Activation of Octamer-Containing Promoters by Either Octamer-Binding Transcription Factor 1 (OTF-1) or OTF-2 and Requirement of an Additional B-Cell-Specific Component for Optimal Transcription of Immunoglobulin Promoters

LITERATURE CITED

• Araki, K., H. Maeda, J. Wang, D. Kitamura, and T. Watanabe. 1988. Purification of a nuclear trans-acting factor involved in the regulated transcription of a human immunoglobulin heavy chain gene. Cell 53:723–730.
   PubMedGoogle Scholar
• Augereau, P., and P. Chambon. 1986. The mouse immunoglobulin heavy-chain enhancer: effect on transcription in vitro and binding of proteins present in HeLa and lymphoid B cell extracts. EMBO J. 5:1791–1797.
   PubMed Web of Science ®Google Scholar
• Berk, A. J., and P. A. Sharp. 1977. Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of SI endonuclease-digested hybrids. Cell 12:721–729.
   PubMed Web of Science ®Google Scholar
• Calame, K. L. 1989. Immunoglobulin gene transcription: molecular mechanisms. Trends Genet. 5:395–399.
   PubMed Web of Science ®Google Scholar
• Clerc, R. G., L. M. Corcoran, J. H. LeBowitz, D. Baltimore, and P. A. Sharp. 1988. The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains. Genes Dev. 2:1570–1581.
   PubMed Web of Science ®Google Scholar
• Cockerill, P. N., and S. P. Klinken. 1990. Octamer-binding proteins in diverse hemopoietic cells. Mol. Cell. Biol. 10:1293–1296.
   PubMedGoogle Scholar
• Dahlberg, J. E., and E. Lund. 1988. The genes and transcription of the major small nuclear RNAs, p. 38–70. In M. L. Birnstiel (ed.), Structure and function of major and minor small nuclear ribonucleoprotein particles. Springer-Verlag, Berlin.
   Google Scholar
• Dente, L., M. Sollazzo, C. Baldari, G. Cesareni, and R. Cortese. 1985. The pEMBL family of single-stranded vectors, p. 101–107. In D. M. Glover (ed.), DNA cloning: a practical approach, vol. 1. IRL Press, Oxford.
   Google Scholar
• Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
   PubMed Web of Science ®Google Scholar
• Falkner, F. G., and H. G. Zachau. 1984. Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements. Nature (London) 310:71–74.
   PubMed Web of Science ®Google Scholar
• Fletcher, C., N. Heintz, and R. G. Roeder. 1987. Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene. Cell 51:773–781.
   PubMed Web of Science ®Google Scholar
• Gerster, T., C. Balmaceda, and R. G. Roeder. 1990. The cell type-specific octamer transcription factor OTF-2 has two domains required for the activation of transcription. EMBO J. 9:1635–1643.
   PubMedGoogle Scholar
• Gerster, T., P. Matthias, M. Thali, J. Jiricny, and W. Schaffner. 1987. Cell type-specificity elements of the immunoglobulin heavy chain enhancer. EMBO J. 6:1323–1330.
   PubMed Web of Science ®Google Scholar
• Gerster, T., and R. G. Roeder. 1988. A herpesvirus transactivating protein interacts with transcription factor OTF-1 and other cellular proteins. Proc. Natl. Acad. Sci. USA 85:6347–6351.
   PubMedGoogle Scholar
• Goding, C. R., and P. O'Hare. 1989. Herpes simplex virus Vmw65-octamer-binding protein interaction: a paradigm for combinatorial control of transcription. Virology 173:363–367.
   PubMed Web of Science ®Google Scholar
• Greaves, R., and P. O'Hare. 1989. Separation of requirements for protein-DNA complex assembly from those for functional activity in the herpes simplex virus regulatory protein Vmw65. J. Virol. 63:1641–1650.
   PubMedGoogle Scholar
• Grosschedl, R., and D. Baltimore. 1985. Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell 41:885–897.
   PubMed Web of Science ®Google Scholar
• Herr, W., R. A. Sturm, R. G. Clerc, L. M. Corcoran, D. Baltimore, P. A. Sharp, H. A. Ingraham, M. G. Rosenfeld, M. Finney, G. Ruvkun, and H. R. Horvitz. 1988. The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev. 2:1513–1516.
   PubMed Web of Science ®Google Scholar
• Jackson, S. P., and R. Tjian. 1989. Purification and analysis of RNA polymerase II transcription factors by using wheat germ agglutinin affinity chromatography. Proc. Natl. Acad. Sci. USA 86:1781–1785.
   PubMed Web of Science ®Google Scholar
• Johnson, D. G., L. Carayannopoulos, J. D. Capra, P. W. Tucker, and J. H. Hanke. 1990. The ubiquitous octamer-binding pro tein(s) is sufficient for transcription of immunoglobulin genes. Mol. Cell. Biol. 10:982–990.
   PubMedGoogle Scholar
• Johnson, P. F., and S. L. McKnight. 1989. Eukaryotic transcriptional regulatory proteins. Annu. Rev. Biochem. 58:799–839.
   PubMed Web of Science ®Google Scholar
• Kemler, I., and W. Schaffner. 1990. Octamer transcription factors and the cell type-specificity of immunoglobulin gene expression. FASEB J. 4:1444–1449.
   PubMedGoogle Scholar
• Ko, H. S., P. Fast, W. McBride, and L. M. Staudt. 1988. A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain. Cell 55:135–144.
   PubMed Web of Science ®Google Scholar
• LaBella, F., P. Gallinari, J. McKinney, and N. Heintz. 1989. Histone H1 subtype-specific consensus elements mediate cell cycle-regulated transcription in vitro. Genes Dev. 3:1982–1990.
   PubMed Web of Science ®Google Scholar
• LaBella, F., H. L. Sive, R. G. Roeder, and N. Heintz. 1988. Cell-cycle regulation of a human histone H2b gene is mediated by the H2b-subtype-specific consensus element. Genes Dev. 2:32–39.
   PubMed Web of Science ®Google Scholar
• Landolfi, N. F., D. J. Capra, and P. W. Tucker. 1986. Interaction of cell-type-specific nuclear proteins with the immunoglobulin VH promoter region sequences. Nature (London) 323:548–551.
   PubMed Web of Science ®Google Scholar
• LeBowitz, J. H., T. Kobayashi, L. Staudt, D. Baltimore, and P. A. Sharp. 1988. Octamer-binding proteins from B or HeLa cells stimulate transcription of the immunoglobulin heavy-chain promoter in vitro. Genes Dev. 2:1227–1237.
   PubMedGoogle Scholar
• Libermann, T. A., M. Lenardo, and D. Baltimore. 1990. Involvement of a second lymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression. Mol. Cell. Biol. 10:3155–3162.
   PubMedGoogle Scholar
• Maniatis, T., S. Goodbourn, and J. A. Fischer. 1987. Regulation of inducible and tissue-specific gene expression. Science 236:1237–1245.
   PubMed Web of Science ®Google Scholar
• Mason, J. O., G. T. Williams, and M. S. Neuberger. 1985. Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence. Cell 41:479–487.
   PubMed Web of Science ®Google Scholar
• Matsui, T., J. Segall, P. A. Weil, and R. G. Roeder. 1980. Multiple factors required for accurate initiation of transcription by purified RNA polymerase II. J. Biol. Chem. 255:11992–11996.
   PubMed Web of Science ®Google Scholar
• Mitchell, P. J., and R. Tjian. 1989. Transcriptional regulation in mammalian cells by sequence-specific DNA-binding proteins. Science 245:371–378.
   PubMed Web of Science ®Google Scholar
• Mizushima-Sugano, J., and R. G. Roeder. 1986. Cell-type- specific transcription of an immunoglobulin κ light-chain gene in vitro. Proc. Natl. Acad. Sci. USA 83:8511–8515.
   PubMed Web of Science ®Google Scholar
• Muller, M. M., S. Ruppert, W. Schaffner, and P. Matthias. 1988. A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. Nature (London) 336:544–551.
   PubMedGoogle Scholar
• Murphy, S., C. Di Liegro, and M. Meili. 1987. The in vitro transcription of the 7SK RNA gene by RNA polymerase III is dependent only on the presence of an upstream promoter. Cell 51:81–87.
   PubMedGoogle Scholar
• Murphy, S., B. Moorefield, and T. Pieler. 1989. Common mechanisms of promoter recognition by RNA polymerases II and III. Trends Genet. 5:122–126.
   PubMedGoogle Scholar
• Murphy, S., A. Pierani, C. Scheidereit, M. Meili, and R. G. Roeder. 1989. Purified octamer binding transcription factors stimulate RNA polymerase III-mediated transcription of the 7SK RNA gene. Cell 59:1071–1080.
   PubMed Web of Science ®Google Scholar
• Nelsen, B., T. Kadesch, and R. Sen. 1990. Complex regulation of the immunoglobulin heavy-chain gene enhancer: μΒ, a new determinant of enhancer function. Mol. Cell. Biol. 10:3145–3154.
   PubMedGoogle Scholar
• O'Hare, P., and C. R. Goding. 1988. Heipes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivator. Cell 52:435–445.
   PubMedGoogle Scholar
• O'Neill, E. A., C. Fletcher, C. R. Burrow, N. Heintz, R. G. Roeder, and T. J. Kelly. 1988. Transcription factor OTF-1 is functionally identical to the DNA replication factor NF-III. Science 241:1210–1213.
   PubMedGoogle Scholar
• Parslow, T. G., D. L. Blair, W. J. Murphy, and D. K. Granner. 1984. Structure of the 5′ ends of immunoglobulin genes: a novel conserved sequence. Proc. Natl. Acad. Sci. USA 81:2650–2654.
   PubMed Web of Science ®Google Scholar
• Poellinger, L., B. K. Yoza, and R. G. Roeder. 1989. Functional cooperativity between protein molecules bound at two distinct sequence elements of the immunoglobulin heavy-chain promoter. Nature (London) 337:573–576.
   PubMed Web of Science ®Google Scholar
• Pruijn, G. J., W. van Driel, and P. C. van der Vliet. 1986. Nuclear factor III, a novel sequence-specific DNA-binding protein from HeLa cells stimulating adenovirus DNA replication. Nature (London) 322:656–659.
   PubMed Web of Science ®Google Scholar
• Ptashne, M. 1988. How eukaryotic transcriptional activators work. Nature (London) 335:683–689.
   PubMed Web of Science ®Google Scholar
• Rosenfeld, P. J., E. A. O'Neill, R. J. Wides, and T. J. Kelly. 1987. Sequence-specific interactions between cellular DNA- binding proteins and the adenovirus origin of DNA replication. Mol. Cell. Biol. 7:875–886.
   PubMed Web of Science ®Google Scholar
• Schaffner, W. 1989. How do different transcription factors binding the same DNA sequence sort out their jobs? Trends Genet. 5:37–39.
   PubMed Web of Science ®Google Scholar
• Scheidereit, C., J. A. Cromlish, T. Gerster, K. Kawakami, C. Balmaceda, R. A. Currie, and R. G. Roeder. 1988. A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homeobox protein. Nature (London) 336:551–557.
   PubMedGoogle Scholar
• Scheidereit, C., A. Heguy, and R. G. Roeder. 1987. Identification and purification of a human lymphoid-specific octamer-binding protein (OTF-2) that activates transcription of an immunoglobulin promoter in vitro. Cell 51:783–793.
   PubMed Web of Science ®Google Scholar
• Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1988. Identification of a novel lymphoid-specific octamer-binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA). EMBO J. 7:4221–4229.
   PubMed Web of Science ®Google Scholar
• Scholer, H. R., A. K. Hatzopoulos, R. Balling, N. Suzuki, and P. Gruss. 1989. A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J. 8:2543–2550.
   PubMed Web of Science ®Google Scholar
• Singh, H., R. Sen, D. Baltimore, and P. A. Sharp. 1986. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature (London) 319:154–158.
   PubMed Web of Science ®Google Scholar
• Sive, H. L., N. Heintz, and R. G. Roeder. 1986. Multiple sequence elements are required for maximal in vitro transcription of a human histone H2B. Mol. Cell. Biol. 6:3329–3340.
   PubMedGoogle Scholar
• Sive, H. L., and R. G. Roeder. 1986. Interaction of a common factor with conserved promoter and enhancer sequences in histone H2B, immunoglobulin, and U2 small nuclear RNA (snRNA) genes. Proc. Natl. Acad. Sci. USA 83:6382–6386.
   PubMed Web of Science ®Google Scholar
• Staudt, L. M., H. Singh, R. Sen, T. Wirth, P. A. Sharp, and D. Baltimore. 1986. A lymphoid-specific protein binding to the octamer motif of immunoglobin genes. Nature (London) 323:640–643.
   PubMed Web of Science ®Google Scholar
• Stem, S., M. Tanaka, and W. Herr. 1989. The Oct-1 homeo- domain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16. Nature (London) 341:624–630.
   PubMedGoogle Scholar
• Sturm, R. A., G. Das, and W. Herr. 1988. The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev. 2:1582–1599.
   PubMed Web of Science ®Google Scholar
• Sturm, R. A., and W. Herr. 1988. The POU domain is a bipartite DNA-binding structure. Nature (London) 336:601–604.
   PubMed Web of Science ®Google Scholar
• Tanaka, M., and W. Herr. 1990. Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. Cell 60:375–386.
   PubMedGoogle Scholar
• Thali, M., M. M. Muller, M. DeLorenzi, P. Matthias, and M. Bienz. 1988. Drosophila homoeotic genes encode transcriptional activators similar to mammalian OTF-2. Nature (London) 336:598–601.
   PubMedGoogle Scholar
• Verrijzer, C. P., A. J. Kai, and P. C. Van der Vliet. 1990. The DNA binding domain (POU domain) of transcription factor oct-1 suffices for stimulation of DNA replication. EMBO J. 9:1883–1888.
   PubMedGoogle Scholar
• Westin, G., T. Gerster, M. M. Muller, G. Schaffner, and W. Schaffner. 1987. OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts. Nucleic Acids Res. 15:6787–6798.
   PubMed Web of Science ®Google Scholar
• Wirth, T., L. Staudt, and D. Baltimore. 1987. An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity. Nature (London) 329:174–178.
   PubMed Web of Science ®Google Scholar
• Workman, J. L., S. M. Abmayr, W. A. Cromlish, and R. G. Roeder. 1988. Transcriptional regulation by the immediate early protein of pseudorabies virus during in vitro nucleosome assembly. Cell 55:211–219.
   PubMedGoogle Scholar
• Workman, J. L., R. G. Roeder, and R. E. Kingston. 1990. An upstream transcription factor, USF (MLTF), facilitates the formation of preinitiation complexes during in vitro chromatin assembly. EMBO J. 9:1299–1308.
   PubMedGoogle Scholar
• Yoza, B. K., and R. G. Roeder. 1990. Identification of a novel factor that interacts with an immunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the lymphoid cell-specific factor OTF-2. Mol. Cell. Biol. 10:2145–2153.
   PubMedGoogle Scholar