Inhibition of ADP/ATP Exchange in Receptor-Interacting Protein-Mediated Necrosis

REFERENCES

• Ahmad, M., S. M. Srinivasula, L. Wang, R. V. Talanian, G. Litwack, T. Fernandes-Alnemri, and E. S. Alnemri. 1997. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. 57:615–619.
   PubMed Web of Science ®Google Scholar
• Baines, C. P., R. A. Kaiser, N. H. Purcell, N. S. Blair, H. Osinska, M. A. Hambleton, E. W. Brunskill, M. R. Sayen, R. A. Gottlieb, G. W. Dorn, J. Robbins, and J. D. Molkentin. 2005. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434:658–662.
   PubMed Web of Science ®Google Scholar
• Belzacq, A. S., H. L. Vieira, F. Verrier, G. Vandecasteele, I. Cohen, M. C. Prevost, E. Larquet, F. Pariselli, P. X. Petit, A. Kahn, R. Rizzuto, C. Brenner, and G. Kroemer. 2003. Bcl-2 and Bax modulate adenine nucleotide translocase activity. Cancer Res. 63:541–546.
   PubMedGoogle Scholar
• Bottero, V., F. Rossi, M. Samson, M. Mari, P. Hofman, and J. F. Peyron. 2001. Ikappa b-alpha, the NF-kappa B inhibitory subunit, interacts with ANT, the mitochondrial ATP/ADP translocator. J. Biol. Chem. 276:21317–21324.
   PubMedGoogle Scholar
• Castedo, M., K. Ferri, T. Roumier, D. Metivier, N. Zamzami, and G. Kroemer. 2002. Quantitation of mitochondrial alterations associated with apoptosis. J. Immunol. Methods 265:39–47.
   PubMed Web of Science ®Google Scholar
• Cauwels, A., B. Janssen, A. Waeytens, C. Cuvelier, and P. Brouckaert. 2003. Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2. Nat. Immunol. 4:387–393.
   PubMed Web of Science ®Google Scholar
• Chipuk, J. E., T. Kuwana, L. Bouchier-Hayes, N. M. Droin, D. D. Newmeyer, M. Schuler, and D. R. Green. 2004. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303:1010–1014.
   PubMed Web of Science ®Google Scholar
• Deng, Y., X. Ren, L. Yang, Y. Lin, and X. Wu. 2003. A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell 115:61–70.
   PubMed Web of Science ®Google Scholar
• Devin, A., Y. Lin, and Z. G. Liu. 2003. The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinases. EMBO Rep. 4:623–627.
   PubMed Web of Science ®Google Scholar
• Ekert, P. G., J. Silke, and D. L. Vaux. 1999. Caspase inhibitors. Cell Death Differ. 6:1081–1086.
   PubMed Web of Science ®Google Scholar
• Fiore, C., V. Trezeguet, A. Le Saux, P. Roux, C. Schwimmer, A. C. Dianoux, F. Noel, G. J. Lauquin, G. Brandolin, and P. V. Vignais. 1998. The mitochondrial ADP/ATP carrier: structural, physiological and pathological aspects. Biochimie 80:137–150.
   PubMed Web of Science ®Google Scholar
• Flierl, A., Y. Chen, P. E. Coskun, R. J. Samulski, and D. C. Wallace. 2005. Adeno-associated virus-mediated gene transfer of the heart/muscle adenine nucleotide translocator (ANT) in mouse. Gene Ther. 12:570–578.
   PubMedGoogle Scholar
• Green, D. R., and G. Kroemer. 2004. The pathophysiology of mitochondrial cell death. Science 305:626–629.
   PubMed Web of Science ®Google Scholar
• Halestrap, A. P., K. Y. Woodfield, and C. P. Connern. 1997. Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. J. Biol. Chem. 272:3346–3354.
   PubMed Web of Science ®Google Scholar
• Hatanaka, T., Y. Kihira, Y. Shinohara, E. Majima, and H. Terada. 2001. Characterization of loops of the yeast mitochondrial ADP/ATP carrier facing the cytosol by site-directed mutagenesis. Biochem. Biophys. Res. Commun. 286:936–942.
   PubMedGoogle Scholar
• Holler, N., R. Zaru, O. Micheau, M. Thome, A. Attinger, S. Valitutti, J. L. Bodmer, P. Schneider, B. Seed, and J. Tschopp. 2000. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat. Immunol. 1:489–495.
   PubMed Web of Science ®Google Scholar
• Jaattela, M., and J. Tschopp. 2003. Caspase-independent cell death in T lymphocytes. Nat. Immunol. 4:416–423.
   PubMed Web of Science ®Google Scholar
• Kamata, H., S. Honda, S. Maeda, L. Chang, H. Hirata, and M. Karin. 2005. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120:649–661.
   PubMed Web of Science ®Google Scholar
• Kelliher, M. A., S. Grimm, Y. Ishida, F. Kuo, B. Z. Stanger, and P. Leder. 1998. The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity 8:297–303.
   PubMed Web of Science ®Google Scholar
• Kokoszka, J. E., K. G. Waymire, S. E. Levy, J. E. Sligh, J. Cai, D. P. Jones, G. R. MacGregor, and D. C. Wallace. 2004. The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature 427:461–465.
   PubMed Web of Science ®Google Scholar
• Kreuz, S., D. Siegmund, J. J. Rumpf, D. Samel, M. Leverkus, O. Janssen, G. Hacker, O. Dittrich-Breiholz, M. Kracht, P. Scheurich, and H. Wajant. 2004. NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP. J. Cell Biol. 166:369–380.
   PubMed Web of Science ®Google Scholar
• Lassus, P., X. Opitz-Araya, and Y. Lazebnik. 2002. Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 297:1352–1354.
   PubMed Web of Science ®Google Scholar
• Lewis, J., A. Devin, A. Miller, Y. Lin, Y. Rodriguez, L. Neckers, and Z. G. Liu. 2000. Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation. J. Biol. Chem. 275:10519–10526.
   PubMed Web of Science ®Google Scholar
• Lin, D. T., and J. D. Lechleiter. 2002. Mitochondrial targeted cyclophilin D protects cells from cell death by peptidyl prolyl isomerization. J. Biol. Chem. 277:31134–31141.
   PubMedGoogle Scholar
• Lin, Y., S. Choksi, H. M. Shen, Q. F. Yang, G. M. Hur, Y. S. Kim, J. H. Tran, S. A. Nedospasov, and Z. G. Liu. 2004. Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J. Biol. Chem. 279:10822–10828.
   PubMed Web of Science ®Google Scholar
• Liu, H., Y. Ma, L. J. Pagliari, H. Perlman, C. Yu, A. Lin, and R. M. Pope. 2004. TNF-alpha-induced apoptosis of macrophages following inhibition of NF-kappaB: a central role for disruption of mitochondria. J. Immunol. 172:1907–1915.
   PubMedGoogle Scholar
• Liu, H., H. Perlman, L. J. Pagliari, and R. M. Pope. 2001. Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation. J. Exp. Med. 194:113–126.
   PubMed Web of Science ®Google Scholar
• Liu, H., and R. M. Pope. 2004. Phagocytes: mechanisms of inflammation and tissue destruction. Rheum. Dis. Clin. N. Am. 30:19–39.
   PubMed Web of Science ®Google Scholar
• Ma, Y., H. Liu, H. Tu-Rapp, H. J. Thiesen, S. M. Ibrahim, S. M. Cole, and R. M. Pope. 2004. Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation. Nat. Immunol. 5:380–387.
   PubMed Web of Science ®Google Scholar
• Machida, K., Y. Hayashi, and H. Osada. 2002. A novel adenine nucleotide translocase inhibitor, MT-21, induces cytochrome c release by a mitochondrial permeability transition-independent mechanism. J. Biol. Chem. 277:31243–31248.
   PubMedGoogle Scholar
• Maianski, N. A., D. Roos, and T. W. Kuijpers. 2003. Tumor necrosis factor alpha induces a caspase-independent death pathway in human neutrophils. Blood 101:1987–1995.
   PubMedGoogle Scholar
• Majewski, N., V. Nogueira, P. Bhaskar, P. E. Coy, J. E. Skeen, K. Gottlob, N. S. Chandel, C. B. Thompson, R. B. Robey, and N. Hay. 2004. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol. Cell 16:819–830.
   PubMed Web of Science ®Google Scholar
• Majima, E., H. Koike, Y. M. Hong, Y. Shinohara, and H. Terada. 1993. Characterization of cysteine residues of mitochondrial ADP/ATP carrier with the SH-reagents eosin 5-maleimide and N-ethylmaleimide. J. Biol. Chem. 268:22181–22187.
   PubMedGoogle Scholar
• Nakagawa, T., S. Shimizu, T. Watanabe, O. Yamaguchi, K. Otsu, H. Yamagata, H. Inohara, T. Kubo, and Y. Tsujimoto. 2005. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 434:652–658.
   PubMed Web of Science ®Google Scholar
• Newmeyer, D. D., and S. Ferguson-Miller. 2003. Mitochondria: releasing power for life and unleashing the machineries of death. Cell 112:481–490.
   PubMed Web of Science ®Google Scholar
• Perlman, H., L. J. Pagliari, C. Georganas, T. Mano, K. Walsh, and R. M. Pope. 1999. FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis. J Exp. Med. 190:1679–1688.
   PubMed Web of Science ®Google Scholar
• Pham, C. G., C. Bubici, F. Zazzeroni, S. Papa, J. Jones, K. Alvarez, S. Jayawardena, E. De Smaele, R. Cong, C. Beaumont, F. M. Torti, S. V. Torti, and G. Franzoso. 2004. Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell 119:529–542.
   PubMed Web of Science ®Google Scholar
• Proskuryakov, S. Y., A. G. Konoplyannikov, and V. L. Gabai. 2003. Necrosis: a specific form of programmed cell death? Exp. Cell Res. 283:1–16.
   PubMed Web of Science ®Google Scholar
• Saelens, X., N. Festjens, E. Parthoens, I. Vanoverberghe, M. Kalai, F. van Kuppeveld, and P. Vandenabeele. 2005. Protein synthesis persists during necrotic cell death. J. Cell Biol. 168:545–551.
   PubMedGoogle Scholar
• Schubert, A., and S. Grimm. 2004. Cyclophilin D, a component of the permeability transition-pore, is an apoptosis repressor. Cancer Res. 64:85–93.
   PubMedGoogle Scholar
• Schulze, K., B. Witzenbichler, C. Christmann, and H. P. Schultheiss. 1999. Disturbance of myocardial energy metabolism in experimental virus myocarditis by antibodies against the adenine nucleotide translocator. Cardiovasc. Res. 44:91–100.
   PubMed Web of Science ®Google Scholar
• Su, H., N. Bidere, L. Zheng, A. Cubre, K. Sakai, J. Dale, L. Salmena, R. Hakem, S. Straus, and M. Lenardo. 2005. Requirement for caspase-8 in NF-kappaB activation by antigen receptor. Science 307:1465–1468.
   PubMed Web of Science ®Google Scholar
• Vanden Berghe, T., M. Kalai, G. van Loo, W. Declercq, and P. Vandenabeele. 2003. Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis. J. Biol. Chem. 278:5622–5629.
   PubMedGoogle Scholar
• Vanden Berghe, T., G. van Loo, X. Saelens, M. Van Gurp, G. Brouckaert, M. Kalai, W. Declercq, and P. Vandenabeele. 2004. Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD. J. Biol. Chem. 279:7925–7933.
   PubMedGoogle Scholar
• Vander Heiden, M. G., N. S. Chandel, P. T. Schumacker, and C. B. Thompson. 1999. Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol. Cell 3:159–167.
   PubMed Web of Science ®Google Scholar
• Vercammen, D., R. Beyaert, G. Denecker, V. Goossens, G. Van Loo, W. Declercq, J. Grooten, W. Fiers, and P. Vandenabeele. 1998. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J. Exp. Med. 187:1477–1485.
   PubMed Web of Science ®Google Scholar
• Verrier, F., A. Deniaud, M. Lebras, D. Metivier, G. Kroemer, B. Mignotte, G. Jan, and C. Brenner. 2004. Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis. Oncogene 23:8049–8064.
   PubMedGoogle Scholar
• Vivarelli, M. S., D. McDonald, M. Miller, N. Cusson, M. Kelliher, and R. S. Geha. 2004. RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. J Exp. Med. 200:399–404.
   PubMedGoogle Scholar
• Weaver, J. G., A. Tarze, T. C. Moffat, M. Lebras, A. Deniaud, C. Brenner, G. D. Bren, M. Y. Morin, B. N. Phenix, L. Dong, S. X. Jiang, V. L. Sim, B. Zurakowski, J. Lallier, H. Hardin, P. Wettstein, R. P. van Heeswijk, A. Douen, R. T. Kroemer, S. T. Hou, S. A. Bennett, D. H. Lynch, G. Kroemer, and A. D. Badley. 2005. Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor. J. Clin. Investig. 115:1828–1838.
   PubMed Web of Science ®Google Scholar
• Yu, L., A. Alva, H. Su, P. Dutt, E. Freundt, S. Welsh, E. H. Baehrecke, and M. J. Lenardo. 2004. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304:1500–1502.
   PubMed Web of Science ®Google Scholar