Phosphorylation of Par-4 by Protein Kinase A Is Critical for Apoptosis

REFERENCES

• Barradas, M., A. Monjas, M. T. Diaz-Meco, M. Serrano, and J. Moscat. 1999. The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J. 18:6362–6369.
   PubMed Web of Science ®Google Scholar
• Boehrer, S., K. U. Chow, E. Puccetti, M. Ruthardt, S. Godzisard, A. Krapohl, B. Schneider, D. Hoelzer, P. S. Mitrou, V. M. Rangnekar, and E. Weidmann. 2001. Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia. Hematol. J. 2:103–107.
   PubMedGoogle Scholar
• Chakraborty, M., S. G. Qiu, K. M. Vasudevan, and V. M. Rangnekar. 2001. Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Cancer Res. 61:7255–7263.
   PubMed Web of Science ®Google Scholar
• Cho, Y. S., Y. G. Park, Y. N. Lee, M. K. Kim, S. Bates, L. Tan, and Y. S. Cho-Chung. 2000. Extracellular protein kinase A as a cancer biomarker: its expression by tumor cells and reversal by a myristate-lacking Cα and RIIβ subunit overexpression. Proc. Natl. Acad. Sci. USA 97:835–840.
   PubMedGoogle Scholar
• Cho-Chung, Y. S., M. Nesterova, K. G. Becker, R. Srivastava, Y. G. Park, Y. N. Lee, Y. S. Cho, M. K. Kim, C. Neary, and C. Cheadle. 2002. Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoy. Ann. N. Y. Acad. Sci. 968:22–36.
   PubMedGoogle Scholar
• Collins, S. P., J. L. Reoma, D. M. Gamm, and M. D. Uhler. 2000. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem. J. 345:673–680.
   PubMed Web of Science ®Google Scholar
• Cook, J., S. Krishnan, S. Ananth, S. F. Sells, Y. Shi, M. M. Walther, W. M. Linehan, V. P. Sukhatme, M. H. Weinstein, and V. M. Rangnekar. 1999. Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma. Oncogene 18:1205–1208.
   PubMed Web of Science ®Google Scholar
• Corbin, J. D., and S. L. Keely. 1977. Characterization and regulation of heart adenosine 3′:5′-monophosphate-dependent protein kinase isozymes. J. Biol. Chem. 252:910–918.
   PubMed Web of Science ®Google Scholar
• Corbin, J. D., T. R. Soderling, and C. R. Park. 1973. Regulation of adenosine 3′,5′-monophosphate-dependent protein kinase. I. Preliminary characterization of the adipose tissue enzyme in crude extracts. J. Biol. Chem. 248:1813–1821.
   Google Scholar
• Cvijic, M. E., T. Kita, W. Shih, R. S. DiPaola, and K. V. Chin. 2000. Extracellular catalytic subunit activity of the cAMP-dependent protein kinase in prostate cancer. Clin. Cancer Res. 6:2309–2317.
   PubMedGoogle Scholar
• El-Guendy, N., and V. M. Rangnekar. 2003. Apoptosis by Par-4 in cancer and neurodegenerative diseases. Exp. Cell Res. 283:51–66.
   PubMed Web of Science ®Google Scholar
• El-Guendy, N., Y. Zhao, S. Gurumurthy, R. Burikhanov, and V. M. Rangnekar. 2003. Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells. Mol. Cell. Biol. 23:5516–5525.
   PubMedGoogle Scholar
• Gibbs, C. S., D. R. Knighton, J. M. Sowadski, S. S. Taylor, and M. J. Zoller. 1992. Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit. J. Biol. Chem. 267:4806–4814.
   PubMedGoogle Scholar
• Harada, H., B. Becknell, M. Wilm, M. Mann, L. J. Huang, S. S. Taylor, J. D. Scott, and S. J. Korsmeyer. 1999. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol. Cell 3:413–422.
   PubMed Web of Science ®Google Scholar
• Kogel, D., C. Reimertz, P. Mech, M. Poppe, M. C. Fruhwald, H. Engemann, K. H. Scheidtmann, and J. H. Prehn. 2001. Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway. Br. J. Cancer 85:1801–1808.
   PubMedGoogle Scholar
• Michalides, R., A. Griekspoor, A. Balkenende, D. Verwoerd, L. Janssen, K. Jalink, A. Floore, A. Velds, L. van't Veer, and J. Neefjes. 2004. Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer. Cancer Cell 5:597–605.
   PubMed Web of Science ®Google Scholar
• Nalca, A., S. G. Qiu, N. El-Guendy, S. Krishnan, and V. M. Rangnekar. 1999. Oncogenic Ras sensitizes cells to apoptosis by Par-4. J. Biol. Chem. 274:29976–29983.
   PubMed Web of Science ®Google Scholar
• Qiu, S. G., S. Krishnan, N. el-Guendy, and V. M. Rangnekar. 1999. Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation. Oncogene 18:7115–7123.
   PubMed Web of Science ®Google Scholar
• Schneider, B. G., S. Y. Rha, H. C. Chung, J. C. Bravo, R. Mera, J. C. Torres, K. T. Plaisance, Jr., R. Schlegel, C. M. McBride, X. T. Reveles, and R. J. Leach. 2003. Regions of allelic imbalance in the distal portion of chromosome 12q in gastric cancer. Mol. Pathol. 56:141–149.
   PubMedGoogle Scholar
• Sells, S. F., D. P. Wood, Jr., S. S. Joshi-Barve, S. Muthukumar, R. J. Jacob, S. A. Crist, S. Humphreys, and V. M. Rangnekar. 1994. Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells. Cell Growth Differ. 5:457–466.
   PubMedGoogle Scholar
• Srivastava, R. K., A. R. Srivastava, S. J. Korsmeyer, M. Nesterova, Y. S. Cho-Chung, and D. L. Longo. 1998. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Mol. Cell. Biol. 18:3509–3517.
   PubMed Web of Science ®Google Scholar
• Stergiopoulos, S. G., and C. A. Stratakis. 2003. Human tumors associated with Carney complex and germline PRKAR1A mutations: a protein kinase A disease. FEBS Lett. 546:59–64.
   PubMed Web of Science ®Google Scholar
• Tortora, G., and F. Ciardiello. 2002. Protein kinase A as target for novel integrated strategies of cancer therapy. Ann. N. Y. Acad. Sci. 968:139–147.
   PubMedGoogle Scholar
• Wang, Y. H., J. D. Scott, G. S. McKnight, and E. G. Krebs. 1991. A constitutively active holoenzyme form of the cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 88:2446–2450.
   PubMedGoogle Scholar
• Wu, K. J., M. Mattioli, H. C. Morse III, and R. Dalla-Favera. 2002. c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cβ) gene. Oncogene 21:7872–7882.
   PubMed Web of Science ®Google Scholar
• Zhong, H., R. E. Voll, and S. Ghosh. 1998. Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1:661–671.
   PubMed Web of Science ®Google Scholar