Selective Repression of Low-Density Lipoprotein Receptor Expression by SP600125: Coupling of Histone H3-Ser10 Phosphorylation and Sp1 Occupancy

REFERENCES

• Bain, J., H. McLauchlan, M. E. Elliott, and P. Cohen. 2003. The specificities of protein kinase inhibitors: an update. Biochem. J. 371:199–204.
   PubMed Web of Science ®Google Scholar
• Bennett, B. L., D. Sasaki, B. W. Murray, E. C. O'Leary, S. T. Sakata, W. Xu, J. C. Leisten, A. Motiwala, S. Pierce, Y. Satoh, S. S. Bhagwat, A. M. Manning, and D. W. Anderson. 2003. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA 98:13681–13686.
   Google Scholar
• Berger, S. L. 2002. Histone modifications in transcriptional regulation. Curr. Opin. Genet. Dev. 12:142–148.
   PubMed Web of Science ®Google Scholar
• Blau, J., H. Xiao, S. McCracken, P. O'Hare, J. Greenblatt, and D. Bentley. 1996. Three functional classes of transcriptional activation domain. Mol. Cell. Biol. 16:2044–2055.
   PubMed Web of Science ®Google Scholar
• Bode, A. M., and Z. Dong. 2005. Inducible covalent posttranslational modification of histone H3. Science's STKE [Online.] www.stke.org/cgi/content/full/sigtrans;2005/281/re4 .
   Google Scholar
• Bogoyevitch, M. A., I. Boehm, A. Oakley, A. J. Ketterman, and R. K. Barr. 2004. Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential. Biochim. Biophys. Acta 1697:89–101.
   PubMed Web of Science ®Google Scholar
• Bonny, C., A. Oberson, S. Negri, C. Sauser, and D. F. Schorderet. 2001. Cell-permeable peptide inhibitor of JNK. Diabetes 50:77–82.
   PubMed Web of Science ®Google Scholar
• Brown, S. A., Weirich, C. S., Newton, E. M., and R. E. Kingston. 1998. Transcriptional activation domains stimulate initiation and elongation at different times and via different residues. EMBO J. 17:3146–3154.
   PubMed Web of Science ®Google Scholar
• Brown, M. S., and J. L. Goldstein. 1986. A receptor mediated pathway for cholesterol homeostasis. Science 232:34–47.
   PubMed Web of Science ®Google Scholar
• Brown, M. S., and J. L. Goldstein. 1997. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89:331–340.
   PubMed Web of Science ®Google Scholar
• Cheung, P., D. Allis, and P. Sassone-Corci. 2000. Signaling to chromatin through histone modifications. Cell 103:263–271.
   PubMed Web of Science ®Google Scholar
• Choi, H., Y. Choi, Y. Cho, Z. Feng, A. Bode, and Z. Dong. 2005. Phosphorylation of Ser28 in histone H3 mediated by the mixed-lineage kinase-like mitogen activated protein triple kinase alpha. J. Biol. Chem. 280:13545–13553.
   PubMedGoogle Scholar
• Reference deleted.
   Google Scholar
• Crosio, C., G. M. Fimia, R. Loury, M. Kimura, Y. Okano, H. Zhou, S. Sen, C. D. Allis, and P. Sassone-Corsi. 2002. Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian aurora kinases. Mol. Cell. Biol. 22:874–885.
   PubMed Web of Science ®Google Scholar
• Curtin, J. F., and T. G. Cotter. 2004. JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU45 prostate carcinoma cells. J. Biol. Chem. 279:17090–17100.
   PubMedGoogle Scholar
• Dawson, P. A., S. L. Hofmann, D. R. van der Westhuyzen, T. C. Sudhof, M. S. Brown, and J. L. Goldstein. 1988. Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1. J. Biol. Chem. 263:3372–3379.
   PubMed Web of Science ®Google Scholar
• Della Ragione, F., V. Criniti, V. Della Pietra, A. Borrielo, A. Oliva, S. Indaco, T. Yamamoto, and V. Zappia. 2001. Genes modulated by histone acetylation as new effectors of butyrate activity. FEBS Lett. 499:199–204.
   PubMed Web of Science ®Google Scholar
• Dhawan, P., A. Bell, A. Kumar, C. Golden, and K. D. Mehta. 1999. Critical role of p42/44MAPK activation in anisomycin and hepatocyte growth factor-induced LDL receptor expression: activation of Raf-1/MEK 1/2/p42/44MAPK cascade alone is sufficient to induce LDL receptor expression. J. Lipid Res. 40:1911–1919.
   PubMedGoogle Scholar
• Du, L., C. S. Lyle, T. B. Obey, W. A. Gaarde, J. A. Muir, B. L. Bennett, and T. C. Chambers. 2004. Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity. J. Biol. Chem. 279:11956–11966.
   Google Scholar
• Duan, H., C. A. Heckman, and L. M. Boxer. 2005. Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. Mol. Cell. Biol. 25:1608–1619.
   PubMed Web of Science ®Google Scholar
• Hartman, M. G., D. Lu, M. Kim, G. J. Kociba, T. Shukri, J. Buteau, X. Wang, W. L. Frankel, D. Guttridge, M. Prentki., S. T. Grey, D. Ron, and T. Hai. 2004. Role for activating transcription factor 3 in stress-induced β-cell apoptosis. Mol. Cell. Biol. 24:5721–5732.
   PubMed Web of Science ®Google Scholar
• He, Z., W. Y. Ma, G. Liu, Y. Zhang, M. Bode, and Z. Dong. 2003. Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1. J. Biol. Chem. 278:10588–10593.
   PubMed Web of Science ®Google Scholar
• Hendzel, M. J., W. Yi, M. A. Mancini, A. Van Hooser, A. Ranalli, B. R. Brinkley, D. P. Bazett-Jones, and C. D. Allis. 1997. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106:348–360.
   PubMed Web of Science ®Google Scholar
• Hilton, T. L., Y. Li, E. L. Dunphy, and E. H. Wang. 2005. TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter. Mol. Cell. Biol. 25:4321–4332.
   PubMedGoogle Scholar
• Huang, W., V. Mishra, S. Batra, I. Dillon, and K. D. Mehta. 2004. Phorbol ester promotes histone H3-Ser10 phosphorylation at low density lipoprotein receptor promoter in a protein kinase C-dependent manner in human hepatoma HepG2 cells. J. Lipid Res. 45:1519–1527.
   PubMedGoogle Scholar
• Jenuwein, T., and C. D. Allis. 2001. Translating the histone code. Science 293:1074–1080.
   PubMed Web of Science ®Google Scholar
• Kapoor, G. S., B. A. Atkins, and K. D. Mehta. 2002. Activation of Raf-1/MEK-1/2/p42/44MAPK cascade is sufficient to uncouple LDL receptor expression from cell growth. Mol. Cell. Biochem. 236:13–22.
   PubMedGoogle Scholar
• Kumar, A., A. Middleton, T. C. Chambers, and K. D. Mehta. 1998. Differential roles of extracellular signal-regulated kinase-1/2 and p38MAPK in interleukin-1β- and tumor necrosis factor-α-induced low density lipoprotein receptor expression in HepG2 cells. J. Biol. Chem. 273:15742–15748.
   PubMedGoogle Scholar
• Labrador, M., and V. G. Corces. 2003. Phosphorylation of histone H3 during transcriptional activation depends on promoter structure. Genes Dev. 17:43–48.
   PubMed Web of Science ®Google Scholar
• Li, F., L. Adam, R. K. Vadlamudi, H. Zhou, S. Sen, J. Chernoff, M. Mandal, and R. Kumar. 2002. p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep. 3:767–773.
   PubMedGoogle Scholar
• Lo, W., E. R. Gamache, K. W. Henry, D. Yang, L. Pillus, and S. L. Berger. 2005. Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms. EMBO J. 24:997–1008.
   PubMedGoogle Scholar
• Mahadevan, L. C., A. C. Willis, and M. J. Barratt. 1991. Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors. Cell 65:775–783.
   PubMed Web of Science ®Google Scholar
• Mariadason, J. M., G. A. Corner, and L. H. Augenlicht. 2000. Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and cucrcumin and implications for chemoprevention of colon cancer. Cancer Res. 60:4561–4572.
   PubMed Web of Science ®Google Scholar
• Mehta, K. D., R. Chang, J. Underwood, J. Wise, and A. Kumar. 1996. Identification of a novel cis-acting element participating in maximal induction of the human LDL receptor gene transcription in response to low cellular cholesterol levels. J. Biol. Chem. 271:33616–33622.
   PubMedGoogle Scholar
• Mehta, K. D., and L. Miller. 1999. Inhibition of stress-activated p38 mitogen-activated protein kinase induces low density lipoprotein receptor expression. Trends Cardiovasc. Dis. 9:201–205.
   PubMedGoogle Scholar
• Nowak, S. J., and V. G. Corces. 2000. Phosphorylation of histone H3 correlates with transcriptionally active loci. Genes Dev. 14:3003–3013.
   PubMed Web of Science ®Google Scholar
• Oliner, J. D., J. M. Andresen, S. K. Hansen, S. Zhou, and R. Tjian. 1996. SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. Genes Dev. 10:2903–2911.
   PubMedGoogle Scholar
• Roth, S. Y., J. M. Denu, and C. D. Allis. 2001. Histone acetyltransferases. Annu. Rev. Biochem. 70:81–120.
   PubMed Web of Science ®Google Scholar
• Salvador, L. M., Y. Park, J. Cottom, E. T. Maizels, J. C. Jones, R. V. Schillace, D. W. Carr, P. Cheung, C. D. Allis, J. L. Jameson, and M. Hunzicker-Dunn. 2001. Follicle-stimulating hormone stimulates protein kinase A-mediated histone H3 phosphorylation and acetylation leading to select gene activation in ovarian granulosa cells. J. Biol. Chem. 276:40146–40155.
   PubMedGoogle Scholar
• Sanchez, H. B., L. Yieh, and T. F. Osborne. 1995. Cooperation by SREBP and Sp1 in sterol regulation of low density lipoprotein receptor gene. J. Biol. Chem. 270:1161–1169.
   PubMed Web of Science ®Google Scholar
• Sassone-Corsi, P., C. A. Mizzen, P. Cheung, C. Crosio, L. Monaco, S. Jacquot, A. Hanauer, and C. D. Allis. 1999. Requirement of Rsk-2 for epidermal growth factor activated phosphorylation of histone H3. Science 285:886–891.
   PubMed Web of Science ®Google Scholar
• Shen, Y. H., J. Godlewski, J. Zhu, P. Sathyanarayana, V. Leaner, M. J. Birrer, A. Rana, and G. Tzivion. 2003. Cross-talk between JNK/SAPK and ERK/MAPK pathways. J. Biol. Chem. 278:26715–26721.
   PubMedGoogle Scholar
• Singh, R. P., P. Dhawan, C. Golden, G. S. Kapoor, and K. D. Mehta. 1999. One-way cross-talk between p38MAPK and p42/44MAPK. Inhibition of p38MAPK induces low density lipoprotein receptor expression through activation of p42/44MAPK cascade. J. Biol. Chem. 274:19593–19600.
   PubMed Web of Science ®Google Scholar
• Soloaga, A., S. Thomson, G. R. Wiggin, N. Rampersaud, M. H. Dyson, C. A. Hazzalin, L. C. Mahadevan, and J. S. C. Arthur. 2003. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J. 22:2788–2797.
   PubMed Web of Science ®Google Scholar
• Spencer, V. A., and J. R. Davie. 1999. Role of covalent modifications of histones in regulating gene expression. Gene 240:1–12.
   PubMedGoogle Scholar
• Strahl, B. D., and C. D. Allis. 2000. The language of covalent modifications. Nature 403:41–45.
   PubMed Web of Science ®Google Scholar
• Strelkov, I. S., and J. R. Davie. 2002. Ser-10 phosphorylation of histone H3 and immediate early gene expression in oncogene-transformed mouse fibroblasts. Cancer Res. 62:75–78.
   PubMedGoogle Scholar
• Thomson, S., L. C. Mahadevan, and A. L. Clayton. 1999. MAP kinase-mediated signaling to nucleosomes and immediate-early gene induction. Semin. Cell Biol. 10:205–214.
   Google Scholar
• Tong, X., L. Yin, S. Joshi, D. W. Rosenberg, and C. Giardina. 2005. Cyclooxygenase-2 regulation in colon cancer cells. J. Biol. Chem. 280:15503–15509.
   PubMed Web of Science ®Google Scholar
• Turner, B. M. 2000. Histone acetylation and an epigenetic code. Bioessays 22:836–845.
   PubMed Web of Science ®Google Scholar
• Van Lint, C., S. Emiliani, and E. Verdin. 1996. The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation. Gene Expr. 5:245–253.
   PubMed Web of Science ®Google Scholar
• Vincenti, M. P., and C. E. Brinckerhoff. 2001. The potential of signal transduction inhibitors for the treatment of arthritis: is it all just JNK? J. Clin. Investig. 108:181–183.
   PubMed Web of Science ®Google Scholar
• Wolffe, A. P. 1998. Chromatin: structure and function, p. 97–108. Academic Press, San Diego, Calif.
   Google Scholar
• Yamamoto, Y., U. N. Verma, S. Prajapati, Y. T. Kwak, and R. B. Gaynor. 2003. Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature 423:655–659.
   PubMed Web of Science ®Google Scholar
• Yankulov, K., J. Blau, T. Purton, S. Roberts, and D. L. Bentley. 1994. Transcriptional elongation by RNA polymerase II is stimulated by transactivators. Cell 77:749–759.
   PubMedGoogle Scholar
• Zhong, S., W. Ma, and Z. Dong. 2000. ERKs and p38 kinases mediate ultraviolet B-induced phosphorylation of histone H3 at serine 10. J. Biol. Chem. 275:20980–20984.
   PubMed Web of Science ®Google Scholar