Deltex Regulates T-Cell Activation by Targeted Degradation of Active MEKK1

REFERENCES

• Avraham, A., S. Jung, Y. Samuels, R. Seger, and Y. Ben-Neriah. 1998. Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes. Eur. J. Immunol. 28:2320–2330.
   PubMedGoogle Scholar
• Baud, V., Z. G. Liu, B. Bennett, N. Suzuki, Y. Xia, and M. Karin. 1999. Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev. 13:1297–1308.
   PubMed Web of Science ®Google Scholar
• Chadee, D. N., T. Yuasa, and J. M. Kyiakis. 2002. Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. Mol. Cell. Biol. 22:737–749.
   PubMedGoogle Scholar
• Chen, Y., and M. Z. Lai. 2001. JNK-induced apoptosis is independent of Fas ligand in Jurkat T cells. J. Biol. Chem. 276:8350–8357.
   PubMedGoogle Scholar
• Costa, G. L., J. M. Benson, C. M. Seroogy, P. Achacoso, C. J. Fathman, and G. P. Nolan. 2000. Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease. J. Immunol. 164:3581–3590.
   PubMed Web of Science ®Google Scholar
• Cuenda, A., and D. S. Dorow. 1998. Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1. Biochem. J. 333:11–15.
   PubMedGoogle Scholar
• Deftos, M. L., Y. W. He, E. W. Ojala, and M. J. Bevan. 1998. Correlating notch signaling with thymocyte maturation. Immunity 9:777–786.
   PubMed Web of Science ®Google Scholar
• Efimova, T., P. LaCelle, J. F. Welter, and R. L. Eckert. 1998. Regulation of human involucrin promoter activity by a protein kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 signal transduction pathway. J. Biol. Chem. 273:24387–24395.
   PubMedGoogle Scholar
• Fang, L. W., T. S. Tai, W. N. Yu, F. Liao, and M. Z. Lai. 2004. Phosphatidylinositide 3-kinase priming couples c-FLIP to T cell activation. J. Biol. Chem. 279:13–18.
   PubMed Web of Science ®Google Scholar
• Gallagher, E. D., S. Gutowski, P. C. Sternweis, and M. H. Cobb. 2004. RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity. J. Biol. Chem. 279:1872–1877.
   PubMed Web of Science ®Google Scholar
• Guan, Z., S. Y. Buckman, A. P. Pentland, D. J. Templeton, and A. R. Morrison. 1998. Induction of cyclooxygenase-2 by the activated MEKK1 → SEK1/MKK4 → p38 mitogen-activated protein kinase pathway. J. Biol. Chem. 273:12901–12908.
   PubMed Web of Science ®Google Scholar
• Gupta-Rossi, N., S. Storck, P. J. Griebel, C. A. Reynaud, J. C. Weill, and A. Dahan. 2003. Specific over-expression of DTX and a new Kelch-like protein in human germinal center B cells. Mol. Immunol. 39:791–799.
   PubMed Web of Science ®Google Scholar
• Hershko, A., A. Ciechanover, and A. Varshavsky. 2000. The ubiquitin system. Nat. Med. 6:1073–1081.
   PubMed Web of Science ®Google Scholar
• Ho, H. Y., H. H. Lee, and M. Z. Lai. 1997. Overexpression of mitogen-activated protein kinase kinase kinase reverses cAMP inhibition of NF-κB in T cells. Eur. J. Immunol. 27:222–226.
   PubMedGoogle Scholar
• Hsu, S. C., M. Gavrilin, M. H. Tsai, J. Han, and M. Z. Lai. 1999. p38 mitogen activated protein kinase is involved in Fas ligand expression. J. Biol. Chem. 274:25769–25776.
   PubMedGoogle Scholar
• Isakov, N., and A. Altman. 2002. Protein kinase Cθ in T cell activation. Annu. Rev. Immunol. 20:761–794.
   PubMed Web of Science ®Google Scholar
• Izon, D. J., J. C. Aster, Y. He, A. Weng, F. G. Karnell, V. Patriub, L. Xu, S. Bakkour, C. Rodriguez, D. Allman, and W. S. Pear. 2002. DTX1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. Immunity 16:231–243.
   PubMedGoogle Scholar
• Jackson, P. K., A. G. Eldridge, E. Freed, L. Furstenthal, J. Y. Hsu, B. K. Kaiser, and J. D. Reimann. 2000. The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol. 10:429–439.
   PubMed Web of Science ®Google Scholar
• Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333–342.
   PubMed Web of Science ®Google Scholar
• Joazeiro, C. A., and A. M. Weissman. 2000. RING finger proteins: mediators of ubiquitin ligase activity. Cell 102:549–552.
   PubMed Web of Science ®Google Scholar
• Kaga, S., S. Ragg, K. A. Rogers, and A. Ochi. 1998. Activation of p21-CDC42/Rac-activated kinases by CD28 signaling: p21-activated kinase (PAK) and MEK kinase 1 (MEKK1) may mediate the interplay between CD3 and CD28 signals. J. Immunol. 160:4182–4189.
   PubMedGoogle Scholar
• Karandikar, M., S. Xu, and M. H. Cobb. 2000. MEKK1 binds raf-1 and the ERK2 cascade components. J. Biol. Chem. 275:40120–40127.
   PubMed Web of Science ®Google Scholar
• Karin, M., Z. Liu, and E. Zandi. 1997. AP-1 function and regulation. Curr. Opin. Cell Biol. 9:240–246.
   PubMed Web of Science ®Google Scholar
• Kishi, N., Z. Tang, Y. Maeda, A. Hirai, R. Mo, M. Ito, S. Suzuki, K. Nakao, T. Kinoshita, T. Kadesch, C. Hui, S. Artavanis-Tsakonas, H. Okano, and K. Matsuno. 2001. Murine homologs of DTX define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Int. J. Dev. Neurosci. 19:21–35.
   PubMedGoogle Scholar
• Kyriakis, J. M., and J. Avruch. 2001. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81:807–869.
   PubMed Web of Science ®Google Scholar
• Lange-Carter, C. A., C. M. Pleiman, A. M. Gardner, K. J. Blumer, and G. L. Johnson. 1993. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260:315–319.
   PubMed Web of Science ®Google Scholar
• Lu, Z., S. Xu, C. Joazeiro, M. H. Cobb, and T. Hunter. 2002. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol. Cell 9:945–956.
   PubMed Web of Science ®Google Scholar
• Maillard, I., S. H. Adler, and W. S. Pear. 2003. Notch and the immune system. Immunity 19:781–791.
   PubMed Web of Science ®Google Scholar
• Matsuda, S., T. Moriguchi, S. Koyasu, and E. Nishida. 1998. T lymphocyte activation signal for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK-JNK signaling pathways sensitive to cyclosporin A. J. Biol. Chem. 273:12378–12382.
   PubMed Web of Science ®Google Scholar
• Matsuno, K., R. J. Diederich, M. J. Go, C. M. Blaumueller, and S. Artavanis-Tsakonas. 1995. DTX acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development 121:2633–2644.
   PubMed Web of Science ®Google Scholar
• Matsuno, K., D. Eastman, T. Mitsiades, A. M. Quinn, M. L. Carcanciu, P. Ordentlich, T. Kadesch, and S. Artavanis-Tsakonas. 1998. Human DTX is a conserved regulator of Notch signalling. Nat. Genet. 19:74–78.
   PubMed Web of Science ®Google Scholar
• Meyer, C. F., X. Wang, C. Chang, D. Templeton, and T. H. Tan. 1996. Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating κB enhancer activation. J. Biol. Chem. 271:8971–8976.
   PubMedGoogle Scholar
• Minden, A., A. Lin, M. McMahon, C. Lange-Carter, B. Derijard, R. J. Davis, G. L. Johnson, and M. Karin. 1994. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266:1719–1723.
   PubMed Web of Science ®Google Scholar
• Novak, T. J., P. M. White, and E. V. Rothenberg. 1990. Regulatory anatomy of the murine interleukin-2 gene. Nucleic Acids Res. 18:4523–4533.
   PubMed Web of Science ®Google Scholar
• Ordentlich, P., A. Lin, C. P. Shen, C. Blaumueller, K. Matsuno, S. Artavanis-Tsaonas, and T. Kadesch. 1998. Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol. Cell. Biol. 18:2230–2239.
   PubMed Web of Science ®Google Scholar
• Pearson, G., F. Robinson, T. B. Gibson, B. E. Xu, M. Karandikar, K. Berman, and M. H. Cobb. 2001. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22:153–183.
   PubMed Web of Science ®Google Scholar
• Pickart, C. M. 2004. Back to the future with ubiquitin. Cell 116:181–190.
   PubMedGoogle Scholar
• Saito, T., S. Chiba, M. Ichikawa, A. Kunisato, T. Asai, K. Shimizu, T. Tamaguchi, G. Yamamoto, S. Seo, K. Kumano, E. Nakagami-Yamaguchi, Y. Hamada, S. Aizawa, and H. Hirai. 2003. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 18:675–685.
   PubMed Web of Science ®Google Scholar
• Salojin, K. V., J. Zhang, and T. L. Delovitch. 1999. TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway. J. Immunol. 163:844–853.
   PubMedGoogle Scholar
• Samelson, L. E. 2002. Signal transduction mediated by the T cell antigen receptor: the role of adaptor protein. Annu. Rev. Immunol. 20:371–394.
   PubMed Web of Science ®Google Scholar
• Takeyama, K., R. C. Aguiar, L. Gu, C. He, G. J. Freeman, J. L. Kutok, J. C. Aster, and M. A. Shipp. 2003. The BAL-binding protein BBAP and related DTX family members exhibit ubiquitin-protein isopeptide ligase activity. J. Biol. Chem. 278:21930–21937.
   PubMedGoogle Scholar
• Werlen, G., E. Jacinto, Y. Xia, and M. Karin. 1998. Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. EMBO J. 17:3101–3111.
   PubMed Web of Science ®Google Scholar
• Widmann, C., P. Gerwins, N. L. Johnson, M. B. Jarpe, and G. L. Johnson. 1998. MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis. Mol. Cell. Biol. 18:2416–2429.
   PubMed Web of Science ®Google Scholar
• Winzen, R., M. Kracht, B. Ritter, A. Wilhelm, C. Y. Chen, A. B. Shyu, M. Muller, M. Gaestel, K. Resch, and H. Holtmann. 1999. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J. 18:4969–4980.
   PubMed Web of Science ®Google Scholar
• Witowsky, J. A., and G. L. Johnson. 2003. Ubiquitination of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways. J. Biol. Chem. 278:1403–1406.
   PubMedGoogle Scholar
• Wu, C. C., S. C. Hsu, H. M. Shih, and M. Z. Lai. 2003. NFATc is a target of p38 mitogen activated protein kinase in T cells. Mol. Cell. Biol. 23:6442–6454.
   PubMedGoogle Scholar
• Xia, Y., Z. Wu, B. Su, B. Murray, and M. Karin. 1998. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev. 12:3369–3381.
   PubMed Web of Science ®Google Scholar
• Xu, S., D. J. Robbins, L. B. Christerson, J. M. English, C. A. Vanderbilt, and M. H. Cobb. 1996. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc. Natl. Acad. Sci. USA 93:5291–5295.
   PubMedGoogle Scholar
• Xu, S., and M. H. Cobb. 1997. MEKK1 binds directly to the c-Jun N-terminal kinases stress-activated protein kinases. J. Biol. Chem. 272:32056–32060.
   PubMed Web of Science ®Google Scholar
• Yamamoto, N., S. Yamamoto, F. Inagaki, M. Kawaichi, A. Fukamizu, N. Kishi, K. Matsuno, K. Nakamura, G. Weinmaster, H. Okano, and M. Nakafuku. 2001. Role of DTX-1 as a transcriptional regulator downstream of the Notch receptor. J. Biol. Chem. 276:45031–45040.
   PubMed Web of Science ®Google Scholar
• Yan, M., T. Dal, J. C. Deak, J. M. Kyriakis, L. I. Zon, J. R. Woodgett, and D. J. Templeton. 1994. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372:798–800.
   PubMed Web of Science ®Google Scholar
• Yujiri, T., S. Sather, G. R. Fanger, and G. L. Johnson. 1998. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science 282:1911–1914.
   PubMed Web of Science ®Google Scholar
• Yun, T. J., and M. J. Bevan. 2003. Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development. J. Immunol. 170:5834–5841.
   PubMedGoogle Scholar