Wing-to-Leg Homeosis by Spineless Causes Apoptosis Regulated by Fish-lips, a Novel Leucine-Rich Repeat Transmembrane Protein

REFERENCES

• Abrams, J. M. 2002. Competition and compensation: coupled to death in development and cancer. Cell 110:403–406.
   PubMed Web of Science ®Google Scholar
• Adachi-Yamada, T., and M. B. O'Connor. 2002. Morphogenetic apoptosis: a mechanism for correcting discontinuities in morphogen gradients. Dev. Biol. 251:74–90.
   PubMedGoogle Scholar
• Adachi-Yamada, T., and M. B. O'Connor. 2004. Mechanisms for removal of developmentally abnormal cells: cell competition and morphogenetic apoptosis. J. Biochem. 136:13–17.
   PubMed Web of Science ®Google Scholar
• Andersen, M. E. 2002. The use of quantitative histological and molecular data for risk assessment and biologically based model development. Toxicol. Pathol. 30:101–106.
   Google Scholar
• Aza-Blanc, P., and T. B. Kornberg. 1999. Ci: a complex transducer of the hedgehog signal. Trends Genet. 15:458–462.
   PubMed Web of Science ®Google Scholar
• Bier, E., H. Vaessin, S. Shepherd, K. Lee, K. McCall, S. Barbel, L. Ackerman, R. Carretto, T. Uemura, E. Grell, L. Y. Jan, and Y. N. Jan. 1989. Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector. Genes Dev. 3:1273–1287.
   PubMed Web of Science ®Google Scholar
• Brand, H., and N. Perrimon. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118:401–415.
   PubMed Web of Science ®Google Scholar
• Campbell, G., T. Weaver, and A. Tomlinson. 1993. Axis specification in the developing Drosophila appendage: the role of wingless, decapentaplegic, and the homeobox gene aristaless. Cell 74:1113–1123.
   PubMed Web of Science ®Google Scholar
• Campbell, G., and A. Tomlinson. 1998. The roles of the homeobox genes aristaless and Distal-less in patterning the legs and wings of Drosophila. Development 125:4483–4493.
   PubMedGoogle Scholar
• Campbell, S., M. Inamdar, V. Rodrigues, V. Raghavan, M. Palazzolo, and A. Chovnick. 1992. The scalloped gene encodes a novel, evolutionarily conserved transcription factor required for sensory organ differentiation in Drosophila. Genes Dev. 6:367–379.
   PubMedGoogle Scholar
• Carroll, S. B., S. D. Weatherbee, and J. A. Langeland. 1995. Homeotic genes and the regulation and evolution of insect wing number. Nature 375:58–61.
   PubMed Web of Science ®Google Scholar
• Casares F., and R. S. Mann. 1998. Control of antennal versus leg development in Drosophila. Nature 392:723–726.
   PubMedGoogle Scholar
• Cohen, S. M., G. Bronner, F. Kuttner, G. Jurgens, and H. Jackle. 1989. Distal-less encodes a homeodomain protein required for limb development in Drosophila. Nature 338:432–434.
   PubMed Web of Science ®Google Scholar
• Davis, R. J. 2000. Signal transduction by the JNK group of MAP kinases. Cell 103:239–252.
   PubMed Web of Science ®Google Scholar
• Dong, P. D. S., J. Chu, and G. Panganiban. 2001. Proximodistal domain specification and interactions in developing Drosophila appendages. Development 128:2365–2372.
   PubMedGoogle Scholar
• Dong, P. D. S., S. J. Dicks, and G. Panganiban. 2002. Distal-less and homothorax regulate multiple targets to pattern the Drosophila antenna. Development 129:1967–1974.
   PubMedGoogle Scholar
• Duncan, D. M., E. A. Burgess, and I. Duncan. 1998. Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor. Genes Dev. 12:1290–1303.
   PubMedGoogle Scholar
• Emmons, R. B., D. Duncan, P. A. Estes, P. Kiefel, J. T. Mosher, M. Sonnenfeld, M. P. Ward, I. Duncan, and S. T. Crews. 1999. The Spineless-Aristapedia and Tango bHLH-PAS proteins interact to control antennal and tarsal development in Drosophila. Development 126:3937–3945.
   PubMed Web of Science ®Google Scholar
• Evan G., and T. Littlewood. 1998. A matter of life and cell death. Science 281:1317–1322.
   PubMed Web of Science ®Google Scholar
• Glise, B., H. Bourbon, and S. Noselli. 1995. hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 83:451–461.
   PubMed Web of Science ®Google Scholar
• Gorfinkiel, N., G. Morata, and I. Guerrero. 1997. The homeobox gene Distal-less induces ventral appendage development in Drosophila. Genes Dev. 11:2259–2271.
   PubMedGoogle Scholar
• Grenier, J. K., and S. B. Carroll. 2000. Functional evolution of the Ultrabithorax protein. Proc. Natl. Acad. Sci. USA 97:704–709.
   PubMedGoogle Scholar
• Grether, M. E., J. M. Abrams, J. Agapite, K. White, and H. Steller. 1995. The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev. 15:1694–1708.
   Google Scholar
• Grimm. S, and G. O. Pflugfelder. 1996. Control of the gene optomotor-blind in Drosophila wing development by decapentaplegic and wingless. Science 271:1601–1604.
   PubMed Web of Science ®Google Scholar
• Hamada, F., Y. Tomoyasu, Y. Takatsu, M. Nakamura, S. Nagai, A. Suzuki, F. Fujita, H. Shibuya, K. Toyoshima, N. Ueno, and T. Akiyama. 1999. Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. Science 283:1739–1742.
   PubMedGoogle Scholar
• Hay, B. A., D. A. Wassarman, and G. M. Rubin. 1995. Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell 83:1253–1262.
   PubMed Web of Science ®Google Scholar
• Hoffman, E. C., H. Reyes, F. F. Chu, F. Sander, L. H. Conley, B. A. Brooks, and O. Hankinson. 1991. Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 252:954–958.
   PubMed Web of Science ®Google Scholar
• Ito, K., W. Awano, K. Suzuki, Y. Hiromi, and D. Yamamoto. 1997. The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurons and glial cells. Development 124:761–771.
   PubMed Web of Science ®Google Scholar
• Jacobson, M. D., M. Weil, and M. C. Raff. 1997. Programmed cell death in animal development. Cell 88:347–354.
   PubMed Web of Science ®Google Scholar
• Kauffman, S. A. 1973. Control circuits for determination and transdetermination. Science 181:310–318.
   PubMed Web of Science ®Google Scholar
• Kim, J., A. Sebring, J. J. Esch, M. E. Kraus, K. Vorwerk, J. Magee, and S. B. Carroll. 1996. Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature 382:133–138.
   PubMed Web of Science ®Google Scholar
• Lecuit, T., W. J. Brook, M. Ng, M. Calleja, H. Sun, and S. M. Cohen. 1996. Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381:387–393.
   PubMedGoogle Scholar
• Lei, W., R. Yu, S. Mandlekar, and A. N. Kong. 1998. Induction of apoptosis and activation of interleukin 1β-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene. Cancer Res. 58:2102–2106.
   PubMedGoogle Scholar
• Liu, X., M. Grammont, and K. D. Irvine. 2000. Roles for scalloped and vestigial in regulating cell affinity and interactions between the wing blade and the wing hinge. Dev. Biol. 228:287–303.
   PubMed Web of Science ®Google Scholar
• Mardon, G., N. M. Solomon, and G. M. Rubin. 1994. dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila. Development 120:3473–3486.
   PubMed Web of Science ®Google Scholar
• Martín-Blanco, E., A, Gampel, J. Ring, K. Virdee, N. Kirov, A. M. Tolkovsky, and A. Martinez-Arias. 1998. puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Genes Dev. 12:557–570.
   PubMed Web of Science ®Google Scholar
• Milán, M., S. Campuzano, and A. García-Bellido. 1997. Developmental parameters of cell death in the wing disc of Drosophila. Proc. Natl. Acad. Sci. USA 94:5691–5696.
   PubMedGoogle Scholar
• Milán, M., L. Pérez, and S. M. Cohen. 2002. Short-range cell interactions and cell survival in the Drosophila wing. Dev. Cell 2:797–805.
   PubMedGoogle Scholar
• Morata, G., and P. Ripoll. 1975. Minutes: mutants of Drosophila autonomously affecting cell division rate. Dev. Biol. 42:211–221.
   PubMed Web of Science ®Google Scholar
• Moreno, E., K. Basler, and G. Morata. 2002. Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing development. Nature 416:755–759.
   PubMed Web of Science ®Google Scholar
• Nellen, D., R. Burke, G. Struhl, and K. Basler. 1996. Direct and long-range action of a DPP morphogen gradient. Cell 85:357–368.
   PubMed Web of Science ®Google Scholar
• Neumann, C. J., and S. M. Cohen. 1997. Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing. Development 124:871–880.
   PubMed Web of Science ®Google Scholar
• Ohshiro, T., and K. Saigo. 1997. Transcriptional regulation of breathless FGF receptor gene by binding of TRACHEALESS/dARNT heterodimers to three central midline elements in Drosophila developing trachea. Development 124:3975–3986.
   PubMed Web of Science ®Google Scholar
• Pai, C.-Y., T.-S. Kuo, J. J. Thomas, E. Kurant, C.-T. Chen, D. A. Bessarab, A. Salzberg, and Y. H. Sun. 1998. The homothorax homeoprotein activates the nuclear localization of another homeoprotein, Extradenticle, and suppresses eye development in Drosophila. Genes Dev. 12:435–446.
   PubMedGoogle Scholar
• Panganiban, G. 2000. Distal-less function during Drosophila appendage and sense organ development. Dev. Dyn. 218:554–562.
   PubMedGoogle Scholar
• Peifer, M., and E. Wieschaus. 1990. The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell 63:1167–1176.
   PubMed Web of Science ®Google Scholar
• Peifer, M., D. Sweeton, M. Casey, and E. Wieschaus. 1994. wingless signal and zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development 120:369–380.
   PubMed Web of Science ®Google Scholar
• Persson, U., H. Izumi, S. Souchelnytskyi, S. Itoh, S. Grimsby, U. Engstrom, C. H. Heldin, K. Funa, and P. ten Dijke. 1998. The L45 loop in type I receptors for TGF-β family members is a critical determinant in specifying Smad isoform activation. FEBS Lett. 434:83–87.
   PubMed Web of Science ®Google Scholar
• Prober, D. A., and B. A. Edgar. 2000. Ras1 promotes cellular growth in the Drosophila wing. Cell 100:435–446.
   PubMed Web of Science ®Google Scholar
• Robertson, J. D., and S. Orrenius. 2000. Molecular mechanisms of apoptosis induced by cytotoxic chemicals. Crit. Rev. Toxicol. 30:609–627.
   PubMed Web of Science ®Google Scholar
• Sato, A., T. Kojima, K. Ui-Tei, Y. Miyata, and K. Saigo. 1999. Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants. Development 126:4421–4430.
   PubMedGoogle Scholar
• Sekelsky, J. J., S. J. Newfeld, L. A. Raftery, E. H. Chartoff, and W. M. Gelbart. 1996. Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139:1347–1358.
   Google Scholar
• Sibatani, A. 1980. Wing homeosis in Lepidoptera: a survey. Dev. Biol. 79:1–18.
   PubMedGoogle Scholar
• Siegfried, E., E. L. Wilder, and N. Perrimon. 1994. Components of wingless signalling in Drosophila. Nature 367:76–80.
   PubMedGoogle Scholar
• Sivasankaran, R., M. Calleja, G. Morata, and K. Basler. 2000. The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family. Mech. Dev. 91:427–431.
   PubMedGoogle Scholar
• Simpson, P., and G. Morata. 1981. Differential mitotic rates and patterns of growth in compartments in the Drosophila wing. Dev. Biol. 85:299–308.
   PubMedGoogle Scholar
• Tanimoto, H., S. Itoh, P. ten Dijke, and T. Tabata. 2000. Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs. Mol. Cell 5:59–71.
   PubMed Web of Science ®Google Scholar
• Yoo, S. J., J. R. Huh, I. Muro, H. Yu, L. Wang, S. L. Wang, R. M. Feldman, R. J. Clem, H. A. Muller, and B. A. Hay. 2002. Hid, Rpr, and Grim negatively regulate DIAP1 levels through distinct mechanisms. Nat. Cell Biol. 4:416–424.
   PubMed Web of Science ®Google Scholar
• Yu, S. Y., S. J. Yoo, L. Yang, C. Zapata, A. Srinivasan, B. A. Hay, and N. E. Baker. 2002. A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye. Development 129:3269–3278.
   PubMed Web of Science ®Google Scholar
• Zecca, M., K. Basler, and G. Struhl. 1996. Direct and long-range action of a wingless morphogen gradient. Cell 87:833–844.
   PubMed Web of Science ®Google Scholar