Promoter and 11-Kilobase Upstream Enhancer Elements Responsible for Hepatoma Cell-Specific Expression of the Rat Ornithine Transcarbamylase Gene

Literature Cited

• Araki, E., F. Shimada, M. Shichiri, M. Mori, and Y. Ebina. 1988. pSV00CAT: low background CAT plasmid. Nucleic Acids Res. 4:1627.
   Google Scholar
• Bagchi, Μ. K., S. Y. Tsai, M. Tsai, and B. W. O'Malley. 1987. Purification and characterization of chicken ovalbumin gene upstream promoter transcription factor from homologous oviduct cells. Mol. Cell. Biol. 7:4151–4158.
   PubMedGoogle Scholar
• Baumhueter, S., G. Courtois, and G. R. Crabtree. 1988. A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the β-fibrinogen gene promoter as HNF-1. EMBO J. 7:2485–2493.
   PubMedGoogle Scholar
• Birkenmeier, E. Η., B. Gwynn, S. Howard, J. Jerry, J. I. Gordon, W. H. Landschulz, and S. L. Me Knight. 1989. Tissuespecific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev. 3:1146–1156.
   PubMed Web of Science ®Google Scholar
• Birnboim, H. C. 1983. A rapid alkaline extraction method for the isolation of plasmid DNA. Methods Enzymol. 100:243–255.
   PubMed Web of Science ®Google Scholar
• Buchman, A. R., L. Burnett, and P. Berg. 1981. The SV40 nucleotide sequence, p. 799–841. In J. Tooze (ed.), DNA tumor viruses, 2nd ed., revised. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Camper, S. A., and S. M. Tilghman. 1989. Postnatal repression of the α-fetoprotein gene is enhancer independent. Genes Dev. 3:537–546.
   PubMedGoogle Scholar
• Cereghini, S., M. Blumenfeld, and M. Yaniv. 1988. A liverspecific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells. Genes Dev. 2:957–974.
   PubMed Web of Science ®Google Scholar
• Cereghini, S., M. Raymondjean, A. G. Carranca, P. Herbomel, and M. Yaniv. 1987. Factors involved in control of tissuespecific expression of albumin gene. Cell 50:627–638.
   PubMed Web of Science ®Google Scholar
• Christy, R. J., V. W. Yang, J. M. Ntambi, D. E. Geiman, W. H. Landschulz, A. D. Friedman, Y. Nakabeppu, T. J. Kelly, and M. D. Lane. 1989. Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev. 3:1323–1335.
   PubMedGoogle Scholar
• Ciliberto, G., L. Dente, and R. Cortese. 1985. Cell-specific expression of a transfected human cq-antitrypsin gene. Cell 41:531–540.
   PubMedGoogle Scholar
• Colantuoni, V., A. Pirozzi, C. Blance, and R. Cortese. 1987. Negative control of liver-specific gene expression: cloned human retinol-binding protein gene is repressed in HeLa cells. EMBO J. 6:631–636.
   PubMedGoogle Scholar
• Costa, R. H., D. R. Grayson, K. G. Xanthopoulos, and J. E. Darnell, Jr. 1988. A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, aj-antitrypsin, albumin, and simian virus 40 genes. Proc. Natl. Acad. Sci. USA 85:3840–3844.
   PubMedGoogle Scholar
• Costa, R. Η., E. Lai, D. R. Grayson, and J. E. Darnell, Jr. 1988. The cell-specific enhancer of the mouse transthyretin (prealbumin) gene binds a common factor at one site and a liver-specific factor(s) at two others sites. Mol. Cell. Biol. 8:81–90.
   PubMedGoogle Scholar
• Courtois, G., S. Baumhueter, and G. R. Crabtree. 1988. Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters. Proc. Natl. Acad. Sci. USA 85:7937–7941.
   PubMedGoogle Scholar
• Courtois, G., J. G. Morgan, L. A. Campbell, G. Fourel, and G. R. Crabtree. 1987. Interaction of a liver-specific nuclear factor with the fibrinogen and oq-antitrypsin promoters. Science 238:688–692.
   PubMed Web of Science ®Google Scholar
• Das, Η. Κ., T. Leff, and J. L. Breslow. 1988. Cell type-specific expression of the human apoB gene is controlled by two cis-acting regulatory regions. J. Biol. Chem. 263:11452–11458.
   PubMedGoogle Scholar
• Frain, M., G. Swart, P. Monaci, A. Nicosia, S. Stampfli, R. Frank, and R. Cortese. 1989. The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. Cell 59:145–157.
   PubMed Web of Science ®Google Scholar
• Friedman, A. D., W. H. Landschulz, and S. L. McKnight. 1989. CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev. 3:1314–1322.
   PubMedGoogle Scholar
• Gerster, T., P. Matthias, M. Thali, J. Jiricny, and W. Schaffner. 1987. Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer. EMBO J. 6:1323–1330.
   PubMed Web of Science ®Google Scholar
• Godbout, R., R. Ingram, and S. M. Tilghman. 1986. Multiple regulatory elements in the intergenic region between the α-fetoprotein and albumin genes. Mol. Cell. Biol. 6:477–487.
   PubMed Web of Science ®Google Scholar
• Godbout, R., R. S. Ingram, and S. M. Tilghman. 1988. Fine- structure mapping of the three mouse α-fetoprotein gene enhancers. Mol. Cell. Biol. 8:1169–1178.
   PubMed Web of Science ®Google Scholar
• Gorman, C. 1985. High efficiency gene transfer into mammalian cells, p. 143–190. In D. M. Glover (ed.), DNA cloning, vol. 2. IRL Press, Oxford.
   Google Scholar
• Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044–1051.
   PubMed Web of Science ®Google Scholar
• Gorski, K., M. Carneiro, and U. Schibler. 1986. Tissue-specific in vitro transcription from the mouse albumin promoter. Cell 47:767–776.
   PubMed Web of Science ®Google Scholar
• Hammer, R. E., R. Krumlauf, S. A. Camper, R. L. Brinster, and S. M. Tilghman. 1987. Diversity of alpha-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science 235:53–58.
   PubMedGoogle Scholar
• Hata, A., T. Tsuzuki, K. Shimada, M. Takiguchi, M. Mori, and I. Matsuda. 1988. Structure of the human ornithine transcarbamylase gene. J. Biochem. 103:302–308.
   PubMedGoogle Scholar
• Hattori, M., and Y. Sakaki. 1986. Dideoxy sequencing method using denatured plasmid templates. Anal. Biochem. 152:232–238.
   PubMed Web of Science ®Google Scholar
• Hatzopoulos, A. K., U. Schlokat, and P. Gruss. 1988. Enhancers and other eri-acting regulatory sequences, p. 43–96. In B. D. Hames and D. M. Glover (ed.), Transcription and splicing. IRL Press, Oxford.
   Google Scholar
• Hayashi, S., K. Goto, T. S. Okada, and H. Kondoh. 1987. Lens-specific enhancer in the third intron regulates expression of the chicken δΐ-crystallin gene. Genes Dev. 1:818–828.
   PubMed Web of Science ®Google Scholar
• Heard, J.-M., P. Herbomel, M.-O. Ott, A. Mottura-Rollier, M. Weiss, and M. Yaniv. 1987. Determinants of rat albumin promoter tissue specificity analyzed by an improved transient expression system. Mol. Cell. Biol. 7:2425–2434.
   PubMedGoogle Scholar
• Herbomel, P., B. Bourachot, and M. Yaniv. 1984. Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma. Cell 39:653–662.
   PubMed Web of Science ®Google Scholar
• Herbst, R. S., N. Friedman, J. E. Darnell, Jr., and L. E. Babiss. 1989. Positive and negative regulatory elements in the mouse albumin enhancer. Proc. Natl. Acad. Sci. USA 86:1553–1557.
   PubMed Web of Science ®Google Scholar
• Howell, B. W., M. Lagace, and G. C. Shore. 1989. Activity of the carbamyl phosphate synthetase I promoter in liver nuclear extracts is dependent on a cis-acting C/EBP recognition element. Mol. Cell. Biol. 9:2928–2933.
   PubMedGoogle Scholar
• Johnson, P. F., W. H. Landschulz, B. J. Graves, and S. L. Mcknight. 1987. Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. Genes Dev. 1:133–146.
   PubMed Web of Science ®Google Scholar
• Laimins, L. A., G. Khoury, C. Gorman, B. Howard, and P. Gruss. 1982. Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus. Proc. Natl. Acad. Sci. USA 79:6453–6457.
   PubMed Web of Science ®Google Scholar
• Landschulz, W. Η., P. F. Johnson, E. Y. Adashi, B. J. Graves, and S. L. Mcknight. 1988. Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev. 2:786–800.
   PubMed Web of Science ®Google Scholar
• Landschulz, W. Η., P. F. Johnson, and S. L. Mcknight. 1988. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240:1759–1764.
   PubMed Web of Science ®Google Scholar
• Lenardo, M., J. W. Pierce, and D. Baltimore. 1987. Proteinbinding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science 236:1573–1577.
   PubMed Web of Science ®Google Scholar
• Li, Y., R. Shen, S. Y. Tsai, and S. L. C. Woo. 1988. Multiple hepatic -acting factors are required for in vitro transcription of the human alpha-l-antitrypsin gene. Mol. Cell. Biol. 8:4362–4369.
   PubMedGoogle Scholar
• Lichtsteiner, S., and U. Schibler. 1989. A glycosylated liverspecific transcription factor stimulates transcription of the albumin gene. Cell 57:1179–1187.
   PubMed Web of Science ®Google Scholar
• Lichtsteiner, S., J. Wuarin, and U. Schibler. 1987. The interplay of DNA-binding proteins on the promoter of the mouse albumin gene. Cell 51:963–973.
   PubMed Web of Science ®Google Scholar
• Lindgren, V., B. De Martinville, A. L. Horwich, L. E. Rosenberg, and U. Francke. 1984. Human ornithine transcarbamylase locus mapped to band Xp21.1 near the Duchenne muscular dystrophy locus. Science 226:698–700.
   PubMedGoogle Scholar
• Miyazaki, J., S. Takaki, K. Araki, F. Tashiro, A. Tominaga, K. Takatsu, and K. Yamamura. 1989. Expression vector system based on the chicken β-actin promoter directs efficient production of interleukin-5. Gene 79:269–277.
   PubMedGoogle Scholar
• Molne, M., C. Houart, J. Szpirer, and C. Szpirer. 1989. Combinatorial control of positive and negative, upstream and intragenic regulatory DNA domains of the mouse alpha-fetoprotein gene. Nucleic Acids Res. 17:3447–3457.
   PubMedGoogle Scholar
• Monaci, P., A. Nicosia, and R. Cortese. 1988. Two different liver-specific factors stimulate in vitro transcription from the human α1-antitrypsin promoter. EMBO J. 7:2075–2087.
   PubMedGoogle Scholar
• Morris, S. M., Jr., D. M. Kepka, W. E. Sweeney, Jr., and E. D. Avner. 1989. Abundance of mRNAs encoding urea cycle enzymes in fetal and neonatal mouse liver. Arch. Biochem. Biophys. 269:175–180.
   PubMedGoogle Scholar
• Muglia, L., and L. B. Rothman-Denes. 1986. Cell type-specific negative regulatory element in the control region of the rat α-fetoprotein gene. Proc. Natl. Acad. Sci. USA 83:7653–7657.
   PubMed Web of Science ®Google Scholar
• Mullins, L. J., G. Veres, C. T. Caskey, and V. Chapman. 1987. Differential methylation of the ornithine carbamoyl transferase gene on active and inactive mouse X chromosomes. Mol. Cell. Biol. 7:3916–3922.
   PubMedGoogle Scholar
• Murakami, T., M. Takiguchi, T. Imomoto, K. Yamamura, and M. Mori. 1989. Tissue- and developmental stage-specific expression of the rat ornithine carbamoyltransferase gene in transgenic mice. Dev. Genet. 10:393–401.
   PubMedGoogle Scholar
• Pinkert, C. A., D. M. Ornitz, R. L. Brinster, and R. D. Palmiter. 1987. An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev. 1:268–276.
   PubMed Web of Science ®Google Scholar
• Reue, K., T. Leff, and J. L. Breslow. 1988. Human apolipoprotein CI11 gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors. J. Biol. Chem. 263:6857–6864.
   PubMed Web of Science ®Google Scholar
• Ryall, J., M. Nguyen, M. Bendayan, and G. C. Shore. 1985. Expression of nuclear genes encoding the urea cycle enzymes, carbamoyl-phosphate synthetase I and ornithine carbamoyl transferase, in rat liver and intestinal mucosa. Eur. J. Biochem. 152:287–292.
   PubMedGoogle Scholar
• Ryall, J. C., M. A. Quantz, and G. C. Shore. 1986. Rat liver and intestinal mucosa differ in the developmental pattern and hormonal regulation of carbamoyl-phosphate synthetase I and ornithine carbamoyl transferase gene expression. Eur. J. Biochem. 156:453–458.
   PubMedGoogle Scholar
• Sanger, F., S. Nicklen, and A. G. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463–5467.
   PubMed Web of Science ®Google Scholar
• Sawadaishi, K., T. Morinaga, and T. Tamaoki. 1988. Interaction of a hepatoma-specific nuclear factor with transcription-regulatory sequences of the human α-fetoprotein and albumin genes. Mol. Cell. Biol. 8:5179–5187.
   PubMedGoogle Scholar
• Scherer, S. E., G. Veres, and C. T. Caskey. 1988. The genetic structure of mouse ornithine transcarbamylase. Nucleic Acids Res. 16:1593–1601.
   PubMedGoogle Scholar
• Schorpp, M., W. Kugler, U. Wagner, and G. U. Ryffel. 1988. Hepatocyte-specific promoter element HP1 of the Xenopus albumin gene interacts with transcriptional factors of mammalian hepatocytes. J. Mol. Biol. 202:307–320.
   PubMedGoogle Scholar
• Shaul, Y., and R. Ben-Levy. 1987. Multiple nuclear proteins in liver cells are bound to hepatitis B virus enhancer element and its upstream sequences. EMBO J. 6:1913–1920.
   PubMedGoogle Scholar
• Takiguchi, Μ., T. Murakami, S. Miura, and M. Mori. 1987. Structure of the rat ornithine carbamoyltransferase gene, a large, X chromosome-linked gene with an atypical promoter. Proc. Natl. Acad. Sci. USA 84:6136–6140.
   PubMedGoogle Scholar
• Tsai, S. Y., I. Sagami, H. Wang, M. Tsai, and B. W. O'Malley. 1987. Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II). Cell 50:701–709.
   PubMedGoogle Scholar
• Veres, G., W. J. Craigen, and C. T. Caskey. 1986. The 5' flanking region of the ornithine transcarbamylase gene contains DNA sequences regulating tissue-specific expression. J. Biol. Chem. 261:7588–7591.
   PubMedGoogle Scholar
• Wang, L., S. P. Tsai, I. Sagami, M. Tsai, and B. W. O'Malley. 1987. Purification and characterization of chicken ovalbumin upstream promoter transcription factor from HeLa cells. J. Biol. Chem. 262:16080–16086.
   PubMedGoogle Scholar
• Weiher, Η., M. Konig, and P. Gruss. 1983. Multiple point mutations affecting the simian virus 40 enhancer. Science 219:626–631.
   PubMed Web of Science ®Google Scholar
• Widen, S. G., and J. Papaconstantinou. 1986. Liver-specific expression of the mouse α-fetoprotein gene is mediated by cis-acting DNA elements. Proc. Natl. Acad. Sci. USA 83:8196–8200.
   PubMed Web of Science ®Google Scholar
• Wijnholds, J., J. N. J. Philipsen, and G. Ab. 1988. Tissuespecific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo. EMBO J. 7:2757–2763.
   PubMedGoogle Scholar
• Wraight, C., K. Lingelbach, and N. Hoogenraad. 1985. Compar ison of ornithine transcarbamylase from rat liver and intestine: evidence for differential regulation of enzyme levels. Eur. J. Biochem. 153:239–242.
   PubMedGoogle Scholar
• Xanthopoulos, K. G., J. Mirkovitch, T. Decker, C. F. Kuo, and J. E. Darnell, Jr. 1989. Cell-specific transcriptional control of the mouse DNA-binding protein mC/EBP. Proc. Natl. Acad. Sci. USA 86:4117–4121.
   PubMedGoogle Scholar