5
Views
29
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Cell Cycle Arrest Caused by CLN Gene Deficiency in Saccharomyces cerevisiae Resembles START-I Arrest and Is Independent of the Mating-Pheromone Signalling Pathway

Pages 6482-6490 | Received 13 Jun 1990, Accepted 13 Sep 1990, Published online: 31 Mar 2023

LITERATURE CITED

  • Beach, D., B. Durkacz, and P. Nurse. 1982. Functionally homologous cell cycle control genes in budding and fission yeast. Nature (London) 300:706–709.
  • Bedard, D. P., G. C. Johnston, and R. A. Singer. 1981. New mutations in the yeast Saccharomyces cerevisiae affecting completion of "start". Curr. Genet. 4:205–214.
  • Bedard, D. P., A. W. Li, R. A. Singer, and G. C. Johnston. 1984. Mating ability during chemically induced G1 arrest of cells of the yeast Saccharomyces cerevisiae. J. Bacteriol. 160:1196–1198.
  • Boeke, J. D., F. LaCroute, and G. R. Fink. 1984. A positive selection for mutants lacking 5′ phosphate decarboxylase activity in yeast:5-fluoro-orotic acid resistance. Mol. Gen. Genet. 197:345–346.
  • Booher, R., and D. Beach. 1986. Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosac- charomyces pombe. Mol. Cell. Biol. 6:3523–3530.
  • Booher, R., and D. Beach. 1987. Interaction between cdcl3+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase. EMBO J. 6:3441–3447.
  • Booher, R., and D. Beach. 1988. Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules. EMBO J. 7:2321–2327.
  • Booher, R. N., C. E. Alfa, J. S. Hyams, and D. H. Beach. 1989. The fission yeast cdc2/cdc13/suc1 protein kinase: regulation of catalytic activity and nuclear localization. Cell 58:485–497.
  • Carter, B. L., and P. E. Sudbery. 1980. Small-sized mutants of Saccharomyces cerevisiae. Genetics 96:561–566.
  • Clarke, L., and J. Carbon. 1980. Isolation of a yeast centromere and construction of functional small circular chromosomes. Nature (London) 287:504–509.
  • Connolly, B. M., V. C. Bugeja, J. R. Piggott, and B. L. A. Carter. 1983. Mating factor dependence of G1 cell cycle mutants of Saccharomyces cerevisiae. Curr. Genet. 7:309–312.
  • Cross, F., L. H. Hartwell, C. Jackson, and J. B. Konopka. 1988. Conjugation in Saccharomyces cerevisiae. Annu. Rev. Cell Biol. 4:429–457.
  • Cross, F., J. Roberts, and H. Weintraub. 1989. Simple and complex cell cycles. Annu. Rev. Cell Biol. 5:341–395.
  • Cross, F. R. 1988. DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae. Mol. Cell. Biol. 8:4675–4684.
  • Cross, F. R. 1989. Further characterization of a size control gene in Saccharomyces cerevisiae. J. Cell Sci. 94(Suppl. 12):117–127.
  • De Barros Lopes, M., J.-Y. Ho, and S. I. Reed. 1990. Mutations in cell division cycle genes CDC36 and CDC39 activate the Saccharomyces cerevisiae mating pheromone response pathway. Mol. Cell. Biol. 10:2966–2972.
  • Dietzei, C., and J. Kurjan. 1987. The yeast SCG1 gene: a Ga-like protein implicated in the a- and α-factor response pathway. Cell 50:1001–1010.
  • Draetta, G., F. Luca, J. Westendorf, L. Brizuela, J. Ruderman, and D. Beach. 1989. Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell 56:829–838.
  • Elion, E. A., P. L. Grisafi, and G. R. Fink. 1990. FUS3 encodes a cdc2+/CDC2S-related kinase required for the transition from mitosis into conjugation. Cell 60:649–664.
  • Evans, T., E. T. Rosenthal, J. Youngblom, D. Distel, and T. Hunt. 1983. Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell 33:389–396.
  • Gautier, J., J. Minshull, M. Lohka, M. Glotzer, T. Hunt, and J. L. Mailer. 1990. Cyclin is a component of maturation-promoting factor from Xenopus. Cell 60:487–494.
  • Hadwiger, J. A., C. Wittenberg, H. E. Richardson, M. De Barros Lopes, and S. I. Reed. 1989. A family of cyclin homologs that control the G1 phase in yeast. Proc. Natl. Acad. Sci. USA 86:6255–6259.
  • Hagan, I., J. Hayles, and P. Nurse. 1988. Cloning and sequencing of the cyclin-related cdcl3+ gene and a cytological study of its role in fission yeast mitosis. J. Cell Sci. 91:587–595.
  • Hartwell, L. H. 1976. Sequential function of gene products relative to DNA synthesis in the yeast cell cycle. J. Mol. Biol. 104:803–817.
  • Hartwell, L. H., and M. W. Unger. 1977. Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division. J. Cell Biol. 75:422–435.
  • Jackson, C. L., and L. H. Hartwell. 1990. Courtship in Saccharomyces cerevisiae: an early cell-cell interaction during mating. Mol. Cell. Biol. 10:2202–2213.
  • Jagadish, M. N., and B. L. Carter. 1977. Genetic control of cell division in yeast cultured at different growth rates. Nature (London) 269:145–147.
  • Jahng, K.-Y., J. Ferguson, and S. I. Reed. 1988. Mutations in a gene encoding the alpha subunit of a Saccharomyces G protein indicate a role in mating pheromone signalling. Mol. Cell. Biol. 8:2484–2493.
  • Johnston, G. C., J. R. Pringle, and L. H. Hartwell. 1977. Coordination of growth with cell division in the yeast Saccha- romyces cerevisiae. Exp. Cell Res. 105:79–98.
  • Johnston, M., and R. W. Davis. 1984. Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae. Mol. Cell. Biol. 4:1440–1448.
  • Kurjan, J. 1985. α-Factor structural gene mutations in Saccharomyces cerevisiae: effects on α-factor production and mating. Mol. Cell. Biol. 5:787–796.
  • Labbe, J.-C., J.-P. Capony, D. Caput, J.-C. Cavadore, J. Derancourt, M. Kaghad, J.-M. Lelias, A. Picard, and M. Doree. 1989. MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B. EMBO J. 8:3053–3058.
  • Lorincz, A. T., and S. I. Reed. 1986. Sequence analysis of temperature-sensitive mutations in the Saccharomyces cerevisiae gene CDC28. Mol. Cell. Biol. 6:4099–4103.
  • Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring, N.Y.
  • McCaffrey, G., F. J. Clay, K. Kelsey, and G. F. Sprague. 1987. Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 7:2680–2690.
  • Minshull, J., J. J. Blow, and T. Hunt. 1989. Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis. Cell 56:947–956.
  • Miyjima, I., M. Nakafuku, N. Nakayama, C. Brenner, and K. Matsumoto. 1987. GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction. Cell 50:1011–1019.
  • Moreno, S., J. Hayles, and P. Nurse. 1989. Regulation of p34cdc2 protein kinase during mitosis. Cell 58:361–372.
  • Murray, A. W. 1989. Cell biology: the cell cycle as a cdc2 cycle [news]. Nature (London) 342:14–15.
  • Murray, A. W., and M. W. Kirschner. 1989. Cyclin synthesis drives the early embryonic cell cycle. Nature (London) 339:275–280.
  • Murray, A. W., M. J. Solomon, and M. W. Kirschner. 1989. The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature (London) 339:280–286.
  • Murray, A. W., and J. W. Szostak. 1983. Pedigree analysis of plasmid segregation in yeast. Cell 34:961–970.
  • Nakayama, N., Y. Kaziro, K. Arai, and K. Matsumoto. 1988. Role of STE genes in the mating factor signaling pathway mediated by GPA1 in Saccharomyces cerevisiae. Mol. Cell. Biol. 8:3777–3783.
  • Nash, R., G. Tokiwa, S. Anand, K. Erickson, and A. B. Futcher. 1988. The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog. EMBO J. 7:4335–4346.
  • Neiman, A. M., F. Chang, K. Komachi, and I. Herskowitz. 1990. CDC36 and CDC39 are negative elements in the signal transduction pathway of yeast. Cell Regulation 1:391–401.
  • Nurse, P. 1985. Cell cycle control genes in yeast. Trends Genet. 1:51–55.
  • Nurse, P., and Y. Bissett. 1981. Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature (London) 292:558–560.
  • Parent, S. A., C. M. Fenimore, and K. Bostian. 1985. Vector systems for the expression, analysis and cloning of DNA sequences in S. cerevisiae. Yeast 1:83–138.
  • Piggott, J. R., R. Rai, and B. L. Carter. 1982. A bifunctional gene product involved in two phases of the yeast cell cycle. Nature (London) 298:391–393.
  • Pines, J., and T. Hunter. 1989. Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the celT cycle and for interaction with p34cdc2. Cell 58:833–846.
  • Pondaven, P., L. Meyer, and D. Beach. 1990. Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components. Genes Dev. 4:9–17.
  • Prendergast, J. A., L. E. Murray, A. Rowley, D. R. Carruthers, R. A. Singer, and G. C. Johnston. 1990. Size selection identifies new genes that regulate Saccharomyces cerevisiae cell proliferation. Genetics 124:81–90.
  • Pringle, J. R., and L. H. Hartwell. 1981. The Saccharomyces cerevisiae life cycle, p. 97–142. In J. Strathem, E. W. Jones, and J. R. Broach (ed.), The molecular biology of the yeast Saccharomyces cerevisiae. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Reed, S. I. 1980. The selection of S. cerevisiae mutants defective in the start event of cell division. Genetics 95:561–577.
  • Reed, S. I., and C. Wittenberg. 1990. A mitotic role for the Cdc28 protein kinase of 5. cerevisiae. Proc. Natl. Acad. Sci. USA 87:5697–5701.
  • Reid, B. J., and L. H. Hartwell. 1977. Regulation of mating in the cell cycle of Saccharomyces cerevisiae. J. Cell Biol. 75:355–365.
  • Richardson, H. E., C. Wittenberg, F. Cross, and S. I. Reed. 1989. An essential G1 function for cyclin-like proteins in yeast. Cell 59:1127–1133.
  • Rogers, S., R. Wells, and M. Rechsteiner. 1986. Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science 234:364–368.
  • Rothstein, R. 1983. One-step gene disruption in yeast. Methods Enzymol. 101:202–211.
  • Scharf, S. J., G. T. Horn, and H. A. Erlich. 1986. Direct cloning and sequence analysis of enzymatically amplified genomic sequences. Science 233:1076–1078.
  • Sherman, F., G. R. Fink, and J. B. Hicks. 1989. Laboratory course manual for methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Shuster, J. R. 1982. Mating-defective ste mutations are suppressed by cell division cycle start mutations in Saccharomyces cerevisiae. Mol. Cell. Biol. 2:1052–1063.
  • Singer, R. A., and G. C. Johnston. 1983. Growth and the cell cycle of the yeast Saccharomyces cerevisiae. II. Relief of cell-cycle constraints allows accelerated cell divisions. Exp. Cell Res. 149:15–26.
  • Singer, R. A., and G. C. Johnston. 1985. Growth and the DNA-division sequence in the yeast Saccharomyces cerevisiae. Exp. Cell Res. 157:387–396.
  • Slater, M. L. 1973. Effects of reversible inhibition of deoxyribonucleic acid synthesis on the yeast cell cycle. J. Bacteriol. 113:263–270.
  • Solomon, M., R. Booher, M. Kirschner, and D. Beach. 1988. Cyclin in fission yeast. Cell 54:738–740.
  • Sudbery, P. E., A. R. Goodey, and B. L. Carter. 1980. Genes which control cell proliferation in the yeast Saccharomyces cerevisiae. Nature (London) 288:401–404.
  • Swenson, K. I., K. M. Farrell, and J. V. Ruderman. 1986. The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes. Cell 47:861–870.
  • Tatchell, K. 1986. RAS genes and growth control in Saccharomyces cerevisiae. J. Bacteriol. 166:364–367.
  • Trueheart, J., J. D. Boeke, and G. R. Fink. 1987. Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein. Mol. Cell. Biol. 7:2316–2328.
  • Wheals, A. E. 1982. Size control models of S. cerevisiae cell proliferation. Mol. Cell. Biol. 2:361–368.
  • Wittenberg, C., K. Sugimoto, and S. I. Reed. 1990. Gl-specific cyclins of Saccharomyces cerevisiae: cell cycle periodicity, regulation by mating pheronmone and association with the p34cdc28 protein kinase. Cell 62:225–237.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.