9
Views
14
CrossRef citations to date
0
Altmetric
Chromosome Structure and Dynamics

Novel PMS1 Alleles Preferentially Affect the Repair of Primer Strand Loops during DNA Replication

, , , &
Pages 9221-9231 | Received 14 Mar 2005, Accepted 21 Jul 2005, Published online: 27 Mar 2023

REFERENCES

  • Ban, C., and W. Yang. 1998. Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis. Cell 95:541–552.
  • Baudin, A., O. Ozier-Kalogeropoulos, A. Denouel, F. Lacroute, and C. Cullin. 1993. A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res. 21:3329–3330.
  • Bellacosa, A. 2001. Functional interactions and signaling properties of mammalian DNA mismatch repair proteins. Cell Death Differ. 8:1076–1092.
  • Bowers, J., P. T. Tran, A. Joshi, R. M. Liskay, and E. Alani. 2001. MSH-MLH complexes formed at a DNA mismatch are disrupted by the PCNA sliding clamp. J. Mol. Biol. 306:957–968.
  • Bronner, C. E., S. M. Baker, P. T. Morrison, G. Warren, L. G. Smith, M. K. Lescoe, M. Kane, C. Earabino, J. Lipford, A. Lindblom, P. Tannergard, R. J. Bollag, A. R. Godwin, D. C. Ward, M. Nordenskjold, R. Fishel, R. Kolodner, and R. M. Liskay. 1994. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary nonpolyposis colon cancer. Nature 368:258–261.
  • Brown, K. D., A. Rathi, R. Kamath, D. I. Beardsley, Q. Zhan, J. L. Mannino, and R. Baskaran. 2003. The mismatch repair system is required for S-phase checkpoint activation. Nat. Genet. 33:80–84.
  • Buermeyer, A. B., S. M. Deschenes, S. M. Baker, and R. M. Liskay. 1999. Mammalian DNA mismatch repair. Annu. Rev. Genet. 33:533–564.
  • Chattoo, B. B., F. Sherman, T. A. Azubalis, T. A. Fjellstedt, D. Mehnert, and M. Ogur. 1979. Selection of lys2 mutants of yeast Saccharomyces cerevisiae by the utilization of α-aminoadipate. Genetics 93:51–65.
  • Clark, A. B., F. Valle, K. Drotschmann, R. K. Gary, and T. A. Kunkel. 2000. Functional interaction of proliferating cell nuclear antigen with MSH2- MSH6 and MSH2-MSH3 complexes. J. Biol. Chem. 275:36498–36501.
  • Dao, V., and P. Modrich. 1998. Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex. J. Biol. Chem. 273:9202–9207.
  • Detloff, P., M. A. White, and T. D. Petes. 1992. Analysis of a gene conversion gradient at the HIS4 locus in Saccharomyces cerevisiae. Genetics 132:113–123.
  • Drotschmann, K., A. Aronshtam, H. J. Fritz, and M. G. Marinus. 1998. The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA. Nucleic Acids Res. 26:948–953.
  • Edelmann, L., and W. Edelmann. 2004. Loss of DNA mismatch repair function and cancer predisposition in the mouse: animal models for human hereditary nonpolyposis colorectal cancer. Am. J. Med. Genet. C 129:91–99.
  • Erdeniz, N., U. H. Mortensen, and R. Rothstein. 1997. Cloning-free PCR-based allele replacement methods. Genome Res. 7:1174–1183.
  • Fan, Q., F. Xu, and T. D. Petes. 1995. Meiosis-specific double-strand DNA breaks at the HIS4 recombination hot spot in the yeast Saccharomyces cerevisiae: control in cis and trans. Mol. Cell. Biol. 15:1679–1688.
  • Fishel, R., M. K. Lescoe, M. R. Rao, N. G. Copeland, N. A. Jenkins, J. Garber, M. Kane, and R. Kolodner. 1993. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75:1027–1038.
  • Fleig, U. N., R. D. Pridmore, and P. Philippsen. 1986. Construction of LYS2 cartridges for use in genetic manipulations of Saccharomyces cerevisiae. Gene 46:237–245.
  • Flores-Rozas, H., D. Clark, and R. D. Kolodner. 2000. Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex. Nat. Genet. 26:375–378.
  • Flores-Rozas, H., and R. D. Kolodner. 1998. The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations. Proc. Natl. Acad. Sci. USA 95:12404–12409.
  • Goldstein, A. L., X. Pan, and J. H. McCusker. 1999. Heterologous URA3MX cassettes for gene replacement in Saccharomyces cerevisiae. Yeast 15:507–511.
  • Gragg, H., B. D. Harfe, and S. Jinks-Robertson. 2002. Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae. Mol. Cell. Biol. 22:8756–8762.
  • Gu, L., Y. Hong, S. McCulloch, H. Watanabe, and G. M. Li. 1998. ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair. Nucleic Acids Res. 26:1173–1178.
  • Guarne, A., S. Ramon-Maiques, E. M. Wolff, R. Ghirlando, X. Hu, J. H. Miller, and W. Yang. 2004. Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair. EMBO J. 23:4134–4145.
  • Habraken, Y., P. Sung, L. Prakash, and S. Prakash. 1997. Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complex. Curr. Biol. 7:790–793.
  • Hall, M. C., J. R. Jordan, and S. W. Matson. 1998. Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD. EMBO J. 17:1535–1541.
  • Hall, M. C., and S. W. Matson. 1999. The Escherichia coli MutL protein physically interacts with MutH and stimulates the MutH-associated endonuclease activity. J. Biol. Chem. 274:1306–1312.
  • Hall, M. C., P. V. Shcherbakova, J. M. Fortune, C. H. Borchers, J. M. Dial, K. B. Tomer, and T. A. Kunkel. 2003. DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair. Nucleic Acids Res. 31:2025–2034.
  • Harfe, B. D., and S. Jinks-Robertson. 2000. DNA mismatch repair and genetic instability. Annu. Rev. Genet. 34:359–399.
  • Harfe, B. D., and S. Jinks-Robertson. 2000. Sequence composition and context effects on the generation and repair of frameshift intermediates in mononucleotide runs in Saccharomyces cerevisiae. Genetics 156:571–578.
  • Harfe, B. D., B. K. Minesinger, and S. Jinks-Robertson. 2000. Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast. Curr. Biol. 10:145–148.
  • Jiricny, J. 1998. Eukaryotic mismatch repair: an update. Mutat. Res. 409:107–121.
  • Johnson, R. E., G. K. Kovvali, L. Prakash, and S. Prakash. 1996. Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability. J. Biol. Chem. 271:7285–7288.
  • Kirchner, J. M., H. Tran, and M. A. Resnick. 2000. A DNA polymerase epsilon mutant that specifically causes +1 frameshift mutations within homonucleotide runs in yeast. Genetics 155:1623–1632.
  • Kleczkowska, H. E., G. Marra, T. Lettieri, and J. Jiricny. 2001. hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci. Genes Dev. 15:724–736.
  • Kolodner, R. D., and G. T. Marsischky. 1999. Eukaryotic DNA mismatch repair. Curr. Opin. Genet. Dev. 9:89–96.
  • Lau, P. J., H. Flores-Rozas, and R. D. Kolodner. 2002. Isolation and characterization of new proliferating cell nuclear antigen (POL30) mutator mutants that are defective in DNA mismatch repair. Mol. Cell. Biol. 22:6669–6680.
  • Lea, D., and C. Coulson. 1948. The distribution of the number of mutants in bacterial populations. J. Genet. 49:264–285.
  • Leach, F. S., N. C. Nicolaides, N. Papadopoulos, B. Liu, J. Jen, R. Parsons, P. Peltomaki, P. Sistonen, L. A. Aaltonen, M. Nystrom-Lahti, X.-Y. Guan, J. Zhang, P. S. Meltzer, J.-W. Yu, F.-T. Kao, D. J. Chen, K. M. Cerosaletti, R. E. K. Fournier, S. Todd, T. Lewis, R. J. Leach, S. L. Naylor, J. Weissenbach, J.-P. Mecklin, H. Jarvinen, G. M. Petersen, S. R. Hamilton, J. Green, J. Jass, P. Watson, H. T. Lynch, J. M. Trent, A. de la Chapelle, K. W. Kinzler, and B. Vogelstein. 1993. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75:1215–1225.
  • Liang, Q., and T. Richardson. 1992. A simple and rapid method for screening transformant yeast colonies using PCR. BioTechniques 13:730–732, 735.
  • Ma, H., S. Kunes, P. J. Schatz, and D. Botstein. 1987. Plasmid construction by homologous recombination in yeast. Gene 58:201–216.
  • Marsischky, G. T., N. Filosi, M. F. Kane, and R. Kolodner. 1996. Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Genes Dev. 10:407–420.
  • Marti, T. M., C. Kunz, and O. Fleck. 2002. DNA mismatch repair and mutation avoidance pathways. J. Cell Physiol. 191:28–41.
  • Mechanic, L. E., B. A. Frankel, and S. W. Matson. 2000. Escherichia coli MutL loads DNA helicase II onto DNA. J. Biol. Chem. 275:38337–38346.
  • Modrich, P., and R. Lahue. 1996. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu. Rev. Biochem. 65:101–133.
  • New, L., K. Liu, and G. F. Crouse. 1993. The yeast gene MSH3 defines a new class of eukaryotic MutS homologues. Mol. Gen. Genet. 239:97–108.
  • Newlon, C. S., L. R. Lipchitz, I. Collins, A. Deshpande, R. J. Devenish, R. P. Green, H. L. Klein, T. G. Palzkill, R. B. Ren, S. Synn, et al. 1991. Analysis of a circular derivative of Saccharomyces cerevisiae chromosome III: a physical map and identification and location of ARS elements. Genetics 129:343–357.
  • Nicolas, A., and T. D. Petes. 1994. Polarity of meiotic gene conversion in fungi: contrasting views. Experientia 50:242–252.
  • Orr-Weaver, T. L., J. W. Szostak, and R. J. Rothstein. 1983. Genetic applications of yeast transformation with linear and gapped plasmids. Methods Enzymol. 101:228–245.
  • Pang, Q., T. A. Prolla, and R. M. Liskay. 1997. Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations. Mol. Cell. Biol. 17:4465–4473.
  • Papadopoulos, N., N. C. Nicolaides, Y.-F. Wei, S. M. Ruben, K. C. Carter, C. A. Rosen, W. A. Haseltine, R. D. Fleischmann, C. M. Fraser, M. D. Adams, J. C. Venter, S. R. Hamilton, G. M. Petersen, P. Watson, H. T. Lynch, P. Peltomaki, J.-P. Mecklin, A. de la Chapelle, K. W. Kinzler, and B. Vogelstein. 1994. Mutation of a mutL homolog in hereditary colon cancer. Science 263:1625–1629.
  • Pavlov, Y. I., I. M. Mian, and T. A. Kunkel. 2003. Evidence for preferential mismatch repair of lagging strand DNA replication errors in yeast. Curr. Biol. 13:744–748.
  • Petes, T. D. 2001. Meiotic recombination hot spots and cold spots. Nat. Rev. Genet. 2:360–369.
  • Prolla, T. A., D. M. Christie, and R. M. Liskay. 1994. Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene. Mol. Cell. Biol. 14:407–415.
  • Prolla, T. A., Q. Pang, E. Alani, R. D. Kolodner, and R. M. Liskay. 1994. MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast. Science 265:1091–1093.
  • Scherer, S., and R. W. Davis. 1979. Replacement of chromosome segments with altered DNA sequences constructed in vitro. Proc. Natl. Acad. Sci. USA 76:4951–4955.
  • Schofield, M. J., and P. Hsieh. 2003. DNA mismatch repair: molecular mechanisms and biological function. Annu. Rev. Microbiol. 57:579–608.
  • Shcherbakova, P. V., and T. A. Kunkel. 1999. Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations. Mol. Cell. Biol. 19:3177–3183.
  • Sherman, F. 1991. Getting started with yeast. Methods Enzymol. 194:3–21.
  • Sia, E. A., R. J. Kokoska, M. Dominska, P. Greenwell, and T. D. Petes. 1997. Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes. Mol. Cell. Biol. 17:2851–2858.
  • Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19–27.
  • Stapleton, A., and T. D. Petes. 1991. The Tn3 beta-lactamase gene acts as a hotspot for meiotic recombination in yeast. Genetics 127:39–51.
  • Stojic, L., R. Brun, and J. Jiricny. 2004. Mismatch repair and DNA damage signalling. DNA Repair 3:1091–1101.
  • Storici, F., L. K. Lewis, and M. A. Resnick. 2001. In vivo site-directed mutagenesis using oligonucleotides. Nat. Biotechnol. 19:773–776.
  • Strand, M., M. C. Earley, G. F. Crouse, and T. D. Petes. 1995. Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 92:10418–10421.
  • Thomas, B. J., and R. Rothstein. 1989. Elevated recombination rates in transcriptionally active DNA. Cell 56:619–630.
  • Tran, H. T., J. D. Keen, M. Kricker, M. A. Resnick, and D. A. Gordenin. 1997. Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants. Mol. Cell. Biol. 17:2859–2865.
  • Tran, P. T., and R. M. Liskay. 2000. Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLα. Mol. Cell. Biol. 20:6390–6398.
  • Twerdi, C. D., J. C. Boyer, and R. A. Farber. 1999. Relative rates of insertion and deletion mutations in a microsatellite sequence in cultured cells. Proc. Natl. Acad. Sci. USA 96:2875–2879.
  • Umar, A., A. B. Buermeyer, J. A. Simon, D. C. Thomas, A. B. Clark, R. M. Liskay, and T. A. Kunkel. 1996. Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell 87:65–73.
  • van der Kemp, P. A., D. Thomas, R. Barbey, R. de Oliveira, and S. Boiteux. 1996. Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine. Proc. Natl. Acad. Sci. USA 93:5197–5202.
  • von Borstel, R. C., E. A. Savage, Q. Wang, U. G. Hennig, R. G. Ritzel, G. S. Lee, M. D. Hamilton, M. A. Chrenek, R. W. Tomaszewski, J. A. Higgins, C. J. Tenove, L. Liviero, P. J. Hastings, C. T. Korch, and C. M. Steinberg. 1998. Topical reversion at the HIS1 locus of Saccharomyces cerevisiae. A tale of three mutants. Genetics 148:1647–1654.
  • Wang, T. F., N. Kleckner, and N. Hunter. 1999. Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction. Proc. Natl. Acad. Sci. USA 96:13914–13919.
  • Welz-Voegele, C., J. E. Stone, P. T. Tran, H. M. Kearney, R. M. Liskay, T. D. Petes, and S. Jinks-Robertson. 2002. Alleles of the yeast PMS1 mismatch-repair gene that differentially affect recombination- and replication-related processes. Genetics 162:1131–1145.
  • Yamaguchi, M., V. Dao, and P. Modrich. 1998. MutS and MutL activate DNA helicase II in a mismatch-dependent manner. J. Biol. Chem. 273:9197–9201.
  • Zhao, X., B. Georgieva, A. Chabes, V. Domkin, J. H. Ippel, J. Schleucher, S. Wijmenga, L. Thelander, and R. Rothstein. 2000. Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality. Mol. Cell. Biol. 20:9076–9083.
  • Zhu, J., C. S. Newlon, and J. A. Huberman. 1992. Localization of a DNA replication origin and termination zone on chromosome III of Saccharomyces cerevisiae. Mol. Cell. Biol. 12:4733–4741.
  • Zou, H., and R. Rothstein. 1997. Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism. Cell 90:87–96.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.