Human Progesterone Receptor Displays Cell Cycle-Dependent Changes in Transcriptional Activity

REFERENCES

• Abel, G. A., G. M. Wochnik, J. Rüegg, A. Rouyer, F. Holsboer, and T. Rein. 2002. Activity of the GR in G2 and mitosis. Mol. Endocrinol. 16:1352–1366.
   PubMedGoogle Scholar
• Ait-Si-Ali, S., S. Ramirez, F.-X. Barre, F. Dkhissi, L. Magnaghi-Jaulin, J. A. Girault, P. Robin, M. Knibiehler, L. L. Pritchard, B. Ducommun, D. Trouche, and A. Harel-Bellan. 1998. Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A. Nature 396:184–186.
   PubMedGoogle Scholar
• Apostolakis, E. M., R. Lanz, and B. W. O'Malley. 30 October 2003, posting date. Pituitary adenylate cyclase activating peptide (PACAP): a pivotal modulator of steroid-induced reproductive behavior in female rodents. Mol. Endocrinol. 18:173–183. [Online.]
   PubMedGoogle Scholar
• Bodwell, J. E., J. C. Webster, C. M. Jewell, J. A. Cidlowski, J. M. Hu, and A. Munck. 1998. Glucocorticoid receptor phosphorylation: overview, function and cell cycle-dependence. J. Steroid Biochem. Mol. Biol. 65:91–99.
   PubMed Web of Science ®Google Scholar
• Boonyaratanakornkit, V., M. P. Scott, V. Ribon, L. Sherman, S. M. Anderson, J. L. Maller, W. T. Miller, and D. P. Edwards. 2001. Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases. Mol. Cell 8:269–280.
   PubMed Web of Science ®Google Scholar
• Carson-Jurica, M. A., W. T. Schrader, and B. W. O'Malley. 1990. Steroid receptor family: structure and functions. Endocr. Rev. 11:201–220.
   PubMed Web of Science ®Google Scholar
• Cato, A. C. B., D. Henderson, and H. Ponta. 1987. The hormone response element of the mouse mammary tumour virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat region. EMBO J. 6:363–368.
   PubMedGoogle Scholar
• Chou, C. F., and M. B. Omary. 1994. Mitotic arrest with anti-microtubule agents or akadaic acid is associated with increased glycoprotein terminal GIcNAc's. J. Cell Sci. 107:1833–1843.
   PubMedGoogle Scholar
• Clemm, D. L., L. Sherman, V. Boonyaratanakornkit, W. T. Schrader, N. L. Weigel, and D. P. Edwards. 2000. Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site specific monoclonal antibody. Mol. Endocrinol. 14:52–65.
   PubMedGoogle Scholar
• Conneely, O. M., B. Mulac-Jericevic, J. P. Lydon, and F. J. DeMayo. 2001. Reproductive functions of the progesterone receptor isoforms: lessons from knock-out mice. Mol. Cell. Endocrinol. 179:97–103.
   PubMed Web of Science ®Google Scholar
• Cram, E. J., B. D. Liu, L. F. Bjeldanes, and G. L. Firestone. 2001. Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter. J. Biol. Chem. 276:22332–22340.
   PubMedGoogle Scholar
• Gioeli, D., S. B. Ficarro, J. J. Kwiek, D. Aaronson, M. Hancock, A. D. Catling, F. M. White, R. E. Christian, R. E. Settlage, J. Shabanowitz, D. F. Hunt, and M. J. Weber. 2002. Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites. J. Biol. Chem. 277:29304–29314.
   PubMed Web of Science ®Google Scholar
• Hissom, J. R., and M. R. Moore. 1987. Progestin effects on growth in the human breast cancer cell line T-47D—possible therapeutic implications. Biochem. Biophys. Res. Commun. 145:706–711.
   PubMed Web of Science ®Google Scholar
• Horwitz, K. B., M. B. Mockus, and B. A. Lessey. 1982. Variant T47D human breast cancer cells with high progesterone receptor levels despite estrogen and antiestrogen resistance. Cell 28:633–642.
   PubMedGoogle Scholar
• Hu, J. M., J. E. Bodwell, and A. Munck. 1994. Cell cycle-dependent glucocorticoid receptor phosphorylation and activity. Mol. Endocrinol. 8:1709–1713.
   PubMedGoogle Scholar
• Karin, M., A. Haslinger, H. Holtgreve, R. I. Richards, P. Krauter, H. M. Westphal, and M. Beato. 1984. Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene. Nature 308:513–519.
   PubMed Web of Science ®Google Scholar
• Kastner, P., A. Krust, B. Turcotte, U. Strupp, L. Tora, H. Gronemeyer, and P. Chambon. 1990. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J. 9:1603–1614.
   PubMed Web of Science ®Google Scholar
• Knotts, T. A., R. S. Orkiszewski, R. G. Cook, D. P. Edwards, and N. L. Weigel. 2001. Identification of a phosphorylation site in the hinge region of the human progesterone receptor and additional amino-terminal phosphorylation sites. J. Biol. Chem. 276:8475–8483.
   PubMed Web of Science ®Google Scholar
• Knudsen, K. E., W. K. Cavenee, and K. C. Arden. 1999. D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability. Cancer Res. 59:2297–2301.
   PubMedGoogle Scholar
• Lambert, J. R., and S. K. Nordeen. 2001. Analysis of steroid hormone-induced histone acetylation by chromatin immunoprecipitation assay. Methods Mol. Biol. 176:273–281.
   PubMedGoogle Scholar
• Lange, C. A. 16 October 2003, posting date. Making sense of cross-talk between steroid hormone receptor and intracellular signaling pathways: who will have the last word? Mol. Endocrinol. 18:269–278. [Online.].
   PubMedGoogle Scholar
• Lange, C. A., T. Shen, and K. B. Horwitz. 2000. Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome. Proc. Natl. Acad. Sci. USA 97:1032–1037.
   PubMed Web of Science ®Google Scholar
• LeGoff, P., M. M. Montano, D. J. Schodin, and B. S. Katzenellenbogen. 1994. Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity. J. Biol. Chem. 269:4458–4466.
   PubMedGoogle Scholar
• Li, X., J. Wong, S. Y. Tsai, M.-J. Tsai, and B. W. O'Malley. 2003. Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Mol. Cell. Biol. 23:3763–3773.
   PubMedGoogle Scholar
• Lim, C. S., C. T. Baumann, H. Htun, W. Xian, M. Irie, C. L. Smith, and G. L. Hager. 1999. Differential localization and activity of the A- and B-forms of the human progesterone receptor using green fluorescent protein chimeras. Mol. Endocrinol. 13:366–375.
   PubMedGoogle Scholar
• Martinez, E. D., and M. Danielsen. 2002. Loss of androgen receptor transcriptional activity at the G(1)/S transition. J. Biol. Chem. 277:29719–29729.
   PubMedGoogle Scholar
• Maurer-Schultze, B., M. Siebert, and I. D. Bassukas. 1988. An in vivo study on the synchronizing effect of hydroxyurea. Exp. Cell Res. 174:230–243.
   PubMed Web of Science ®Google Scholar
• Mulac-Jericevic, B., J. P. Lydon, F. J. DeMayo, and O. M. Conneely. 2003. Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc. Natl. Acad. Sci. USA 100:9744–9749.
   PubMed Web of Science ®Google Scholar
• Musgrove, E. A., C. S. L. Lee, and R. L. Sutherland. 1991. Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor α, epidermal growth factor receptor, c-fos, and c-myc genes. Mol. Cell. Biol. 11:5032–5043.
   PubMed Web of Science ®Google Scholar
• Narayanan, R., A. A. Adigun, D. P. Edwards, and N. L. Weigel. 2004. Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator. Mol. Cell. Biol. 25:264–277.
   Google Scholar
• Narayanan, R., V. A. Tovar Sepulveda, M. Falzon, and N. L. Weigel. 2004. The functional consequences of cross talk between the vitamin D receptor and ERK signaling pathways are cell specific. J. Biol. Chem. 279:47298–47310.
   PubMedGoogle Scholar
• Neuman, E., M. H. Ladha, N. Lin, T. M. Upton, S. J. Miller, J. DiRenzo, R. G. Pestell, P. W. Hinds, S. F. Dowdy, M. Brown, and M. E. Ewen. 1997. Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4. Mol. Cell. Biol. 17:5338–5347.
   PubMed Web of Science ®Google Scholar
• Olea-Serrano, N., N. Deuleeschouwer, G. Leclercq, and J. C. Henson. 1985. Assay for estrogen and progesterone receptors of breast cancer cell lines in monolayer culture. Eur. J. Cancer Clin. Oncol. 21:965–973.
   PubMedGoogle Scholar
• Qiu, M., A. Olsen, E. Faivre, K. B. Horwitz, and C. A. Lange. 2003. Mitogen activated protein kinase regulates nuclear association of human progesterone receptors. Mol. Endocrinol. 17:628–642.
   PubMedGoogle Scholar
• Richer, J. K., B. M. Jacobsen, N. G. Manning, M. G. Abel, D. M. Wolf, and K. B. Horwitz. 2002. Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells. J. Biol. Chem. 277:5209–5218.
   PubMed Web of Science ®Google Scholar
• Shen, T., K. B. Horwitz, and C. A. Lange. 2001. Transcriptional hyperactivity of human progesterone receptors is coupled to their ligand-dependent down-regulation by mitogen-activated protein kinase-dependent phosphorylation of serine 294. Mol. Cell. Biol. 21:6122–6131.
   PubMed Web of Science ®Google Scholar
• Slater, E. P., A. C. B. Cato, M. Karin, J. D. Baxter, and M. Beato. 1988. Progesterone induction of metallothionein-IIA gene expression. Mol. Endocrinol. 2:485–491.
   PubMedGoogle Scholar
• Stenoien, D. L., M. G. Mancini, K. Patel, E. A. Allegretto, C. L. Smith, and M. A. Mancini. 2000. Subnuclear trafficking of estrogen receptor-α and steroid receptor coactivator-1. Mol. Endocrinol. 14:518–534.
   PubMedGoogle Scholar
• Stenoien, D. L., K. Patel, M. G. Mancini, M. Dutertre, C. L. Smith, B. W. O'Malley, and M. Mancini. 2001. FRAP reveals that mobility of oestrogen receptor-α is ligand- and proteasome-dependent. Nat. Cell Biol. 3:15–23.
   PubMed Web of Science ®Google Scholar
• Tsai, M.-J., and B. W. O'Malley. 1994. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 63:451–486.
   PubMed Web of Science ®Google Scholar
• Weigel, N. L., C. A. Beck, P. A. Estes, P. Prendergast, M. Altmann, K. Christensen, and D. P. Edwards. 1992. Ligands induce conformational changes in the carboxyl-terminus of progesterone receptors which are detected by a site-directed antipeptide monoclonal antibody. Mol. Endocrinol. 6:1585–1597.
   PubMedGoogle Scholar
• Xu, Y., L. Klein-Hitpass, and M. K. Bagchi. 2000. E1A-mediated repression of progesterone receptor-dependent transactivation involves inhibition of the assembly of a multisubunit coactivation complex. Mol. Cell. Biol. 20:2138–2146.
   PubMedGoogle Scholar
• Yamamoto, A., Y. Hashimoto, K. Kohri, E. Ogata, S. Kato, K. Ikeda, and M. Nakanishi. 2000. Cyclin E as a coactivator of the androgen receptor. J. Cell Biol. 150:873–880.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., W. Bai, V. E. Allgood, and N. L. Weigel. 1994. Multiple signaling pathways activate the chicken progesterone receptor. Mol. Endocrinol. 8:577–584.
   PubMedGoogle Scholar
• Zhang, Y., C. A. Beck, A. Poletti, D. P. Edwards, and N. L. Weigel. 1995. Identification of a group of Ser-Pro motif hormone-inducible phosphorylation sites in the human progesterone receptor. Mol. Endocrinol. 9:1029–1040.
   PubMedGoogle Scholar