Two Members of the Mouse mdr Gene Family Confer Multidrug Resistance with Overlapping but Distinct Drug Specificities

Literature Cited

• Ames, G. F.-L. 1986. Bacterial periplasmic transport systems: structure, mechanism and evolution. Annu. Rev. Biochem. 55:397–425.
   PubMed Web of Science ®Google Scholar
• Arceci, R. J., J. M. Croop, S. B. Horwitz, and D. Housman. 1988. The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. Proc. Natl. Acad. Sci. USA 85:4350–4354.
   PubMed Web of Science ®Google Scholar
• Cangelosi, G. A., G. Martinetti, J. A. Leigh, C. C. Lee, C. Theines, and E. W. Nester. 1989. Role of Agrobacterium tume- faciens ChvA protein in export of p-l,2-glucan. J. Bacteriol. 171:1609–1615.
   PubMed Web of Science ®Google Scholar
• Chen, C., J. E. Chin, K. Ueda, D. P. Clark, I. Pastan, M. M. Gottesman, and I. B. Roninson. 1986. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47:381–389.
   PubMed Web of Science ®Google Scholar
• Choi, K., C. Chen, M. Kriegler, and I. B. Roninson. 1988. An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene. Cell 53:519–529.
   PubMed Web of Science ®Google Scholar
• Conter, V., and W. T. Beck. 1984. Acquisition of multiple drug resistance by CCRF-CEM cells selected for different degrees of resistance to vincristine. Cancer Treat. Rep. 68:831–839.
   PubMedGoogle Scholar
• Cornwell, M. M., A. R. Safa, R. Felsted, M. M. Gottesman, and I. Pastan. 1986. Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150-170 kDa protein detected by photoaffinity labelling. Proc. Natl. Acad. Sci. USA 83:3847–3850.
   PubMed Web of Science ®Google Scholar
• Cornwell, M. M., T. Tsuruo, M. M. Gottesman, and I. Pastan. 1987. ATP-binding properties of P-glycoprotein from multidrugresistant KB cells. FASEB J. 1:51–54.
   PubMed Web of Science ®Google Scholar
• Croop, J. M., M. Raymond, D. Haber, A. Devault, R. J. Arceci, P. Gros, and D. E. Housman. 1988. The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol. Cell. Biol. 9:1346–1350.
   Google Scholar
• Dano, K. 1973. Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells. Biochim. Biophys. Acta 323:466–483.
   PubMed Web of Science ®Google Scholar
• Endicott, J. A., P. F. Juranka, F. Sarangi, J. H. Gerlach, K. L. Deuchars, and V. Ling. 1987. Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells. Mol. Cell. Biol. 7:4075–4081.
   PubMedGoogle Scholar
• Endicott, J. A., and V. Ling. 1989. The biochemistry of P- glycoprotein-mediated multidrug resistance. Annu. Rev. Biochem. 58:137–171.
   PubMed Web of Science ®Google Scholar
• Felmlee, T., S. Pellett, and R. A. Welch. 1985. Nucleotide sequence of an Escherichia coli chromosomal hemolysin. J. Bacteriol. 163:94–105.
   PubMed Web of Science ®Google Scholar
• Fojo, A., S. Akiyama, M. M. Gottesman, and I. Pastan. 1985. Reduced drug accumulation in multiple drug-resistant human KB carcinoma cell lines. Cancer Res. 45:3002–3007.
   PubMed Web of Science ®Google Scholar
• Foote, S. J., J. K. Thompson, A. F. Cowman, and D. J. Kemp. 1989. Amplification of the multidrug-resistance gene in some chloroquine-resistant isolates of P. falciparum. Cell 57:921–930.
   PubMed Web of Science ®Google Scholar
• Furie, N., D. H. Bing, R. J. Feldmann, D. J. Robison, J. P. Burnier, and B. C. Furie. 1982. Computer-generated models of blood coagulation factor Xa, factor lXa, and thrombin based upon structural homology with other serine proteases. J. Biol. Chem. 257:3875–3882.
   PubMedGoogle Scholar
• Gerlach, J. H., N. Kartner, D. R. Bell, and V. Ling. 1986. Multidrug resistance. Cancer Surv. 5:25–46.
   PubMedGoogle Scholar
• Glaser, P., H. Sakamoto, J. Bellalou, A. Ullmann, and A. Danchin. 1988. Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-heamolysin bifunctional protein of Borde- ttella pertussis. EMBO J. 7:3997–4004.
   PubMedGoogle Scholar
• Gonzales, F. J. 1989. The molecular biology of cytochrome P450s. Pharmacol. Rev. 40:243–288.
   Web of Science ®Google Scholar
• Gros, P., Y. Ben Neriah, J. Croop, and D. Housman. 1986. Isolation and expression of a complementary DNA that confers multidrug resistance. Nature (London) 323:728–731.
   PubMed Web of Science ®Google Scholar
• Gros, P., J. M. Croop, and D. Housman. 1986. Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47:371–380.
   PubMed Web of Science ®Google Scholar
• Gros, P., M. Raymond, J. Bell, and D. Housman. 1988. Cloning and characterization of a second member of the mouse mdr gene family. Mol. Cell. Biol. 8:2770–2778.
   PubMed Web of Science ®Google Scholar
• Gubler, U., and B. J. Hoffman. 1983. A simple and very efficient method of generating cDNA libraries. Gene 25:263–269.
   PubMed Web of Science ®Google Scholar
• Hammond, J., R. M. Johnstone, and P. Gros. 1989. Enhanced efflux of [3H]vinblastine from Chinese hamster ovary cells transfected with a full length complementary DNA clone for the mdrl gene. Cancer Res. 49:3867–3871.
   PubMed Web of Science ®Google Scholar
• Hsu, S. I. H., L. Lothstein, and S. B. Horwitz. 1989. Differential overexpression of three mdr gene family members in multidrug resistant J774-2 mouse cells. Evidence that distinct P-glycopro- tein precursors are encoded by unique mdr genes. J. Biol. Chem. 264:12053–12062.
   PubMed Web of Science ®Google Scholar
• Kartner, N., D. Evernden-Porcelle, G. Bradley, and V. Ling. 1985. Detection of P-glycoprotein in multidrug resistant cell lines by monoclonal antibodies. Nature (London) 316:820–823.
   PubMed Web of Science ®Google Scholar
• Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680–685.
   PubMed Web of Science ®Google Scholar
• Lindberg, R. L. P., and M. Negishi. 1989. Alteration of mouse cytochrome P450 substrate specificity by mutation of a single amino-acid residue. Nature (London) 339:632–634.
   PubMed Web of Science ®Google Scholar
• Ling, V., and L. H. Thompson. 1974. Reduced permeability in CHO cells as a mechanism of resistance to colchicine. J. Cell. Physiol. 83:103–116.
   PubMed Web of Science ®Google Scholar
• Lothstein, L., S. I. H. Hsu, S. B. Horwitz, and L. Greenberger. 1989. Alternate overexpression of two phosphoglycoprotein genes is associated with changes in multidrug resistance in a J774.2 cell line. J. Biol. Chem. 264:16054.
   PubMed Web of Science ®Google Scholar
• Maxam, A. M., and W. Gilbert. 1977. A new method for sequencing DNA. Proc. Natl. Acad. Sci. USA 74:560–564.
   PubMed Web of Science ®Google Scholar
• McGrath, J. P., and A. Varshavsky. 1989. The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein. Nature (London) 340:400–404.
   PubMed Web of Science ®Google Scholar
• Moscow, J. A., and K. H. Cowan. 1988. Multidrug resistance. J. Natl. Cancer Inst. 80:14–20.
   PubMed Web of Science ®Google Scholar
• Ng, W. F., F. Sarangi, R. K. Zastawny, L. Veinot-Drebot, and V. Ling. 1989. Identification of members of the P-glycoprotein multigene family. Mol. Cell. Biol. 9:1224–1232.
   PubMed Web of Science ®Google Scholar
• Pollard, J. W., and C. P. Stanners. 1979. Characterization of cells lines showing growth control isolated from both the wild type and a leucyl-tRNA synthetase mutant of Chinese hamster ovary cells. J. Cell. Physiol. 98:571–585.
   PubMed Web of Science ®Google Scholar
• Rappolee, D. A., D. Mark, M. J. Banda, and Z. Werb. 1988. Wound macrophages express TGF-α and other growth factors in vivo: analysis by mRNA phenotyping. Science 241:708–712.
   PubMed Web of Science ®Google Scholar
• Raymond, M., and P. Gros. 1989. Mammalian multidrug-resistance gene: correlation of exon organization with structural domains and duplication of an ancestral gene. Proc. Natl. Acad. Sci. USA 86:64–88.
   Google Scholar
• Raymond, M., E. Rose, D. E. Housman, and P. Gros. 1990. Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells. Mol. Cell. Biol. 10:1642–1650.
   PubMed Web of Science ®Google Scholar
• Safa, A. R., C. J. Glover, M. B. Meyers, J. L. Biedler, and R. L. Felsted. 1986. Vinblastine photoaffinity labelling of a high molecular weight surface membrane glycoprotein specific for multidrug resistant cells. J. Biol. Chem. 261:6137–6140.
   PubMed Web of Science ®Google Scholar
• Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain termination inhibitors. Proc. Natl. Acad. Sci. USA 74:5463–5467.
   PubMed Web of Science ®Google Scholar
• Schurr, E., M. Raymond, J. Bell, and P. Gros. 1989. Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdr1 cDNA. Cancer Res. 49:2729–2734.
   PubMed Web of Science ®Google Scholar
• Scotto, K. W., J. L. Biedler, and P. W. Melera. 1986. Amplifi cation and expression of gene associated with multidrug resistance in mammalian cells. Science 232:751–755.
   PubMed Web of Science ®Google Scholar
• Stanfield, S. W., L. Ielpi, D. O'Brochta, D. R. Helinski, and G. S. Ditta. 1988. The ndvA gene product of Rhizobium meliloti is required for β-(1→2)-glucan production and has homology to the ATP-binding export protein HlyB. J. Bacteriol. 170:3523–3530.
   PubMed Web of Science ®Google Scholar
• Strathdee, C. A., and R. Y. C. Lo. 1989. Cloning, nucleotide sequence, and characterization of gene encoding the secretion function of Pasteurella haemolytica leukotoxin determinant. J. Bacteriol. 171:916–928.
   PubMedGoogle Scholar
• Towbin, Β., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350–4354.
   PubMed Web of Science ®Google Scholar
• Tsuruo, T., H. Iida, E. Ohkochi, S. Tsukagoshi, and K. Sakurai. 1983. Establishment and properties of vincristine-resistant human myelogenous leukemia K562. Gann 74:751–758.
   PubMedGoogle Scholar
• Ueda, K., C. Cardarelli, M. M. Gottesman, and I. Pastan. 1987. Expression of a full-length cDNA clone for the human "MDR1" gene confers resistance to colchicine, doxorubicin and vinblastine. Proc. Natl. Acad. Sci. USA 84:3004–3008.
   PubMed Web of Science ®Google Scholar
• Van Der Bliek, A. M., F. Bass, T. Ten Houte de Lange, P. M. Kooiman, T. Van Der Velde-Koerts, and P. Borst. 1987. The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver. EMBO J. 6:3325–3331.
   PubMed Web of Science ®Google Scholar
• Wigler, M., A. Pellicer, S. Silverstein, R. Axel, G. Urlaub, and L. Chasin. 1979. DNA-mediated transfer of the adenine phospho-rybosyltransferase locus into mammalian cells. Proc. Natl. Acad. Sci. USA 76:1373–1376.
   PubMed Web of Science ®Google Scholar
• Wong, G. G., J. S. Witek, P. A. Temple, K. M. Wilkens, A. C. Leary, D. P. Luxenberg, S. S. Jones, E. L. Brown, R. M. Kay, E. C. Orr, C. Shoemaker, D. W. Golde, R. J. Kaufman, R. M. Hewick, E. A. Wang, and S. C. Clark. 1985. Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins. Science 228:810–815.
   PubMed Web of Science ®Google Scholar