Novel Checkpoint Response to Genotoxic Stress Mediated by Nucleolin-Replication Protein A Complex Formation

REFERENCES

• Araujo, S. J., and R. D. Wood. 1999. Protein complexes in nucleotide excision repair. Mutat. Res. 435:23–33.
   PubMedGoogle Scholar
• Bembenek, J., and H. Yu. 2003. Regulation of CDC14: pathways and checkpoints of mitotic exit. Front. Biosci. 8:d1275–d1287.
   PubMedGoogle Scholar
• Biamonti, G., and S. Riva. 1994. New insights into the auxiliary domains of eukaryotic RNA binding proteins. FEBS Lett. 340:1–8.
   PubMedGoogle Scholar
• Bivona, T. G., I. Perez De Castro, I. M. Ahearn, T. M. Grana, V. K. Chiu, P. J. Lockyer, P. J. Cullen, A. Pellicer, A. D. Cox, and M. R. Philips. 2003. Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1. Nature 424:694–698.
   PubMedGoogle Scholar
• Block, W. D., Y. Yu, and S. P. Lees-Miller. 2004. Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32-kDa subunit of replication protein A at threonine 21. Nucleic Acids Res. 32:997–1005.
   PubMed Web of Science ®Google Scholar
• Brill, S. J., and B. Stillman. 1989. Yeast replication factor-A functions in the unwinding of the SV40 origin of replication. Nature 342:92–95.
   PubMed Web of Science ®Google Scholar
• Callebaut, C., J. Blanco, N. Benkirane, B. Krust, E. Jacotot, G. Guichard, N. Seddiki, J. Svab, E. Dam, S. Muller, J. P. Briand, and A. G. Hovanessian. 1998. Identification of V3 loop-binding proteins as potential receptors implicated in the binding of HIV particles to CD4+ cells. J. Biol. Chem. 273:21988–21997.
   PubMedGoogle Scholar
• Carty, M. P., M. Zernik-Kobak, S. McGrath, and K. Dixon. 1994. UV light-induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single-stranded DNA-binding protein. EMBO J. 13:2114–2123.
   PubMed Web of Science ®Google Scholar
• Chen, C. Y., R. Gherzi, J. S. Andersen, G. Gaietta, K. Jurchott, H. D. Royer, M. Mann, and M. Karin. 2000. Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. Genes Dev. 14:1236–1248.
   PubMedGoogle Scholar
• Costanzo, V., K. Robertson, C. Y. Ying, E. Kim, E. Avvedimento, M. Gottesman, D. Grieco, and J. Gautier. 2000. Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol. Cell 6:649–659.
   PubMedGoogle Scholar
• Costanzo, V., D. Shechter, P. J. Lupardus, K. A. Cimprich, M. Gottesman, and J. Gautier. 2003. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol. Cell 11:203–213.
   PubMed Web of Science ®Google Scholar
• Creancier, L., H. Prats, C. Zanibellato, F. Amalric, and B. Bugler. 1993. Determination of the functional domains involved in nucleolar targeting of nucleolin. Mol. Biol. Cell 4:1239–1250.
   PubMed Web of Science ®Google Scholar
• Daniely, Y., and J. A. Borowiec. 2000. Formation of a complex between nucleolin and replication protein A after cell stress prevents initiation of DNA replication. J. Cell Biol. 149:799–810.
   PubMed Web of Science ®Google Scholar
• Daniely, Y., D. D. Dimitrova, and J. A. Borowiec. 2002. Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation. Mol. Cell. Biol. 22:6014–6022.
   PubMedGoogle Scholar
• Dimitrova, D. S., and D. M. Gilbert. 2000. Stability and nuclear distribution of mammalian replication protein A heterotrimeric complex. Exp. Cell Res. 254:321–327.
   PubMedGoogle Scholar
• Dodson, G. E., Y. Shi, and R. S. Tibbetts. 2004. DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells. J. Biol. Chem. 279:34010–34014.
   PubMed Web of Science ®Google Scholar
• Du, Y. C., and B. Stillman. 2002. Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis. Cell 109:835–848.
   PubMed Web of Science ®Google Scholar
• Elias, E., N. Lalun, M. Lorenzato, L. Blache, P. Chelidze, M. F. O'Donohue, D. Ploton, and H. Bobichon. 2003. Cell-cycle-dependent three-dimensional redistribution of nuclear proteins, P 120, pKi-67, and SC 35 splicing factor, in the presence of the topoisomerase I inhibitor camptothecin. Exp. Cell Res. 291:176–188.
   PubMedGoogle Scholar
• Falck, J., N. Mailand, R. G. Syljuasen, J. Bartek, and J. Lukas. 2001. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410:842–847.
   PubMed Web of Science ®Google Scholar
• Gabellini, D., M. R. Green, and R. Tupler. 2002. Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle. Cell 110:339–348.
   PubMedGoogle Scholar
• Ghisolfi, L., G. Joseph, F. Amalric, and M. Erard. 1992. The glycine-rich domain of nucleolin has an unusual supersecondary structure responsible for its RNA-helix-destabilizing properties. J. Biol. Chem. 267:2955–2959.
   PubMed Web of Science ®Google Scholar
• Ginisty, H., H. Sicard, B. Roger, and P. Bouvet. 1999. Structure and functions of nucleolin. J. Cell Sci. 112:761–772.
   PubMed Web of Science ®Google Scholar
• Grinstein, E., P. Wernet, P. J. Snijders, F. Rosl, I. Weinert, W. Jia, R. Kraft, C. Schewe, M. Schwabe, S. Hauptmann, M. Dietel, C. J. Meijer, and H. D. Royer. 2002. Nucleolin as activator of human papillomavirus type 18 oncogene transcription in cervical cancer. J. Exp. Med. 196:1067–1078.
   PubMed Web of Science ®Google Scholar
• Gulli, M. P., J. P. Girard, D. Zabetakis, B. Lapeyre, T. Melese, and M. Caizergues-Ferrer. 1995. gar2 is a nucleolar protein from Schizosaccharomyces pombe required for 18S rRNA and 40S ribosomal subunit accumulation. Nucleic Acids Res. 23:1912–1918.
   PubMed Web of Science ®Google Scholar
• Haluska, P., Jr., A. Saleem, T. K. Edwards, and E. H. Rubin. 1998. Interaction between the N terminus of human topoisomerase I and SV40 large T antigen. Nucleic Acids Res. 26:1841–1847.
   PubMedGoogle Scholar
• Hanakahi, L. A., L. A. Dempsey, M. J. Li, and N. Maizels. 1997. Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1. Proc. Natl. Acad. Sci. USA 94:3605–3610.
   PubMed Web of Science ®Google Scholar
• Hannan, K. M., R. D. Hannan, and L. I. Rothblum. 1998. Transcription by RNA polymerase I. Front. Biosci. 3:d376–d398.
   PubMedGoogle Scholar
• Heine, M. A., M. L. Rankin, and P. J. DiMario. 1993. The Gly/Arg-rich (GAR) domain of Xenopus nucleolin facilitates in vitro nucleic acid binding and in vivo nucleolar localization. Mol. Biol. Cell 4:1189–1204.
   PubMed Web of Science ®Google Scholar
• Henricksen, L. A., C. B. Umbricht, and M. S. Wold. 1994. Recombinant replication protein A: expression, complex formation, and functional characterization. J. Biol. Chem. 269:11121–11132.
   PubMed Web of Science ®Google Scholar
• Iftode, C., and J. A. Borowiec. 1998. Unwinding of origin-specific structures by human replication protein A occurs in a two-step process. Nucleic Acids Res. 26:5636–5643.
   PubMedGoogle Scholar
• Iftode, C., Y. Daniely, and J. A. Borowiec. 1999. Replication protein A (RPA): the eukaryotic SSB. Crit. Rev. Biochem. Mol. Biol. 34:141–180.
   PubMed Web of Science ®Google Scholar
• Jayaraman, L., N. C. Moorthy, K. G. Murthy, J. L. Manley, M. Bustin, and C. Prives. 1998. High mobility group protein-1 (HMG-1) is a unique activator of p53. Genes Dev. 12:462–472.
   PubMed Web of Science ®Google Scholar
• Karpova, T. S., C. T. Baumann, L. He, X. Wu, A. Grammer, P. Lipsky, G. L. Hager, and J. G. McNally. 2003. Fluorescence resonance energy transfer from cyan to yellow fluorescent protein detected by acceptor photobleaching using confocal microscopy and a single laser. J. Microsc. 209:56–70.
   PubMed Web of Science ®Google Scholar
• Kondo, K., and M. Inouye. 1992. Yeast NSR1 protein that has structural similarity to mammalian nucleolin is involved in pre-rRNA processing. J. Biol. Chem. 267:16252–16258.
   PubMed Web of Science ®Google Scholar
• Lee, W. C., D. Zabetakis, and T. Melese. 1992. NSR1 is required for pre-rRNA processing and for the proper maintenance of steady-state levels of ribosomal subunits. Mol. Cell. Biol. 12:3865–3871.
   PubMed Web of Science ®Google Scholar
• Liu, J. S., S. R. Kuo, M. M. McHugh, T. A. Beerman, and T. Melendy. 2000. Adozelesin triggers DNA damage response pathways and arrests SV40 DNA replication through replication protein A inactivation. J. Biol. Chem. 275:1391–1397.
   PubMedGoogle Scholar
• Liu, J. S., S. R. Kuo, X. Yin, T. A. Beerman, and T. Melendy. 2001. DNA damage by the enediyne C-1027 results in the inhibition of DNA replication by loss of replication protein A function and activation of DNA-dependent protein kinase. Biochemistry 40:14661–14668.
   PubMedGoogle Scholar
• Luch, A. 2002. Cell cycle control and cell division: implications for chemically induced carcinogenesis. Chembiochem 3:506–516.
   PubMed Web of Science ®Google Scholar
• Matsumoto, T., T. Eki, and J. Hurwitz. 1990. Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system. Proc. Natl. Acad. Sci. USA 87:9712–9716.
   PubMedGoogle Scholar
• Messmer, B., and C. Dreyer. 1993. Requirements for nuclear translocation and nucleolar accumulation of nucleolin of Xenopus laevis. Eur. J. Cell Biol. 61:369–382.
   PubMedGoogle Scholar
• Nisole, S., B. Krust, C. Callebaut, G. Guichard, S. Muller, J. P. Briand, and A. G. Hovanessian. 1999. The anti-HIV pseudopeptide HB-19 forms a complex with the cell-surface-expressed nucleolin independent of heparan sulfate proteoglycans. J. Biol. Chem. 274:27875–27884.
   PubMed Web of Science ®Google Scholar
• Painter, R. B., and B. R. Young. 1980. Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc. Natl. Acad. Sci. USA 77:7315–7317.
   PubMed Web of Science ®Google Scholar
• Petrini, J. H. 2000. The Mre11 complex and ATM: collaborating to navigate S phase. Curr. Opin. Cell Biol. 12:293–296.
   PubMedGoogle Scholar
• Poyurovsky, M. V., X. Jacq, C. Ma, O. Karni-Schmidt, P. J. Parker, M. Chalfie, J. L. Manley, and C. Prives. 2003. Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. Mol. Cell 12:875–887.
   PubMedGoogle Scholar
• Roger, B., A. Moisand, F. Amalric, and P. Bouvet. 2002. Repression of RNA polymerase I transcription by nucleolin is independent of the RNA sequence that is transcribed. J. Biol. Chem. 277:10209–10219.
   PubMed Web of Science ®Google Scholar
• Rubbi, C. P., and J. Milner. 2003. Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses. EMBO J. 22:6068–6077.
   PubMed Web of Science ®Google Scholar
• Schmidt-Zachmann, M. S., and E. A. Nigg. 1993. Protein localization to the nucleolus: a search for targeting domains in nucleolin. J. Cell Sci. 105:799–806.
   PubMed Web of Science ®Google Scholar
• Sengupta, T. K., S. Bandyopadhyay, D. J. Fernandes, and E. K. Spicer. 2003. Identification of nucleolin as an AU-rich element binding protein involved in bcl-2 mRNA stabilization. J. Biol. Chem. 279:10855–10863.
   PubMedGoogle Scholar
• Siliciano, J. D., C. E. Canman, Y. Taya, K. Sakaguchi, E. Appella, and M. B. Kastan. 1997. DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev. 11:3471–3481.
   PubMed Web of Science ®Google Scholar
• Sporbert, A., A. Gahl, R. Ankerhold, H. Leonhardt, and M. C. Cardoso. 2002. DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters. Mol. Cell 10:1355–1365.
   PubMed Web of Science ®Google Scholar
• Tibbetts, R. S., K. M. Brumbaugh, J. M. Williams, J. N. Sarkaria, W. A. Cliby, S. Y. Shieh, Y. Taya, C. Prives, and R. T. Abraham. 1999. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13:152–157.
   PubMed Web of Science ®Google Scholar
• Vassin, V. M., M. S. Wold, and J. A. Borowiec. 2004. Replication protein A (RPA) phosphorylation prevents RPA association with replication centers. Mol. Cell. Biol. 24:1930–1943.
   PubMed Web of Science ®Google Scholar
• Wang, X., and J. E. Haber. 2004. Role of Saccharomyces single-stranded DNA-binding protein RPA in the strand invasion step of double-strand break repair. PLoS Biol. 2:104–112
   Google Scholar
• Wang, Y., J. Guan, H. Wang, D. Leeper, and G. Iliakis. 2001. Regulation of DNA replication after heat shock by replication protein A-nucleolin interactions. J. Biol. Chem. 276:20579–20588.
   PubMed Web of Science ®Google Scholar
• Wang, Y., A. R. Perrault, and G. Iliakis. 1998. Replication protein A as a potential regulator of DNA replication in cells exposed to hyperthermia. Radiat. Res. 149:284–293.
   PubMedGoogle Scholar
• Weber, J. D., L. J. Taylor, M. F. Roussel, C. J. Sherr, and D. Bar-Sagi. 1999. Nucleolar Arf sequesters Mdm2 and activates p53. Nat. Cell Biol. 1:20–26.
   PubMed Web of Science ®Google Scholar
• Wold, M. S. 1997. Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu. Rev. Biochem. 66:61–92.
   PubMed Web of Science ®Google Scholar
• Ying, G. G., P. Proost, J. van Damme, M. Bruschi, M. Introna, and J. Golay. 2000. Nucleolin, a novel partner for the Myb transcription factor family that regulates their activity. J. Biol. Chem. 275:4152–4158.
   PubMedGoogle Scholar
• Zou, L., and S. J. Elledge. 2003. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300:1542–1548.
   PubMed Web of Science ®Google Scholar
• Zou, L., D. Liu, and S. J. Elledge. 2003. Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc. Natl. Acad. Sci. USA 100:13827–13832.
   PubMed Web of Science ®Google Scholar