroscience. John Wiley, New York, N.Y.
  • Depczynski, B., K. Nichol, Z. Fathi, T. Iismaa, J. Shine, and A. Cunningham. 1998. Distribution and characterization of the cell types expressing GALR2 mRNA in brain and pituitary gland. Ann. N. Y. Acad. Sci. 863:120–128.
  • Elliott-Hunt, C. R., B. Marsh, A. Bacon, R. Pope, P. Vanderplank, and D. Wynick. 2004. Galanin acts as a neuroprotective factor to the hippocampus. Proc. Natl. Acad. Sci. USA 101:5105–5110.
  • Erickson, J. C., K. E. Clegg, and R. D. Palmiter. 1996. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381:415–421.
  • Erickson, J. C., R. S. Ahima, G. Hollopeter, J. S. Flier, and R. D. Palmiter. 1997. Endocrine function of neuropeptide Y knockout mice. Regul. Pept. 70:199–202.
  • Erickson, J. C., G. Hollopeter, and R. D. Palmiter. 1996. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274:1704–1707.
  • Fathi, Z., Cunningham, A. M., L. G. Iben, P. B. Battaglino, S. A. Ward, K. A. Nichol, K. A. Pine, J. Wang, M. E. Goldstein, T. P. Iismaa, and I. A. Zimanyi. 1997. Cloning, pharmacological characterization and distribution of a novel galanin receptor. Brain Res. Mol. Brain Res. 51:49–59.
  • Fathi, Z., A. M. Cunningham, L. G. Iben, P. B. Battaglino, S. A. Ward, K. A. Nichol, K. A. Pine, J. Wang, M. E. Goldstein, T. P. Iismaa, and I. A. Zimanyi. 1998. Cloning, pharmacological characterization and distribution of a novel galanin receptor. Brain Res. Mol. Brain Res. 53:348.
  • Fetissov, S. O., A. S. Jacoby, P. R. Brumovsky, J. Shine, T. P. Iismaa, and T. Hokfelt. 2003. Altered hippocampal expression of neuropeptides in seizure-prone GALR1 knockout mice. Epilepsia 44:1022–1033.
  • Finn, P. D., D. K. Clifton, and R. A. Steiner. 1998. The regulation of galanin gene expression in gonadotropin-releasing hormone neurons. Mol. Cell. Endocrinol. 140:137–142.
  • Gundlach, A. L., T. C. Burazin, and J. A. Larm. 2001. Distribution, regulation and role of hypothalamic galanin systems: renewed interest in a pleiotropic peptide family. Clin. Exp. Pharmacol. Physiol. 28:100–105.
  • Gustafson, E. L., K. E. Smith, M. M. Durkin, C. Gerald, and T. A. Branchek. 1996. Distribution of a rat galanin receptor mRNA in rat brain. Neuroreport 7:953–957.
  • Hohmann, J. G., S. M. Krasnow, D. N. Teklemichael, D. K. Clifton, D. Wynick, and R. A. Steiner. 2003. Neuroendocrine profiles in galanin-overexpressing and knockout mice. Neuroendocrinology 77:354–366.
  • Holmes, A., J. W. Kinney, C. C. Wrenn, Q. Li, R. J. Yang, L. Ma, J. Vishwanath, M. C. Saavedra, C. E. Innerfield, A. S. Jacoby, J. Shine, T. P. Iismaa, and J. N. Crawley. 2003. Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze. Neuropsychopharmacology 28:1031–1044.
  • Howard, A. D., C. Tan, L. L. Shiao, O. C. Palyha, K. K. McKee, D. H. Weinberg, S. D. Feighner, M. A. Cascieri, R. G. Smith, L. H. Van Der Ploeg, and K. A. Sullivan. 1997. Molecular cloning and characterization of a new receptor for galanin. FEBS Lett. 405:285–290.
  • Iismaa, T. P., and J. Shine. 1999. Galanin and galanin receptors. Results Probl. Cell Differ. 26:257–291.
  • Jacoby, A. S., Y. J. Hort, G. Constantinescu, J. Shine, and T. P. Iismaa. 2002. Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity. Brain Res. Mol. Brain Res. 107:195–200.
  • Kieffer, B. L., and C. Gaveriaux-Ruff. 2002. Exploring the opioid system by gene knockout. Prog. Neurobiol. 66:285–306.
  • Kinney J. W., A. M. Barr, B. Conti, M. Behrens, and T. Bartfai. 2004. Initial behavioral characterization of galanin receptor subtype 2 knockout mice, abstr. 1008.13. In Abstr. 34th Annu. Meet. Soc. Neurosci., Society for Neuroscience, Washington, D.C.
  • Kolakowski, L. F., Jr., G. P. O'Neill, A. D. Howard, S. R. Broussard, K. A. Sullivan, S. D. Feighner, M. Sawzdargo, T. Nguyen, S. Kargman, L. L. Shiao, D. L. Hreniuk, C. P. Tan, J. Evans, M. Abramovitz, A. Chateauneuf, N. Coulombe, G. Ng, M. P. Johnson, A. Tharian, H. Khoshbouei, S. R. George, R. G. Smith, and B. F. O'Dowd. 1998. Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3. J. Neurochem. 71:2239–2251.
  • Krasnow, S. M., J. G. Hohmann, A. Gragerov, D. K. Clifton, and R. A. Steiner. 2004. Analysis of the contribution of galanin receptors 1 and 2 to the central actions of galanin-like peptide. Neuroendocrinology 79:268–277.
  • Ma, X., Y. G. Tong, R. Schmidt, W. Brown, K. Payza, L. Hodzic, C. Pou, C. Godbout, T. Hokfelt, and Z. Q. Xu. 2001. Effects of galanin receptor agonists on locus coeruleus neurons. Brain Res. 919:169–174.
  • Mahoney, S. A., R. Hosking, S. Farrant, F. E. Holmes, A. S. Jacoby, J. Shine, T. P. Iismaa, M. K. Scott, R. Schmidt, and D. Wynick. 2003. The second galanin receptor GalR2 plays a key role in neurite outgrowth from adult sensory neurons. J. Neurosci. 23:416–421.
  • Mazarati, A., X. Lu, K. Kilk, U. Langel, C. Wasterlain, and T. Bartfai. 2004. Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus. Eur. J. Neurosci. 19:3235–3244.
  • Mazarati, A., X. Lu, S. Shinmei, H. Badie-Mahdavi, and T. Bartfai. 2004. Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice. Neuroscience 128:431–441.
  • Melander, T., T. Hokfelt, and A. Rokaeus. 1986. Distribution of galaninlike immunoreactivity in the rat central nervous system. J. Comp. Neurol. 248:475–517.
  • Melander, T., T. Hokfelt, A. Rokaeus, J. Fahrenkrug, K. Tatemoto, and V. Mutt. 1985. Distribution of galanin-like immunoreactivity in the gastro-intestinal tract of several mammalian species. Cell Tissue Res. 239:253–270.
  • Mennicken, F., C. Hoffert, M. Pelletier, S. Ahmad, and D. O'Donnell. 2002. Restricted distribution of galanin receptor 3 (GalR3) mRNA in the adult rat central nervous system. J. Chem. Neuroanat. 24:257–268.
  • Niiro, N., J. Nishimura, K. Hirano, H. Nakano, and H. Kanaide. 1998. Mechanisms of galanin-induced contraction in the rat myometrium. Br. J. Pharmacol. 124:1623–1632.
  • O'Donnell, D., S. Ahmad, C. Wahlestedt, and P. Walker. 1999. Expression of the novel galanin receptor subtype GALR2 in the adult rat CNS: distinct distribution from GALR1. J. Comp. Neurol. 409:469–481.
  • Ottlecz, A., G. D. Snyder, and S. M. McCann. 1988. Regulatory role of galanin in control of hypothalamic-anterior pituitary function. Proc. Natl. Acad. Sci. USA 85:9861–9865.
  • Pang, L., T. Hashemi, H. J. Lee, M. Maguire, M. P. Graziano, M. Bayne, B. Hawes, G. Wong, and S. Wang. 1998. The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization. J. Neurochem. 71:2252–2259.
  • Phillips, R. G., and J. E. LeDoux. 1994. Lesions of the dorsal hippocampal formation interfere with background but not foreground contextual fear conditioning. Learn. Mem. 1:34–44.
  • Saar, K., A. M. Mazarati, R. Mahlapuu, G. Hallnemo, U. Soomets, K. Kilk, S. Hellberg, M. Pooga, B. R. Tolf, T. S. Shi, T. Hokfelt, C. Wasterlain, T. Bartfai, and U. Langel. 2002. Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc. Natl. Acad. Sci. USA 99:7136–7141.
  • Schwartz, M. W., and G. J. Morton. 2002. Obesity: keeping hunger at bay. Nature 418:595–597.
  • Skofitsch, G., and D. M. Jacobowitz. 1986. Quantitative distribution of galanin-like immunoreactivity in the rat central nervous system. Peptides 7:609–613.
  • Skofitsch, G., and D. M. Jacobowitz. 1985. Immunohistochemical mapping of galanin-like neurons in the rat central nervous system. Peptides 6:509–546.
  • Smith, K. E., C. Forray, M. W. Walker, K. A. Jones, J. A. Tamm, J. Bard, T. A. Branchek, D. L. Linemeyer, and C. Gerald. 1997. Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover. J. Biol. Chem. 272:24612–24616.
  • Sten Shi, T. J., X. Zhang, K. Holmberg, Z. Q. Xu, and T. Hokfelt. 1997. Expression and regulation of galanin-R2 receptors in rat primary sensory neurons: effect of axotomy and inflammation. Neurosci. Lett. 237:57–60.
  • Tatemoto, K., A. Rokaeus, H. Jornvall, T. J. McDonald, and V. Mutt. 1983. Galanin—a novel biologically active peptide from porcine intestine. FEBS Lett. 164:124–128.
  • Thiele, T. E., G. I. Miura, D. J. Marsh, I. L. Bernstein, and R. D. Palmiter. 2000. Neurobiological responses to ethanol in mutant mice lacking neuropeptide Y or the Y5 receptor. Pharmacol. Biochem. Behav. 67:683–691.
  • Vrontakis, M. E., I. C. Schroedter, H. Cosby, and H. G. Friesen. 1992. Expression and secretion of galanin during pregnancy in the rat. Endocrinology 130:458–464.
  • Vrontakis, M., I. Schroedter, V. Leite, and H. G. Friesen. 1993. Estrogen regulation and localization of galanin gene expression in the rat uterus. Biol. Reprod. 49:1245–1250.
  • Wang, S., T. Hashemi, S. Fried, A. L. Clemmons, and B. E. Hawes. 1998. Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes. Biochemistry 37:6711–6717.
  • Wang, S., L. Ghibaudi, T. Hashemi, C. He, C. Strader, M. Bayne, H. Davis, and J. J. Hwa. 1998. The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation. FEBS Lett. 434:277–282.
  • Wittau, N., R. Grosse, F. Kalkbrenner, A. Gohla, G. Schultz, and T. Gudermann. 2000. The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to G(q), G(i) and G(12) proteins. Oncogene 19:4199–4209.
  • Wrenn, C. C., J. W. Kinney, L. K. Marriott, A. Holmes, A. P. Harris, M. C. Saavedra, G. Starosta, C. E. Innerfield, A. S. Jacoby, J. Shine, T. P. Iismaa, G. L. Wenk, and J. N. Crawley. 2004. Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor. Eur. J. Neurosci. 19:1384–1396.
  • Wu, W. P., J. X. Hao, L. Lundstrom, Z. Wiesenfeld-Hallin, U. Langel, T. Bartfai, and X. J. Xu. 2003. Systemic galnon, a low-molecular weight galanin receptor agonist, reduces heat hyperalgesia in rats with nerve injury. Eur. J. Pharmacol. 482:133–137.
  • Zhang, X., Z. O. Xu, T. J. Shi, M. Landry, K. Holmberg, G. Ju, Y. G. Tong, L. Bao, X. P. Cheng, Z. Wiesenfeld-Hallin, A. Lozano, J. Dostrovsky, and T. Hokfelt. 1998. Regulation of expression of galanin and galanin receptors in dorsal root ganglia and spinal cord after axotomy and inflammation. Ann. N. Y. Acad. Sci. 863:402–413.

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