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Cell Growth and Development

Novel Yeast Protein Kinase (YPK1 Gene Product) Is a 40-Kilodalton Phosphotyrosyl Protein Associated with Protein-Tyrosine Kinase Activity

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Pages 6244-6256 | Received 04 Jun 1990, Accepted 23 Aug 1990, Published online: 31 Mar 2023

LITERATURE CITED

  • Ammerer, G., C. P. Hunter, J. H. Rothman, G. C. Saari, L. A. Valls, and T. H. Stevens. 1986. PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors. Mol. Cell. Biol. 6:2490–2499.
  • Botstein, D., and G. R. Fink. 1988. Yeast: an experimental organism for modem biology. Science 240:1439–1443.
  • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254.
  • Braun, S., W. E. Raymond, and E. F. Racker. 1984. Synthetic tyrosine polymers as substrates and inhibitors of tyrosinespecific protein kinases. J. Biol. Chem. 259:2051–2054.
  • Brugge, J. S., G. Jarosik, J. Anderson, A. Queral-Lustig, M. Fedor-Chaiken, and J. R. Broach. 1987. Expression of Rous sarcoma virus transforming pp60v-src in Saccharomyces cerevisiae. Mol. Cell. Biol. 7:2180–2187.
  • Burnette, W. N. 1981. "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem. 112:195–203.
  • Carlson, M., and D. Botstein. 1982. Two differentially regulated mRNAs with different 5′-ends encode secreted and intracellular forms of yeast invertase. Cell 28:145–154.
  • Castellanos, R. M. P., and M. J. Mazon. 1985. Identification of phosphotyrosine in yeast proteins and of a protein tyrosine kinase associated with the plasma membrane. J. Biol. Chem. 260:8240–8242.
  • Celenza, J. L., and M. Carlson. 1986. A yeast gene that is essential for release from glucose repression encodes a protein kinase. Science 233:1175–1180.
  • Cleveland, D. W., S. G. Risher, M. W. Kirschner, and U. K. Laemmli. 1977. Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. J. Biol. Chem. 252:1102–1106.
  • Cooper, J., and T. Hunter. 1983. Regulation of cell growth and transformation by tyrosine-specific protein kinases: the search for important cellular substrate proteins. Curr. Top. Microbiol. Immunol. 107:125–161.
  • Cooper, J. A., B. M. Sefton, and T. Hunter. 1983. Detection and quantification of phosphotyrosine in protein. Methods Enzymol. 99:387–402.
  • Davis, T. N., and J. Thorner. 1987. Isolation of the yeast calmodulin gene using synthetic oligonucleotide probes. Methods Enzymol. 139:248–262.
  • DeClue, J. E., and G. S. Martin. 1987. Phosphorylation of talin at tyrosine in Rous sarcoma virus-transformed cells. Mol. Cell. Biol. 7:371–378.
  • Draetta, G., H. Piwnica-Worms, D. Morrison, B. Druker, T. Roberts, and D. Beach. 1988. Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature (London) 336:738–744.
  • Ferrell, J. E., and G. S. Martin. 1989. Thrombin stimulates the activities of multiple previously unidentified protein kinases in platelets. J. Biol. Chem. 254:7961–7977.
  • Foster, R., J. Thorner, and G. S. Martin. 1989. Nucleotidyla- tion, not phosphorylation, is the major source of the phosphotyrosine detected in enteric bacteria. J. Bacteriol. 171:272–279.
  • Fuller, R. S., A. Brake, and J. Thorner. 1989. Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease. Proc. Natl. Acad. Sci. USA 86:1434–1438.
  • Gould, K. L., and P. Nurse. 1989. Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature (London) 342:39–45.
  • Hanks, S. K., A. M. Quinn, and T. Hunter. 1988. The protein- kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241:42–52.
  • Hunkapiller, M. W., E. Lujan, F. Ostrander, and L. E. Hood. 1983. Isolation of microgram quantities of proteins from polyacrylamide gels for amino acid sequence analysis. Methods Enzymol. 91:227–236.
  • Hunter, T. 1989. Oncogene products in the cytoplasm: the protein kinases, p. 147–173. In R. A. Weinberg (ed.), Oncogenes and the molecular origins of cancer. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Hunter, T., and J. A. Cooper. 1985. Protein-tyrosine kinases. Annu. Rev. Biochem. 54:897–930.
  • Jones, E. W. 1977. Proteinase mutants of Saccharomyces cerevisiae. Genetics 85:23–33.
  • Jones, W. E. 1984. The synthesis and function of proteases in Saccharomyces: genetic approaches. Annu. Rev. Genet. 18:233–270.
  • Julius, D., R. Schekman, and J. Thorner. 1984. Glycosylation and processing of prepro-a-factor through the yeast secretory pathway. Cell 36:309–318.
  • Kamps, M. P., and B. M. Sefton. 1988. Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine. Oncogene 2:305–315.
  • Kanik-Ennulat, C., and N. Neff. 1990. Vanadate-resistant mutants of Saccharomyces cerevisiae show alterations in protein phosphorylation and growth control. Mol. Cell. Biol. 10:898–909.
  • Kornbluth, S., R. Jove, and H. Hanafusa. 1987. Characterization of avian and viral pp60src proteins expressed in yeast. Proc. Natl. Acad. Sci. USA 84:4455–1459.
  • Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 277:680–685.
  • Lee, R. W. H., and W. B. Huttner. 1983. Tyrosine-O-sulfated proteins of PC 12 pheochromocytoma cells and their sulfation by a tyrosylprotein sulfotransferase. J. Biol. Chem. 258:11326–11334.
  • Marquardt, H., M. N. Lioubin, and T. Ikeda. 1987. Complete amino acid sequence of human transforming growth factor type β2. J. Biol. Chem. 262:1217–12131.
  • Mechler, B., H. Muller, and D. H. Wolf. 1987. Muturation of vacuolar (lysosomal) enzymes in yeast: proteinase YscA and proteinase YscB are catalysts of the processing and activation event of carboxypeptidase YscY. EMBO J. 6:2157–2163.
  • Mendenhall, M. D., C. A. Jones, and S. I. Reed. 1987. Dual regulation of the yeast CDC28-p40 protein kinase complex: cell cycle, pheromone and nutrient limitation effects. Cell 50:927–935.
  • Morrissey, J. H. 1981. Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. Anal. Biochem. 117:307–310.
  • Nurse, P. 1990. Universal control mechanism regulating onset of M phase. Nature (London) 344:503–508.
  • Pringle, J. R., and L. H. Hartwell. 1981. The Saccharomyces cerevisiae cell cycle, p. 97–142. In J. N. Strathem, E. W. Jones, and J. R. Broach (ed.), Molecular biology of the yeast Saccharomyces: life cycle and inheritance. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Radke, K., and G. S. Martin. 1979. Transformation by Rous sarcoma virus: effects of src gene expression on the synthesis and phosphorylation of cellular polypeptides. Proc. Natl. Acad. Sci. USA 76:5212–5216.
  • Reed, S. I., J. A. Hadwiger, and A. T. Lorincz. 1985. Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28. Proc. Natl. Acad. Aci. USA 82:4055–4059.
  • Reneke, J., K. Blumer, W. F. Courchesne, and J. Thorner. 1988. the carboxyl terminal domain of the yeast α-factor receptor is a regulatory domain. Cell 55:221–234.
  • Ross, A. H., D. Baltimore, and H. N. Eisen. 1981. Phosphotyrosine-containing proteins isolated by affinity chromatography with antibodies to a synthetic hapten. Nature (London) 294:654–656.
  • Sanger, F., S. Nlcklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463–5467.
  • Schieven, G., J. Thorner, and G. S. Martin. 1986. Proteintyrosine kinase activity in Saccharomyces cerevisiae. Science 231:390–393.
  • Sela, M. 1962. Inhibition of ribonuclease by copolymers of glutamic acid and aromatic amino acids. J. Biol. Chem. 237:418–421.
  • Sela, M., and L. A. Steiner. 1963. Inhibition of lysozyme by some copolymers of amino acids. Biochemistry 2:416–421.
  • Sherman, F., G. R. Fink, and C. W. Laurence. 1979. Methods in yeast genetics: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Tan, J. L., and J. A. Spudich. 1990. Developmentally regulated protein-tyrosine kinase genes in Dictyostelium discoideum. Mol. Cell. Biol. 10:3578–3583.
  • Yarden, Y., and A. Ullrich. 1988. Growth factor receptor tyrosine kinases. Annu. Rev. Biochem. 57:443–478.

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