21
Views
41
CrossRef citations to date
0
Altmetric
Article

Study of Long-Distance Functional Interactions between Su(Hw) Insulators That Can Regulate Enhancer-Promoter Communication in Drosophila melanogaster

, , , , , , , , , , & show all
Pages 754-761 | Received 17 Jun 2005, Accepted 03 Nov 2005, Published online: 27 Mar 2023

REFERENCES

  • Ameres, S. L., L. Drueppel, K. Pfleiderer, A. Schmidt, W. Hillen, and C. Berens. 2005. Inducible DNA-loop formation blocks transcriptional activation by an SV40 enhancer. EMBO J. 24:358–367.
  • Bi, X., and J. R. Broach. 1999. UASrpg can function as a heterochromatin boundary element in yeast. Genes Dev. 13:1089–1101.
  • Blanton, J., M. Gaszner, and P. Schedl. 2003. Protein:protein interactions and the pairing of boundary elements in vivo. Genes Dev. 17:664–675.
  • Bondarenko, V. A., Y. V. Liu, Y. I. Jiang, and V. M. Studitsky. 2003. Communication over a large distance: enhancers and insulators. Biochem. Cell Biol. 81:241–251.
  • Bondarenko, V. A., Y. I. Jiang, and V. M. Studitsky. 2003. Rationally designed insulator-like elements can block enhancer action in vitro. EMBO J. 22:4728–4737.
  • Bonifer, C., M. Vidal, F. Grosveld, and A. E. Sippel. 1990. Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice. EMBO J. 9:2843–2848.
  • Brasset, E., and C. Vaury. 2005. Insulators are fundamental components of the eukaryotic genomes. Heredity 94:571–576.
  • Burgess-Beusse, B., C. Farrell, M. Gaszner, M. Litt, V. Mutskov, F. Recillas-Targa, M. Simpson, A. West, and G. Felsenfeld. 2002. The insulation of genes from external enhancers and silencing chromatin. Proc. Natl. Acad. Sci. USA 99:16433–16437.
  • Byrd, K., and V. G. Corces. 2003. Visualization of chromatin domains created by the gypsy insulator of Drosophila. J. Cell Biol. 162:565–574.
  • Cai, H., and M. Levine. 1995. Modulation of enhancer-promoter interactions by insulators in the Drosophila embryo. Nature 376:533–536.
  • Cai, H. N., and M. Levine. 1997. The gypsy insulator can function as a promoter-specific silencer in the Drosophila embryo. EMBO J. 16:1732–1741.
  • Cai, H. N., and P. Shen. 2001. Effects of cis arrangement of chromatin insulators on enhancer-blocking activity. Science 291:493–495.
  • Cai, H. N., Z. Zhang, J. R. Adams, and P. Shen. 2001. Genomic context modulates insulator activity through promoter competition. Development 128:4339–4347.
  • Capelson, M., and V. G. Corces. 2004. Boundary elements and nuclear organization. Biol. Cell 96:617–629.
  • Carter, D., L. Chakalova, C. S. Osborne, Y. F. Dai, and P. Fraser. 2002. Long-range chromatin regulatory interactions in vivo. Nat. Genet. 32:623–626.
  • Chambeyron, S., and W. A. Bickmore. 2004. Does looping and clustering in the nucleus regulate gene expression? Curr. Opin. Cell Biol. 16:256–262.
  • Dorsett, D. 1993. Distance-independent inactivation of an enhancer by the suppressor of Hairy-wing DNA-binding protein of Drosophila. Genetics 134:1135–1144.
  • Dorsett, D. 1999. Distant liaisons: long-range enhancer-promoter interactions in Drosophila. Curr. Opin. Genet. Dev. 9:505–514.
  • Dunaway, M., J. Y. Hwang, M. Xiong, and H.-L. Yuen. 1997. The activity of the scs and scs′ insulator elements is not dependent on chromosomal context. Mol. Cell. Biol. 17:182–189.
  • Gause, M., P. Morcillo, and D. Dorsett. 2001. Insulation of enhancer-promoter communication by a gypsy transposon insert in the Drosophila cut gene: cooperation between suppressor of hairy-wing and modifier of mdg4 proteins. Mol. Cell. Biol. 21:4807–4817.
  • Georgiev, P., and M. Kozycina. 1996. Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations. Genetics 142:425–436.
  • Gerasimova, T. I., K. Byrd, and V. G. Corces. 2000. A chromatin insulator determines the nuclear localization of DNA. Mol. Cell 6:1025–1035.
  • Gerasimova, T. I., and V. G. Corces. 1998. Polycomb and trithorax group proteins mediate the function of a chromatin insulator. Cell 92:511–521.
  • Geyer, P. K., C. Spana, and V. Corces. 1986. On the molecular mechanism of gypsy-induced mutations at the yellow locus of Drosophila melanogaster. EMBO J. 5:2657–2662.
  • Geyer, P. K., and I. Clark. 2002. Protecting against promiscuity: the regulatory role of insulators. Cell. Mol. Life Sci. 59:2112–2127.
  • Geyer, P. K., and V. G. Corces. 1987. Separate regulatory elements are responsible for the complex pattern of tissue-specific and developmental transcription of the yellow locus in Drosophila melanogaster. Genes Dev. 1:996–1004.
  • Geyer, P. K., and V. G. Corces. 1992. DNA position-specific repression of transcription by a Drosophila zinc finger protein. Genes Dev. 6:1865–1873.
  • Golic, K. G., and S. Lindquist. 1989. The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome. Cell 59:499–509.
  • Golovnin, A., I. Birukova, O. Romanova, M. Silicheva, A. Parshikov, E. Savitskaya, V. Pirrotta, and P. Georgiev. 2003. An endogenous Su(Hw) insulator separates the yellow gene from the Achaete-scute gene complex in Drosophila. Development 130:3249–3258.
  • Golovnin, A., E. Melnick, A. Mazur, and P. Georgiev. 2005. Drosophila Su(Hw) insulator can stimulate transcription of a weakened yellow promoter over a distance. Genetics 170:1133–1142.
  • Gyurkovics, H., J. Gausz, J. Kummer, and F. Karch. 1990. A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation. EMBO J. 9:2579–2585.
  • Hagstrom, K., M. Muller, and P. Schedl. 1997. A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex. Genetics 146:1365–1380.
  • Hogga, I., J. Mihaly, S. Barges, and F. Karch. 2001. Replacement of Fab-7 by the gypsy or scs insulator disrupts long-distance regulatory interactions in the Abd-B gene of the bithorax complex. Mol. Cell 8:1145–1151.
  • Holdridge, C., and D. Dorsett. 1991. Repression of hsp70 heat shock gene transcription by the suppressor of hairy-wing protein of Drosophila melanogaster. Mol. Cell. Biol. 11:1894–1900.
  • Ishii, K., G. Arib, C. Lin, G. Van Houwe, and U. K. Laemmli. 2002. Chromatin boundaries in budding yeast: the nuclear pore connection. Cell 109:551–562.
  • Karess, R. E., and G. M. Rubin. 1984. Analysis of P transposable element functions in Drosophila. Cell 38:135–146.
  • Kellum, R., and P. Schedl. 1991. A position-effect assay for boundaries of higher order chromosomal domains. Cell 64:941–950.
  • Kellum, R., and P. Schedl. 1992. A group of scs elements function as domain boundaries in an enhancer-blocking assay. Mol. Cell. Biol. 12:2424–2431.
  • Kravchenko, E., E. Savitskaya, O. Kravchuk, A. Parshikov, P. Georgiev, and M. Savitsky. 2005. Pairing between gypsy insulators facilitates the enhancer action in trans throughout the Drosophila genome. Mol. Cell. Biol. 25:9283–9291.
  • Kuhn, E. J., and P. K. Geyer. 2003. Genomic insulators: connecting properties to mechanism. Curr. Opin. Cell Biol. 15:259–265.
  • Kuhn, E. J., M. M. Viering, K. M. Rhodes, and P. K. Geyer. 2003. A test of insulator interactions in Drosophila. EMBO J. 22:2463–2471.
  • Lindsley, D. L., and G. G. Zimm. 1992. The genome of Drosophila melanogaster. Academic Press, New York, N.Y.
  • Majumder, P., and H. N. Cai. 2003. The functional analysis of insulator interactions in the Drosophila embryo. Proc. Natl. Acad. Sci. USA 100:5223–5228.
  • Mallin, D. R., J. S. Myung, J. S. Patton, and P. K. Geyer. 1998. Polycomb group repression is blocked by the Drosophila suppressor of Hairy-wing [Su(Hw)] insulator. Genetics 148:331–339.
  • Martin, M., Y. B. Meng, and W. Chia. 1989. Regulatory elements involved in the tissue-specific expression of the yellow gene of Drosophila. Mol. Gen. Genet. 218:118–126.
  • Mongelard, F., and V. G. Corces. 2001. Two insulators are not better than one. Nat. Struct. Biol. 8:192–194.
  • Muravyova, E., A. Golovnin, E. Gracheva, A Parshikov, T. Belenkaya, V. Pirrotta, and P. Georgiev. 2001. Loss of insulator activity by paired Su(Hw) chromatin insulators. Science 291:495–498.
  • Mutskov, V. J., C. M. Farrell, P. A. Wade, A. P. Wolffe, and G. Felsenfeld. 2002. The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation. Genes Dev. 16:1540–1554.
  • Oki, M., and R. T. Kamakaka. 2002. Blockers and barriers to transcription: competing activities? Curr. Opin. Cell Biol. 14:299–304.
  • Parnell, T. J., and P. K. Geyer. 2000. Differences in insulator properties revealed by enhancer blocking assays on episomes. EMBO J. 19:5864–5874.
  • Parnell, T. J., M. M. Viering, A. Skjesol, C. Helou, E. J. Kuhn, and P. K. Geyer. 2003. An endogenous Suppressor of Hairy-wing insulator separates regulatory domains in Drosophila. Proc. Natl. Acad. Sci. USA 100:13436–13441.
  • Patrinos, G. P., M. de Krom, E. de Boer, A. Langeveld, A. M. Imam, J. Strouboulis, W. de Laat, and F. G. Grosveld. 2004. Multiple interactions between regulatory regions are required to stabilize an active chromatin hub. Genes Dev. 18:1495–1509.
  • Recillas-Targa, F., A. C. Bell, and G. Felsenfeld. 1999. Positional enhancer-blocking activity of the chicken beta-globin insulator in transiently transfected cells. Proc. Natl. Acad. Sci. USA 96:14354–14359.
  • Roseman, R. R., V. Pirrotta, and P. K. Geyer. 1993. The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects. EMBO J. 12:435–442.
  • Roseman, R. R., E. A. Johnson, C. K. Rodesch, M. Bjerke, R. N. Nagoshi, and P. K. Geyer. 1995. A P element containing suppressor of Hairy-wing binding regions has novel properties for mutagenesis in Drosophila melanogaster. Genetics 141:1061–1074.
  • Rubin, G. M., and A. C. Spradling. 1982. Genetic transformation of Drosophila with transposable element vectors. Science 218:348–353.
  • Scott, K. S., and P. K. Geyer. 1995. Effects of the su(Hw) insulator protein on the expression of the divergently transcribed Drosophila yolk protein genes. EMBO J. 14:6258–6267.
  • Scott, K. S., A. D. Taubman, and P. K. Geyer. 1999. Enhancer blocking by the Drosophila gypsy insulator depends upon insulator anatomy and enhancer strength. Genetics 153:787–798.
  • Siegal, M. L., and D. L. Hartl. 2000. Application of Cre/loxP in Drosophila. Site-specific recombination and transgene coplacement. Methods Mol. Biol. 136:487–495.
  • Sigrist, C. J. A., and V. Pirrotta. 1997. Chromatin insulator elements block the silencing of a target gene by the Drosophila polycomb response element (PRE) but allow trans interactions between PREs on different chromosomes. Genetics 147:209–221.
  • Smith, P. A., and V. G. Corces. 1995. The suppressor of Hairy-wing protein regulates the tissue-specific expression of the Drosophila gypsy retrotransposon. Genetics 139:215–228.
  • Spradling, A. C., and G. M. Rubin. 1982. Transposition of cloned P elements into Drosophila germ line chromosomes. Science 218:341–347.
  • Sun, F. L., and S. C. Elgin. 1999. Putting boundaries on silence. Cell 99:459–462.
  • Tolhuis, B., R. J. Palstra, E. Splinter, F. Grosveld, and W. de Laat. 2002. Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol. Cell 10:1453–1465.
  • Vakoc, C. R., D. L. Letting, N. Gheldof, T. Sawado, M. A. Bender, M. Groudine, M. J. Weiss, J. Dekker, and G. A. Blobel. 2005. Proximity among distant regulatory elements at the β-globin locus requires GATA-1 and FOG-1. Mol. Cell 17:453–462.
  • Wei, W., and M. D. Brennan. 2000. Polarity of transcriptional enhancement revealed by an insulator element. Proc. Natl. Acad. Sci. USA 97:14518–14523.
  • Wei, W., and M. D. Brennan. 2001. The gypsy insulator can act as a promoter-specific transcriptional stimulator. Mol. Cell. Biol. 21:7714–7720.
  • West, A. G., M. Gaszner, and G. Felsenfeld. 2002. Insulators: many functions, many mechanisms. Genes Dev. 16:271–288.
  • West, A. G., and P. Fraser. 2005. Remote control of gene transcription. Hum. Mol. Genet. 14:101–111.
  • Zhou, J., H. N. Cai, S. Ohtsuki, and M. Levine. 1997. The regulation of enhancer-promoter interactions in the Drosophila embryo. Cold Spring Harbor Symp. Quant. Biol. 62:307–312.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.